Amino acid dipepetide frequency for Alloiococcus otitis ATCC 51267

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.73AlaAla: 4.73 ± 0.125	0.503AlaCys: 0.503 ± 0.032	5.015AlaAsp: 5.015 ± 0.106	4.395AlaGlu: 4.395 ± 0.131	3.071AlaPhe: 3.071 ± 0.078	6.027AlaGly: 6.027 ± 0.112	1.178AlaHis: 1.178 ± 0.049	5.922AlaIle: 5.922 ± 0.12	4.861AlaLys: 4.861 ± 0.102	7.525AlaLeu: 7.525 ± 0.148	1.909AlaMet: 1.909 ± 0.062	3.313AlaAsn: 3.313 ± 0.08	1.882AlaPro: 1.882 ± 0.071	3.804AlaGln: 3.804 ± 0.088	2.97AlaArg: 2.97 ± 0.074	5.321AlaSer: 5.321 ± 0.115	3.305AlaThr: 3.305 ± 0.073	4.643AlaVal: 4.643 ± 0.105	0.612AlaTrp: 0.612 ± 0.041	2.667AlaTyr: 2.667 ± 0.069	0.0AlaXaa: 0.0 ± 0.0
Cys	0.24CysAla: 0.24 ± 0.023	0.039CysCys: 0.039 ± 0.008	0.292CysAsp: 0.292 ± 0.026	0.181CysGlu: 0.181 ± 0.022	0.228CysPhe: 0.228 ± 0.022	0.484CysGly: 0.484 ± 0.035	0.129CysHis: 0.129 ± 0.015	0.24CysIle: 0.24 ± 0.02	0.168CysLys: 0.168 ± 0.021	0.575CysLeu: 0.575 ± 0.032	0.08CysMet: 0.08 ± 0.012	0.164CysAsn: 0.164 ± 0.018	0.289CysPro: 0.289 ± 0.028	0.398CysGln: 0.398 ± 0.026	0.222CysArg: 0.222 ± 0.019	0.298CysSer: 0.298 ± 0.026	0.201CysThr: 0.201 ± 0.021	0.228CysVal: 0.228 ± 0.02	0.027CysTrp: 0.027 ± 0.007	0.154CysTyr: 0.154 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.186AspAla: 3.186 ± 0.077	0.335AspCys: 0.335 ± 0.029	4.149AspAsp: 4.149 ± 0.118	4.551AspGlu: 4.551 ± 0.111	3.486AspPhe: 3.486 ± 0.084	4.395AspGly: 4.395 ± 0.145	1.827AspHis: 1.827 ± 0.074	4.555AspIle: 4.555 ± 0.114	4.298AspLys: 4.298 ± 0.095	9.4AspLeu: 9.4 ± 0.161	1.64AspMet: 1.64 ± 0.061	2.471AspAsn: 2.471 ± 0.076	3.059AspPro: 3.059 ± 0.083	7.353AspGln: 7.353 ± 0.176	3.787AspArg: 3.787 ± 0.099	3.757AspSer: 3.757 ± 0.099	2.605AspThr: 2.605 ± 0.078	3.523AspVal: 3.523 ± 0.083	0.764AspTrp: 0.764 ± 0.043	3.523AspTyr: 3.523 ± 0.097	0.0AspXaa: 0.0 ± 0.0
Glu	6.253GluAla: 6.253 ± 0.127	0.25GluCys: 0.25 ± 0.024	6.171GluAsp: 6.171 ± 0.143	7.439GluGlu: 7.439 ± 0.197	2.328GluPhe: 2.328 ± 0.077	4.728GluGly: 4.728 ± 0.111	0.786GluHis: 0.786 ± 0.04	4.855GluIle: 4.855 ± 0.096	4.327GluLys: 4.327 ± 0.097	5.522GluLeu: 5.522 ± 0.123	1.741GluMet: 1.741 ± 0.055	3.055GluAsn: 3.055 ± 0.072	2.004GluPro: 2.004 ± 0.098	1.993GluGln: 1.993 ± 0.079	2.623GluArg: 2.623 ± 0.077	4.122GluSer: 4.122 ± 0.079	3.278GluThr: 3.278 ± 0.084	5.319GluVal: 5.319 ± 0.122	0.567GluTrp: 0.567 ± 0.036	1.907GluTyr: 1.907 ± 0.069	0.0GluXaa: 0.0 ± 0.0
Phe	2.931PheAla: 2.931 ± 0.088	0.213PheCys: 0.213 ± 0.018	3.182PheAsp: 3.182 ± 0.075	2.463PheGlu: 2.463 ± 0.062	2.047PhePhe: 2.047 ± 0.077	2.884PheGly: 2.884 ± 0.082	0.721PheHis: 0.721 ± 0.037	3.42PheIle: 3.42 ± 0.102	2.437PheLys: 2.437 ± 0.071	4.196PheLeu: 4.196 ± 0.107	0.944PheMet: 0.944 ± 0.043	2.114PheAsn: 2.114 ± 0.066	1.351PhePro: 1.351 ± 0.05	1.794PheGln: 1.794 ± 0.053	1.396PheArg: 1.396 ± 0.059	2.734PheSer: 2.734 ± 0.089	2.315PheThr: 2.315 ± 0.074	2.681PheVal: 2.681 ± 0.077	0.369PheTrp: 0.369 ± 0.027	1.673PheTyr: 1.673 ± 0.064	0.0PheXaa: 0.0 ± 0.0
Gly	4.553GlyAla: 4.553 ± 0.118	0.314GlyCys: 0.314 ± 0.029	4.362GlyAsp: 4.362 ± 0.116	4.264GlyGlu: 4.264 ± 0.14	2.915GlyPhe: 2.915 ± 0.08	4.641GlyGly: 4.641 ± 0.118	1.515GlyHis: 1.515 ± 0.056	5.04GlyIle: 5.04 ± 0.123	4.147GlyLys: 4.147 ± 0.106	7.679GlyLeu: 7.679 ± 0.136	1.728GlyMet: 1.728 ± 0.062	2.416GlyAsn: 2.416 ± 0.078	2.102GlyPro: 2.102 ± 0.072	4.918GlyGln: 4.918 ± 0.127	3.069GlyArg: 3.069 ± 0.083	4.161GlySer: 4.161 ± 0.094	3.332GlyThr: 3.332 ± 0.091	4.9GlyVal: 4.9 ± 0.104	0.552GlyTrp: 0.552 ± 0.036	2.58GlyTyr: 2.58 ± 0.069	0.0GlyXaa: 0.0 ± 0.0
His	1.02HisAla: 1.02 ± 0.044	0.125HisCys: 0.125 ± 0.014	1.304HisAsp: 1.304 ± 0.067	1.088HisGlu: 1.088 ± 0.043	1.061HisPhe: 1.061 ± 0.044	1.209HisGly: 1.209 ± 0.056	0.515HisHis: 0.515 ± 0.033	1.226HisIle: 1.226 ± 0.054	0.918HisLys: 0.918 ± 0.046	1.96HisLeu: 1.96 ± 0.078	0.384HisMet: 0.384 ± 0.025	0.755HisAsn: 0.755 ± 0.038	1.037HisPro: 1.037 ± 0.042	1.043HisGln: 1.043 ± 0.049	0.743HisArg: 0.743 ± 0.041	0.965HisSer: 0.965 ± 0.048	0.901HisThr: 0.901 ± 0.042	1.08HisVal: 1.08 ± 0.044	0.152HisTrp: 0.152 ± 0.018	1.033HisTyr: 1.033 ± 0.048	0.0HisXaa: 0.0 ± 0.0
Ile	5.635IleAla: 5.635 ± 0.137	0.431IleCys: 0.431 ± 0.026	5.364IleAsp: 5.364 ± 0.099	4.752IleGlu: 4.752 ± 0.098	3.137IlePhe: 3.137 ± 0.093	4.896IleGly: 4.896 ± 0.105	1.211IleHis: 1.211 ± 0.053	5.019IleIle: 5.019 ± 0.128	4.034IleLys: 4.034 ± 0.096	7.267IleLeu: 7.267 ± 0.16	1.499IleMet: 1.499 ± 0.059	3.061IleAsn: 3.061 ± 0.087	2.757IlePro: 2.757 ± 0.08	3.328IleGln: 3.328 ± 0.079	2.669IleArg: 2.669 ± 0.075	4.348IleSer: 4.348 ± 0.089	3.381IleThr: 3.381 ± 0.09	4.598IleVal: 4.598 ± 0.1	0.54IleTrp: 0.54 ± 0.039	2.344IleTyr: 2.344 ± 0.082	0.0IleXaa: 0.0 ± 0.0
Lys	4.582LysAla: 4.582 ± 0.112	0.174LysCys: 0.174 ± 0.018	4.99LysAsp: 4.99 ± 0.121	5.306LysGlu: 5.306 ± 0.117	1.669LysPhe: 1.669 ± 0.054	3.857LysGly: 3.857 ± 0.1	0.95LysHis: 0.95 ± 0.045	3.796LysIle: 3.796 ± 0.09	4.036LysLys: 4.036 ± 0.109	5.362LysLeu: 5.362 ± 0.11	1.421LysMet: 1.421 ± 0.051	2.673LysAsn: 2.673 ± 0.077	2.088LysPro: 2.088 ± 0.089	2.872LysGln: 2.872 ± 0.088	2.851LysArg: 2.851 ± 0.083	3.578LysSer: 3.578 ± 0.083	3.015LysThr: 3.015 ± 0.076	3.872LysVal: 3.872 ± 0.088	0.497LysTrp: 0.497 ± 0.035	1.765LysTyr: 1.765 ± 0.061	0.0LysXaa: 0.0 ± 0.0
Leu	9.502LeuAla: 9.502 ± 0.158	0.369LeuCys: 0.369 ± 0.029	7.815LeuAsp: 7.815 ± 0.129	6.928LeuGlu: 6.928 ± 0.12	4.149LeuPhe: 4.149 ± 0.121	6.7LeuGly: 6.7 ± 0.115	1.579LeuHis: 1.579 ± 0.051	6.959LeuIle: 6.959 ± 0.157	5.941LeuLys: 5.941 ± 0.108	9.541LeuLeu: 9.541 ± 0.214	2.145LeuMet: 2.145 ± 0.067	4.539LeuAsn: 4.539 ± 0.094	3.91LeuPro: 3.91 ± 0.096	3.605LeuGln: 3.605 ± 0.091	3.305LeuArg: 3.305 ± 0.092	7.187LeuSer: 7.187 ± 0.12	5.84LeuThr: 5.84 ± 0.111	7.872LeuVal: 7.872 ± 0.143	0.612LeuTrp: 0.612 ± 0.037	3.046LeuTyr: 3.046 ± 0.087	0.0LeuXaa: 0.0 ± 0.0
Met	2.088MetAla: 2.088 ± 0.071	0.066MetCys: 0.066 ± 0.011	1.669MetAsp: 1.669 ± 0.06	1.459MetGlu: 1.459 ± 0.056	0.618MetPhe: 0.618 ± 0.038	1.689MetGly: 1.689 ± 0.07	0.296MetHis: 0.296 ± 0.024	1.558MetIle: 1.558 ± 0.066	1.595MetLys: 1.595 ± 0.058	1.741MetLeu: 1.741 ± 0.057	0.525MetMet: 0.525 ± 0.031	1.037MetAsn: 1.037 ± 0.047	0.749MetPro: 0.749 ± 0.039	0.76MetGln: 0.76 ± 0.045	0.911MetArg: 0.911 ± 0.038	1.464MetSer: 1.464 ± 0.064	1.843MetThr: 1.843 ± 0.059	1.825MetVal: 1.825 ± 0.063	0.103MetTrp: 0.103 ± 0.013	0.501MetTyr: 0.501 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	2.539AsnAla: 2.539 ± 0.071	0.197AsnCys: 0.197 ± 0.018	2.381AsnAsp: 2.381 ± 0.072	2.441AsnGlu: 2.441 ± 0.077	1.932AsnPhe: 1.932 ± 0.057	2.706AsnGly: 2.706 ± 0.089	1.049AsnHis: 1.049 ± 0.052	3.172AsnIle: 3.172 ± 0.092	2.523AsnLys: 2.523 ± 0.067	4.508AsnLeu: 4.508 ± 0.097	1.02AsnMet: 1.02 ± 0.046	1.776AsnAsn: 1.776 ± 0.072	2.16AsnPro: 2.16 ± 0.07	3.085AsnGln: 3.085 ± 0.097	2.201AsnArg: 2.201 ± 0.069	2.135AsnSer: 2.135 ± 0.06	1.899AsnThr: 1.899 ± 0.063	2.316AsnVal: 2.316 ± 0.068	0.464AsnTrp: 0.464 ± 0.029	1.849AsnTyr: 1.849 ± 0.063	0.0AsnXaa: 0.0 ± 0.0
Pro	2.334ProAla: 2.334 ± 0.072	0.162ProCys: 0.162 ± 0.017	3.137ProAsp: 3.137 ± 0.088	2.938ProGlu: 2.938 ± 0.105	1.65ProPhe: 1.65 ± 0.063	2.792ProGly: 2.792 ± 0.127	0.772ProHis: 0.772 ± 0.035	2.517ProIle: 2.517 ± 0.071	2.071ProLys: 2.071 ± 0.07	3.258ProLeu: 3.258 ± 0.074	0.702ProMet: 0.702 ± 0.035	1.835ProAsn: 1.835 ± 0.064	0.667ProPro: 0.667 ± 0.037	1.49ProGln: 1.49 ± 0.053	1.127ProArg: 1.127 ± 0.047	2.484ProSer: 2.484 ± 0.075	1.724ProThr: 1.724 ± 0.057	2.632ProVal: 2.632 ± 0.084	0.252ProTrp: 0.252 ± 0.024	1.299ProTyr: 1.299 ± 0.05	0.0ProXaa: 0.0 ± 0.0
Gln	6.864GlnAla: 6.864 ± 0.153	0.15GlnCys: 0.15 ± 0.019	4.457GlnAsp: 4.457 ± 0.103	4.951GlnGlu: 4.951 ± 0.124	1.663GlnPhe: 1.663 ± 0.064	3.442GlnGly: 3.442 ± 0.098	0.63GlnHis: 0.63 ± 0.037	3.001GlnIle: 3.001 ± 0.084	2.773GlnLys: 2.773 ± 0.085	4.352GlnLeu: 4.352 ± 0.09	1.092GlnMet: 1.092 ± 0.05	1.952GlnAsn: 1.952 ± 0.058	1.65GlnPro: 1.65 ± 0.063	1.564GlnGln: 1.564 ± 0.06	1.566GlnArg: 1.566 ± 0.059	2.935GlnSer: 2.935 ± 0.078	2.677GlnThr: 2.677 ± 0.07	5.53GlnVal: 5.53 ± 0.114	0.32GlnTrp: 0.32 ± 0.026	1.468GlnTyr: 1.468 ± 0.05	0.0GlnXaa: 0.0 ± 0.0
Arg	2.539ArgAla: 2.539 ± 0.072	0.183ArgCys: 0.183 ± 0.018	2.667ArgAsp: 2.667 ± 0.072	2.728ArgGlu: 2.728 ± 0.088	1.743ArgPhe: 1.743 ± 0.056	2.414ArgGly: 2.414 ± 0.093	0.76ArgHis: 0.76 ± 0.036	2.903ArgIle: 2.903 ± 0.074	2.644ArgLys: 2.644 ± 0.08	4.463ArgLeu: 4.463 ± 0.098	0.948ArgMet: 0.948 ± 0.042	1.624ArgAsn: 1.624 ± 0.062	1.579ArgPro: 1.579 ± 0.059	2.472ArgGln: 2.472 ± 0.075	2.028ArgArg: 2.028 ± 0.073	2.276ArgSer: 2.276 ± 0.075	1.899ArgThr: 1.899 ± 0.068	2.931ArgVal: 2.931 ± 0.078	0.298ArgTrp: 0.298 ± 0.025	1.626ArgTyr: 1.626 ± 0.064	0.0ArgXaa: 0.0 ± 0.0
Ser	3.613SerAla: 3.613 ± 0.106	0.294SerCys: 0.294 ± 0.023	4.261SerAsp: 4.261 ± 0.101	3.297SerGlu: 3.297 ± 0.093	2.985SerPhe: 2.985 ± 0.08	4.703SerGly: 4.703 ± 0.101	1.472SerHis: 1.472 ± 0.057	4.241SerIle: 4.241 ± 0.1	3.57SerLys: 3.57 ± 0.098	7.297SerLeu: 7.297 ± 0.153	1.25SerMet: 1.25 ± 0.052	2.492SerAsn: 2.492 ± 0.079	2.346SerPro: 2.346 ± 0.072	4.535SerGln: 4.535 ± 0.101	2.666SerArg: 2.666 ± 0.08	3.869SerSer: 3.869 ± 0.1	2.683SerThr: 2.683 ± 0.074	3.703SerVal: 3.703 ± 0.078	0.526SerTrp: 0.526 ± 0.034	2.469SerTyr: 2.469 ± 0.072	0.0SerXaa: 0.0 ± 0.0
Thr	3.523ThrAla: 3.523 ± 0.091	0.218ThrCys: 0.218 ± 0.02	3.311ThrAsp: 3.311 ± 0.089	2.857ThrGlu: 2.857 ± 0.08	2.098ThrPhe: 2.098 ± 0.058	4.021ThrGly: 4.021 ± 0.087	0.979ThrHis: 0.979 ± 0.041	4.056ThrIle: 4.056 ± 0.091	2.498ThrLys: 2.498 ± 0.074	4.918ThrLeu: 4.918 ± 0.095	1.016ThrMet: 1.016 ± 0.051	2.104ThrAsn: 2.104 ± 0.077	2.075ThrPro: 2.075 ± 0.059	1.93ThrGln: 1.93 ± 0.065	1.882ThrArg: 1.882 ± 0.059	3.379ThrSer: 3.379 ± 0.092	2.439ThrThr: 2.439 ± 0.084	3.691ThrVal: 3.691 ± 0.099	0.493ThrTrp: 0.493 ± 0.03	1.962ThrTyr: 1.962 ± 0.065	0.0ThrXaa: 0.0 ± 0.0
Val	4.888ValAla: 4.888 ± 0.105	0.351ValCys: 0.351 ± 0.023	5.0ValAsp: 5.0 ± 0.107	4.793ValGlu: 4.793 ± 0.119	2.929ValPhe: 2.929 ± 0.081	4.688ValGly: 4.688 ± 0.116	1.166ValHis: 1.166 ± 0.045	4.834ValIle: 4.834 ± 0.109	4.311ValLys: 4.311 ± 0.116	6.552ValLeu: 6.552 ± 0.139	1.593ValMet: 1.593 ± 0.06	3.155ValAsn: 3.155 ± 0.089	2.32ValPro: 2.32 ± 0.064	3.02ValGln: 3.02 ± 0.077	2.613ValArg: 2.613 ± 0.076	4.67ValSer: 4.67 ± 0.104	3.855ValThr: 3.855 ± 0.089	4.922ValVal: 4.922 ± 0.117	0.499ValTrp: 0.499 ± 0.037	2.494ValTyr: 2.494 ± 0.086	0.0ValXaa: 0.0 ± 0.0
Trp	0.482TrpAla: 0.482 ± 0.029	0.043TrpCys: 0.043 ± 0.009	0.53TrpAsp: 0.53 ± 0.032	0.489TrpGlu: 0.489 ± 0.038	0.339TrpPhe: 0.339 ± 0.029	0.468TrpGly: 0.468 ± 0.03	0.174TrpHis: 0.174 ± 0.017	0.542TrpIle: 0.542 ± 0.035	0.39TrpLys: 0.39 ± 0.025	1.133TrpLeu: 1.133 ± 0.047	0.193TrpMet: 0.193 ± 0.023	0.384TrpAsn: 0.384 ± 0.041	0.291TrpPro: 0.291 ± 0.025	0.538TrpGln: 0.538 ± 0.036	0.324TrpArg: 0.324 ± 0.024	0.515TrpSer: 0.515 ± 0.038	0.429TrpThr: 0.429 ± 0.037	0.474TrpVal: 0.474 ± 0.033	0.066TrpTrp: 0.066 ± 0.012	0.232TrpTyr: 0.232 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.151TyrAla: 2.151 ± 0.061	0.22TyrCys: 0.22 ± 0.02	2.607TyrAsp: 2.607 ± 0.076	1.95TyrGlu: 1.95 ± 0.073	1.813TyrPhe: 1.813 ± 0.066	2.445TyrGly: 2.445 ± 0.078	0.811TyrHis: 0.811 ± 0.042	2.418TyrIle: 2.418 ± 0.071	1.811TyrLys: 1.811 ± 0.065	4.296TyrLeu: 4.296 ± 0.109	0.667TyrMet: 0.667 ± 0.034	1.435TyrAsn: 1.435 ± 0.056	1.527TyrPro: 1.527 ± 0.06	2.531TyrGln: 2.531 ± 0.076	1.776TyrArg: 1.776 ± 0.055	2.073TyrSer: 2.073 ± 0.07	1.829TyrThr: 1.829 ± 0.057	1.911TyrVal: 1.911 ± 0.061	0.32TyrTrp: 0.32 ± 0.024	1.568TyrTyr: 1.568 ± 0.061	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1627 proteins (512849 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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