Amino acid dipepetide frequency for Planomicrobium sp. YIM 101495

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.526AlaAla: 8.526 ± 0.138
0.619AlaCys: 0.619 ± 0.029
4.708AlaAsp: 4.708 ± 0.097
6.809AlaGlu: 6.809 ± 0.101
3.883AlaPhe: 3.883 ± 0.078
6.832AlaGly: 6.832 ± 0.101
1.493AlaHis: 1.493 ± 0.039
6.378AlaIle: 6.378 ± 0.103
4.599AlaLys: 4.599 ± 0.091
8.622AlaLeu: 8.622 ± 0.121
2.518AlaMet: 2.518 ± 0.058
2.702AlaAsn: 2.702 ± 0.056
2.708AlaPro: 2.708 ± 0.084
2.722AlaGln: 2.722 ± 0.057
3.37AlaArg: 3.37 ± 0.062
4.741AlaSer: 4.741 ± 0.077
3.989AlaThr: 3.989 ± 0.073
6.904AlaVal: 6.904 ± 0.108
0.689AlaTrp: 0.689 ± 0.031
2.648AlaTyr: 2.648 ± 0.058
0.0AlaXaa: 0.0 ± 0.0
Cys
0.44CysAla: 0.44 ± 0.023
0.06CysCys: 0.06 ± 0.01
0.304CysAsp: 0.304 ± 0.021
0.4CysGlu: 0.4 ± 0.023
0.258CysPhe: 0.258 ± 0.019
0.565CysGly: 0.565 ± 0.031
0.146CysHis: 0.146 ± 0.013
0.323CysIle: 0.323 ± 0.02
0.231CysLys: 0.231 ± 0.019
0.511CysLeu: 0.511 ± 0.027
0.129CysMet: 0.129 ± 0.012
0.197CysAsn: 0.197 ± 0.017
0.317CysPro: 0.317 ± 0.022
0.176CysGln: 0.176 ± 0.015
0.303CysArg: 0.303 ± 0.017
0.377CysSer: 0.377 ± 0.021
0.317CysThr: 0.317 ± 0.022
0.361CysVal: 0.361 ± 0.022
0.04CysTrp: 0.04 ± 0.007
0.177CysTyr: 0.177 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
4.531AspAla: 4.531 ± 0.077
0.29AspCys: 0.29 ± 0.02
2.686AspAsp: 2.686 ± 0.066
4.839AspGlu: 4.839 ± 0.082
2.724AspPhe: 2.724 ± 0.065
4.044AspGly: 4.044 ± 0.09
1.152AspHis: 1.152 ± 0.037
3.6AspIle: 3.6 ± 0.063
2.556AspLys: 2.556 ± 0.058
5.106AspLeu: 5.106 ± 0.085
1.5AspMet: 1.5 ± 0.044
1.635AspAsn: 1.635 ± 0.053
2.311AspPro: 2.311 ± 0.068
1.763AspGln: 1.763 ± 0.049
2.764AspArg: 2.764 ± 0.056
2.728AspSer: 2.728 ± 0.06
2.497AspThr: 2.497 ± 0.06
4.009AspVal: 4.009 ± 0.075
0.708AspTrp: 0.708 ± 0.033
1.989AspTyr: 1.989 ± 0.054
0.0AspXaa: 0.0 ± 0.0
Glu
6.956GluAla: 6.956 ± 0.118
0.298GluCys: 0.298 ± 0.022
4.169GluAsp: 4.169 ± 0.075
8.029GluGlu: 8.029 ± 0.123
2.812GluPhe: 2.812 ± 0.062
5.132GluGly: 5.132 ± 0.088
1.574GluHis: 1.574 ± 0.037
4.968GluIle: 4.968 ± 0.077
5.293GluLys: 5.293 ± 0.103
8.04GluLeu: 8.04 ± 0.109
2.777GluMet: 2.777 ± 0.06
2.919GluAsn: 2.919 ± 0.069
2.382GluPro: 2.382 ± 0.068
4.195GluGln: 4.195 ± 0.076
4.478GluArg: 4.478 ± 0.093
3.7GluSer: 3.7 ± 0.065
4.511GluThr: 4.511 ± 0.08
5.683GluVal: 5.683 ± 0.083
0.984GluTrp: 0.984 ± 0.039
1.984GluTyr: 1.984 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
3.673PheAla: 3.673 ± 0.075
0.294PheCys: 0.294 ± 0.018
2.669PheAsp: 2.669 ± 0.059
3.164PheGlu: 3.164 ± 0.061
2.326PhePhe: 2.326 ± 0.066
3.719PheGly: 3.719 ± 0.086
0.999PheHis: 0.999 ± 0.035
3.482PheIle: 3.482 ± 0.089
2.037PheLys: 2.037 ± 0.045
4.415PheLeu: 4.415 ± 0.093
1.234PheMet: 1.234 ± 0.042
1.631PheAsn: 1.631 ± 0.045
1.634PhePro: 1.634 ± 0.043
1.466PheGln: 1.466 ± 0.038
1.817PheArg: 1.817 ± 0.052
2.955PheSer: 2.955 ± 0.057
2.594PheThr: 2.594 ± 0.056
3.29PheVal: 3.29 ± 0.072
0.454PheTrp: 0.454 ± 0.023
1.559PheTyr: 1.559 ± 0.051
0.0PheXaa: 0.0 ± 0.0
Gly
6.003GlyAla: 6.003 ± 0.113
0.462GlyCys: 0.462 ± 0.023
3.703GlyAsp: 3.703 ± 0.085
5.369GlyGlu: 5.369 ± 0.087
3.509GlyPhe: 3.509 ± 0.065
5.577GlyGly: 5.577 ± 0.101
1.495GlyHis: 1.495 ± 0.047
5.909GlyIle: 5.909 ± 0.108
4.679GlyLys: 4.679 ± 0.075
6.89GlyLeu: 6.89 ± 0.106
2.435GlyMet: 2.435 ± 0.057
2.61GlyAsn: 2.61 ± 0.061
1.901GlyPro: 1.901 ± 0.045
2.465GlyGln: 2.465 ± 0.063
3.191GlyArg: 3.191 ± 0.066
4.343GlySer: 4.343 ± 0.102
4.557GlyThr: 4.557 ± 0.099
5.36GlyVal: 5.36 ± 0.084
0.823GlyTrp: 0.823 ± 0.031
2.575GlyTyr: 2.575 ± 0.052
0.0GlyXaa: 0.0 ± 0.0
His
1.67HisAla: 1.67 ± 0.046
0.145HisCys: 0.145 ± 0.013
1.072HisAsp: 1.072 ± 0.04
1.474HisGlu: 1.474 ± 0.047
1.071HisPhe: 1.071 ± 0.036
1.508HisGly: 1.508 ± 0.046
0.607HisHis: 0.607 ± 0.033
1.292HisIle: 1.292 ± 0.042
0.804HisLys: 0.804 ± 0.032
2.114HisLeu: 2.114 ± 0.051
0.51HisMet: 0.51 ± 0.023
0.567HisAsn: 0.567 ± 0.026
1.227HisPro: 1.227 ± 0.039
0.771HisGln: 0.771 ± 0.025
0.998HisArg: 0.998 ± 0.031
1.095HisSer: 1.095 ± 0.036
1.044HisThr: 1.044 ± 0.034
1.439HisVal: 1.439 ± 0.041
0.234HisTrp: 0.234 ± 0.018
0.754HisTyr: 0.754 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.503IleAla: 6.503 ± 0.101
0.422IleCys: 0.422 ± 0.019
4.094IleAsp: 4.094 ± 0.063
5.493IleGlu: 5.493 ± 0.077
2.918IlePhe: 2.918 ± 0.077
5.901IleGly: 5.901 ± 0.108
1.45IleHis: 1.45 ± 0.041
4.816IleIle: 4.816 ± 0.092
2.967IleLys: 2.967 ± 0.063
6.286IleLeu: 6.286 ± 0.11
1.696IleMet: 1.696 ± 0.047
2.317IleAsn: 2.317 ± 0.058
3.03IlePro: 3.03 ± 0.069
2.423IleGln: 2.423 ± 0.051
3.382IleArg: 3.382 ± 0.066
4.337IleSer: 4.337 ± 0.075
3.836IleThr: 3.836 ± 0.069
5.224IleVal: 5.224 ± 0.095
0.582IleTrp: 0.582 ± 0.028
2.005IleTyr: 2.005 ± 0.055
0.0IleXaa: 0.0 ± 0.0
Lys
