Amino acid dipepetide frequency for Frondihabitans sp. 762G35

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.684AlaAla: 18.684 ± 0.234
0.594AlaCys: 0.594 ± 0.024
7.597AlaAsp: 7.597 ± 0.104
7.175AlaGlu: 7.175 ± 0.114
4.016AlaPhe: 4.016 ± 0.064
12.013AlaGly: 12.013 ± 0.123
2.175AlaHis: 2.175 ± 0.05
5.254AlaIle: 5.254 ± 0.079
2.816AlaLys: 2.816 ± 0.071
13.98AlaLeu: 13.98 ± 0.143
2.295AlaMet: 2.295 ± 0.052
2.327AlaAsn: 2.327 ± 0.074
6.773AlaPro: 6.773 ± 0.116
3.49AlaGln: 3.49 ± 0.067
8.934AlaArg: 8.934 ± 0.117
8.457AlaSer: 8.457 ± 0.104
8.509AlaThr: 8.509 ± 0.137
11.725AlaVal: 11.725 ± 0.132
1.716AlaTrp: 1.716 ± 0.048
2.325AlaTyr: 2.325 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
0.541CysAla: 0.541 ± 0.026
0.037CysCys: 0.037 ± 0.007
0.258CysAsp: 0.258 ± 0.017
0.212CysGlu: 0.212 ± 0.013
0.158CysPhe: 0.158 ± 0.014
0.5CysGly: 0.5 ± 0.022
0.113CysHis: 0.113 ± 0.011
0.176CysIle: 0.176 ± 0.012
0.062CysLys: 0.062 ± 0.007
0.45CysLeu: 0.45 ± 0.022
0.05CysMet: 0.05 ± 0.007
0.091CysAsn: 0.091 ± 0.009
0.25CysPro: 0.25 ± 0.018
0.112CysGln: 0.112 ± 0.012
0.295CysArg: 0.295 ± 0.019
0.361CysSer: 0.361 ± 0.023
0.327CysThr: 0.327 ± 0.021
0.4CysVal: 0.4 ± 0.019
0.06CysTrp: 0.06 ± 0.009
0.087CysTyr: 0.087 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
8.102AspAla: 8.102 ± 0.095
0.237AspCys: 0.237 ± 0.017
4.748AspAsp: 4.748 ± 0.079
4.197AspGlu: 4.197 ± 0.081
1.78AspPhe: 1.78 ± 0.044
5.719AspGly: 5.719 ± 0.093
1.21AspHis: 1.21 ± 0.038
2.136AspIle: 2.136 ± 0.052
0.935AspLys: 0.935 ± 0.037
6.695AspLeu: 6.695 ± 0.091
0.655AspMet: 0.655 ± 0.026
0.936AspAsn: 0.936 ± 0.033
3.98AspPro: 3.98 ± 0.065
1.499AspGln: 1.499 ± 0.043
4.747AspArg: 4.747 ± 0.078
3.099AspSer: 3.099 ± 0.053
3.067AspThr: 3.067 ± 0.059
5.705AspVal: 5.705 ± 0.089
0.888AspTrp: 0.888 ± 0.033
1.239AspTyr: 1.239 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
7.052GluAla: 7.052 ± 0.104
0.187GluCys: 0.187 ± 0.014
2.025GluAsp: 2.025 ± 0.051
2.705GluGlu: 2.705 ± 0.062
1.621GluPhe: 1.621 ± 0.038
3.917GluGly: 3.917 ± 0.066
1.324GluHis: 1.324 ± 0.04
2.604GluIle: 2.604 ± 0.06
1.468GluLys: 1.468 ± 0.041
5.535GluLeu: 5.535 ± 0.095
0.826GluMet: 0.826 ± 0.03
1.198GluAsn: 1.198 ± 0.035
2.723GluPro: 2.723 ± 0.057
1.853GluGln: 1.853 ± 0.051
4.845GluArg: 4.845 ± 0.095
3.03GluSer: 3.03 ± 0.061
3.308GluThr: 3.308 ± 0.07
4.457GluVal: 4.457 ± 0.079
0.766GluTrp: 0.766 ± 0.027
0.951GluTyr: 0.951 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
4.265PheAla: 4.265 ± 0.072
0.198PheCys: 0.198 ± 0.015
2.427PheAsp: 2.427 ± 0.055
1.724PheGlu: 1.724 ± 0.047
1.165PhePhe: 1.165 ± 0.039
3.401PheGly: 3.401 ± 0.062
0.562PheHis: 0.562 ± 0.025
1.039PheIle: 1.039 ± 0.034
0.488PheLys: 0.488 ± 0.021
2.974PheLeu: 2.974 ± 0.06
0.385PheMet: 0.385 ± 0.019
0.624PheAsn: 0.624 ± 0.029
1.402PhePro: 1.402 ± 0.036
0.841PheGln: 0.841 ± 0.028
1.863PheArg: 1.863 ± 0.046
1.933PheSer: 1.933 ± 0.041
2.204PheThr: 2.204 ± 0.046
3.17PheVal: 3.17 ± 0.063
0.45PheTrp: 0.45 ± 0.022
0.659PheTyr: 0.659 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
10.699GlyAla: 10.699 ± 0.122
0.469GlyCys: 0.469 ± 0.023
5.112GlyAsp: 5.112 ± 0.065
4.27GlyGlu: 4.27 ± 0.074
3.296GlyPhe: 3.296 ± 0.069
7.631GlyGly: 7.631 ± 0.124
1.864GlyHis: 1.864 ± 0.046
4.615GlyIle: 4.615 ± 0.065
2.097GlyLys: 2.097 ± 0.051
9.181GlyLeu: 9.181 ± 0.114
1.53GlyMet: 1.53 ± 0.046
1.757GlyAsn: 1.757 ± 0.055
3.88GlyPro: 3.88 ± 0.062
2.491GlyGln: 2.491 ± 0.055
6.964GlyArg: 6.964 ± 0.105
6.537GlySer: 6.537 ± 0.118
6.107GlyThr: 6.107 ± 0.147
8.164GlyVal: 8.164 ± 0.097
1.422GlyTrp: 1.422 ± 0.04
2.114GlyTyr: 2.114 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
2.135HisAla: 2.135 ± 0.047
0.095HisCys: 0.095 ± 0.009
1.426HisAsp: 1.426 ± 0.038
1.082HisGlu: 1.082 ± 0.031
0.564HisPhe: 0.564 ± 0.025
1.877HisGly: 1.877 ± 0.046
0.512HisHis: 0.512 ± 0.024
0.608HisIle: 0.608 ± 0.027
0.249HisLys: 0.249 ± 0.016
2.07HisLeu: 2.07 ± 0.052
0.232HisMet: 0.232 ± 0.016
0.317HisAsn: 0.317 ± 0.019
1.473HisPro: 1.473 ± 0.037
0.463HisGln: 0.463 ± 0.021
1.566HisArg: 1.566 ± 0.037
0.928HisSer: 0.928 ± 0.029
0.893HisThr: 0.893 ± 0.032
1.671HisVal: 1.671 ± 0.04
0.239HisTrp: 0.239 ± 0.015
0.409HisTyr: 0.409 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
5.957IleAla: 5.957 ± 0.078
0.21IleCys: 0.21 ± 0.016
3.144IleAsp: 3.144 ± 0.052
2.357IleGlu: 2.357 ± 0.049
1.118IlePhe: 1.118 ± 0.04
4.245IleGly: 4.245 ± 0.085
0.672IleHis: 0.672 ± 0.027
1.427IleIle: 1.427 ± 0.049
0.802IleLys: 0.802 ± 0.035
3.839IleLeu: 3.839 ± 0.069
0.542IleMet: 0.542 ± 0.027
0.878IleAsn: 0.878 ± 0.035
2.22IlePro: 2.22 ± 0.049
0.984IleGln: 0.984 ± 0.037
2.723IleArg: 2.723 ± 0.057
2.212IleSer: 2.212 ± 0.049
2.803IleThr: 2.803 ± 0.06
4.545IleVal: 4.545 ± 0.081
0.455IleTrp: 0.455 ± 0.025
0.672IleTyr: 0.672 ± 0.026
0.0IleXaa: 0.0 ± 0.0
Lys
2.73LysAla: 2.73 ± 0.068
0.066LysCys: 0.066 ± 0.008
1.055LysAsp: 1.055 ± 0.042
0.873LysGlu: 0.873 ± 0.028
0.472LysPhe: 0.472 ± 0.023
1.702LysGly: 1.702 ± 0.05
0.452LysHis: 0.452 ± 0.019
1.025LysIle: 1.025 ± 0.04
0.909LysLys: 0.909 ± 0.032
1.867LysLeu: 1.867 ± 0.046
0.378LysMet: 0.378 ± 0.022
0.608LysAsn: 0.608 ± 0.03
1.253LysPro: 1.253 ± 0.037
0.782LysGln: 0.782 ± 0.031
1.637LysArg: 1.637 ± 0.039
1.351LysSer: 1.351 ± 0.044
1.584LysThr: 1.584 ± 0.048
1.707LysVal: 1.707 ± 0.047
0.255LysTrp: 0.255 ± 0.016
0.464LysTyr: 0.464 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
14.36LeuAla: 14.36 ± 0.164
0.441LeuCys: 0.441 ± 0.023
6.959LeuAsp: 6.959 ± 0.105
5.067LeuGlu: 5.067 ± 0.085
2.996LeuPhe: 2.996 ± 0.069
9.526LeuGly: 9.526 ± 0.123
1.788LeuHis: 1.788 ± 0.044
3.706LeuIle: 3.706 ± 0.068
1.825LeuLys: 1.825 ± 0.053
10.575LeuLeu: 10.575 ± 0.148
1.372LeuMet: 1.372 ± 0.036
1.679LeuAsn: 1.679 ± 0.042
5.677LeuPro: 5.677 ± 0.094
2.385LeuGln: 2.385 ± 0.052
7.627LeuArg: 7.627 ± 0.11
5.891LeuSer: 5.891 ± 0.071
6.432LeuThr: 6.432 ± 0.077
10.229LeuVal: 10.229 ± 0.138
1.225LeuTrp: 1.225 ± 0.036
1.683LeuTyr: 1.683 ± 0.043
0.0LeuXaa: 0.0 ± 0.0
Met
1.927MetAla: 1.927 ± 0.042
0.086MetCys: 0.086 ± 0.008
0.652MetAsp: 0.652 ± 0.028
0.557MetGlu: 0.557 ± 0.023
0.4MetPhe: 0.4 ± 0.02
1.058MetGly: 1.058 ± 0.031
0.28MetHis: 0.28 ± 0.017
0.8MetIle: 0.8 ± 0.031
0.435MetLys: 0.435 ± 0.023
1.502MetLeu: 1.502 ± 0.041
0.262MetMet: 0.262 ± 0.017
0.415MetAsn: 0.415 ± 0.02
0.924MetPro: 0.924 ± 0.027
0.426MetGln: 0.426 ± 0.022
1.105MetArg: 1.105 ± 0.035
1.334MetSer: 1.334 ± 0.04
1.72MetThr: 1.72 ± 0.036
1.131MetVal: 1.131 ± 0.036
0.136MetTrp: 0.136 ± 0.011
0.242MetTyr: 0.242 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
2.428AsnAla: 2.428 ± 0.07
0.108AsnCys: 0.108 ± 0.01
1.225AsnAsp: 1.225 ± 0.035
0.852AsnGlu: 0.852 ± 0.035
0.629AsnPhe: 0.629 ± 0.026
2.022AsnGly: 2.022 ± 0.061
0.373AsnHis: 0.373 ± 0.021
0.78AsnIle: 0.78 ± 0.032
0.418AsnLys: 0.418 ± 0.022
1.857AsnLeu: 1.857 ± 0.046
0.297AsnMet: 0.297 ± 0.018
0.49AsnAsn: 0.49 ± 0.02
1.478AsnPro: 1.478 ± 0.041
0.582AsnGln: 0.582 ± 0.026
1.26AsnArg: 1.26 ± 0.036
1.084AsnSer: 1.084 ± 0.036
1.213AsnThr: 1.213 ± 0.045
1.76AsnVal: 1.76 ± 0.044
0.273AsnTrp: 0.273 ± 0.019
0.512AsnTyr: 0.512 ± 0.027
0.0AsnXaa: 0.0 ± 0.0
Pro
