Amino acid dipepetide frequency for Kocuria palustris PEL

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.248AlaAla: 19.248 ± 0.257	0.778AlaCys: 0.778 ± 0.036	7.607AlaAsp: 7.607 ± 0.093	9.303AlaGlu: 9.303 ± 0.116	3.34AlaPhe: 3.34 ± 0.066	11.284AlaGly: 11.284 ± 0.132	2.433AlaHis: 2.433 ± 0.053	4.398AlaIle: 4.398 ± 0.067	2.31AlaLys: 2.31 ± 0.069	12.847AlaLeu: 12.847 ± 0.157	2.882AlaMet: 2.882 ± 0.065	1.779AlaAsn: 1.779 ± 0.051	6.402AlaPro: 6.402 ± 0.118	5.609AlaGln: 5.609 ± 0.091	8.609AlaArg: 8.609 ± 0.135	7.189AlaSer: 7.189 ± 0.106	5.322AlaThr: 5.322 ± 0.089	10.911AlaVal: 10.911 ± 0.145	1.77AlaTrp: 1.77 ± 0.045	1.955AlaTyr: 1.955 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.86CysAla: 0.86 ± 0.032	0.077CysCys: 0.077 ± 0.012	0.354CysAsp: 0.354 ± 0.023	0.339CysGlu: 0.339 ± 0.021	0.234CysPhe: 0.234 ± 0.017	0.67CysGly: 0.67 ± 0.032	0.133CysHis: 0.133 ± 0.013	0.211CysIle: 0.211 ± 0.016	0.061CysLys: 0.061 ± 0.008	0.655CysLeu: 0.655 ± 0.027	0.112CysMet: 0.112 ± 0.012	0.09CysAsn: 0.09 ± 0.012	0.325CysPro: 0.325 ± 0.023	0.17CysGln: 0.17 ± 0.015	0.529CysArg: 0.529 ± 0.023	0.409CysSer: 0.409 ± 0.023	0.39CysThr: 0.39 ± 0.022	0.466CysVal: 0.466 ± 0.022	0.1CysTrp: 0.1 ± 0.012	0.133CysTyr: 0.133 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.216AspAla: 7.216 ± 0.097	0.266AspCys: 0.266 ± 0.019	4.753AspAsp: 4.753 ± 0.09	4.557AspGlu: 4.557 ± 0.085	1.631AspPhe: 1.631 ± 0.045	6.272AspGly: 6.272 ± 0.088	1.463AspHis: 1.463 ± 0.042	2.023AspIle: 2.023 ± 0.05	0.979AspLys: 0.979 ± 0.043	6.287AspLeu: 6.287 ± 0.092	1.066AspMet: 1.066 ± 0.034	0.784AspAsn: 0.784 ± 0.033	4.923AspPro: 4.923 ± 0.082	2.245AspGln: 2.245 ± 0.06	4.621AspArg: 4.621 ± 0.084	3.425AspSer: 3.425 ± 0.065	2.652AspThr: 2.652 ± 0.055	4.676AspVal: 4.676 ± 0.072	0.875AspTrp: 0.875 ± 0.035	1.194AspTyr: 1.194 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	8.62GluAla: 8.62 ± 0.107	0.335GluCys: 0.335 ± 0.02	4.5GluAsp: 4.5 ± 0.079	3.746GluGlu: 3.746 ± 0.067	1.651GluPhe: 1.651 ± 0.044	4.921GluGly: 4.921 ± 0.083	2.048GluHis: 2.048 ± 0.045	3.386GluIle: 3.386 ± 0.068	1.503GluLys: 1.503 ± 0.059	7.219GluLeu: 7.219 ± 0.112	1.129GluMet: 1.129 ± 0.038	1.219GluAsn: 1.219 ± 0.042	3.607GluPro: 3.607 ± 0.071	3.758GluGln: 3.758 ± 0.085	5.328GluArg: 5.328 ± 0.104	3.51GluSer: 3.51 ± 0.077	3.554GluThr: 3.554 ± 0.063	4.789GluVal: 4.789 ± 0.085	0.756GluTrp: 0.756 ± 0.03	1.02GluTyr: 1.02 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.454PheAla: 3.454 ± 0.069	0.203PheCys: 0.203 ± 0.015	2.048PheAsp: 2.048 ± 0.046	1.749PheGlu: 1.749 ± 0.045	0.929PhePhe: 0.929 ± 0.039	2.982PheGly: 2.982 ± 0.073	0.588PheHis: 0.588 ± 0.024	0.969PheIle: 0.969 ± 0.038	0.47PheLys: 0.47 ± 0.024	2.592PheLeu: 2.592 ± 0.058	0.545PheMet: 0.545 ± 0.029	0.56PheAsn: 0.56 ± 0.028	1.299PhePro: 1.299 ± 0.045	0.785PheGln: 0.785 ± 0.029	1.741PheArg: 1.741 ± 0.044	1.708PheSer: 1.708 ± 0.048	1.789PheThr: 1.789 ± 0.051	2.38PheVal: 2.38 ± 0.058	0.452PheTrp: 0.452 ± 0.024	0.626PheTyr: 0.626 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	10.631GlyAla: 10.631 ± 0.134	0.647GlyCys: 0.647 ± 0.029	4.53GlyAsp: 4.53 ± 0.087	5.221GlyGlu: 5.221 ± 0.09	2.89GlyPhe: 2.89 ± 0.058	7.704GlyGly: 7.704 ± 0.13	2.031GlyHis: 2.031 ± 0.052	4.301GlyIle: 4.301 ± 0.081	2.056GlyLys: 2.056 ± 0.06	9.296GlyLeu: 9.296 ± 0.123	2.446GlyMet: 2.446 ± 0.051	1.365GlyAsn: 1.365 ± 0.047	4.55GlyPro: 4.55 ± 0.08	3.47GlyGln: 3.47 ± 0.076	7.166GlyArg: 7.166 ± 0.096	6.177GlySer: 6.177 ± 0.089	5.442GlyThr: 5.442 ± 0.088	6.745GlyVal: 6.745 ± 0.098	1.556GlyTrp: 1.556 ± 0.044	1.906GlyTyr: 1.906 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.153HisAla: 2.153 ± 0.053	0.182HisCys: 0.182 ± 0.015	1.563HisAsp: 1.563 ± 0.042	1.466HisGlu: 1.466 ± 0.04	0.52HisPhe: 0.52 ± 0.03	2.235HisGly: 2.235 ± 0.064	0.612HisHis: 0.612 ± 0.028	0.611HisIle: 0.611 ± 0.027	0.338HisLys: 0.338 ± 0.022	2.279HisLeu: 2.279 ± 0.058	0.362HisMet: 0.362 ± 0.022	0.335HisAsn: 0.335 ± 0.022	1.591HisPro: 1.591 ± 0.043	0.733HisGln: 0.733 ± 0.028	2.055HisArg: 2.055 ± 0.059	1.169HisSer: 1.169 ± 0.038	1.054HisThr: 1.054 ± 0.039	1.597HisVal: 1.597 ± 0.046	0.338HisTrp: 0.338 ± 0.017	0.438HisTyr: 0.438 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.647IleAla: 5.647 ± 0.117	0.338IleCys: 0.338 ± 0.02	2.917IleAsp: 2.917 ± 0.065	2.779IleGlu: 2.779 ± 0.058	1.201IlePhe: 1.201 ± 0.045	4.172IleGly: 4.172 ± 0.074	0.753IleHis: 0.753 ± 0.032	1.576IleIle: 1.576 ± 0.055	0.702IleLys: 0.702 ± 0.033	3.575IleLeu: 3.575 ± 0.078	0.773IleMet: 0.773 ± 0.033	0.793IleAsn: 0.793 ± 0.033	2.31IlePro: 2.31 ± 0.05	1.079IleGln: 1.079 ± 0.036	2.608IleArg: 2.608 ± 0.057	2.457IleSer: 2.457 ± 0.06	2.537IleThr: 2.537 ± 0.056	3.811IleVal: 3.811 ± 0.086	0.444IleTrp: 0.444 ± 0.023	0.721IleTyr: 0.721 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	2.52LysAla: 2.52 ± 0.074	0.069LysCys: 0.069 ± 0.009	1.276LysAsp: 1.276 ± 0.043	1.037LysGlu: 1.037 ± 0.043	0.423LysPhe: 0.423 ± 0.028	1.548LysGly: 1.548 ± 0.053	0.452LysHis: 0.452 ± 0.023	0.918LysIle: 0.918 ± 0.04	0.748LysLys: 0.748 ± 0.036	1.711LysLeu: 1.711 ± 0.049	0.395LysMet: 0.395 ± 0.026	0.454LysAsn: 0.454 ± 0.023	1.119LysPro: 1.119 ± 0.046	0.658LysGln: 0.658 ± 0.028	1.469LysArg: 1.469 ± 0.053	1.068LysSer: 1.068 ± 0.039	1.114LysThr: 1.114 ± 0.043	1.563LysVal: 1.563 ± 0.058	0.201LysTrp: 0.201 ± 0.013	0.371LysTyr: 0.371 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	12.37LeuAla: 12.37 ± 0.158	0.715LeuCys: 0.715 ± 0.028	6.291LeuAsp: 6.291 ± 0.114	6.823LeuGlu: 6.823 ± 0.105	2.55LeuPhe: 2.55 ± 0.066	9.399LeuGly: 9.399 ± 0.138	2.047LeuHis: 2.047 ± 0.055	4.378LeuIle: 4.378 ± 0.086	1.829LeuLys: 1.829 ± 0.056	10.421LeuLeu: 10.421 ± 0.132	2.048LeuMet: 2.048 ± 0.063	1.862LeuAsn: 1.862 ± 0.05	5.614LeuPro: 5.614 ± 0.082	3.096LeuGln: 3.096 ± 0.065	7.957LeuArg: 7.957 ± 0.12	6.818LeuSer: 6.818 ± 0.09	5.542LeuThr: 5.542 ± 0.085	8.366LeuVal: 8.366 ± 0.127	1.362LeuTrp: 1.362 ± 0.052	1.503LeuTyr: 1.503 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.726MetAla: 2.726 ± 0.067	0.146MetCys: 0.146 ± 0.015	1.148MetAsp: 1.148 ± 0.04	0.974MetGlu: 0.974 ± 0.037	0.532MetPhe: 0.532 ± 0.027	1.799MetGly: 1.799 ± 0.05	0.433MetHis: 0.433 ± 0.023	1.025MetIle: 1.025 ± 0.036	0.431MetLys: 0.431 ± 0.022	2.267MetLeu: 2.267 ± 0.056	0.458MetMet: 0.458 ± 0.025	0.425MetAsn: 0.425 ± 0.023	1.308MetPro: 1.308 ± 0.039	0.664MetGln: 0.664 ± 0.028	1.566MetArg: 1.566 ± 0.048	1.792MetSer: 1.792 ± 0.043	1.696MetThr: 1.696 ± 0.041	1.651MetVal: 1.651 ± 0.045	0.212MetTrp: 0.212 ± 0.018	0.32MetTyr: 0.32 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	1.906AsnAla: 1.906 ± 0.05	0.111AsnCys: 0.111 ± 0.011	0.979AsnAsp: 0.979 ± 0.038	0.856AsnGlu: 0.856 ± 0.034	0.48AsnPhe: 0.48 ± 0.024	1.527AsnGly: 1.527 ± 0.051	0.375AsnHis: 0.375 ± 0.021	0.745AsnIle: 0.745 ± 0.031	0.345AsnLys: 0.345 ± 0.025	1.686AsnLeu: 1.686 ± 0.048	0.391AsnMet: 0.391 ± 0.021	0.359AsnAsn: 0.359 ± 0.023	1.313AsnPro: 1.313 ± 0.042	0.566AsnGln: 0.566 ± 0.027	1.245AsnArg: 1.245 ± 0.037	0.859AsnSer: 0.859 ± 0.035	0.913AsnThr: 0.913 ± 0.034	1.336AsnVal: 1.336 ± 0.042	0.275AsnTrp: 0.275 ± 0.019	0.404AsnTyr: 0.404 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	6.896ProAla: 6.896 ± 0.098	0.235ProCys: 0.235 ± 0.018	3.682ProAsp: 3.682 ± 0.082	5.334ProGlu: 5.334 ± 0.084	1.48ProPhe: 1.48 ± 0.048	5.405ProGly: 5.405 ± 0.081	1.207ProHis: 1.207 ± 0.044	1.747ProIle: 1.747 ± 0.046	1.017ProLys: 1.017 ± 0.046	4.924ProLeu: 4.924 ± 0.09	1.068ProMet: 1.068 ± 0.036	0.884ProAsn: 0.884 ± 0.033	2.115ProPro: 2.115 ± 0.066	2.614ProGln: 2.614 ± 0.053	3.655ProArg: 3.655 ± 0.071	3.794ProSer: 3.794 ± 0.075	2.841ProThr: 2.841 ± 0.057	4.907ProVal: 4.907 ± 0.077	0.929ProTrp: 0.929 ± 0.03	0.947ProTyr: 0.947 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	4.66GlnAla: 4.66 ± 0.092	0.167GlnCys: 0.167 ± 0.015	2.501GlnAsp: 2.501 ± 0.066	2.599GlnGlu: 2.599 ± 0.058	0.844GlnPhe: 0.844 ± 0.036	2.84GlnGly: 2.84 ± 0.063	0.868GlnHis: 0.868 ± 0.033	1.739GlnIle: 1.739 ± 0.044	0.841GlnLys: 0.841 ± 0.036	4.083GlnLeu: 4.083 ± 0.082	0.76GlnMet: 0.76 ± 0.03	0.659GlnAsn: 0.659 ± 0.028	2.068GlnPro: 2.068 ± 0.052	1.88GlnGln: 1.88 ± 0.059	3.625GlnArg: 3.625 ± 0.071	1.723GlnSer: 1.723 ± 0.045	1.835GlnThr: 1.835 ± 0.046	2.608GlnVal: 2.608 ± 0.054	0.645GlnTrp: 0.645 ± 0.029	0.574GlnTyr: 0.574 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	8.756ArgAla: 8.756 ± 0.129	0.514ArgCys: 0.514 ± 0.026	4.189ArgAsp: 4.189 ± 0.069	5.2ArgGlu: 5.2 ± 0.09	2.269ArgPhe: 2.269 ± 0.055	5.834ArgGly: 5.834 ± 0.106	1.578ArgHis: 1.578 ± 0.046	3.491ArgIle: 3.491 ± 0.071	1.446ArgLys: 1.446 ± 0.049	7.575ArgLeu: 7.575 ± 0.126	1.952ArgMet: 1.952 ± 0.05	1.079ArgAsn: 1.079 ± 0.039	4.361ArgPro: 4.361 ± 0.085	2.632ArgGln: 2.632 ± 0.058	7.735ArgArg: 7.735 ± 0.13	4.952ArgSer: 4.952 ± 0.089	4.776ArgThr: 4.776 ± 0.074	5.257ArgVal: 5.257 ± 0.078	1.284ArgTrp: 1.284 ± 0.031	1.361ArgTyr: 1.361 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	8.098SerAla: 8.098 ± 0.096	0.366SerCys: 0.366 ± 0.021	3.256SerAsp: 3.256 ± 0.071	3.828SerGlu: 3.828 ± 0.073	1.902SerPhe: 1.902 ± 0.048	6.369SerGly: 6.369 ± 0.096	1.15SerHis: 1.15 ± 0.045	2.336SerIle: 2.336 ± 0.057	1.112SerLys: 1.112 ± 0.044	5.595SerLeu: 5.595 ± 0.093	1.633SerMet: 1.633 ± 0.045	0.992SerAsn: 0.992 ± 0.037	3.45SerPro: 3.45 ± 0.058	2.151SerGln: 2.151 ± 0.055	4.351SerArg: 4.351 ± 0.073	4.603SerSer: 4.603 ± 0.092	3.806SerThr: 3.806 ± 0.06	4.673SerVal: 4.673 ± 0.069	1.031SerTrp: 1.031 ± 0.034	1.118SerTyr: 1.118 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	7.348ThrAla: 7.348 ± 0.092	0.312ThrCys: 0.312 ± 0.02	3.242ThrAsp: 