Amino acid dipepetide frequency for Mycobacterium virus Ardmore

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.495AlaAla: 14.495 ± 1.784
0.987AlaCys: 0.987 ± 0.242
7.71AlaAsp: 7.71 ± 0.74
7.155AlaGlu: 7.155 ± 0.779
2.899AlaPhe: 2.899 ± 0.465
9.931AlaGly: 9.931 ± 1.514
2.837AlaHis: 2.837 ± 0.513
4.194AlaIle: 4.194 ± 0.574
3.824AlaLys: 3.824 ± 0.436
8.204AlaLeu: 8.204 ± 0.907
2.406AlaMet: 2.406 ± 0.365
2.282AlaAsn: 2.282 ± 0.376
5.49AlaPro: 5.49 ± 0.642
3.393AlaGln: 3.393 ± 0.445
7.71AlaArg: 7.71 ± 0.786
5.551AlaSer: 5.551 ± 0.661
5.86AlaThr: 5.86 ± 0.523
7.094AlaVal: 7.094 ± 0.803
2.652AlaTrp: 2.652 ± 0.426
2.221AlaTyr: 2.221 ± 0.301
0.0AlaXaa: 0.0 ± 0.0
Cys
0.925CysAla: 0.925 ± 0.279
0.123CysCys: 0.123 ± 0.094
1.48CysAsp: 1.48 ± 0.398
0.617CysGlu: 0.617 ± 0.205
0.123CysPhe: 0.123 ± 0.081
1.357CysGly: 1.357 ± 0.34
0.123CysHis: 0.123 ± 0.09
0.247CysIle: 0.247 ± 0.144
0.432CysLys: 0.432 ± 0.169
0.987CysLeu: 0.987 ± 0.27
0.123CysMet: 0.123 ± 0.084
0.37CysAsn: 0.37 ± 0.164
0.987CysPro: 0.987 ± 0.316
0.37CysGln: 0.37 ± 0.162
0.864CysArg: 0.864 ± 0.261
0.432CysSer: 0.432 ± 0.158
0.617CysThr: 0.617 ± 0.201
0.617CysVal: 0.617 ± 0.179
0.308CysTrp: 0.308 ± 0.132
0.247CysTyr: 0.247 ± 0.124
0.0CysXaa: 0.0 ± 0.0
Asp
6.847AspAla: 6.847 ± 0.602
0.987AspCys: 0.987 ± 0.257
4.379AspAsp: 4.379 ± 0.534
3.578AspGlu: 3.578 ± 0.494
2.036AspPhe: 2.036 ± 0.242
6.785AspGly: 6.785 ± 0.639
1.295AspHis: 1.295 ± 0.263
2.159AspIle: 2.159 ± 0.386
1.48AspLys: 1.48 ± 0.251
6.045AspLeu: 6.045 ± 0.526
1.049AspMet: 1.049 ± 0.258
1.912AspAsn: 1.912 ± 0.387
4.811AspPro: 4.811 ± 0.588
2.467AspGln: 2.467 ± 0.327
5.243AspArg: 5.243 ± 0.599
4.009AspSer: 4.009 ± 0.594
4.133AspThr: 4.133 ± 0.51
4.565AspVal: 4.565 ± 0.549
1.727AspTrp: 1.727 ± 0.293
1.85AspTyr: 1.85 ± 0.399
0.0AspXaa: 0.0 ± 0.0
Glu
6.168GluAla: 6.168 ± 0.718
0.74GluCys: 0.74 ± 0.242
3.146GluAsp: 3.146 ± 0.382
2.899GluGlu: 2.899 ± 0.652
2.159GluPhe: 2.159 ± 0.385
3.022GluGly: 3.022 ± 0.436
1.48GluHis: 1.48 ± 0.399
2.036GluIle: 2.036 ± 0.351
1.789GluLys: 1.789 ± 0.292
5.12GluLeu: 5.12 ± 0.751
1.604GluMet: 1.604 ± 0.334
2.529GluAsn: 2.529 ± 0.363
2.776GluPro: 2.776 ± 0.512
2.652GluGln: 2.652 ± 0.461
4.688GluArg: 4.688 ± 0.62
2.776GluSer: 2.776 ± 0.408
3.763GluThr: 3.763 ± 0.618
3.639GluVal: 3.639 ± 0.523
1.48GluTrp: 1.48 ± 0.259