4.448LysAla: 4.448 ± 0.078
0.193LysCys: 0.193 ± 0.015
3.046LysAsp: 3.046 ± 0.065
5.523LysGlu: 5.523 ± 0.089
1.689LysPhe: 1.689 ± 0.053
3.729LysGly: 3.729 ± 0.069
1.039LysHis: 1.039 ± 0.03
3.337LysIle: 3.337 ± 0.068
4.314LysLys: 4.314 ± 0.078
4.828LysLeu: 4.828 ± 0.077
1.963LysMet: 1.963 ± 0.045
2.318LysAsn: 2.318 ± 0.05
2.05LysPro: 2.05 ± 0.053
2.524LysGln: 2.524 ± 0.054
3.253LysArg: 3.253 ± 0.058
2.793LysSer: 2.793 ± 0.065
3.212LysThr: 3.212 ± 0.068
3.819LysVal: 3.819 ± 0.071
0.709LysTrp: 0.709 ± 0.026
1.582LysTyr: 1.582 ± 0.048
0.0LysXaa: 0.0 ± 0.0
Leu
9.032LeuAla: 9.032 ± 0.121
0.513LeuCys: 0.513 ± 0.027
4.914LeuAsp: 4.914 ± 0.084
7.192LeuGlu: 7.192 ± 0.104
4.833LeuPhe: 4.833 ± 0.098
6.637LeuGly: 6.637 ± 0.084
2.024LeuHis: 2.024 ± 0.049
6.399LeuIle: 6.399 ± 0.124
5.598LeuLys: 5.598 ± 0.09
10.424LeuLeu: 10.424 ± 0.155
2.639LeuMet: 2.639 ± 0.056
3.429LeuAsn: 3.429 ± 0.064
4.252LeuPro: 4.252 ± 0.069
3.525LeuGln: 3.525 ± 0.07
3.968LeuArg: 3.968 ± 0.074
6.225LeuSer: 6.225 ± 0.094
5.801LeuThr: 5.801 ± 0.084
6.667LeuVal: 6.667 ± 0.104
0.842LeuTrp: 0.842 ± 0.034
3.059LeuTyr: 3.059 ± 0.059
0.0LeuXaa: 0.0 ± 0.0
Met
2.476MetAla: 2.476 ± 0.058
0.117MetCys: 0.117 ± 0.013
1.65MetAsp: 1.65 ± 0.047
2.374MetGlu: 2.374 ± 0.05
1.066MetPhe: 1.066 ± 0.031
1.766MetGly: 1.766 ± 0.047
0.497MetHis: 0.497 ± 0.027
1.997MetIle: 1.997 ± 0.053
2.42MetLys: 2.42 ± 0.054
2.602MetLeu: 2.602 ± 0.058
0.901MetMet: 0.901 ± 0.034
1.45MetAsn: 1.45 ± 0.041
1.181MetPro: 1.181 ± 0.032
1.075MetGln: 1.075 ± 0.041
1.277MetArg: 1.277 ± 0.037
1.592MetSer: 1.592 ± 0.041
1.985MetThr: 1.985 ± 0.047
1.837MetVal: 1.837 ± 0.047
0.216MetTrp: 0.216 ± 0.015
0.684MetTyr: 0.684 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
2.886AsnAla: 2.886 ± 0.069
0.237AsnCys: 0.237 ± 0.017
1.87AsnAsp: 1.87 ± 0.052
2.877AsnGlu: 2.877 ± 0.066
1.439AsnPhe: 1.439 ± 0.047
3.059AsnGly: 3.059 ± 0.07
0.768AsnHis: 0.768 ± 0.032
2.459AsnIle: 2.459 ± 0.062
1.774AsnLys: 1.774 ± 0.056
3.162AsnLeu: 3.162 ± 0.06
1.052AsnMet: 1.052 ± 0.036
1.27AsnAsn: 1.27 ± 0.047
1.896AsnPro: 1.896 ± 0.051
1.202AsnGln: 1.202 ± 0.037
1.914AsnArg: 1.914 ± 0.047
1.822AsnSer: 1.822 ± 0.053
1.676AsnThr: 1.676 ± 0.043
2.517AsnVal: 2.517 ± 0.057
0.366AsnTrp: 0.366 ± 0.022
1.175AsnTyr: 1.175 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
3.192ProAla: 3.192 ± 0.07
0.172ProCys: 0.172 ± 0.015
2.265ProAsp: 2.265 ± 0.054
3.756ProGlu: 3.756 ± 0.072
2.044ProPhe: 2.044 ± 0.052
2.702ProGly: 2.702 ± 0.076
0.858ProHis: 0.858 ± 0.034
2.53ProIle: 2.53 ± 0.057
1.951ProLys: 1.951 ± 0.047
3.637ProLeu: 3.637 ± 0.077
0.878ProMet: 0.878 ± 0.036
1.373ProAsn: 1.373 ± 0.048
1.053ProPro: 1.053 ± 0.036
1.173ProGln: 1.173 ± 0.035
1.25ProArg: 1.25 ± 0.044
2.174ProSer: 2.174 ± 0.048
1.835ProThr: 1.835 ± 0.051
3.441ProVal: 3.441 ± 0.062
0.367ProTrp: 0.367 ± 0.021
1.336ProTyr: 1.336 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
3.153GlnAla: 3.153 ± 0.069
0.166GlnCys: 0.166 ± 0.016
1.588GlnAsp: 1.588 ± 0.04
2.982GlnGlu: 2.982 ± 0.057
1.584GlnPhe: 1.584 ± 0.04
2.317GlnGly: 2.317 ± 0.059
0.733GlnHis: 0.733 ± 0.029
2.133GlnIle: 2.133 ± 0.055
2.109GlnLys: 2.109 ± 0.058
4.21GlnLeu: 4.21 ± 0.075
1.143GlnMet: 1.143 ± 0.038
1.247GlnAsn: 1.247 ± 0.039
1.349GlnPro: 1.349 ± 0.043
1.894GlnGln: 1.894 ± 0.055
1.723GlnArg: 1.723 ± 0.044
1.953GlnSer: 1.953 ± 0.046
1.956GlnThr: 1.956 ± 0.053
2.424GlnVal: 2.424 ± 0.06
0.396GlnTrp: 0.396 ± 0.022
1.096GlnTyr: 1.096 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
3.241ArgAla: 3.241 ± 0.074
0.252ArgCys: 0.252 ± 0.018
2.334ArgAsp: 2.334 ± 0.057
3.634ArgGlu: 3.634 ± 0.073
2.224ArgPhe: 2.224 ± 0.064
2.799ArgGly: 2.799 ± 0.069
0.978ArgHis: 0.978 ± 0.034
3.423ArgIle: 3.423 ± 0.067
3.251ArgLys: 3.251 ± 0.06
4.677ArgLeu: 4.677 ± 0.078
1.519ArgMet: 1.519 ± 0.043
1.877ArgAsn: 1.877 ± 0.049
1.642ArgPro: 1.642 ± 0.046
1.822ArgGln: 1.822 ± 0.054
2.189ArgArg: 2.189 ± 0.057
2.541ArgSer: 2.541 ± 0.055
2.461ArgThr: 2.461 ± 0.053
3.052ArgVal: 3.052 ± 0.056
0.405ArgTrp: 0.405 ± 0.024
1.612ArgTyr: 1.612 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
4.506SerAla: 4.506 ± 0.087
0.336SerCys: 0.336 ± 0.023
2.924SerAsp: 2.924 ± 0.068
3.884SerGlu: 3.884 ± 0.062
3.099SerPhe: 3.099 ± 0.067
4.991SerGly: 4.991 ± 0.085
1.151SerHis: 1.151 ± 0.045
4.294SerIle: 4.294 ± 0.078
2.864SerLys: 2.864 ± 0.055
5.628SerLeu: 5.628 ± 0.09
1.707SerMet: 1.707 ± 0.039
1.807SerAsn: 1.807 ± 0.05
2.169SerPro: 2.169 ± 0.051
1.651SerGln: 1.651 ± 0.045
2.641SerArg: 2.641 ± 0.061
3.481SerSer: 3.481 ± 0.074
2.901SerThr: 2.901 ± 0.057
4.232SerVal: 4.232 ± 0.063
0.616SerTrp: 0.616 ± 0.029
1.979SerTyr: 1.979 ± 0.044
0.0SerXaa: 0.0 ± 0.0
Thr
5.078ThrAla: 5.078 ± 0.096
0.309ThrCys: 0.309 ± 0.022
3.195ThrAsp: 3.195 ± 0.059
4.147ThrGlu: 4.147 ± 0.078
2.457ThrPhe: 2.457 ± 0.06
4.592ThrGly: 4.592 ± 0.081
1.079ThrHis: 1.079 ± 0.037
4.242ThrIle: 4.242 ± 0.085
2.77ThrLys: 2.77 ± 0.058
5.05ThrLeu: 5.05 ± 0.083
1.355ThrMet: 1.355 ± 0.043
1.886ThrAsn: 1.886 ± 0.048
2.32ThrPro: 2.32 ± 0.057
1.418ThrGln: 1.418 ± 0.045
2.101ThrArg: 2.101 ± 0.05
2.988ThrSer: 2.988 ± 0.065
2.738ThrThr: 2.738 ± 0.069
4.769ThrVal: 4.769 ± 0.1
0.487ThrTrp: 0.487 ± 0.026
1.793ThrTyr: 1.793 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
5.93ValAla: 5.93 ± 0.1
0.472ValCys: 0.472 ± 0.023
3.863ValAsp: 3.863 ± 0.08
5.578ValGlu: 5.578 ± 0.094
3.388ValPhe: 3.388 ± 0.075
4.824ValGly: 4.824 ± 0.079
1.482ValHis: 1.482 ± 0.043
5.247ValIle: 5.247 ± 0.086
4.042ValLys: 4.042 ± 0.078
7.5ValLeu: 7.5 ± 0.093
2.06ValMet: 2.06 ± 0.048
2.654ValAsn: 2.654 ± 0.05
2.947ValPro: 2.947 ± 0.071
2.423ValGln: 2.423 ± 0.051
3.195ValArg: 3.195 ± 0.069
4.544ValSer: 4.544 ± 0.073
4.523ValThr: 4.523 ± 0.092
5.226ValVal: 5.226 ± 0.098
0.702ValTrp: 0.702 ± 0.032
2.246ValTyr: 2.246 ± 0.048
0.0ValXaa: 0.0 ± 0.0
Trp
0.674TrpAla: 0.674 ± 0.027
0.052TrpCys: 0.052 ± 0.008
0.469TrpAsp: 0.469 ± 0.021
0.689TrpGlu: 0.689 ± 0.029
0.493TrpPhe: 0.493 ± 0.027
0.675TrpGly: 0.675 ± 0.033
0.204TrpHis: 0.204 ± 0.013
0.861TrpIle: 0.861 ± 0.034
0.618TrpLys: 0.618 ± 0.027
1.2TrpLeu: 1.2 ± 0.039
0.361TrpMet: 0.361 ± 0.022
0.454TrpAsn: 0.454 ± 0.023
0.276TrpPro: 0.276 ± 0.02
0.449TrpGln: 0.449 ± 0.023
0.447TrpArg: 0.447 ± 0.025
0.587TrpSer: 0.587 ± 0.025
0.592TrpThr: 0.592 ± 0.028
0.596TrpVal: 0.596 ± 0.026
0.129TrpTrp: 0.129 ± 0.013
0.284TrpTyr: 0.284 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.543TyrAla: 2.543 ± 0.062
0.222TyrCys: 0.222 ± 0.017
1.909TyrAsp: 1.909 ± 0.046
2.669TyrGlu: 2.669 ± 0.055
1.595TyrPhe: 1.595 ± 0.044
2.488TyrGly: 2.488 ± 0.058
0.668TyrHis: 0.668 ± 0.029
1.993TyrIle: 1.993 ± 0.054
1.491TyrLys: 1.491 ± 0.047
3.073TyrLeu: 3.073 ± 0.069
0.787TyrMet: 0.787 ± 0.033
1.079TyrAsn: 1.079 ± 0.05
1.341TyrPro: 1.341 ± 0.042
1.018TyrGln: 1.018 ± 0.041
1.671TyrArg: 1.671 ± 0.044
1.884TyrSer: 1.884 ± 0.05
1.75TyrThr: 1.75 ± 0.047
1.993TyrVal: 1.993 ± 0.048
0.363TyrTrp: 0.363 ± 0.021
1.104TyrTyr: 1.104 ± 0.044
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2829 proteins (847762 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski