Amino acid dipepetide frequency for Planctomyces sp. SCGC AG-212-M04

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.711AlaAla: 13.711 ± 0.243	1.098AlaCys: 1.098 ± 0.041	6.016AlaAsp: 6.016 ± 0.117	6.653AlaGlu: 6.653 ± 0.139	3.658AlaPhe: 3.658 ± 0.087	8.735AlaGly: 8.735 ± 0.135	1.774AlaHis: 1.774 ± 0.054	5.431AlaIle: 5.431 ± 0.093	4.521AlaLys: 4.521 ± 0.104	9.258AlaLeu: 9.258 ± 0.152	2.412AlaMet: 2.412 ± 0.065	2.856AlaAsn: 2.856 ± 0.068	5.036AlaPro: 5.036 ± 0.107	3.364AlaGln: 3.364 ± 0.11	6.673AlaArg: 6.673 ± 0.135	6.109AlaSer: 6.109 ± 0.113	5.837AlaThr: 5.837 ± 0.116	7.993AlaVal: 7.993 ± 0.135	1.572AlaTrp: 1.572 ± 0.06	2.085AlaTyr: 2.085 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	0.909CysAla: 0.909 ± 0.041	0.223CysCys: 0.223 ± 0.024	0.617CysAsp: 0.617 ± 0.028	0.627CysGlu: 0.627 ± 0.035	0.429CysPhe: 0.429 ± 0.028	1.121CysGly: 1.121 ± 0.055	0.407CysHis: 0.407 ± 0.033	0.439CysIle: 0.439 ± 0.027	0.391CysLys: 0.391 ± 0.03	1.143CysLeu: 1.143 ± 0.038	0.188CysMet: 0.188 ± 0.019	0.293CysAsn: 0.293 ± 0.024	0.577CysPro: 0.577 ± 0.031	0.35CysGln: 0.35 ± 0.023	0.944CysArg: 0.944 ± 0.042	0.659CysSer: 0.659 ± 0.037	0.545CysThr: 0.545 ± 0.031	0.796CysVal: 0.796 ± 0.041	0.151CysTrp: 0.151 ± 0.014	0.248CysTyr: 0.248 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	5.829AspAla: 5.829 ± 0.114	0.575AspCys: 0.575 ± 0.03	3.421AspAsp: 3.421 ± 0.089	3.929AspGlu: 3.929 ± 0.091	2.25AspPhe: 2.25 ± 0.061	5.301AspGly: 5.301 ± 0.127	1.354AspHis: 1.354 ± 0.045	2.245AspIle: 2.245 ± 0.069	1.941AspLys: 1.941 ± 0.07	5.656AspLeu: 5.656 ± 0.095	0.952AspMet: 0.952 ± 0.038	1.375AspAsn: 1.375 ± 0.049	3.716AspPro: 3.716 ± 0.076	2.152AspGln: 2.152 ± 0.063	4.308AspArg: 4.308 ± 0.099	3.086AspSer: 3.086 ± 0.073	2.114AspThr: 2.114 ± 0.056	4.503AspVal: 4.503 ± 0.094	1.007AspTrp: 1.007 ± 0.046	1.438AspTyr: 1.438 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	6.499GluAla: 6.499 ± 0.124	0.61GluCys: 0.61 ± 0.031	2.709GluAsp: 2.709 ± 0.079	3.683GluGlu: 3.683 ± 0.092	2.592GluPhe: 2.592 ± 0.062	4.147GluGly: 4.147 ± 0.076	1.368GluHis: 1.368 ± 0.05	3.167GluIle: 3.167 ± 0.078	3.091GluLys: 3.091 ± 0.087	6.513GluLeu: 6.513 ± 0.127	1.445GluMet: 1.445 ± 0.055	1.678GluAsn: 1.678 ± 0.05	2.945GluPro: 2.945 ± 0.079	2.709GluGln: 2.709 ± 0.086	4.793GluArg: 4.793 ± 0.103	3.69GluSer: 3.69 ± 0.087	3.289GluThr: 3.289 ± 0.083	4.194GluVal: 4.194 ± 0.08	1.006GluTrp: 1.006 ± 0.042	1.405GluTyr: 1.405 ± 0.06	0.0GluXaa: 0.0 ± 0.0