1.912GluTyr: 1.912 ± 0.342
0.0GluXaa: 0.0 ± 0.0
Phe
3.269PheAla: 3.269 ± 0.508
0.185PheCys: 0.185 ± 0.101
2.221PheAsp: 2.221 ± 0.493
1.789PheGlu: 1.789 ± 0.345
0.925PhePhe: 0.925 ± 0.306
2.899PheGly: 2.899 ± 0.667
0.37PheHis: 0.37 ± 0.138
1.48PheIle: 1.48 ± 0.398
0.802PheLys: 0.802 ± 0.227
1.912PheLeu: 1.912 ± 0.303
0.679PheMet: 0.679 ± 0.239
1.234PheAsn: 1.234 ± 0.388
1.604PhePro: 1.604 ± 0.311
0.987PheGln: 0.987 ± 0.305
1.48PheArg: 1.48 ± 0.266
1.172PheSer: 1.172 ± 0.257
2.591PheThr: 2.591 ± 0.431
2.221PheVal: 2.221 ± 0.344
0.555PheTrp: 0.555 ± 0.153
0.987PheTyr: 0.987 ± 0.273
0.0PheXaa: 0.0 ± 0.0
Gly
8.882GlyAla: 8.882 ± 1.427
0.925GlyCys: 0.925 ± 0.295
6.353GlyAsp: 6.353 ± 0.689
3.393GlyGlu: 3.393 ± 0.542
2.776GlyPhe: 2.776 ± 0.543
11.596GlyGly: 11.596 ± 2.561
2.036GlyHis: 2.036 ± 0.328
4.565GlyIle: 4.565 ± 0.685
2.529GlyLys: 2.529 ± 0.467
5.798GlyLeu: 5.798 ± 0.621
2.467GlyMet: 2.467 ± 0.551
2.714GlyAsn: 2.714 ± 0.409
4.379GlyPro: 4.379 ± 0.572
2.467GlyGln: 2.467 ± 0.604
5.12GlyArg: 5.12 ± 0.812
6.045GlySer: 6.045 ± 0.953
7.094GlyThr: 7.094 ± 0.977
5.86GlyVal: 5.86 ± 0.594
2.406GlyTrp: 2.406 ± 0.375
2.221GlyTyr: 2.221 ± 0.419
0.0GlyXaa: 0.0 ± 0.0
His
1.85HisAla: 1.85 ± 0.422
0.617HisCys: 0.617 ± 0.254
0.987HisAsp: 0.987 ± 0.209
1.234HisGlu: 1.234 ± 0.26
0.37HisPhe: 0.37 ± 0.125
1.665HisGly: 1.665 ± 0.261
1.049HisHis: 1.049 ± 0.282
1.542HisIle: 1.542 ± 0.333
0.617HisLys: 0.617 ± 0.214
1.357HisLeu: 1.357 ± 0.298
0.617HisMet: 0.617 ± 0.16
0.679HisAsn: 0.679 ± 0.196
1.85HisPro: 1.85 ± 0.28
0.925HisGln: 0.925 ± 0.269
2.837HisArg: 2.837 ± 0.649
0.802HisSer: 0.802 ± 0.233
1.789HisThr: 1.789 ± 0.527
1.48HisVal: 1.48 ± 0.385
0.493HisTrp: 0.493 ± 0.161
0.864HisTyr: 0.864 ± 0.225
0.0HisXaa: 0.0 ± 0.0
Ile
5.12IleAla: 5.12 ± 0.539
0.617IleCys: 0.617 ± 0.254
3.886IleAsp: 3.886 ± 0.486
3.084IleGlu: 3.084 ± 0.403
0.679IlePhe: 0.679 ± 0.251
3.393IleGly: 3.393 ± 0.534
1.604IleHis: 1.604 ± 0.336
1.604IleIle: 1.604 ± 0.34
0.864IleLys: 0.864 ± 0.247
1.789IleLeu: 1.789 ± 0.447
0.432IleMet: 0.432 ± 0.15
2.097IleAsn: 2.097 ± 0.291
2.899IlePro: 2.899 ± 0.377
1.665IleGln: 1.665 ± 0.294
2.714IleArg: 2.714 ± 0.511
2.282IleSer: 2.282 ± 0.493
3.454IleThr: 3.454 ± 0.459
2.714IleVal: 2.714 ± 0.393
1.11IleTrp: 1.11 ± 0.302
0.802IleTyr: 0.802 ± 0.225
0.0IleXaa: 0.0 ± 0.0
Lys
3.763LysAla: 3.763 ± 0.572
0.308LysCys: 0.308 ± 0.142
1.727LysAsp: 1.727 ± 0.282
1.48LysGlu: 1.48 ± 0.283
1.172LysPhe: 1.172 ± 0.217
2.837LysGly: 2.837 ± 0.378
1.11LysHis: 1.11 ± 0.256
0.802LysIle: 0.802 ± 0.252
1.172LysLys: 1.172 ± 0.355
2.529LysLeu: 2.529 ± 0.451
0.679LysMet: 0.679 ± 0.17
0.987LysAsn: 0.987 ± 0.205
1.48LysPro: 1.48 ± 0.346
1.604LysGln: 1.604 ± 0.267
1.665LysArg: 1.665 ± 0.326
1.542LysSer: 1.542 ± 0.289
2.159LysThr: 2.159 ± 0.311
2.406LysVal: 2.406 ± 0.367
0.679LysTrp: 0.679 ± 0.173
1.11LysTyr: 1.11 ± 0.283
0.0LysXaa: 0.0 ± 0.0
Leu
7.587LeuAla: 7.587 ± 0.804
0.925LeuCys: 0.925 ± 0.229
4.811LeuAsp: 4.811 ± 0.572
4.009LeuGlu: 4.009 ± 0.479
2.282LeuPhe: 2.282 ± 0.322
5.305LeuGly: 5.305 ± 0.521
1.11LeuHis: 1.11 ± 0.323
3.084LeuIle: 3.084 ± 0.443
1.912LeuLys: 1.912 ± 0.323
4.565LeuLeu: 4.565 ± 0.608
1.419LeuMet: 1.419 ± 0.317
2.714LeuAsn: 2.714 ± 0.396
5.49LeuPro: 5.49 ± 0.747
3.084LeuGln: 3.084 ± 0.46
5.366LeuArg: 5.366 ± 0.704
5.798LeuSer: 5.798 ± 0.591
5.613LeuThr: 5.613 ± 0.509
5.058LeuVal: 5.058 ± 0.633
1.172LeuTrp: 1.172 ± 0.313
2.097LeuTyr: 2.097 ± 0.366
0.0LeuXaa: 0.0 ± 0.0
Met
2.467MetAla: 2.467 ± 0.422
0.123MetCys: 0.123 ± 0.085
1.542MetAsp: 1.542 ± 0.342
0.925MetGlu: 0.925 ± 0.212
0.802MetPhe: 0.802 ± 0.241
1.727MetGly: 1.727 ± 0.316
0.185MetHis: 0.185 ± 0.101
0.617MetIle: 0.617 ± 0.182
0.493MetLys: 0.493 ± 0.229
1.789MetLeu: 1.789 ± 0.328
0.493MetMet: 0.493 ± 0.223
0.987MetAsn: 0.987 ± 0.223
1.295MetPro: 1.295 ± 0.298
0.432MetGln: 0.432 ± 0.135
1.665MetArg: 1.665 ± 0.363
3.146MetSer: 3.146 ± 0.49
2.097MetThr: 2.097 ± 0.344
1.604MetVal: 1.604 ± 0.389
0.247MetTrp: 0.247 ± 0.119
0.247MetTyr: 0.247 ± 0.109
0.0MetXaa: 0.0 ± 0.0
Asn
3.701AsnAla: 3.701 ± 0.436
0.062AsnCys: 0.062 ± 0.06
1.974AsnAsp: 1.974 ± 0.36
1.542AsnGlu: 1.542 ± 0.283
0.925AsnPhe: 0.925 ± 0.304
4.688AsnGly: 4.688 ± 0.905
0.864AsnHis: 0.864 ± 0.195
1.604AsnIle: 1.604 ± 0.438
1.234AsnLys: 1.234 ± 0.267
2.529AsnLeu: 2.529 ± 0.385
0.493AsnMet: 0.493 ± 0.164
1.727AsnAsn: 1.727 ± 0.347
2.714AsnPro: 2.714 ± 0.377
1.11AsnGln: 1.11 ± 0.327
1.912AsnArg: 1.912 ± 0.355
1.419AsnSer: 1.419 ± 0.304
2.714AsnThr: 2.714 ± 0.369
2.036AsnVal: 2.036 ± 0.391
0.74AsnTrp: 0.74 ± 0.158
0.802AsnTyr: 0.802 ± 0.183
0.0AsnXaa: 0.0 ± 0.0
Pro
5.49ProAla: 5.49 ± 0.682
0.679ProCys: 0.679 ± 0.221
4.503ProAsp: 4.503 ± 0.598
4.009ProGlu: 4.009 ± 0.5
1.604ProPhe: 1.604 ± 0.318
6.6ProGly: 6.6 ± 0.737
1.665ProHis: 1.665 ± 0.347
2.221ProIle: 2.221 ± 0.347
2.406ProLys: 2.406 ± 0.477
4.441ProLeu: 4.441 ± 0.603
1.727ProMet: 1.727 ± 0.409
2.282ProAsn: 2.282 ± 0.421
3.393ProPro: 3.393 ± 0.602
2.159ProGln: 2.159 ± 0.36
3.146ProArg: 3.146 ± 0.599
2.837ProSer: 2.837 ± 0.404
2.961ProThr: 2.961 ± 0.481
4.996ProVal: 4.996 ± 0.649
1.172ProTrp: 1.172 ± 0.269
1.234ProTyr: 1.234 ± 0.294
0.0ProXaa: 0.0 ± 0.0
Gln
4.503GlnAla: 4.503 ± 0.586
0.247GlnCys: 0.247 ± 0.126
1.727GlnAsp: 1.727 ± 0.294
1.912GlnGlu: 1.912 ± 0.362
1.295GlnPhe: 1.295 ± 0.236
2.097GlnGly: 2.097 ± 0.479
0.617GlnHis: 0.617 ± 0.253
2.036GlnIle: 2.036 ± 0.394
1.049GlnLys: 1.049 ± 0.209
3.208GlnLeu: 3.208 ± 0.539
0.617GlnMet: 0.617 ± 0.211
0.802GlnAsn: 0.802 ± 0.285
2.529GlnPro: 2.529 ± 0.44
1.234GlnGln: 1.234 ± 0.234
2.344GlnArg: 2.344 ± 0.373
2.529GlnSer: 2.529 ± 0.429
1.604GlnThr: 1.604 ± 0.338
2.344GlnVal: 2.344 ± 0.372
0.74GlnTrp: 0.74 ± 0.202
0.925GlnTyr: 0.925 ± 0.275
0.0GlnXaa: 0.0 ± 0.0
Arg
6.6ArgAla: 6.6 ± 0.663
1.049ArgCys: 1.049 ± 0.382
4.133ArgAsp: 4.133 ± 0.613
4.256ArgGlu: 4.256 ± 0.642
2.036ArgPhe: 2.036 ± 0.378
4.379ArgGly: 4.379 ± 0.571
1.789ArgHis: 1.789 ± 0.385
3.208ArgIle: 3.208 ± 0.58
2.776ArgLys: 2.776 ± 0.531
5.49ArgLeu: 5.49 ± 0.749
2.406ArgMet: 2.406 ± 0.437
2.467ArgAsn: 2.467 ± 0.444
3.269ArgPro: 3.269 ± 0.482
2.036ArgGln: 2.036 ± 0.365
6.292ArgArg: 6.292 ± 0.961
4.071ArgSer: 4.071 ± 0.526
3.516ArgThr: 3.516 ± 0.639
5.551ArgVal: 5.551 ± 0.596
1.974ArgTrp: 1.974 ± 0.367
1.789ArgTyr: 1.789 ± 0.359
0.0ArgXaa: 0.0 ± 0.0
Ser
5.675SerAla: 5.675 ± 0.843
0.617SerCys: 0.617 ± 0.215
4.133SerAsp: 4.133 ± 0.441
3.146SerGlu: 3.146 ± 0.473
1.912SerPhe: 1.912 ± 0.383
6.908SerGly: 6.908 ± 0.907
1.172SerHis: 1.172 ± 0.308
2.961SerIle: 2.961 ± 0.445
2.036SerLys: 2.036 ± 0.432
3.948SerLeu: 3.948 ± 0.422
1.604SerMet: 1.604 ± 0.317
2.591SerAsn: 2.591 ± 0.422
3.393SerPro: 3.393 ± 0.415
1.234SerGln: 1.234 ± 0.303
3.763SerArg: 3.763 ± 0.47
3.886SerSer: 3.886 ± 0.689
3.208SerThr: 3.208 ± 0.447
4.565SerVal: 4.565 ± 0.621
1.48SerTrp: 1.48 ± 0.26
1.419SerTyr: 1.419 ± 0.232
0.0SerXaa: 0.0 ± 0.0
Thr
7.155ThrAla: 7.155 ± 0.683
0.679ThrCys: 0.679 ± 0.232
4.071ThrAsp: 4.071 ± 0.623
3.393ThrGlu: 3.393 ± 0.426
1.604ThrPhe: 1.604 ± 0.318
5.983ThrGly: 5.983 ± 0.666
2.282ThrHis: 2.282 ± 0.437
3.516ThrIle: 3.516 ± 0.388
2.282ThrLys: 2.282 ± 0.387
4.811ThrLeu: 4.811 ± 0.566
1.48ThrMet: 1.48 ± 0.268
2.406ThrAsn: 2.406 ± 0.484
4.503ThrPro: 4.503 ± 0.508
2.036ThrGln: 2.036 ± 0.348
3.701ThrArg: 3.701 ± 0.466
4.133ThrSer: 4.133 ± 0.45
5.058ThrThr: 5.058 ± 0.704
5.058ThrVal: 5.058 ± 0.607
1.049ThrTrp: 1.049 ± 0.299
1.912ThrTyr: 1.912 ± 0.377
0.0ThrXaa: 0.0 ± 0.0
Val
7.587ValAla: 7.587 ± 0.716
0.925ValCys: 0.925 ± 0.256
5.058ValAsp: 5.058 ± 0.58
5.181ValGlu: 5.181 ± 0.726
2.221ValPhe: 2.221 ± 0.414
5.86ValGly: 5.86 ± 0.708
1.172ValHis: 1.172 ± 0.284
2.652ValIle: 2.652 ± 0.494
2.036ValLys: 2.036 ± 0.356
4.873ValLeu: 4.873 ± 0.56
1.542ValMet: 1.542 ± 0.263
2.344ValAsn: 2.344 ± 0.369
4.133ValPro: 4.133 ± 0.451
2.776ValGln: 2.776 ± 0.373
4.565ValArg: 4.565 ± 0.663
4.626ValSer: 4.626 ± 0.522
5.181ValThr: 5.181 ± 0.503
5.922ValVal: 5.922 ± 0.672
1.912ValTrp: 1.912 ± 0.422
1.295ValTyr: 1.295 ± 0.267
0.0ValXaa: 0.0 ± 0.0
Trp
2.159TrpAla: 2.159 ± 0.294
0.247TrpCys: 0.247 ± 0.125
1.85TrpAsp: 1.85 ± 0.354
1.11TrpGlu: 1.11 ± 0.348
0.74TrpPhe: 0.74 ± 0.193
0.864TrpGly: 0.864 ± 0.206
0.493TrpHis: 0.493 ± 0.164
1.234TrpIle: 1.234 ± 0.268
0.864TrpLys: 0.864 ± 0.205
1.974TrpLeu: 1.974 ± 0.385
0.802TrpMet: 0.802 ± 0.248
0.802TrpAsn: 0.802 ± 0.27
1.11TrpPro: 1.11 ± 0.363
0.987TrpGln: 0.987 ± 0.303
1.974TrpArg: 1.974 ± 0.464
1.419TrpSer: 1.419 ± 0.286
1.542TrpThr: 1.542 ± 0.319
1.912TrpVal: 1.912 ± 0.43
1.11TrpTrp: 1.11 ± 0.235
0.493TrpTyr: 0.493 ± 0.152
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.652TyrAla: 2.652 ± 0.476
0.308TyrCys: 0.308 ± 0.129
1.665TyrAsp: 1.665 ± 0.456
1.665TyrGlu: 1.665 ± 0.323
0.802TyrPhe: 0.802 ± 0.204
1.727TyrGly: 1.727 ± 0.382
0.37TyrHis: 0.37 ± 0.119
1.049TyrIle: 1.049 ± 0.239
0.617TyrLys: 0.617 ± 0.207
2.036TyrLeu: 2.036 ± 0.372
0.185TyrMet: 0.185 ± 0.107
0.864TyrAsn: 0.864 ± 0.236
1.419TyrPro: 1.419 ± 0.21
0.74TyrGln: 0.74 ± 0.184
2.036TyrArg: 2.036 ± 0.415
1.172TyrSer: 1.172 ± 0.283
2.221TyrThr: 2.221 ± 0.422
2.221TyrVal: 2.221 ± 0.347
0.679TyrTrp: 0.679 ± 0.241
0.617TyrTyr: 0.617 ± 0.181
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 87 proteins (16213 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski