Amino acid dipepetide frequency for Acetivibrio ethanolgignens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.659AlaAla: 6.659 ± 0.096	1.021AlaCys: 1.021 ± 0.03	4.024AlaAsp: 4.024 ± 0.067	5.498AlaGlu: 5.498 ± 0.086	3.013AlaPhe: 3.013 ± 0.065	5.598AlaGly: 5.598 ± 0.092	0.911AlaHis: 0.911 ± 0.03	5.137AlaIle: 5.137 ± 0.082	4.983AlaLys: 4.983 ± 0.088	6.599AlaLeu: 6.599 ± 0.086	2.215AlaMet: 2.215 ± 0.053	2.547AlaAsn: 2.547 ± 0.046	1.865AlaPro: 1.865 ± 0.049	1.94AlaGln: 1.94 ± 0.045	2.908AlaArg: 2.908 ± 0.047	3.753AlaSer: 3.753 ± 0.069	3.266AlaThr: 3.266 ± 0.071	5.922AlaVal: 5.922 ± 0.082	0.547AlaTrp: 0.547 ± 0.025	2.835AlaTyr: 2.835 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.812CysAla: 0.812 ± 0.031	0.279CysCys: 0.279 ± 0.018	0.803CysAsp: 0.803 ± 0.031	0.951CysGlu: 0.951 ± 0.032	0.663CysPhe: 0.663 ± 0.029	1.392CysGly: 1.392 ± 0.04	0.327CysHis: 0.327 ± 0.016	1.146CysIle: 1.146 ± 0.039	0.855CysLys: 0.855 ± 0.029	1.15CysLeu: 1.15 ± 0.034	0.436CysMet: 0.436 ± 0.022	0.641CysAsn: 0.641 ± 0.028	0.587CysPro: 0.587 ± 0.03	0.467CysGln: 0.467 ± 0.021	0.735CysArg: 0.735 ± 0.025	0.873CysSer: 0.873 ± 0.032	0.711CysThr: 0.711 ± 0.029	0.955CysVal: 0.955 ± 0.033	0.121CysTrp: 0.121 ± 0.011	0.59CysTyr: 0.59 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	3.547AspAla: 3.547 ± 0.068	0.799AspCys: 0.799 ± 0.033	2.585AspAsp: 2.585 ± 0.068	4.43AspGlu: 4.43 ± 0.077	2.832AspPhe: 2.832 ± 0.059	4.036AspGly: 4.036 ± 0.081	0.603AspHis: 0.603 ± 0.026	4.654AspIle: 4.654 ± 0.074	4.056AspLys: 4.056 ± 0.075	4.206AspLeu: 4.206 ± 0.071	1.742AspMet: 1.742 ± 0.039	2.296AspAsn: 2.296 ± 0.049	1.311AspPro: 1.311 ± 0.042	0.928AspGln: 0.928 ± 0.032	2.373AspArg: 2.373 ± 0.079	3.023AspSer: 3.023 ± 0.063	3.088AspThr: 3.088 ± 0.065	3.407AspVal: 3.407 ± 0.067	0.569AspTrp: 0.569 ± 0.023	2.863AspTyr: 2.863 ± 0.057	0.0AspXaa: 0.0 ± 0.0
Glu	6.195GluAla: 6.195 ± 0.087	0.881GluCys: 0.881 ± 0.031	4.325GluAsp: 4.325 ± 0.072	8.604GluGlu: 8.604 ± 0.115	2.745GluPhe: 2.745 ± 0.06	4.726GluGly: 4.726 ± 0.077	1.344GluHis: 1.344 ± 0.037	6.169GluIle: 6.169 ± 0.093	7.91GluLys: 7.91 ± 0.106	8.052GluLeu: 8.052 ± 0.101	2.303GluMet: 2.303 ± 0.051	4.359GluAsn: 4.359 ± 0.079	1.956GluPro: 1.956 ± 0.051	3.061GluGln: 3.061 ± 0.06	3.918GluArg: 3.918 ± 0.074	3.478GluSer: 3.478 ± 0.06	3.831GluThr: 3.831 ± 0.068	4.758GluVal: 4.758 ± 0.065	0.645GluTrp: 0.645 ± 0.03	3.393GluTyr: 3.393 ± 0.061	0.0GluXaa: 0.0 ± 0.0