3.242 ± 0.057	3.409ThrGlu: 3.409 ± 0.07	1.458ThrPhe: 1.458 ± 0.043	5.849ThrGly: 5.849 ± 0.079	1.083ThrHis: 1.083 ± 0.036	2.22ThrIle: 2.22 ± 0.059	0.904ThrLys: 0.904 ± 0.045	4.797ThrLeu: 4.797 ± 0.078	1.119ThrMet: 1.119 ± 0.035	0.873ThrAsn: 0.873 ± 0.034	3.394ThrPro: 3.394 ± 0.074	1.684ThrGln: 1.684 ± 0.046	3.56ThrArg: 3.56 ± 0.074	3.285ThrSer: 3.285 ± 0.06	3.346ThrThr: 3.346 ± 0.068	5.057ThrVal: 5.057 ± 0.063	0.907ThrTrp: 0.907 ± 0.029	1.028ThrTyr: 1.028 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	9.208ValAla: 9.208 ± 0.112	0.599ValCys: 0.599 ± 0.027	5.037ValAsp: 5.037 ± 0.082	5.4ValGlu: 5.4 ± 0.087	2.383ValPhe: 2.383 ± 0.057	6.51ValGly: 6.51 ± 0.098	1.745ValHis: 1.745 ± 0.043	3.849ValIle: 3.849 ± 0.082	1.363ValLys: 1.363 ± 0.047	9.705ValLeu: 9.705 ± 0.136	1.77ValMet: 1.77 ± 0.049	1.43ValAsn: 1.43 ± 0.045	4.318ValPro: 4.318 ± 0.065	2.514ValGln: 2.514 ± 0.056	5.886ValArg: 5.886 ± 0.092	4.774ValSer: 4.774 ± 0.081	4.478ValThr: 4.478 ± 0.078	8.23ValVal: 8.23 ± 0.129	1.006ValTrp: 1.006 ± 0.036	1.299ValTyr: 1.299 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.694TrpAla: 1.694 ± 0.049	0.119TrpCys: 0.119 ± 0.013	0.809TrpAsp: 0.809 ± 0.033	0.846TrpGlu: 0.846 ± 0.03	0.559TrpPhe: 0.559 ± 0.025	1.093TrpGly: 1.093 ± 0.033	0.306TrpHis: 0.306 ± 0.019	0.721TrpIle: 0.721 ± 0.031	0.299TrpLys: 0.299 ± 0.021	1.656TrpLeu: 1.656 ± 0.05	0.341TrpMet: 0.341 ± 0.02	0.378TrpAsn: 0.378 ± 0.021	0.695TrpPro: 0.695 ± 0.03	0.603TrpGln: 0.603 ± 0.028	1.091TrpArg: 1.091 ± 0.04	1.037TrpSer: 1.037 ± 0.041	0.831TrpThr: 0.831 ± 0.034	1.081TrpVal: 1.081 ± 0.036	0.36TrpTrp: 0.36 ± 0.023	0.276TrpTyr: 0.276 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.967TyrAla: 1.967 ± 0.053	0.139TyrCys: 0.139 ± 0.013	1.225TyrAsp: 1.225 ± 0.046	1.135TyrGlu: 1.135 ± 0.038	0.591TyrPhe: 0.591 ± 0.03	1.719TyrGly: 1.719 ± 0.045	0.325TyrHis: 0.325 ± 0.021	0.549TyrIle: 0.549 ± 0.025	0.364TyrLys: 0.364 ± 0.019	1.823TyrLeu: 1.823 ± 0.044	0.322TyrMet: 0.322 ± 0.019	0.351TyrAsn: 0.351 ± 0.024	0.918TyrPro: 0.918 ± 0.035	0.608TyrGln: 0.608 ± 0.027	1.444TyrArg: 1.444 ± 0.039	1.069TyrSer: 1.069 ± 0.037	0.955TyrThr: 0.955 ± 0.034	1.4TyrVal: 1.4 ± 0.041	0.29TyrTrp: 0.29 ± 0.018	0.4TyrTyr: 0.4 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2561 proteins (840818 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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