7.39ProAla: 7.39 ± 0.116
0.177ProCys: 0.177 ± 0.013
3.584ProAsp: 3.584 ± 0.054
3.58ProGlu: 3.58 ± 0.054
1.722ProPhe: 1.722 ± 0.042
5.198ProGly: 5.198 ± 0.075
0.977ProHis: 0.977 ± 0.035
1.96ProIle: 1.96 ± 0.049
1.15ProLys: 1.15 ± 0.037
4.966ProLeu: 4.966 ± 0.081
0.783ProMet: 0.783 ± 0.027
1.008ProAsn: 1.008 ± 0.034
2.12ProPro: 2.12 ± 0.062
1.478ProGln: 1.478 ± 0.035
3.604ProArg: 3.604 ± 0.067
3.602ProSer: 3.602 ± 0.069
3.786ProThr: 3.786 ± 0.078
5.116ProVal: 5.116 ± 0.085
0.812ProTrp: 0.812 ± 0.026
0.987ProTyr: 0.987 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
3.419GlnAla: 3.419 ± 0.063
0.105GlnCys: 0.105 ± 0.01
1.269GlnAsp: 1.269 ± 0.034
1.463GlnGlu: 1.463 ± 0.046
0.818GlnPhe: 0.818 ± 0.029
2.169GlnGly: 2.169 ± 0.05
0.573GlnHis: 0.573 ± 0.025
1.309GlnIle: 1.309 ± 0.037
0.762GlnLys: 0.762 ± 0.031
2.816GlnLeu: 2.816 ± 0.058
0.42GlnMet: 0.42 ± 0.021
0.721GlnAsn: 0.721 ± 0.032
1.425GlnPro: 1.425 ± 0.043
1.117GlnGln: 1.117 ± 0.043
2.107GlnArg: 2.107 ± 0.052
1.542GlnSer: 1.542 ± 0.041
1.668GlnThr: 1.668 ± 0.046
2.308GlnVal: 2.308 ± 0.058
0.361GlnTrp: 0.361 ± 0.019
0.591GlnTyr: 0.591 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
8.856ArgAla: 8.856 ± 0.123
0.279ArgCys: 0.279 ± 0.016
4.5ArgAsp: 4.5 ± 0.078
4.135ArgGlu: 4.135 ± 0.077
2.455ArgPhe: 2.455 ± 0.059
5.681ArgGly: 5.681 ± 0.088
1.509ArgHis: 1.509 ± 0.047
3.499ArgIle: 3.499 ± 0.057
1.352ArgLys: 1.352 ± 0.038
7.723ArgLeu: 7.723 ± 0.115
1.507ArgMet: 1.507 ± 0.041
1.303ArgAsn: 1.303 ± 0.04
3.94ArgPro: 3.94 ± 0.075
2.022ArgGln: 2.022 ± 0.047
6.823ArgArg: 6.823 ± 0.116
4.767ArgSer: 4.767 ± 0.081
4.11ArgThr: 4.11 ± 0.067
6.226ArgVal: 6.226 ± 0.081
1.078ArgTrp: 1.078 ± 0.036
1.486ArgTyr: 1.486 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
7.7SerAla: 7.7 ± 0.087
0.315SerCys: 0.315 ± 0.018
3.576SerAsp: 3.576 ± 0.068
2.684SerGlu: 2.684 ± 0.05
2.178SerPhe: 2.178 ± 0.046
6.552SerGly: 6.552 ± 0.113
1.06SerHis: 1.06 ± 0.031
2.788SerIle: 2.788 ± 0.053
1.409SerLys: 1.409 ± 0.04
6.027SerLeu: 6.027 ± 0.083
1.17SerMet: 1.17 ± 0.034
1.309SerAsn: 1.309 ± 0.036
3.415SerPro: 3.415 ± 0.068
1.585SerGln: 1.585 ± 0.044
4.437SerArg: 4.437 ± 0.073
4.544SerSer: 4.544 ± 0.078
4.863SerThr: 4.863 ± 0.093
5.209SerVal: 5.209 ± 0.07
1.029SerTrp: 1.029 ± 0.031
1.318SerTyr: 1.318 ± 0.041
0.0SerXaa: 0.0 ± 0.0
Thr
8.437ThrAla: 8.437 ± 0.151
0.287ThrCys: 0.287 ± 0.023
3.694ThrAsp: 3.694 ± 0.072
2.897ThrGlu: 2.897 ± 0.05
2.071ThrPhe: 2.071 ± 0.049
6.373ThrGly: 6.373 ± 0.113
1.11ThrHis: 1.11 ± 0.035
2.959ThrIle: 2.959 ± 0.067
1.482ThrLys: 1.482 ± 0.045
6.468ThrLeu: 6.468 ± 0.075
0.914ThrMet: 0.914 ± 0.031
1.356ThrAsn: 1.356 ± 0.051
4.334ThrPro: 4.334 ± 0.076
1.521ThrGln: 1.521 ± 0.044
4.067ThrArg: 4.067 ± 0.063
4.386ThrSer: 4.386 ± 0.088
5.021ThrThr: 5.021 ± 0.132
6.627ThrVal: 6.627 ± 0.151
1.028ThrTrp: 1.028 ± 0.034
1.287ThrTyr: 1.287 ± 0.051
0.0ThrXaa: 0.0 ± 0.0
Val
12.477ValAla: 12.477 ± 0.135
0.443ValCys: 0.443 ± 0.019
6.376ValAsp: 6.376 ± 0.086
4.977ValGlu: 4.977 ± 0.076
3.027ValPhe: 3.027 ± 0.055
7.718ValGly: 7.718 ± 0.097
1.677ValHis: 1.677 ± 0.042
3.896ValIle: 3.896 ± 0.081
1.792ValLys: 1.792 ± 0.054
9.167ValLeu: 9.167 ± 0.118
1.295ValMet: 1.295 ± 0.035
1.705ValAsn: 1.705 ± 0.051
5.024ValPro: 5.024 ± 0.079
2.169ValGln: 2.169 ± 0.049
5.897ValArg: 5.897 ± 0.09
5.764ValSer: 5.764 ± 0.086
6.675ValThr: 6.675 ± 0.142
10.54ValVal: 10.54 ± 0.132
1.095ValTrp: 1.095 ± 0.038
1.671ValTyr: 1.671 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
1.426TrpAla: 1.426 ± 0.039
0.087TrpCys: 0.087 ± 0.01
0.628TrpAsp: 0.628 ± 0.024
0.568TrpGlu: 0.568 ± 0.025
0.574TrpPhe: 0.574 ± 0.025
1.011TrpGly: 1.011 ± 0.031
0.3TrpHis: 0.3 ± 0.018
0.665TrpIle: 0.665 ± 0.028
0.319TrpLys: 0.319 ± 0.016
1.621TrpLeu: 1.621 ± 0.043
0.27TrpMet: 0.27 ± 0.015
0.458TrpAsn: 0.458 ± 0.022
0.682TrpPro: 0.682 ± 0.029
0.539TrpGln: 0.539 ± 0.023
1.147TrpArg: 1.147 ± 0.035
1.111TrpSer: 1.111 ± 0.037
0.872TrpThr: 0.872 ± 0.034
1.032TrpVal: 1.032 ± 0.033
0.319TrpTrp: 0.319 ± 0.019
0.264TrpTyr: 0.264 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.27TyrAla: 2.27 ± 0.05
0.118TyrCys: 0.118 ± 0.01
1.319TyrAsp: 1.319 ± 0.037
1.019TyrGlu: 1.019 ± 0.036
0.717TyrPhe: 0.717 ± 0.029
1.885TyrGly: 1.885 ± 0.046
0.281TyrHis: 0.281 ± 0.019
0.558TyrIle: 0.558 ± 0.028
0.401TyrLys: 0.401 ± 0.02
2.133TyrLeu: 2.133 ± 0.049
0.209TyrMet: 0.209 ± 0.014
0.462TyrAsn: 0.462 ± 0.023
1.026TyrPro: 1.026 ± 0.029
0.619TyrGln: 0.619 ± 0.027
1.605TyrArg: 1.605 ± 0.04
1.231TyrSer: 1.231 ± 0.033
1.161TyrThr: 1.161 ± 0.044
1.665TyrVal: 1.665 ± 0.043
0.283TyrTrp: 0.283 ± 0.019
0.459TyrTyr: 0.459 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3211 proteins (1020046 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski