Amino acid dipepetide frequency for Halotalea alkalilenta

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.921AlaAla: 13.921 ± 0.141	1.234AlaCys: 1.234 ± 0.035	5.312AlaAsp: 5.312 ± 0.075	7.416AlaGlu: 7.416 ± 0.098	4.015AlaPhe: 4.015 ± 0.064	9.415AlaGly: 9.415 ± 0.087	2.245AlaHis: 2.245 ± 0.044	5.585AlaIle: 5.585 ± 0.07	2.723AlaLys: 2.723 ± 0.051	16.055AlaLeu: 16.055 ± 0.156	3.082AlaMet: 3.082 ± 0.058	2.615AlaAsn: 2.615 ± 0.047	5.481AlaPro: 5.481 ± 0.088	4.704AlaGln: 4.704 ± 0.074	9.469AlaArg: 9.469 ± 0.095	6.777AlaSer: 6.777 ± 0.073	5.274AlaThr: 5.274 ± 0.069	7.565AlaVal: 7.565 ± 0.09	1.736AlaTrp: 1.736 ± 0.039	2.355AlaTyr: 2.355 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	1.287CysAla: 1.287 ± 0.037	0.125CysCys: 0.125 ± 0.01	0.586CysAsp: 0.586 ± 0.02	0.561CysGlu: 0.561 ± 0.025	0.343CysPhe: 0.343 ± 0.018	0.938CysGly: 0.938 ± 0.029	0.26CysHis: 0.26 ± 0.014	0.374CysIle: 0.374 ± 0.016	0.161CysLys: 0.161 ± 0.012	0.991CysLeu: 0.991 ± 0.035	0.174CysMet: 0.174 ± 0.013	0.208CysAsn: 0.208 ± 0.014	0.421CysPro: 0.421 ± 0.022	0.306CysGln: 0.306 ± 0.016	0.698CysArg: 0.698 ± 0.026	0.494CysSer: 0.494 ± 0.022	0.382CysThr: 0.382 ± 0.019	0.71CysVal: 0.71 ± 0.026	0.136CysTrp: 0.136 ± 0.009	0.274CysTyr: 0.274 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.947AspAla: 6.947 ± 0.079	0.493AspCys: 0.493 ± 0.022	3.488AspAsp: 3.488 ± 0.065	3.991AspGlu: 3.991 ± 0.064	2.117AspPhe: 2.117 ± 0.045	4.823AspGly: 4.823 ± 0.077	1.369AspHis: 1.369 ± 0.039	2.45AspIle: 2.45 ± 0.055	1.279AspLys: 1.279 ± 0.036	5.197AspLeu: 5.197 ± 0.07	1.085AspMet: 1.085 ± 0.025	1.267AspAsn: 1.267 ± 0.04	3.436AspPro: 3.436 ± 0.058	2.314AspGln: 2.314 ± 0.045	4.029AspArg: 4.029 ± 0.065	2.493AspSer: 2.493 ± 0.047	2.456AspThr: 2.456 ± 0.05	3.553AspVal: 3.553 ± 0.056	1.035AspTrp: 1.035 ± 0.032	1.754AspTyr: 1.754 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	7.869GluAla: 7.869 ± 0.117	0.474GluCys: 0.474 ± 0.019	2.433GluAsp: 2.433 ± 0.045	3.587GluGlu: 3.587 ± 0.074	1.771GluPhe: 1.771 ± 0.046	4.803GluGly: 4.803 ± 0.065	1.718GluHis: 1.718 ± 0.038	3.17GluIle: 3.17 ± 0.052	1.413GluLys: 1.413 ± 0.035	7.467GluLeu: 7.467 ± 0.082	1.369GluMet: 1.369 ± 0.033	1.304GluAsn: 1.304 ± 0.036	2.894GluPro: 2.894 ± 0.054	3.11GluGln: 3.11 ± 0.056	7.63GluArg: 7.63 ± 0.118	3.167GluSer: 3.167 ± 0.055	2.717GluThr: 2.717 ± 0.049	4.612GluVal: 4.612 ± 0.066	0.837GluTrp: 0.837 ± 0.03	1.24GluTyr: 1.24 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.211PheAla: 4.211 ± 0.068	0.398PheCys: 0.398 ± 0.02	3.127PheAsp: 3.127 ± 0.057	2.556PheGlu: 2.556 ± 0.05	1.32PhePhe: 1.32 ± 0.037	3.415PheGly: 3.415 ± 0.061	0.74PheHis: 0.74 ± 0.029	1.809PheIle: 1.809 ± 0.038	0.831PheLys: 0.831 ± 0.024	2.871PheLeu: 2.871 ± 0.057	0.726PheMet: 0.726 ± 0.023	1.043PheAsn: 1.043 ± 0.028	1.403PhePro: 1.403 ± 0.031	1.034PheGln: 1.034 ± 0.033	1.883PheArg: 1.883 ± 0.038	2.558PheSer: 2.558 ± 0.047	1.966PheThr: 1.966 ± 0.044	2.48PheVal: 2.48 ± 0.048	0.478PheTrp: 0.478 ± 0.02	0.916PheTyr: 0.916 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	8.531GlyAla: 8.531 ± 0.096	0.914GlyCys: 0.914 ± 0.028	4.263GlyAsp: 4.263 ± 0.068	5.775GlyGlu: 5.775 ± 0.084	3.564GlyPhe: 3.564 ± 0.057	6.842GlyGly: 6.842 ± 0.095	1.931GlyHis: 1.931 ± 0.045	4.615GlyIle: 4.615 ± 0.063	2.367GlyLys: 2.367 ± 0.045	9.427GlyLeu: 9.427 ± 0.092	2.342GlyMet: 2.342 ± 0.048	1.948GlyAsn: 1.948 ± 0.045	2.831GlyPro: 2.831 ± 0.048	3.014GlyGln: 3.014 ± 0.053	6.272GlyArg: 6.272 ± 0.08	4.509GlySer: 4.509 ± 0.068	3.66GlyThr: 3.66 ± 0.059	6.674GlyVal: 6.674 ± 0.083	1.547GlyTrp: 1.547 ± 0.036	2.536GlyTyr: 2.536 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.576HisAla: 2.576 ± 0.045	0.285HisCys: 0.285 ± 0.016	1.268HisAsp: 1.268 ± 0.037	1.026HisGlu: 1.026 ± 0.033	0.942HisPhe: 0.942 ± 0.026	2.201HisGly: 2.201 ± 0.048	0.689HisHis: 0.689 ± 0.025	0.814HisIle: 0.814 ± 0.029	0.418HisLys: 0.418 ± 0.019	2.381HisLeu: 2.381 ± 0.05	0.425HisMet: 0.425 ± 0.018	0.426HisAsn: 0.426 ± 0.02	1.642HisPro: 1.642 ± 0.041	0.917HisGln: 0.917 ± 0.029	1.955HisArg: 1.955 ± 0.045	1.103HisSer: 1.103 ± 0.03	0.912HisThr: 0.912 ± 0.028	1.25HisVal: 1.25 ± 0.035	0.443HisTrp: 0.443 ± 0.02	0.71HisTyr: 0.71 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.435IleAla: 6.435 ± 0.093	0.482IleCys: 0.482 ± 0.017	4.21IleAsp: 4.21 ± 0.059	4.442IleGlu: 4.442 ± 0.061	1.388IlePhe: 1.388 ± 0.039	4.934IleGly: 4.934 ± 0.062	1.023IleHis: 1.023 ± 0.031	1.922IleIle: 1.922 ± 0.051	1.28IleLys: 1.28 ± 0.036	3.729IleLeu: 3.729 ± 0.066	0.74IleMet: 0.74 ± 0.027	1.436IleAsn: 1.436 ± 0.037	2.075IlePro: 2.075 ± 0.047	1.463IleGln: 1.463 ± 0.037	2.826IleArg: 2.826 ± 0.044	3.018IleSer: 3.018 ± 0.057	2.408IleThr: 2.408 ± 0.044	3.374IleVal: 3.374 ± 0.055	0.468IleTrp: 0.468 ± 0.021	1.066IleTyr: 1.066 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	2.623LysAla: 2.623 ± 0.05	0.146LysCys: 0.146 ± 0.012	0.981LysAsp: 0.981 ± 0.035	1.105LysGlu: 1.105 ± 0.035	0.554LysPhe: 0.554 ± 0.024	1.902LysGly: 1.902 ± 0.041	0.517LysHis: 0.517 ± 0.023	1.111LysIle: 1.111 ± 0.034	0.67LysLys: 0.67 ± 0.029	2.671LysLeu: 2.671 ± 0.052	0.51LysMet: 0.51 ± 0.02	0.521LysAsn: 0.521 ± 0.022	1.283LysPro: 1.283 ± 0.034	0.908LysGln: 0.908 ± 0.03	2.512LysArg: 2.512 ± 0.047	1.334LysSer: 1.334 ± 0.039	1.134LysThr: 1.134 ± 0.03	1.873LysVal: 1.873 ± 0.044	0.271LysTrp: 0.271 ± 0.014	0.453LysTyr: 0.453 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	15.189LeuAla: 15.189 ± 0.167	1.224LeuCys: 1.224 ± 0.036	8.06LeuAsp: 8.06 ± 0.086	8.205LeuGlu: 8.205 ± 0.093	4.009LeuPhe: 4.009 ± 0.079	10.067LeuGly: 10.067 ± 0.096	2.247LeuHis: 2.247 ± 0.051	5.878LeuIle: 5.878 ± 0.078	2.912LeuLys: 2.912 ± 0.057	12.712LeuLeu: 12.712 ± 0.156	2.39LeuMet: 2.39 ± 0.049	2.551LeuAsn: 2.551 ± 0.047	6.221LeuPro: 6.221 ± 0.078	2.698LeuGln: 2.698 ± 0.053	7.978LeuArg: 7.978 ± 0.093	7.201LeuSer: 7.201 ± 0.069	5.164LeuThr: 5.164 ± 0.061	8.437LeuVal: 8.437 ± 0.093	1.319LeuTrp: 1.319 ± 0.034	2.437LeuTyr: 2.437 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.601MetAla: 2.601 ± 0.05	0.133MetCys: 0.133 ± 0.011	0.903MetAsp: 0.903 ± 0.033	0.968MetGlu: 0.968 ± 0.026	0.685MetPhe: 0.685 ± 0.024	1.477MetGly: 1.477 ± 0.036	0.417MetHis: 0.417 ± 0.02	1.401MetIle: 1.401 ± 0.037	0.707MetLys: 0.707 ± 0.024	2.821MetLeu: 2.821 ± 0.055	0.567MetMet: 0.567 ± 0.022	0.707MetAsn: 0.707 ± 0.023	1.38MetPro: 1.38 ± 0.034	0.819MetGln: 0.819 ± 0.028	1.803MetArg: 1.803 ± 0.042	1.741MetSer: 1.741 ± 0.039	1.415MetThr: 1.415 ± 0.036	1.776MetVal: 1.776 ± 0.04	0.18MetTrp: 0.18 ± 0.012	0.324MetTyr: 0.324 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.862AsnAla: 2.862 ± 0.055	0.201AsnCys: 0.201 ± 0.015	1.365AsnAsp: 1.365 ± 0.033	1.144AsnGlu: 1.144 ± 0.03	0.853AsnPhe: 0.853 ± 0.03	1.966AsnGly: 1.966 ± 0.041	0.535AsnHis: 0.535 ± 0.023	1.005AsnIle: 1.005 ± 0.029	0.446AsnLys: 0.446 ± 0.021	2.636AsnLeu: 2.636 ± 0.049	0.433AsnMet: 0.433 ± 0.019	0.562AsnAsn: 0.562 ± 0.025	1.557AsnPro: 1.557 ± 0.035	0.985AsnGln: 0.985 ± 0.026	1.78AsnArg: 1.78 ± 0.043	1.091AsnSer: 1.091 ± 0.031	1.035AsnThr: 1.035 ± 0.034	1.74AsnVal: 1.74 ± 0.038	0.33AsnTrp: 0.33 ± 0.017	0.597AsnTyr: 0.597 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	5.396ProAla: 5.396 ± 0.069	0.404ProCys: 0.404 ± 0.02	2.835ProAsp: 2.835 ± 0.05	3.49ProGlu: 3.49 ± 0.059	1.906ProPhe: 1.906 ± 0.042	4.481ProGly: 4.481 ± 0.068	1.063ProHis: 1.063 ± 0.025	2.182ProIle: 2.182 ± 0.038	1.101ProLys: 1.101 ± 0.036	5.938ProLeu: 5.938 ± 0.089	1.153ProMet: 1.153 ± 0.03	1.193ProAsn: 1.193 ± 0.034	2.307ProPro: 2.307 ± 0.049	1.73ProGln: 1.73 ± 0.034	3.604ProArg: 3.604 ± 0.06	3.252ProSer: 3.252 ± 0.06	2.308ProThr: 2.308 ± 0.038	3.623ProVal: 3.623 ± 0.056	0.807ProTrp: 0.807 ± 0.027	1.149ProTyr: 1.149 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.836GlnAla: 4.836 ± 0.076	0.255GlnCys: 0.255 ± 0.014	1.349GlnAsp: 1.349 ± 0.035	1.598GlnGlu: 1.598 ± 0.041	0.987GlnPhe: 0.987 ± 0.031	3.263GlnGly: 3.263 ± 0.063	0.799GlnHis: 0.799 ± 0.023	1.572GlnIle: 1.572 ± 0.037	0.65GlnLys: 0.65 ± 0.028	4.346GlnLeu: 4.346 ± 0.066	0.86GlnMet: 0.86 ± 0.029	0.67GlnAsn: 0.67 ± 0.025	1.953GlnPro: 1.953 ± 0.042	1.775GlnGln: 1.775 ± 0.048	4.111GlnArg: 4.111 ± 0.072	1.954GlnSer: 1.954 ± 0.042	1.476GlnThr: 1.476 ± 0.041	2.788GlnVal: 2.788 ± 0.047	0.569GlnTrp: 0.569 ± 0.023	0.67GlnTyr: 0.67 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	8.406ArgAla: 8.406 ± 0.102	0.711ArgCys: 0.711 ± 0.028	4.219ArgAsp: 4.219 ± 0.061	5.31ArgGlu: 5.31 ± 0.083	3.469ArgPhe: 3.469 ± 0.052	5.426ArgGly: 5.426 ± 0.076	2.183ArgHis: 2.183 ± 0.041	4.141ArgIle: 4.141 ± 0.054	1.63ArgLys: 1.63 ± 0.04	11.025ArgLeu: 11.025 ± 0.127	2.025ArgMet: 2.025 ± 0.043	1.583ArgAsn: 1.583 ± 0.034	3.387ArgPro: 3.387 ± 0.055	3.26ArgGln: 3.26 ± 0.061	6.735ArgArg: 6.735 ± 0.092	3.933ArgSer: 3.933 ± 0.052	3.017ArgThr: 3.017 ± 0.052	5.418ArgVal: 5.418 ± 0.066	1.276ArgTrp: 1.276 ± 0.035	2.354ArgTyr: 2.354 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	6.4SerAla: 6.4 ± 0.082	0.432SerCys: 0.432 ± 0.017	2.899SerAsp: 2.899 ± 0.049	3.191SerGlu: 3.191 ± 0.058	2.204SerPhe: 2.204 ± 0.042	5.441SerGly: 5.441 ± 0.073	1.275SerHis: 1.275 ± 0.036	2.874SerIle: 2.874 ± 0.051	1.214SerLys: 1.214 ± 0.033	6.833SerLeu: 6.833 ± 0.086	1.355SerMet: 1.355 ± 0.03	1.387SerAsn: 1.387 ± 0.033	2.999SerPro: 2.999 ± 0.051	1.971SerGln: 1.971 ± 0.054	4.372SerArg: 4.372 ± 0.062	3.582SerSer: 3.582 ± 0.069	2.755SerThr: 2.755 ± 0.045	4.001SerVal: 4.001 ± 0.057	0.765SerTrp: 0.765 ± 0.026	1.332SerTyr: 1.332 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	4.691ThrAla: 4.691 ± 0.068	0.342ThrCys: 0.342 ± 0.016	2.192ThrAsp: 2.192 ± 0.048	2.275ThrGlu: 2.275 ± 0.043	1.667ThrPhe: 1.667 ± 0.039	3.823ThrGly: 3.823 ± 0.058	1.057ThrHis: 1.057 ± 0.028	2.058ThrIle: 2.058 ± 0.043	0.851ThrLys: 0.851 ± 0.031	6.912ThrLeu: 6.912 ± 0.075	0.922ThrMet: 0.922 ± 0.026	1.012ThrAsn: 1.012 ± 0.031	3.208ThrPro: 3.208 ± 0.053	1.647ThrGln: 1.647 ± 0.037	3.334ThrArg: 3.334 ± 0.053	2.606ThrSer: 2.606 ± 0.049	2.332ThrThr: 2.332 ± 0.043	3.239ThrVal: 3.239 ± 0.05	0.555ThrTrp: 0.555 ± 0.022	0.958ThrTyr: 0.958 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	8.372ValAla: 8.372 ± 0.082	0.735ValCys: 0.735 ± 0.022	4.267ValAsp: 4.267 ± 0.063	5.305ValGlu: 5.305 ± 0.077	2.502ValPhe: 2.502 ± 0.044	5.449ValGly: 5.449 ± 0.083	1.349ValHis: 1.349 ± 0.033	4.208ValIle: 4.208 ± 0.064	1.667ValLys: 1.667 ± 0.044	7.694ValLeu: 7.694 ± 0.083	1.833ValMet: 1.833 ± 0.044	1.785ValAsn: 1.785 ± 0.048	3.48ValPro: 3.48 ± 0.062	2.009ValGln: 2.009 ± 0.048	4.798ValArg: 4.798 ± 0.059	4.314ValSer: 4.314 ± 0.061	3.59ValThr: 3.59 ± 0.058	5.848ValVal: 5.848 ± 0.085	0.828ValTrp: 0.828 ± 0.028	1.432ValTyr: 1.432 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.165TrpAla: 1.165 ± 0.034	0.206TrpCys: 0.206 ± 0.012	0.53TrpAsp: 0.53 ± 0.019	0.637TrpGlu: 0.637 ± 0.022	0.52TrpPhe: 0.52 ± 0.021	0.877TrpGly: 0.877 ± 0.026	0.385TrpHis: 0.385 ± 0.017	0.702TrpIle: 0.702 ± 0.025	0.321TrpLys: 0.321 ± 0.015	2.315TrpLeu: 2.315 ± 0.055	0.354TrpMet: 0.354 ± 0.016	0.404TrpAsn: 0.404 ± 0.018	0.724TrpPro: 0.724 ± 0.03	0.763TrpGln: 0.763 ± 0.03	1.463TrpArg: 1.463 ± 0.036	0.827TrpSer: 0.827 ± 0.03	0.595TrpThr: 0.595 ± 0.023	0.879TrpVal: 0.879 ± 0.026	0.228TrpTrp: 0.228 ± 0.013	0.294TrpTyr: 0.294 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.661TyrAla: 2.661 ± 0.045	0.236TyrCys: 0.236 ± 0.016	1.291TyrAsp: 1.291 ± 0.042	1.001TyrGlu: 1.001 ± 0.034	0.948TyrPhe: 0.948 ± 0.029	2.018TyrGly: 2.018 ± 0.043	0.582TyrHis: 0.582 ± 0.022	0.845TyrIle: 0.845 ± 0.028	0.439TyrLys: 0.439 ± 0.018	2.878TyrLeu: 2.878 ± 0.046	0.482TyrMet: 0.482 ± 0.02	0.502TyrAsn: 0.502 ± 0.02	1.242TyrPro: 1.242 ± 0.037	1.052TyrGln: 1.052 ± 0.03	2.256TyrArg: 2.256 ± 0.043	1.327TyrSer: 1.327 ± 0.036	1.085TyrThr: 1.085 ± 0.034	1.625TyrVal: 1.625 ± 0.04	0.38TyrTrp: 0.38 ± 0.016	0.695TyrTyr: 0.695 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3715 proteins (1214334 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---