Amino acid dipepetide frequency for Acetobacterium bakii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.118AlaAla: 6.118 ± 0.117	1.04AlaCys: 1.04 ± 0.036	3.884AlaAsp: 3.884 ± 0.065	4.429AlaGlu: 4.429 ± 0.067	3.474AlaPhe: 3.474 ± 0.067	5.371AlaGly: 5.371 ± 0.094	1.074AlaHis: 1.074 ± 0.029	6.375AlaIle: 6.375 ± 0.078	4.511AlaLys: 4.511 ± 0.08	7.607AlaLeu: 7.607 ± 0.093	2.484AlaMet: 2.484 ± 0.052	2.904AlaAsn: 2.904 ± 0.06	1.957AlaPro: 1.957 ± 0.043	2.267AlaGln: 2.267 ± 0.05	2.49AlaArg: 2.49 ± 0.052	3.81AlaSer: 3.81 ± 0.062	3.706AlaThr: 3.706 ± 0.071	5.528AlaVal: 5.528 ± 0.089	0.513AlaTrp: 0.513 ± 0.02	2.462AlaTyr: 2.462 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.827CysAla: 0.827 ± 0.027	0.227CysCys: 0.227 ± 0.014	0.767CysAsp: 0.767 ± 0.026	0.862CysGlu: 0.862 ± 0.029	0.549CysPhe: 0.549 ± 0.023	1.282CysGly: 1.282 ± 0.041	0.298CysHis: 0.298 ± 0.018	1.038CysIle: 1.038 ± 0.033	0.716CysLys: 0.716 ± 0.024	1.085CysLeu: 1.085 ± 0.034	0.345CysMet: 0.345 ± 0.018	0.539CysAsn: 0.539 ± 0.023	0.659CysPro: 0.659 ± 0.028	0.399CysGln: 0.399 ± 0.02	0.515CysArg: 0.515 ± 0.024	0.743CysSer: 0.743 ± 0.024	0.669CysThr: 0.669 ± 0.028	0.82CysVal: 0.82 ± 0.031	0.072CysTrp: 0.072 ± 0.008	0.445CysTyr: 0.445 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.017AspAla: 4.017 ± 0.079	0.755AspCys: 0.755 ± 0.027	2.923AspAsp: 2.923 ± 0.053	4.101AspGlu: 4.101 ± 0.074	2.905AspPhe: 2.905 ± 0.055	3.565AspGly: 3.565 ± 0.068	1.073AspHis: 1.073 ± 0.032	4.935AspIle: 4.935 ± 0.075	3.274AspLys: 3.274 ± 0.062	5.394AspLeu: 5.394 ± 0.075	1.596AspMet: 1.596 ± 0.041	2.328AspAsn: 2.328 ± 0.044	2.086AspPro: 2.086 ± 0.047	1.907AspGln: 1.907 ± 0.043	2.036AspArg: 2.036 ± 0.045	2.708AspSer: 2.708 ± 0.049	2.764AspThr: 2.764 ± 0.051	3.788AspVal: 3.788 ± 0.061	0.543AspTrp: 0.543 ± 0.024	2.7AspTyr: 2.7 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	5.279GluAla: 5.279 ± 0.072	0.697GluCys: 0.697 ± 0.025	3.595GluAsp: 3.595 ± 0.052	5.175GluGlu: 5.175 ± 0.098	2.438GluPhe: 2.438 ± 0.047	3.862GluGly: 3.862 ± 0.069	1.082GluHis: 1.082 ± 0.031	6.581GluIle: 6.581 ± 0.088	6.701GluLys: 6.701 ± 0.094	6.566GluLeu: 6.566 ± 0.088	2.389GluMet: 2.389 ± 0.053	4.262GluAsn: 4.262 ± 0.058	1.829GluPro: 1.829 ± 0.047	2.05GluGln: 2.05 ± 0.045	2.553GluArg: 2.553 ± 0.06	3.615GluSer: 3.615 ± 0.056	3.839GluThr: 3.839 ± 0.064	4.376GluVal: 4.376 ± 0.06	0.501GluTrp: 0.501 ± 0.019	2.29GluTyr: 2.29 ± 0.056	0.0GluXaa: 0.0 ± 0.0
Phe	2.91PheAla: 2.91 ± 0.053	0.644PheCys: 0.644 ± 0.026	2.623PheAsp: 2.623 ± 0.048	2.928PheGlu: 2.928 ± 0.052	2.19PhePhe: 2.19 ± 0.05	3.394PheGly: 3.394 ± 0.061	0.715PheHis: 0.715 ± 0.025	3.846PheIle: 3.846 ± 0.069	2.706PheLys: 2.706 ± 0.057	4.107PheLeu: 4.107 ± 0.082	1.303PheMet: 1.303 ± 0.039	2.175PheAsn: 2.175 ± 0.048	1.429PhePro: 1.429 ± 0.042	1.285PheGln: 1.285 ± 0.034	1.364PheArg: 1.364 ± 0.036	3.305PheSer: 3.305 ± 0.057	2.504PheThr: 2.504 ± 0.046	2.884PheVal: 2.884 ± 0.061	0.404PheTrp: 0.404 ± 0.022	1.79PheTyr: 1.79 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	4.929GlyAla: 4.929 ± 0.09	1.159GlyCys: 1.159 ± 0.037	3.664GlyAsp: 3.664 ± 0.06	4.455GlyGlu: 4.455 ± 0.081	3.531GlyPhe: 3.531 ± 0.052	5.057GlyGly: 5.057 ± 0.089	1.187GlyHis: 1.187 ± 0.033	6.93GlyIle: 6.93 ± 0.092	5.071GlyLys: 5.071 ± 0.084	6.843GlyLeu: 6.843 ± 0.093	2.255GlyMet: 2.255 ± 0.047	3.128GlyAsn: 3.128 ± 0.061	1.564GlyPro: 1.564 ± 0.044	2.028GlyGln: 2.028 ± 0.046	2.581GlyArg: 2.581 ± 0.06	4.185GlySer: 4.185 ± 0.07	4.065GlyThr: 4.065 ± 0.076	5.159GlyVal: 5.159 ± 0.075	0.647GlyTrp: 0.647 ± 0.033	2.929GlyTyr: 2.929 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	0.983HisAla: 0.983 ± 0.029	0.276HisCys: 0.276 ± 0.017	0.913HisAsp: 0.913 ± 0.025	1.057HisGlu: 1.057 ± 0.032	0.862HisPhe: 0.862 ± 0.029	1.278HisGly: 1.278 ± 0.034	0.508HisHis: 0.508 ± 0.026	1.318HisIle: 1.318 ± 0.039	0.892HisLys: 0.892 ± 0.029	1.587HisLeu: 1.587 ± 0.039	0.441HisMet: 0.441 ± 0.02	0.716HisAsn: 0.716 ± 0.028	0.868HisPro: 0.868 ± 0.028	0.713HisGln: 0.713 ± 0.024	0.738HisArg: 0.738 ± 0.026	1.017HisSer: 1.017 ± 0.032	0.795HisThr: 0.795 ± 0.029	1.016HisVal: 1.016 ± 0.03	0.155HisTrp: 0.155 ± 0.012	0.745HisTyr: 0.745 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.477IleAla: 6.477 ± 0.077	1.101IleCys: 1.101 ± 0.033	5.032IleAsp: 5.032 ± 0.077	5.99IleGlu: 5.99 ± 0.074	3.888IlePhe: 3.888 ± 0.078	6.281IleGly: 6.281 ± 0.089	1.429IleHis: 1.429 ± 0.037	7.557IleIle: 7.557 ± 0.11	5.952IleLys: 5.952 ± 0.087	8.177IleLeu: 8.177 ± 0.116	2.355IleMet: 2.355 ± 0.054	4.342IleAsn: 4.342 ± 0.075	3.59IlePro: 3.59 ± 0.06	2.593IleGln: 2.593 ± 0.051	3.234IleArg: 3.234 ± 0.058	5.526IleSer: 5.526 ± 0.092	4.958IleThr: 4.958 ± 0.071	5.467IleVal: 5.467 ± 0.074	0.527IleTrp: 0.527 ± 0.022	2.787IleTyr: 2.787 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	4.966LysAla: 4.966 ± 0.075	0.678LysCys: 0.678 ± 0.028	3.868LysAsp: 3.868 ± 0.057	5.801LysGlu: 5.801 ± 0.089	2.037LysPhe: 2.037 ± 0.053	4.179LysGly: 4.179 ± 0.062	1.052LysHis: 1.052 ± 0.035	6.296LysIle: 6.296 ± 0.082	6.343LysLys: 6.343 ± 0.108	5.594LysLeu: 5.594 ± 0.073	2.287LysMet: 2.287 ± 0.047	4.437LysAsn: 4.437 ± 0.071	2.196LysPro: 2.196 ± 0.05	2.014LysGln: 2.014 ± 0.042	2.949LysArg: 2.949 ± 0.084	3.857LysSer: 3.857 ± 0.069	4.351LysThr: 4.351 ± 0.076	4.147LysVal: 4.147 ± 0.064	0.512LysTrp: 0.512 ± 0.021	2.508LysTyr: 2.508 ± 0.055	0.0LysXaa: 0.0 ± 0.0
Leu	7.036LeuAla: 7.036 ± 0.092	1.237LeuCys: 1.237 ± 0.034	5.24LeuAsp: 5.24 ± 0.069	6.49LeuGlu: 6.49 ± 0.094	4.288LeuPhe: 4.288 ± 0.076	6.854LeuGly: 6.854 ± 0.093	1.393LeuHis: 1.393 ± 0.035	7.868LeuIle: 7.868 ± 0.122	7.119LeuLys: 7.119 ± 0.096	8.809LeuLeu: 8.809 ± 0.112	2.897LeuMet: 2.897 ± 0.062	4.674LeuAsn: 4.674 ± 0.068	3.507LeuPro: 3.507 ± 0.064	2.433LeuGln: 2.433 ± 0.053	3.277LeuArg: 3.277 ± 0.055	6.462LeuSer: 6.462 ± 0.076	5.328LeuThr: 5.328 ± 0.074	6.059LeuVal: 6.059 ± 0.089	0.67LeuTrp: 0.67 ± 0.026	3.026LeuTyr: 3.026 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	2.531MetAla: 2.531 ± 0.048	0.274MetCys: 0.274 ± 0.016	1.922MetAsp: 1.922 ± 0.046	2.213MetGlu: 2.213 ± 0.049	0.922MetPhe: 0.922 ± 0.03	2.419MetGly: 2.419 ± 0.058	0.397MetHis: 0.397 ± 0.022	2.576MetIle: 2.576 ± 0.051	2.43MetLys: 2.43 ± 0.046	2.613MetLeu: 2.613 ± 0.057	0.918MetMet: 0.918 ± 0.031	1.66MetAsn: 1.66 ± 0.033	1.138MetPro: 1.138 ± 0.033	0.752MetGln: 0.752 ± 0.027	1.036MetArg: 1.036 ± 0.031	1.758MetSer: 1.758 ± 0.042	1.75MetThr: 1.75 ± 0.045	2.24MetVal: 2.24 ± 0.049	0.146MetTrp: 0.146 ± 0.012	0.658MetTyr: 0.658 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.394AsnAla: 3.394 ± 0.059	0.631AsnCys: 0.631 ± 0.029	2.523AsnAsp: 2.523 ± 0.054	3.231AsnGlu: 3.231 ± 0.058	1.962AsnPhe: 1.962 ± 0.043	3.409AsnGly: 3.409 ± 0.074	0.947AsnHis: 0.947 ± 0.035	4.277AsnIle: 4.277 ± 0.07	3.19AsnLys: 3.19 ± 0.059	4.542AsnLeu: 4.542 ± 0.069	1.389AsnMet: 1.389 ± 0.038	2.412AsnAsn: 2.412 ± 0.055	2.407AsnPro: 2.407 ± 0.044	1.918AsnGln: 1.918 ± 0.047	2.136AsnArg: 2.136 ± 0.047	2.456AsnSer: 2.456 ± 0.053	2.558AsnThr: 2.558 ± 0.052	2.853AsnVal: 2.853 ± 0.054	0.415AsnTrp: 0.415 ± 0.02	1.965AsnTyr: 1.965 ± 0.045	0.0AsnXaa: 0.0 ± 0.0
Pro	2.102ProAla: 2.102 ± 0.049	0.422ProCys: 0.422 ± 0.02	2.222ProAsp: 2.222 ± 0.046	3.171ProGlu: 3.171 ± 0.058	1.682ProPhe: 1.682 ± 0.044	2.604ProGly: 2.604 ± 0.06	0.652ProHis: 0.652 ± 0.024	2.844ProIle: 2.844 ± 0.051	2.096ProLys: 2.096 ± 0.047	3.166ProLeu: 3.166 ± 0.055	1.007ProMet: 1.007 ± 0.032	1.451ProAsn: 1.451 ± 0.041	0.872ProPro: 0.872 ± 0.03	1.113ProGln: 1.113 ± 0.031	1.07ProArg: 1.07 ± 0.032	1.754ProSer: 1.754 ± 0.042	1.86ProThr: 1.86 ± 0.043	2.713ProVal: 2.713 ± 0.049	0.319ProTrp: 0.319 ± 0.017	1.269ProTyr: 1.269 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	2.242GlnAla: 2.242 ± 0.049	0.402GlnCys: 0.402 ± 0.02	1.435GlnAsp: 1.435 ± 0.038	2.255GlnGlu: 2.255 ± 0.05	1.201GlnPhe: 1.201 ± 0.033	2.246GlnGly: 2.246 ± 0.049	0.527GlnHis: 0.527 ± 0.025	2.584GlnIle: 2.584 ± 0.05	2.422GlnLys: 2.422 ± 0.045	2.982GlnLeu: 2.982 ± 0.056	0.985GlnMet: 0.985 ± 0.029	1.654GlnAsn: 1.654 ± 0.042	0.887GlnPro: 0.887 ± 0.029	1.034GlnGln: 1.034 ± 0.033	1.305GlnArg: 1.305 ± 0.035	1.804GlnSer: 1.804 ± 0.044	1.731GlnThr: 1.731 ± 0.04	1.887GlnVal: 1.887 ± 0.047	0.34GlnTrp: 0.34 ± 0.018	1.066GlnTyr: 1.066 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.201ArgAla: 2.201 ± 0.051	0.477ArgCys: 0.477 ± 0.022	2.106ArgAsp: 2.106 ± 0.046	2.946ArgGlu: 2.946 ± 0.06	1.711ArgPhe: 1.711 ± 0.041	2.352ArgGly: 2.352 ± 0.074	0.669ArgHis: 0.669 ± 0.025	3.45ArgIle: 3.45 ± 0.058	2.874ArgLys: 2.874 ± 0.079	3.51ArgLeu: 3.51 ± 0.06	1.143ArgMet: 1.143 ± 0.034	1.865ArgAsn: 1.865 ± 0.038	1.12ArgPro: 1.12 ± 0.038	1.274ArgGln: 1.274 ± 0.037	1.627ArgArg: 1.627 ± 0.091	2.012ArgSer: 2.012 ± 0.04	1.813ArgThr: 1.813 ± 0.04	2.357ArgVal: 2.357 ± 0.048	0.285ArgTrp: 0.285 ± 0.017	1.382ArgTyr: 1.382 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	3.81SerAla: 3.81 ± 0.067	0.702SerCys: 0.702 ± 0.026	3.22SerAsp: 3.22 ± 0.057	3.822SerGlu: 3.822 ± 0.061	2.963SerPhe: 2.963 ± 0.058	4.789SerGly: 4.789 ± 0.085	1.038SerHis: 1.038 ± 0.031	4.971SerIle: 4.971 ± 0.078	3.532SerLys: 3.532 ± 0.062	5.564SerLeu: 5.564 ± 0.083	1.844SerMet: 1.844 ± 0.042	2.524SerAsn: 2.524 ± 0.061	1.996SerPro: 1.996 ± 0.042	2.022SerGln: 2.022 ± 0.046	2.285SerArg: 2.285 ± 0.046	3.262SerSer: 3.262 ± 0.062	2.944SerThr: 2.944 ± 0.059	4.029SerVal: 4.029 ± 0.071	0.493SerTrp: 0.493 ± 0.025	2.076SerTyr: 2.076 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	4.45ThrAla: 4.45 ± 0.095	0.613ThrCys: 0.613 ± 0.023	2.919ThrAsp: 2.919 ± 0.052	3.34ThrGlu: 3.34 ± 0.053	2.249ThrPhe: 2.249 ± 0.051	4.726ThrGly: 4.726 ± 0.071	0.918ThrHis: 0.918 ± 0.031	4.808ThrIle: 4.808 ± 0.069	3.244ThrLys: 3.244 ± 0.062	5.373ThrLeu: 5.373 ± 0.071	1.531ThrMet: 1.531 ± 0.034	2.398ThrAsn: 2.398 ± 0.057	2.375ThrPro: 2.375 ± 0.046	1.713ThrGln: 1.713 ± 0.05	1.906ThrArg: 1.906 ± 0.044	2.903ThrSer: 2.903 ± 0.056	3.274ThrThr: 3.274 ± 0.093	4.079ThrVal: 4.079 ± 0.078	0.442ThrTrp: 0.442 ± 0.02	1.899ThrTyr: 1.899 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	4.858ValAla: 4.858 ± 0.077	0.889ValCys: 0.889 ± 0.029	3.847ValAsp: 3.847 ± 0.059	4.327ValGlu: 4.327 ± 0.07	3.349ValPhe: 3.349 ± 0.064	4.504ValGly: 4.504 ± 0.078	1.032ValHis: 1.032 ± 0.036	5.816ValIle: 5.816 ± 0.08	4.442ValLys: 4.442 ± 0.067	6.73ValLeu: 6.73 ± 0.096	2.074ValMet: 2.074 ± 0.039	3.037ValAsn: 3.037 ± 0.054	2.289ValPro: 2.289 ± 0.045	1.728ValGln: 1.728 ± 0.038	2.211ValArg: 2.211 ± 0.043	4.207ValSer: 4.207 ± 0.077	3.971ValThr: 3.971 ± 0.082	4.935ValVal: 4.935 ± 0.078	0.455ValTrp: 0.455 ± 0.021	2.215ValTyr: 2.215 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.503TrpAla: 0.503 ± 0.026	0.11TrpCys: 0.11 ± 0.011	0.472TrpAsp: 0.472 ± 0.021	0.56TrpGlu: 0.56 ± 0.023	0.414TrpPhe: 0.414 ± 0.023	0.579TrpGly: 0.579 ± 0.023	0.151TrpHis: 0.151 ± 0.014	0.618TrpIle: 0.618 ± 0.026	0.484TrpLys: 0.484 ± 0.02	0.817TrpLeu: 0.817 ± 0.031	0.257TrpMet: 0.257 ± 0.017	0.386TrpAsn: 0.386 ± 0.019	0.21TrpPro: 0.21 ± 0.014	0.3TrpGln: 0.3 ± 0.018	0.279TrpArg: 0.279 ± 0.017	0.423TrpSer: 0.423 ± 0.021	0.396TrpThr: 0.396 ± 0.027	0.494TrpVal: 0.494 ± 0.022	0.087TrpTrp: 0.087 ± 0.009	0.294TrpTyr: 0.294 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.37TyrAla: 2.37 ± 0.052	0.523TyrCys: 0.523 ± 0.025	2.223TyrAsp: 2.223 ± 0.047	2.529TyrGlu: 2.529 ± 0.046	1.893TyrPhe: 1.893 ± 0.051	2.615TyrGly: 2.615 ± 0.049	0.735TyrHis: 0.735 ± 0.027	2.574TyrIle: 2.574 ± 0.057	2.074TyrLys: 2.074 ± 0.047	3.599TyrLeu: 3.599 ± 0.073	0.85TyrMet: 0.85 ± 0.036	1.728TyrAsn: 1.728 ± 0.042	1.41TyrPro: 1.41 ± 0.038	1.445TyrGln: 1.445 ± 0.04	1.584TyrArg: 1.584 ± 0.033	2.078TyrSer: 2.078 ± 0.048	1.886TyrThr: 1.886 ± 0.057	2.085TyrVal: 2.085 ± 0.049	0.307TyrTrp: 0.307 ± 0.019	1.478TyrTyr: 1.478 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3495 proteins (1076816 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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