Amino acid dipepetide frequency for Bifidobacterium callitrichidarum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.111AlaAla: 14.111 ± 0.182	1.051AlaCys: 1.051 ± 0.035	7.559AlaAsp: 7.559 ± 0.112	6.444AlaGlu: 6.444 ± 0.107	3.461AlaPhe: 3.461 ± 0.068	9.52AlaGly: 9.52 ± 0.124	2.098AlaHis: 2.098 ± 0.058	5.652AlaIle: 5.652 ± 0.087	5.027AlaLys: 5.027 ± 0.092	9.866AlaLeu: 9.866 ± 0.12	3.105AlaMet: 3.105 ± 0.064	3.631AlaAsn: 3.631 ± 0.074	4.043AlaPro: 4.043 ± 0.092	3.995AlaGln: 3.995 ± 0.077	5.766AlaArg: 5.766 ± 0.109	6.371AlaSer: 6.371 ± 0.089	6.153AlaThr: 6.153 ± 0.096	8.536AlaVal: 8.536 ± 0.12	1.486AlaTrp: 1.486 ± 0.046	2.73AlaTyr: 2.73 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	0.987CysAla: 0.987 ± 0.034	0.109CysCys: 0.109 ± 0.011	0.543CysAsp: 0.543 ± 0.025	0.477CysGlu: 0.477 ± 0.027	0.314CysPhe: 0.314 ± 0.018	0.985CysGly: 0.985 ± 0.038	0.195CysHis: 0.195 ± 0.018	0.412CysIle: 0.412 ± 0.019	0.274CysLys: 0.274 ± 0.019	0.765CysLeu: 0.765 ± 0.028	0.23CysMet: 0.23 ± 0.016	0.245CysAsn: 0.245 ± 0.018	0.46CysPro: 0.46 ± 0.024	0.231CysGln: 0.231 ± 0.018	0.558CysArg: 0.558 ± 0.028	0.541CysSer: 0.541 ± 0.026	0.51CysThr: 0.51 ± 0.025	0.783CysVal: 0.783 ± 0.034	0.162CysTrp: 0.162 ± 0.013	0.224CysTyr: 0.224 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	7.159AspAla: 7.159 ± 0.117	0.551AspCys: 0.551 ± 0.027	4.556AspAsp: 4.556 ± 0.106	4.766AspGlu: 4.766 ± 0.088	2.264AspPhe: 2.264 ± 0.05	6.212AspGly: 6.212 ± 0.108	1.276AspHis: 1.276 ± 0.043	3.208AspIle: 3.208 ± 0.063	2.552AspLys: 2.552 ± 0.068	5.088AspLeu: 5.088 ± 0.08	1.684AspMet: 1.684 ± 0.044	1.887AspAsn: 1.887 ± 0.052	3.56AspPro: 3.56 ± 0.063	2.021AspGln: 2.021 ± 0.05	3.458AspArg: 3.458 ± 0.08	3.891AspSer: 3.891 ± 0.08	3.547AspThr: 3.547 ± 0.077	4.882AspVal: 4.882 ± 0.074	1.17AspTrp: 1.17 ± 0.042	2.103AspTyr: 2.103 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	6.286GluAla: 6.286 ± 0.104	0.449GluCys: 0.449 ± 0.024	3.357GluAsp: 3.357 ± 0.073	3.254GluGlu: 3.254 ± 0.077	1.773GluPhe: 1.773 ± 0.053	3.818GluGly: 3.818 ± 0.082	1.663GluHis: 1.663 ± 0.05	2.742GluIle: 2.742 ± 0.061	2.196GluLys: 2.196 ± 0.062	5.119GluLeu: 5.119 ± 0.096	1.326GluMet: 1.326 ± 0.037	1.984GluAsn: 1.984 ± 0.051	2.744GluPro: 2.744 ± 0.07	2.59GluGln: 2.59 ± 0.059	3.945GluArg: 3.945 ± 0.089	3.373GluSer: 3.373 ± 0.064	3.641GluThr: 3.641 ± 0.068	3.443GluVal: 3.443 ± 0.073	0.762GluTrp: 0.762 ± 0.028	1.831GluTyr: 1.831 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	3.931PheAla: 3.931 ± 0.076	0.356PheCys: 0.356 ± 0.022	2.681PheAsp: 2.681 ± 0.056	1.787PheGlu: 1.787 ± 0.054	1.135PhePhe: 1.135 ± 0.044	3.244PheGly: 3.244 ± 0.075	0.698PheHis: 0.698 ± 0.026	1.669PheIle: 1.669 ± 0.051	1.244PheLys: 1.244 ± 0.045	2.759PheLeu: 2.759 ± 0.069	0.756PheMet: 0.756 ± 0.03	1.275PheAsn: 1.275 ± 0.036	1.381PhePro: 1.381 ± 0.042	0.957PheGln: 0.957 ± 0.04	1.723PheArg: 1.723 ± 0.048	2.127PheSer: 2.127 ± 0.054	2.402PheThr: 2.402 ± 0.048	2.653PheVal: 2.653 ± 0.066	0.493PheTrp: 0.493 ± 0.029	0.948PheTyr: 0.948 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	7.38GlyAla: 7.38 ± 0.116	0.783GlyCys: 0.783 ± 0.028	4.796GlyAsp: 4.796 ± 0.083	4.76GlyGlu: 4.76 ± 0.086	3.306GlyPhe: 3.306 ± 0.063	6.205GlyGly: 6.205 ± 0.113	1.672GlyHis: 1.672 ± 0.049	4.637GlyIle: 4.637 ± 0.072	4.041GlyLys: 4.041 ± 0.084	7.327GlyLeu: 7.327 ± 0.108	2.23GlyMet: 2.23 ± 0.045	2.768GlyAsn: 2.768 ± 0.078	2.647GlyPro: 2.647 ± 0.058	2.731GlyGln: 2.731 ± 0.066	4.651GlyArg: 4.651 ± 0.087	5.344GlySer: 5.344 ± 0.093	5.536GlyThr: 5.536 ± 0.106	6.269GlyVal: 6.269 ± 0.097	1.365GlyTrp: 1.365 ± 0.039	2.866GlyTyr: 2.866 ± 0.072	0.0GlyXaa: 0.0 ± 0.0
His	2.112HisAla: 2.112 ± 0.052	0.211HisCys: 0.211 ± 0.016	1.505HisAsp: 1.505 ± 0.046	1.168HisGlu: 1.168 ± 0.037	0.593HisPhe: 0.593 ± 0.022	1.903HisGly: 1.903 ± 0.051	0.546HisHis: 0.546 ± 0.024	1.128HisIle: 1.128 ± 0.04	0.646HisLys: 0.646 ± 0.027	1.619HisLeu: 1.619 ± 0.049	0.559HisMet: 0.559 ± 0.025	0.634HisAsn: 0.634 ± 0.025	1.295HisPro: 1.295 ± 0.042	0.578HisGln: 0.578 ± 0.028	1.371HisArg: 1.371 ± 0.045	0.939HisSer: 0.939 ± 0.027	1.119HisThr: 1.119 ± 0.032	1.727HisVal: 1.727 ± 0.046	0.344HisTrp: 0.344 ± 0.021	0.616HisTyr: 0.616 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.571IleAla: 6.571 ± 0.1	0.597IleCys: 0.597 ± 0.029	3.93IleAsp: 3.93 ± 0.066	3.108IleGlu: 3.108 ± 0.068	1.469IlePhe: 1.469 ± 0.053	4.636IleGly: 4.636 ± 0.094	0.998IleHis: 0.998 ± 0.032	2.905IleIle: 2.905 ± 0.063	1.862IleLys: 1.862 ± 0.051	3.916IleLeu: 3.916 ± 0.072	1.187IleMet: 1.187 ± 0.041	1.855IleAsn: 1.855 ± 0.049	2.744IlePro: 2.744 ± 0.056	1.353IleGln: 1.353 ± 0.042	3.026IleArg: 3.026 ± 0.072	2.926IleSer: 2.926 ± 0.07	3.497IleThr: 3.497 ± 0.07	4.462IleVal: 4.462 ± 0.081	0.584IleTrp: 0.584 ± 0.028	1.173IleTyr: 1.173 