Phe	2.74PheAla: 2.74 ± 0.058	0.769PheCys: 0.769 ± 0.022	2.516PheAsp: 2.516 ± 0.057	2.824PheGlu: 2.824 ± 0.054	1.986PhePhe: 1.986 ± 0.053	2.846PheGly: 2.846 ± 0.065	0.811PheHis: 0.811 ± 0.034	2.885PheIle: 2.885 ± 0.066	2.265PheLys: 2.265 ± 0.054	4.165PheLeu: 4.165 ± 0.089	1.21PheMet: 1.21 ± 0.035	1.614PheAsn: 1.614 ± 0.045	1.272PhePro: 1.272 ± 0.039	1.247PheGln: 1.247 ± 0.039	1.713PheArg: 1.713 ± 0.044	3.038PheSer: 3.038 ± 0.061	2.299PheThr: 2.299 ± 0.049	2.802PheVal: 2.802 ± 0.056	0.413PheTrp: 0.413 ± 0.02	1.744PheTyr: 1.744 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	4.629GlyAla: 4.629 ± 0.081	1.207GlyCys: 1.207 ± 0.036	3.25GlyAsp: 3.25 ± 0.063	4.87GlyGlu: 4.87 ± 0.072	3.022GlyPhe: 3.022 ± 0.054	4.536GlyGly: 4.536 ± 0.117	1.14GlyHis: 1.14 ± 0.038	6.178GlyIle: 6.178 ± 0.109	5.772GlyLys: 5.772 ± 0.08	5.786GlyLeu: 5.786 ± 0.087	2.211GlyMet: 2.211 ± 0.054	3.081GlyAsn: 3.081 ± 0.059	1.078GlyPro: 1.078 ± 0.036	1.947GlyGln: 1.947 ± 0.043	3.149GlyArg: 3.149 ± 0.059	4.017GlySer: 4.017 ± 0.08	3.899GlyThr: 3.899 ± 0.083	4.641GlyVal: 4.641 ± 0.077	0.61GlyTrp: 0.61 ± 0.024	3.119GlyTyr: 3.119 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	0.9HisAla: 0.9 ± 0.032	0.304HisCys: 0.304 ± 0.019	0.782HisAsp: 0.782 ± 0.032	1.034HisGlu: 1.034 ± 0.028	0.819HisPhe: 0.819 ± 0.028	1.114HisGly: 1.114 ± 0.034	0.346HisHis: 0.346 ± 0.022	1.412HisIle: 1.412 ± 0.043	0.968HisLys: 0.968 ± 0.029	1.438HisLeu: 1.438 ± 0.039	0.507HisMet: 0.507 ± 0.022	0.702HisAsn: 0.702 ± 0.028	0.752HisPro: 0.752 ± 0.03	0.526HisGln: 0.526 ± 0.026	0.774HisArg: 0.774 ± 0.027	0.967HisSer: 0.967 ± 0.03	0.899HisThr: 0.899 ± 0.031	0.822HisVal: 0.822 ± 0.028	0.162HisTrp: 0.162 ± 0.013	0.74HisTyr: 0.74 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.451IleAla: 5.451 ± 0.087	1.311IleCys: 1.311 ± 0.042	4.172IleAsp: 4.172 ± 0.07	5.667IleGlu: 5.667 ± 0.078	2.967IlePhe: 2.967 ± 0.064	5.047IleGly: 5.047 ± 0.09	1.334IleHis: 1.334 ± 0.04	5.368IleIle: 5.368 ± 0.104	4.821IleLys: 4.821 ± 0.069	7.117IleLeu: 7.117 ± 0.103	1.884IleMet: 1.884 ± 0.044	3.184IleAsn: 3.184 ± 0.058	2.969IlePro: 2.969 ± 0.056	2.372IleGln: 2.372 ± 0.052	3.682IleArg: 3.682 ± 0.064	5.355IleSer: 5.355 ± 0.092	4.449IleThr: 4.449 ± 0.086	4.793IleVal: 4.793 ± 0.082	0.611IleTrp: 0.611 ± 0.029	2.921IleTyr: 2.921 ± 0.059	0.0IleXaa: 0.0 ± 0.0
Lys	5.479LysAla: 5.479 ± 0.086	0.756LysCys: 0.756 ± 0.031	4.04LysAsp: 4.04 ± 0.087	8.165LysGlu: 8.165 ± 0.104	1.954LysPhe: 1.954 ± 0.049	4.636LysGly: 4.636 ± 0.062	1.053LysHis: 1.053 ± 0.035	5.159LysIle: 5.159 ± 0.062	7.365LysLys: 7.365 ± 0.114	6.185LysLeu: 6.185 ± 0.079	2.08LysMet: 2.08 ± 0.048	4.145LysAsn: 4.145 ± 0.067	2.101LysPro: 2.101 ± 0.046	2.664LysGln: 2.664 ± 0.056	3.592LysArg: 3.592 ± 0.067	3.681LysSer: 3.681 ± 0.067	4.087LysThr: 4.087 ± 0.073	4.628LysVal: 4.628 ± 0.074	0.688LysTrp: 0.688 ± 0.026	3.092LysTyr: 3.092 ± 0.059	0.0LysXaa: 0.0 ± 0.0
Leu	6.61LeuAla: 6.61 ± 0.101	1.464LeuCys: 1.464 ± 0.037	4.873LeuAsp: 4.873 ± 0.075	7.406LeuGlu: 7.406 ± 0.094	3.979LeuPhe: 3.979 ± 0.073	5.948LeuGly: 5.948 ± 0.1	1.485LeuHis: 1.485 ± 0.043	5.988LeuIle: 5.988 ± 0.097	6.951LeuLys: 6.951 ± 0.086	9.382LeuLeu: 9.382 ± 0.136	2.487LeuMet: 2.487 ± 0.053	3.853LeuAsn: 3.853 ± 0.062	3.488LeuPro: 3.488 ± 0.068	2.855LeuGln: 2.855 ± 0.057	3.838LeuArg: 3.838 ± 0.068	6.788LeuSer: 6.788 ± 0.097	5.062LeuThr: 5.062 ± 0.091	5.568LeuVal: 5.568 ± 0.094	0.844LeuTrp: 0.844 ± 0.03	3.449LeuTyr: 3.449 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	2.367MetAla: 2.367 ± 0.055	0.334MetCys: 0.334 ± 0.018	1.761MetAsp: 1.761 ± 0.043	2.797MetGlu: 2.797 ± 0.056	0.916MetPhe: 0.916 ± 0.031	1.854MetGly: 1.854 ± 0.045	0.395MetHis: 0.395 ± 0.018	1.951MetIle: 1.951 ± 0.049	2.505MetLys: 2.505 ± 0.054	2.598MetLeu: 2.598 ± 0.058	0.754MetMet: 0.754 ± 0.029	1.513MetAsn: 1.513 ± 0.041	1.031MetPro: 1.031 ± 0.034	0.92MetGln: 0.92 ± 0.028	1.122MetArg: 1.122 ± 0.034	1.674MetSer: 1.674 ± 0.042	1.542MetThr: 1.542 ± 0.039	1.926MetVal: 1.926 ± 0.048	0.214MetTrp: 0.214 ± 0.016	0.936MetTyr: 0.936 ± 0.033	0.0MetXaa: 0.0 ± 0.0
Asn	3.054AsnAla: 3.054 ± 0.053	0.633AsnCys: 0.633 ± 0.027	2.072AsnAsp: 2.072 ± 0.047	3.042AsnGlu: 3.042 ± 0.052	1.69AsnPhe: 1.69 ± 0.042	3.521AsnGly: 3.521 ± 0.062	0.806AsnHis: 0.806 ± 0.028	3.571AsnIle: 3.571 ± 0.069	3.099AsnLys: 3.099 ± 0.054	3.862AsnLeu: 3.862 ± 0.059	1.356AsnMet: 1.356 ± 0.04	2.053AsnAsn: 2.053 ± 0.056	2.032AsnPro: 2.032 ± 0.048	1.616AsnGln: 1.616 ± 0.044	2.223AsnArg: 2.223 ± 0.051	2.389AsnSer: 2.389 ± 0.058	2.508AsnThr: 2.508 ± 0.054	2.784AsnVal: 2.784 ± 0.054	0.422AsnTrp: 0.422 ± 0.021	1.924AsnTyr: 1.924 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	2.206ProAla: 2.206 ± 0.053	0.396ProCys: 0.396 ± 0.02	1.852ProAsp: 1.852 ± 0.041	3.283ProGlu: 3.283 ± 0.068	1.42ProPhe: 1.42 ± 0.041	2.101ProGly: 2.101 ± 0.052	0.491ProHis: 0.491 ± 0.024	2.09ProIle: 2.09 ± 0.046	1.98ProLys: 1.98 ± 0.049	2.677ProLeu: 2.677 ± 0.057	0.876ProMet: 0.876 ± 0.028	1.222ProAsn: 1.222 ± 0.037	0.723ProPro: 0.723 ± 0.025	0.936ProGln: 0.936 ± 0.035	0.936ProArg: 0.936 ± 0.03	1.613ProSer: 1.613 ± 0.043	1.577ProThr: 1.577 ± 0.046	2.733ProVal: 2.733 ± 0.054	0.244ProTrp: 0.244 ± 0.014	1.398ProTyr: 1.398 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.234GlnAla: 2.234 ± 0.045	0.359GlnCys: 0.359 ± 0.019	1.37GlnAsp: 1.37 ± 0.039	2.729GlnGlu: 2.729 ± 0.056	1.156GlnPhe: 1.156 ± 0.035	1.915GlnGly: 1.915 ± 0.043	0.402GlnHis: 0.402 ± 0.018	2.56GlnIle: 2.56 ± 0.055	2.773GlnLys: 2.773 ± 0.053	3.075GlnLeu: 3.075 ± 0.056	1.139GlnMet: 1.139 ± 0.04	1.474GlnAsn: 1.474 ± 0.04	0.909GlnPro: 0.909 ± 0.033	1.047GlnGln: 1.047 ± 0.039	1.429GlnArg: 1.429 ± 0.043	1.594GlnSer: 1.594 ± 0.046	1.629GlnThr: 1.629 ± 0.072	2.001GlnVal: 2.001 ± 0.047	0.272GlnTrp: 0.272 ± 0.019	1.291GlnTyr: 1.291 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.706ArgAla: 2.706 ± 0.058	0.576ArgCys: 0.576 ± 0.025	2.171ArgAsp: 2.171 ± 0.052	4.136ArgGlu: 4.136 ± 0.074	1.908ArgPhe: 1.908 ± 0.049	2.485ArgGly: 2.485 ± 0.06	0.709ArgHis: 0.709 ± 0.03	3.696ArgIle: 3.696 ± 0.061	3.609ArgLys: 3.609 ± 0.066	4.459ArgLeu: 4.459 ± 0.078	1.516ArgMet: 1.516 ± 0.036	2.144ArgAsn: 2.144 ± 0.048	1.238ArgPro: 1.238 ± 0.041	1.725ArgGln: 1.725 ± 0.067	2.21ArgArg: 2.21 ± 0.055	2.01ArgSer: 2.01 ± 0.043	2.105ArgThr: 2.105 ± 0.05	2.838ArgVal: 2.838 ± 0.054	0.408ArgTrp: 0.408 ± 0.021	1.924ArgTyr: 1.924 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	3.692SerAla: 3.692 ± 0.054	0.911SerCys: 0.911 ± 0.035	3.14SerAsp: 3.14 ± 0.071	4.311SerGlu: 4.311 ± 0.069	2.902SerPhe: 2.902 ± 0.058	4.528SerGly: 4.528 ± 0.081	1.003SerHis: 1.003 ± 0.032	4.539SerIle: 4.539 ± 0.074	3.646SerLys: 3.646 ± 0.061	5.364SerLeu: 5.364 ± 0.09	1.733SerMet: 1.733 ± 0.047	2.371SerAsn: 2.371 ± 0.056	1.58SerPro: 1.58 ± 0.042	1.902SerGln: 1.902 ± 0.042	2.697SerArg: 2.697 ± 0.055	3.628SerSer: 3.628 ± 0.084	2.798SerThr: 2.798 ± 0.061	4.155SerVal: 4.155 ± 0.072	0.546SerTrp: 0.546 ± 0.028	2.632SerTyr: 2.632 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	4.248ThrAla: 4.248 ± 0.081	0.592ThrCys: 0.592 ± 0.023	2.994ThrAsp: 2.994 ± 0.08	4.067ThrGlu: 4.067 ± 0.068	1.993ThrPhe: 1.993 ± 0.05	4.372ThrGly: 4.372 ± 0.089	0.856ThrHis: 0.856 ± 0.031	4.057ThrIle: 4.057 ± 0.08	3.609ThrLys: 3.609 ± 0.064	4.949ThrLeu: 4.949 ± 0.084	1.454ThrMet: 1.454 ± 0.036	2.037ThrAsn: 2.037 ± 0.047	1.981ThrPro: 1.981 ± 0.046	1.537ThrGln: 1.537 ± 0.041	1.992ThrArg: 1.992 ± 0.047	2.827ThrSer: 2.827 ± 0.062	2.923ThrThr: 2.923 ± 0.064	4.35ThrVal: 4.35 ± 0.101	0.489ThrTrp: 0.489 ± 0.022	2.053ThrTyr: 2.053 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	4.629ValAla: 4.629 ± 0.068	1.121ValCys: 1.121 ± 0.032	3.647ValAsp: 3.647 ± 0.064	4.845ValGlu: 4.845 ± 0.082	2.921ValPhe: 2.921 ± 0.062	3.934ValGly: 3.934 ± 0.069	1.008ValHis: 1.008 ± 0.03	5.227ValIle: 5.227 ± 0.072	4.918ValLys: 4.918 ± 0.075	6.417ValLeu: 6.417 ± 0.079	1.882ValMet: 1.882 ± 0.051	2.89ValAsn: 2.89 ± 0.049	2.332ValPro: 2.332 ± 0.044	1.78ValGln: 1.78 ± 0.044	2.785ValArg: 2.785 ± 0.056	4.437ValSer: 4.437 ± 0.07	4.003ValThr: 4.003 ± 0.091	4.688ValVal: 4.688 ± 0.085	0.618ValTrp: 0.618 ± 0.026	2.72ValTyr: 2.72 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.485TrpAla: 0.485 ± 0.022	0.13TrpCys: 0.13 ± 0.012	0.525TrpAsp: 0.525 ± 0.026	0.776TrpGlu: 0.776 ± 0.026	0.383TrpPhe: 0.383 ± 0.019	0.607TrpGly: 0.607 ± 0.026	0.147TrpHis: 0.147 ± 0.013	0.666TrpIle: 0.666 ± 0.023	0.746TrpLys: 0.746 ± 0.029	0.89TrpLeu: 0.89 ± 0.03	0.259TrpMet: 0.259 ± 0.016	0.55TrpAsn: 0.55 ± 0.026	0.19TrpPro: 0.19 ± 0.015	0.352TrpGln: 0.352 ± 0.022	0.376TrpArg: 0.376 ± 0.018	0.469TrpSer: 0.469 ± 0.024	0.363TrpThr: 0.363 ± 0.018	0.46TrpVal: 0.46 ± 0.025	0.107TrpTrp: 0.107 ± 0.01	0.392TrpTyr: 0.392 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.597TyrAla: 2.597 ± 0.047	0.653TyrCys: 0.653 ± 0.027	2.448TyrAsp: 2.448 ± 0.049	3.219TyrGlu: 3.219 ± 0.053	1.891TyrPhe: 1.891 ± 0.046	2.95TyrGly: 2.95 ± 0.055	0.797TyrHis: 0.797 ± 0.031	3.021TyrIle: 3.021 ± 0.051	2.718TyrLys: 2.718 ± 0.052	3.947TyrLeu: 3.947 ± 0.067	1.067TyrMet: 1.067 ± 0.033	1.981TyrAsn: 1.981 ± 0.046	1.361TyrPro: 1.361 ± 0.038	1.536TyrGln: 1.536 ± 0.041	2.122TyrArg: 2.122 ± 0.043	2.462TyrSer: 2.462 ± 0.051	2.34TyrThr: 2.34 ± 0.056	2.568TyrVal: 2.568 ± 0.061	0.342TyrTrp: 0.342 ± 0.018	2.054TyrTyr: 2.054 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3375 proteins (1009164 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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