Phe	3.84PheAla: 3.84 ± 0.077	0.473PheCys: 0.473 ± 0.032	2.692PheAsp: 2.692 ± 0.065	2.397PheGlu: 2.397 ± 0.06	1.277PhePhe: 1.277 ± 0.046	3.378PheGly: 3.378 ± 0.077	0.86PheHis: 0.86 ± 0.038	1.494PheIle: 1.494 ± 0.045	1.246PheLys: 1.246 ± 0.042	3.592PheLeu: 3.592 ± 0.088	0.684PheMet: 0.684 ± 0.035	1.215PheAsn: 1.215 ± 0.05	1.814PhePro: 1.814 ± 0.059	1.282PheGln: 1.282 ± 0.043	2.516PheArg: 2.516 ± 0.07	2.253PheSer: 2.253 ± 0.058	1.975PheThr: 1.975 ± 0.06	2.913PheVal: 2.913 ± 0.079	0.563PheTrp: 0.563 ± 0.031	0.813PheTyr: 0.813 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	6.786GlyAla: 6.786 ± 0.109	1.088GlyCys: 1.088 ± 0.044	4.602GlyAsp: 4.602 ± 0.1	4.585GlyGlu: 4.585 ± 0.101	3.1GlyPhe: 3.1 ± 0.081	6.809GlyGly: 6.809 ± 0.167	1.728GlyHis: 1.728 ± 0.061	3.755GlyIle: 3.755 ± 0.089	4.045GlyLys: 4.045 ± 0.104	7.528GlyLeu: 7.528 ± 0.114	2.053GlyMet: 2.053 ± 0.062	2.292GlyAsn: 2.292 ± 0.069	3.669GlyPro: 3.669 ± 0.09	3.214GlyGln: 3.214 ± 0.119	5.872GlyArg: 5.872 ± 0.098	4.88GlySer: 4.88 ± 0.092	4.402GlyThr: 4.402 ± 0.089	5.785GlyVal: 5.785 ± 0.112	1.388GlyTrp: 1.388 ± 0.054	2.189GlyTyr: 2.189 ± 0.066	0.0GlyXaa: 0.0 ± 0.0
His	1.988HisAla: 1.988 ± 0.063	0.292HisCys: 0.292 ± 0.023	1.276HisAsp: 1.276 ± 0.046	1.224HisGlu: 1.224 ± 0.045	0.875HisPhe: 0.875 ± 0.039	1.842HisGly: 1.842 ± 0.061	0.595HisHis: 0.595 ± 0.035	0.842HisIle: 0.842 ± 0.042	0.61HisLys: 0.61 ± 0.031	2.013HisLeu: 2.013 ± 0.061	0.355HisMet: 0.355 ± 0.025	0.575HisAsn: 0.575 ± 0.032	1.485HisPro: 1.485 ± 0.049	0.726HisGln: 0.726 ± 0.033	1.532HisArg: 1.532 ± 0.051	1.132HisSer: 1.132 ± 0.043	0.987HisThr: 0.987 ± 0.043	1.611HisVal: 1.611 ± 0.05	0.469HisTrp: 0.469 ± 0.028	0.588HisTyr: 0.588 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.797IleAla: 5.797 ± 0.1	0.567IleCys: 0.567 ± 0.033	3.438IleAsp: 3.438 ± 0.075	3.363IleGlu: 3.363 ± 0.069	1.328IlePhe: 1.328 ± 0.051	4.068IleGly: 4.068 ± 0.091	0.996IleHis: 0.996 ± 0.034	1.775IleIle: 1.775 ± 0.054	1.522IleLys: 1.522 ± 0.055	3.998IleLeu: 3.998 ± 0.085	0.657IleMet: 0.657 ± 0.035	1.43IleAsn: 1.43 ± 0.051	2.605IlePro: 2.605 ± 0.068	1.49IleGln: 1.49 ± 0.052	3.338IleArg: 3.338 ± 0.071	2.717IleSer: 2.717 ± 0.071	2.538IleThr: 2.538 ± 0.064	3.931IleVal: 3.931 ± 0.068	0.582IleTrp: 0.582 ± 0.029	1.034IleTyr: 1.034 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.305LysAla: 4.305 ± 0.097	0.345LysCys: 0.345 ± 0.023	2.416LysAsp: 2.416 ± 0.087	2.618LysGlu: 2.618 ± 0.08	1.363LysPhe: 1.363 ± 0.052	2.721LysGly: 2.721 ± 0.073	0.878LysHis: 0.878 ± 0.038	1.79LysIle: 1.79 ± 0.055	2.412LysLys: 2.412 ± 0.084	4.187LysLeu: 4.187 ± 0.083	1.013LysMet: 1.013 ± 0.043	1.276LysAsn: 1.276 ± 0.05	2.763LysPro: 2.763 ± 0.089	1.686LysGln: 1.686 ± 0.058	2.665LysArg: 2.665 ± 0.072	2.803LysSer: 2.803 ± 0.082	2.372LysThr: 2.372 ± 0.061	2.915LysVal: 2.915 ± 0.077	0.634LysTrp: 0.634 ± 0.031	1.021LysTyr: 1.021 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	11.06LeuAla: 11.06 ± 0.188	1.157LeuCys: 1.157 ± 0.043	5.45LeuAsp: 5.45 ± 0.106	6.088LeuGlu: 6.088 ± 0.112	3.49LeuPhe: 3.49 ± 0.101	7.232LeuGly: 7.232 ± 0.128	1.973LeuHis: 1.973 ± 0.062	4.605LeuIle: 4.605 ± 0.093	4.762LeuLys: 4.762 ± 0.101	9.414LeuLeu: 9.414 ± 0.174	2.037LeuMet: 2.037 ± 0.06	2.887LeuAsn: 2.887 ± 0.064	5.311LeuPro: 5.311 ± 0.097	3.143LeuGln: 3.143 ± 0.076	6.518LeuArg: 6.518 ± 0.118	6.179LeuSer: 6.179 ± 0.102	5.621LeuThr: 5.621 ± 0.102	6.92LeuVal: 6.92 ± 0.101	1.428LeuTrp: 1.428 ± 0.049	1.904LeuTyr: 1.904 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	2.174MetAla: 2.174 ± 0.065	0.228MetCys: 0.228 ± 0.018	0.945MetAsp: 0.945 ± 0.041	1.029MetGlu: 1.029 ± 0.039	0.798MetPhe: 0.798 ± 0.041	1.448MetGly: 1.448 ± 0.05	0.444MetHis: 0.444 ± 0.024	1.019MetIle: 1.019 ± 0.038	1.053MetLys: 1.053 ± 0.048	2.253MetLeu: 2.253 ± 0.062	0.491MetMet: 0.491 ± 0.028	0.734MetAsn: 0.734 ± 0.037	1.41MetPro: 1.41 ± 0.051	0.907MetGln: 0.907 ± 0.046	1.457MetArg: 1.457 ± 0.05	1.616MetSer: 1.616 ± 0.054	1.534MetThr: 1.534 ± 0.053	1.376MetVal: 1.376 ± 0.052	0.275MetTrp: 0.275 ± 0.021	0.367MetTyr: 0.367 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.873AsnAla: 2.873 ± 0.072	0.33AsnCys: 0.33 ± 0.025	1.648AsnAsp: 1.648 ± 0.057	1.67AsnGlu: 1.67 ± 0.057	1.011AsnPhe: 1.011 ± 0.04	2.737AsnGly: 2.737 ± 0.074	0.595AsnHis: 0.595 ± 0.03	1.299AsnIle: 1.299 ± 0.047	0.853AsnLys: 0.853 ± 0.039	2.754AsnLeu: 2.754 ± 0.066	0.531AsnMet: 0.531 ± 0.033	0.945AsnAsn: 0.945 ± 0.063	2.007AsnPro: 2.007 ± 0.07	1.091AsnGln: 1.091 ± 0.044	2.055AsnArg: 2.055 ± 0.058	1.673AsnSer: 1.673 ± 0.053	1.42AsnThr: 1.42 ± 0.056	2.218AsnVal: 2.218 ± 0.061	0.523AsnTrp: 0.523 ± 0.03	0.816AsnTyr: 0.816 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	6.355ProAla: 6.355 ± 0.117	0.401ProCys: 0.401 ± 0.035	3.498ProAsp: 3.498 ± 0.088	4.124ProGlu: 4.124 ± 0.083	1.988ProPhe: 1.988 ± 0.068	4.508ProGly: 4.508 ± 0.1	1.073ProHis: 1.073 ± 0.039	2.463ProIle: 2.463 ± 0.075	2.422ProLys: 2.422 ± 0.066	4.488ProLeu: 4.488 ± 0.094	1.173ProMet: 1.173 ± 0.071	1.706ProAsn: 1.706 ± 0.054	3.245ProPro: 3.245 ± 0.091	2.028ProGln: 2.028 ± 0.072	3.232ProArg: 3.232 ± 0.081	3.441ProSer: 3.441 ± 0.087	3.125ProThr: 3.125 ± 0.082	4.278ProVal: 4.278 ± 0.106	0.763ProTrp: 0.763 ± 0.036	1.197ProTyr: 1.197 ± 0.053	0.0ProXaa: 0.0 ± 0.0
Gln	3.896GlnAla: 3.896 ± 0.114	0.375GlnCys: 0.375 ± 0.028	1.435GlnAsp: 1.435 ± 0.052	1.879GlnGlu: 1.879 ± 0.07	1.529GlnPhe: 1.529 ± 0.047	2.407GlnGly: 2.407 ± 0.074	0.774GlnHis: 0.774 ± 0.036	1.955GlnIle: 1.955 ± 0.06	1.738GlnLys: 1.738 ± 0.077	3.835GlnLeu: 3.835 ± 0.094	0.912GlnMet: 0.912 ± 0.035	0.942GlnAsn: 0.942 ± 0.044	2.295GlnPro: 2.295 ± 0.142	1.71GlnGln: 1.71 ± 0.116	2.664GlnArg: 2.664 ± 0.073	2.359GlnSer: 2.359 ± 0.07	2.204GlnThr: 2.204 ± 0.065	2.536GlnVal: 2.536 ± 0.081	0.577GlnTrp: 0.577 ± 0.033	0.783GlnTyr: 0.783 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	5.86ArgAla: 5.86 ± 0.114	0.722ArgCys: 0.722 ± 0.039	3.985ArgAsp: 3.985 ± 0.088	4.55ArgGlu: 4.55 ± 0.109	2.967ArgPhe: 2.967 ± 0.076	4.722ArgGly: 4.722 ± 0.097	1.473ArgHis: 1.473 ± 0.056	3.824ArgIle: 3.824 ± 0.076	2.709ArgLys: 2.709 ± 0.078	7.557ArgLeu: 7.557 ± 0.133	1.769ArgMet: 1.769 ± 0.052	1.909ArgAsn: 1.909 ± 0.06	3.797ArgPro: 3.797 ± 0.098	2.727ArgGln: 2.727 ± 0.071	5.902ArgArg: 5.902 ± 0.107	4.134ArgSer: 4.134 ± 0.095	3.618ArgThr: 3.618 ± 0.083	4.804ArgVal: 4.804 ± 0.1	1.274ArgTrp: 1.274 ± 0.052	1.683ArgTyr: 1.683 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	5.983SerAla: 5.983 ± 0.098	0.56SerCys: 0.56 ± 0.029	3.363SerAsp: 3.363 ± 0.076	3.425SerGlu: 3.425 ± 0.077	2.139SerPhe: 2.139 ± 0.062	5.453SerGly: 5.453 ± 0.094	1.185SerHis: 1.185 ± 0.049	2.882SerIle: 2.882 ± 0.073	2.476SerLys: 2.476 ± 0.071	6.228SerLeu: 6.228 ± 0.127	1.381SerMet: 1.381 ± 0.044	1.814SerAsn: 1.814 ± 0.058	3.78SerPro: 3.78 ± 0.091	2.38SerGln: 2.38 ± 0.073	4.166SerArg: 4.166 ± 0.084	4.068SerSer: 4.068 ± 0.108	3.366SerThr: 3.366 ± 0.087	4.199SerVal: 4.199 ± 0.091	0.912SerTrp: 0.912 ± 0.042	1.294SerTyr: 1.294 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	5.788ThrAla: 5.788 ± 0.095	0.563ThrCys: 0.563 ± 0.035	2.865ThrAsp: 2.865 ± 0.073	2.872ThrGlu: 2.872 ± 0.077	2.176ThrPhe: 2.176 ± 0.056	4.975ThrGly: 4.975 ± 0.097	1.08ThrHis: 1.08 ± 0.039	2.877ThrIle: 2.877 ± 0.071	2.035ThrLys: 2.035 ± 0.059	5.492ThrLeu: 5.492 ± 0.101	1.123ThrMet: 1.123 ± 0.044	1.609ThrAsn: 1.609 ± 0.051	3.447ThrPro: 3.447 ± 0.076	1.725ThrGln: 1.725 ± 0.062	3.272ThrArg: 3.272 ± 0.093	3.331ThrSer: 3.331 ± 0.077	3.269ThrThr: 3.269 ± 0.083	4.1ThrVal: 4.1 ± 0.092	0.862ThrTrp: 0.862 ± 0.044	1.21ThrTyr: 1.21 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	7.735ValAla: 7.735 ± 0.126	0.93ValCys: 0.93 ± 0.058	4.508ValAsp: 4.508 ± 0.1	4.675ValGlu: 4.675 ± 0.099	2.813ValPhe: 2.813 ± 0.072	5.128ValGly: 5.128 ± 0.098	1.527ValHis: 1.527 ± 0.044	3.768ValIle: 3.768 ± 0.084	2.784ValLys: 2.784 ± 0.086	7.242ValLeu: 7.242 ± 0.127	1.566ValMet: 1.566 ± 0.055	2.099ValAsn: 2.099 ± 0.056	3.767ValPro: 3.767 ± 0.095	2.526ValGln: 2.526 ± 0.061	4.969ValArg: 4.969 ± 0.103	4.489ValSer: 4.489 ± 0.095	4.389ValThr: 4.389 ± 0.087	6.0ValVal: 6.0 ± 0.112	1.135ValTrp: 1.135 ± 0.04	1.641ValTyr: 1.641 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	1.324TrpAla: 1.324 ± 0.05	0.203TrpCys: 0.203 ± 0.018	0.865TrpAsp: 0.865 ± 0.04	0.717TrpGlu: 0.717 ± 0.031	0.583TrpPhe: 0.583 ± 0.035	0.979TrpGly: 0.979 ± 0.044	0.411TrpHis: 0.411 ± 0.024	0.818TrpIle: 0.818 ± 0.034	0.904TrpLys: 0.904 ± 0.044	1.769TrpLeu: 1.769 ± 0.056	0.402TrpMet: 0.402 ± 0.024	0.682TrpAsn: 0.682 ± 0.032	0.763TrpPro: 0.763 ± 0.037	0.686TrpGln: 0.686 ± 0.035	1.168TrpArg: 1.168 ± 0.043	1.038TrpSer: 1.038 ± 0.044	0.959TrpThr: 0.959 ± 0.044	0.932TrpVal: 0.932 ± 0.039	0.339TrpTrp: 0.339 ± 0.028	0.307TrpTyr: 0.307 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.082TyrAla: 2.082 ± 0.056	0.317TyrCys: 0.317 ± 0.02	1.405TyrAsp: 1.405 ± 0.048	1.423TyrGlu: 1.423 ± 0.05	0.914TyrPhe: 0.914 ± 0.04	2.057TyrGly: 2.057 ± 0.083	0.521TyrHis: 0.521 ± 0.032	0.728TyrIle: 0.728 ± 0.03	0.667TyrLys: 0.667 ± 0.041	2.258TyrLeu: 2.258 ± 0.06	0.412TyrMet: 0.412 ± 0.029	0.734TyrAsn: 0.734 ± 0.042	1.078TyrPro: 1.078 ± 0.046	0.907TyrGln: 0.907 ± 0.048	1.943TyrArg: 1.943 ± 0.055	1.398TyrSer: 1.398 ± 0.043	1.108TyrThr: 1.108 ± 0.046	1.685TyrVal: 1.685 ± 0.054	0.389TyrTrp: 0.389 ± 0.029	0.669TyrTyr: 0.669 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1771 proteins (596544 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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