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	5.08LysAla: 5.08 ± 0.098	0.188LysCys: 0.188 ± 0.014	2.82LysAsp: 2.82 ± 0.074	2.211LysGlu: 2.211 ± 0.062	1.098LysPhe: 1.098 ± 0.035	2.778LysGly: 2.778 ± 0.065	0.858LysHis: 0.858 ± 0.028	1.84LysIle: 1.84 ± 0.052	1.896LysLys: 1.896 ± 0.061	3.429LysLeu: 3.429 ± 0.067	0.905LysMet: 0.905 ± 0.032	1.476LysAsn: 1.476 ± 0.051	2.459LysPro: 2.459 ± 0.062	1.587LysGln: 1.587 ± 0.046	2.457LysArg: 2.457 ± 0.071	2.344LysSer: 2.344 ± 0.059	2.873LysThr: 2.873 ± 0.073	2.836LysVal: 2.836 ± 0.06	0.538LysTrp: 0.538 ± 0.026	1.224LysTyr: 1.224 ± 0.041	0.0LysXaa: 0.0 ± 0.0
Leu	10.379LeuAla: 10.379 ± 0.154	0.84LeuCys: 0.84 ± 0.038	6.056LeuAsp: 6.056 ± 0.097	4.301LeuGlu: 4.301 ± 0.084	3.078LeuPhe: 3.078 ± 0.073	6.967LeuGly: 6.967 ± 0.098	1.702LeuHis: 1.702 ± 0.044	4.753LeuIle: 4.753 ± 0.086	3.893LeuLys: 3.893 ± 0.067	7.803LeuLeu: 7.803 ± 0.125	2.313LeuMet: 2.313 ± 0.069	3.077LeuAsn: 3.077 ± 0.059	4.489LeuPro: 4.489 ± 0.067	2.375LeuGln: 2.375 ± 0.063	4.724LeuArg: 4.724 ± 0.094	5.284LeuSer: 5.284 ± 0.09	5.77LeuThr: 5.77 ± 0.086	6.385LeuVal: 6.385 ± 0.121	1.066LeuTrp: 1.066 ± 0.04	2.174LeuTyr: 2.174 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.892MetAla: 2.892 ± 0.067	0.257MetCys: 0.257 ± 0.016	1.39MetAsp: 1.39 ± 0.044	1.121MetGlu: 1.121 ± 0.037	0.883MetPhe: 0.883 ± 0.038	1.87MetGly: 1.87 ± 0.048	0.505MetHis: 0.505 ± 0.025	1.357MetIle: 1.357 ± 0.043	1.034MetLys: 1.034 ± 0.035	2.565MetLeu: 2.565 ± 0.058	0.692MetMet: 0.692 ± 0.037	0.984MetAsn: 0.984 ± 0.034	1.494MetPro: 1.494 ± 0.046	0.808MetGln: 0.808 ± 0.034	1.566MetArg: 1.566 ± 0.04	1.777MetSer: 1.777 ± 0.042	2.015MetThr: 2.015 ± 0.047	1.785MetVal: 1.785 ± 0.052	0.294MetTrp: 0.294 ± 0.017	0.518MetTyr: 0.518 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.71AsnAla: 3.71 ± 0.071	0.229AsnCys: 0.229 ± 0.016	2.182AsnAsp: 2.182 ± 0.06	1.877AsnGlu: 1.877 ± 0.051	0.899AsnPhe: 0.899 ± 0.036	3.577AsnGly: 3.577 ± 0.094	0.702AsnHis: 0.702 ± 0.027	1.653AsnIle: 1.653 ± 0.043	1.259AsnLys: 1.259 ± 0.048	2.78AsnLeu: 2.78 ± 0.061	0.788AsnMet: 0.788 ± 0.028	1.24AsnAsn: 1.24 ± 0.061	2.365AsnPro: 2.365 ± 0.056	1.278AsnGln: 1.278 ± 0.046	2.066AsnArg: 2.066 ± 0.052	1.576AsnSer: 1.576 ± 0.05	2.178AsnThr: 2.178 ± 0.061	2.506AsnVal: 2.506 ± 0.055	0.494AsnTrp: 0.494 ± 0.025	0.967AsnTyr: 0.967 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	5.457ProAla: 5.457 ± 0.113	0.301ProCys: 0.301 ± 0.02	3.608ProAsp: 3.608 ± 0.075	3.422ProGlu: 3.422 ± 0.066	1.665ProPhe: 1.665 ± 0.047	3.563ProGly: 3.563 ± 0.067	0.919ProHis: 0.919 ± 0.036	2.334ProIle: 2.334 ± 0.05	1.848ProLys: 1.848 ± 0.051	3.832ProLeu: 3.832 ± 0.079	1.096ProMet: 1.096 ± 0.04	1.696ProAsn: 1.696 ± 0.046	1.296ProPro: 1.296 ± 0.045	1.657ProGln: 1.657 ± 0.05	2.164ProArg: 2.164 ± 0.064	2.966ProSer: 2.966 ± 0.065	2.946ProThr: 2.946 ± 0.06	4.056ProVal: 4.056 ± 0.079	0.729ProTrp: 0.729 ± 0.035	1.471ProTyr: 1.471 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	3.71GlnAla: 3.71 ± 0.062	0.293GlnCys: 0.293 ± 0.021	1.71GlnAsp: 1.71 ± 0.044	1.527GlnGlu: 1.527 ± 0.04	1.048GlnPhe: 1.048 ± 0.04	2.283GlnGly: 2.283 ± 0.059	0.729GlnHis: 0.729 ± 0.028	1.775GlnIle: 1.775 ± 0.045	1.08GlnLys: 1.08 ± 0.04	3.325GlnLeu: 3.325 ± 0.066	0.952GlnMet: 0.952 ± 0.03	1.024GlnAsn: 1.024 ± 0.041	1.822GlnPro: 1.822 ± 0.067	1.614GlnGln: 1.614 ± 0.053	2.189GlnArg: 2.189 ± 0.059	2.29GlnSer: 2.29 ± 0.067	2.021GlnThr: 2.021 ± 0.052	2.392GlnVal: 2.392 ± 0.05	0.633GlnTrp: 0.633 ± 0.032	1.156GlnTyr: 1.156 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	5.119ArgAla: 5.119 ± 0.087	0.496ArgCys: 0.496 ± 0.024	3.379ArgAsp: 3.379 ± 0.088	3.619ArgGlu: 3.619 ± 0.084	2.386ArgPhe: 2.386 ± 0.07	3.62ArgGly: 3.62 ± 0.071	1.465ArgHis: 1.465 ± 0.04	3.525ArgIle: 3.525 ± 0.062	2.655ArgLys: 2.655 ± 0.055	5.357ArgLeu: 5.357 ± 0.109	1.832ArgMet: 1.832 ± 0.049	2.096ArgAsn: 2.096 ± 0.048	2.44ArgPro: 2.44 ± 0.059	2.155ArgGln: 2.155 ± 0.057	4.502ArgArg: 4.502 ± 0.144	2.963ArgSer: 2.963 ± 0.07	3.443ArgThr: 3.443 ± 0.071	3.86ArgVal: 3.86 ± 0.07	0.926ArgTrp: 0.926 ± 0.034	1.815ArgTyr: 1.815 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	6.262SerAla: 6.262 ± 0.097	0.488SerCys: 0.488 ± 0.027	3.953SerAsp: 3.953 ± 0.091	3.062SerGlu: 3.062 ± 0.064	2.118SerPhe: 2.118 ± 0.049	5.783SerGly: 5.783 ± 0.102	1.22SerHis: 1.22 ± 0.038	3.129SerIle: 3.129 ± 0.06	2.313SerLys: 2.313 ± 0.055	5.199SerLeu: 5.199 ± 0.085	1.632SerMet: 1.632 ± 0.048	2.024SerAsn: 2.024 ± 0.06	2.453SerPro: 2.453 ± 0.062	2.055SerGln: 2.055 ± 0.054	3.348SerArg: 3.348 ± 0.07	4.07SerSer: 4.07 ± 0.104	3.764SerThr: 3.764 ± 0.084	4.568SerVal: 4.568 ± 0.084	0.865SerTrp: 0.865 ± 0.035	1.629SerTyr: 1.629 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	6.796ThrAla: 6.796 ± 0.099	0.491ThrCys: 0.491 ± 0.024	4.156ThrAsp: 4.156 ± 0.086	2.97ThrGlu: 2.97 ± 0.064	2.269ThrPhe: 2.269 ± 0.058	5.621ThrGly: 5.621 ± 0.085	1.173ThrHis: 1.173 ± 0.04	3.635ThrIle: 3.635 ± 0.068	2.331ThrLys: 2.331 ± 0.057	5.76ThrLeu: 5.76 ± 0.085	1.499ThrMet: 1.499 ± 0.045	2.067ThrAsn: 2.067 ± 0.064	3.594ThrPro: 3.594 ± 0.071	1.9ThrGln: 1.9 ± 0.05	2.966ThrArg: 2.966 ± 0.065	3.629ThrSer: 3.629 ± 0.072	4.027ThrThr: 4.027 ± 0.093	5.916ThrVal: 5.916 ± 0.112	0.891ThrTrp: 0.891 ± 0.035	1.734ThrTyr: 1.734 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	8.24ValAla: 8.24 ± 0.12	0.815ValCys: 0.815 ± 0.033	4.77ValAsp: 4.77 ± 0.09	4.155ValGlu: 4.155 ± 0.078	2.893ValPhe: 2.893 ± 0.059	5.071ValGly: 5.071 ± 0.093	1.359ValHis: 1.359 ± 0.043	4.46ValIle: 4.46 ± 0.088	3.105ValLys: 3.105 ± 0.073	6.874ValLeu: 6.874 ± 0.107	1.962ValMet: 1.962 ± 0.046	2.739ValAsn: 2.739 ± 0.061	3.886ValPro: 3.886 ± 0.068	2.015ValGln: 2.015 ± 0.046	4.352ValArg: 4.352 ± 0.083	4.973ValSer: 4.973 ± 0.087	5.369ValThr: 5.369 ± 0.102	6.016ValVal: 6.016 ± 0.1	1.073ValTrp: 1.073 ± 0.034	1.908ValTyr: 1.908 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	1.258TrpAla: 1.258 ± 0.041	0.178TrpCys: 0.178 ± 0.015	0.83TrpAsp: 0.83 ± 0.034	0.605TrpGlu: 0.605 ± 0.027	0.58TrpPhe: 0.58 ± 0.028	0.969TrpGly: 0.969 ± 0.036	0.364TrpHis: 0.364 ± 0.024	0.76TrpIle: 0.76 ± 0.032	0.652TrpLys: 0.652 ± 0.027	1.561TrpLeu: 1.561 ± 0.056	0.432TrpMet: 0.432 ± 0.026	0.686TrpAsn: 0.686 ± 0.032	0.548TrpPro: 0.548 ± 0.027	0.641TrpGln: 0.641 ± 0.029	1.011TrpArg: 1.011 ± 0.04	0.935TrpSer: 0.935 ± 0.033	0.917TrpThr: 0.917 ± 0.037	0.956TrpVal: 0.956 ± 0.038	0.324TrpTrp: 0.324 ± 0.023	0.478TrpTyr: 0.478 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.165TyrAla: 3.165 ± 0.064	0.321TyrCys: 0.321 ± 0.018	2.055TyrAsp: 2.055 ± 0.052	1.663TyrGlu: 1.663 ± 0.047	0.983TyrPhe: 0.983 ± 0.042	2.691TyrGly: 2.691 ± 0.059	0.473TyrHis: 0.473 ± 0.02	1.223TyrIle: 1.223 ± 0.041	0.987TyrLys: 0.987 ± 0.038	2.485TyrLeu: 2.485 ± 0.065	0.624TyrMet: 0.624 ± 0.029	0.942TyrAsn: 0.942 ± 0.037	1.304TyrPro: 1.304 ± 0.041	1.034TyrGln: 1.034 ± 0.038	1.813TyrArg: 1.813 ± 0.049	1.614TyrSer: 1.614 ± 0.045	1.7TyrThr: 1.7 ± 0.058	2.004TyrVal: 2.004 ± 0.043	0.484TyrTrp: 0.484 ± 0.022	0.952TyrTyr: 0.952 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2443 proteins (852745 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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