Amino acid dipepetide frequency for Legionella spiritensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.797AlaAla: 6.797 ± 0.108	1.23AlaCys: 1.23 ± 0.039	3.724AlaAsp: 3.724 ± 0.062	4.048AlaGlu: 4.048 ± 0.075	3.337AlaPhe: 3.337 ± 0.057	5.897AlaGly: 5.897 ± 0.105	1.737AlaHis: 1.737 ± 0.045	6.239AlaIle: 6.239 ± 0.081	3.909AlaLys: 3.909 ± 0.065	9.381AlaLeu: 9.381 ± 0.103	2.576AlaMet: 2.576 ± 0.054	3.238AlaAsn: 3.238 ± 0.057	2.525AlaPro: 2.525 ± 0.048	3.135AlaGln: 3.135 ± 0.07	4.499AlaArg: 4.499 ± 0.079	4.891AlaSer: 4.891 ± 0.075	3.994AlaThr: 3.994 ± 0.065	5.252AlaVal: 5.252 ± 0.089	0.906AlaTrp: 0.906 ± 0.03	2.448AlaTyr: 2.448 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.817CysAla: 0.817 ± 0.032	0.212CysCys: 0.212 ± 0.017	0.657CysAsp: 0.657 ± 0.027	0.675CysGlu: 0.675 ± 0.028	0.681CysPhe: 0.681 ± 0.027	0.948CysGly: 0.948 ± 0.036	0.424CysHis: 0.424 ± 0.022	0.626CysIle: 0.626 ± 0.027	0.527CysLys: 0.527 ± 0.026	1.406CysLeu: 1.406 ± 0.044	0.26CysMet: 0.26 ± 0.016	0.467CysAsn: 0.467 ± 0.023	0.523CysPro: 0.523 ± 0.024	0.536CysGln: 0.536 ± 0.023	0.647CysArg: 0.647 ± 0.033	0.76CysSer: 0.76 ± 0.028	0.519CysThr: 0.519 ± 0.025	0.747CysVal: 0.747 ± 0.029	0.16CysTrp: 0.16 ± 0.014	0.452CysTyr: 0.452 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	3.798AspAla: 3.798 ± 0.071	0.677AspCys: 0.677 ± 0.026	2.878AspAsp: 2.878 ± 0.058	3.725AspGlu: 3.725 ± 0.075	2.468AspPhe: 2.468 ± 0.06	3.043AspGly: 3.043 ± 0.057	1.164AspHis: 1.164 ± 0.036	4.125AspIle: 4.125 ± 0.067	3.628AspLys: 3.628 ± 0.056	4.945AspLeu: 4.945 ± 0.075	1.345AspMet: 1.345 ± 0.04	2.537AspAsn: 2.537 ± 0.041	2.11AspPro: 2.11 ± 0.049	1.689AspGln: 1.689 ± 0.046	2.337AspArg: 2.337 ± 0.049	3.088AspSer: 3.088 ± 0.055	2.485AspThr: 2.485 ± 0.06	3.457AspVal: 3.457 ± 0.067	0.733AspTrp: 0.733 ± 0.03	2.31AspTyr: 2.31 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	4.297GluAla: 4.297 ± 0.08	0.48GluCys: 0.48 ± 0.022	2.709GluAsp: 2.709 ± 0.061	3.97GluGlu: 3.97 ± 0.083	2.166GluPhe: 2.166 ± 0.049	2.969GluGly: 2.969 ± 0.057	1.62GluHis: 1.62 ± 0.049	4.043GluIle: 4.043 ± 0.07	4.342GluLys: 4.342 ± 0.078	6.22GluLeu: 6.22 ± 0.098	1.452GluMet: 1.452 ± 0.043	2.684GluAsn: 2.684 ± 0.053	1.913GluPro: 1.913 ± 0.048	3.587GluGln: 3.587 ± 0.069	3.088GluArg: 3.088 ± 0.062	3.332GluSer: 3.332 ± 0.062	3.134GluThr: 3.134 ± 0.057	3.055GluVal: 3.055 ± 0.065	0.604GluTrp: 0.604 ± 0.027	1.684GluTyr: 1.684 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	3.452PheAla: 3.452 ± 0.074	0.636PheCys: 0.636 ± 0.022	2.42PheAsp: 2.42 ± 0.051	2.156PheGlu: 2.156 ± 0.05	2.37PhePhe: 2.37 ± 0.056	2.637PheGly: 2.637 ± 0.061	1.115PheHis: 1.115 ± 0.038	3.358PheIle: 3.358 ± 0.069	2.198PheLys: 2.198 ± 0.044	4.669PheLeu: 4.669 ± 0.081	0.999PheMet: 0.999 ± 0.035	2.14PheAsn: 2.14 ± 0.054	1.764PhePro: 1.764 ± 0.041	1.654PheGln: 1.654 ± 0.044	1.703PheArg: 1.703 ± 0.048	3.285PheSer: 3.285 ± 0.063	2.369PheThr: 2.369 ± 0.044	2.558PheVal: 2.558 ± 0.054	0.561PheTrp: 0.561 ± 0.027	1.673PheTyr: 1.673 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	4.372GlyAla: 4.372 ± 0.078	0.86GlyCys: 0.86 ± 0.031	3.133GlyAsp: 3.133 ± 0.06	3.474GlyGlu: 3.474 ± 0.061	3.289GlyPhe: 3.289 ± 0.067	4.224GlyGly: 4.224 ± 0.088	1.732GlyHis: 1.732 ± 0.042	4.799GlyIle: 4.799 ± 0.073	4.017GlyLys: 4.017 ± 0.065	6.938GlyLeu: 6.938 ± 0.109	1.946GlyMet: 1.946 ± 0.052	2.473GlyAsn: 2.473 ± 0.055	1.723GlyPro: 1.723 ± 0.048	2.822GlyGln: 2.822 ± 0.067	3.034GlyArg: 3.034 ± 0.062	3.695GlySer: 3.695 ± 0.061	3.006GlyThr: 3.006 ± 0.056	4.417GlyVal: 4.417 ± 0.076	0.918GlyTrp: 0.918 ± 0.029	2.58GlyTyr: 2.58 ± 0.05	0.001GlyXaa: 0.001 ± 0.001
His	2.027HisAla: 2.027 ± 0.051	0.408HisCys: 0.408 ± 0.023	1.345HisAsp: 1.345 ± 0.036	1.32HisGlu: 1.32 ± 0.033	1.307HisPhe: 1.307 ± 0.042	1.871HisGly: 1.871 ± 0.045	1.057HisHis: 1.057 ± 0.04	1.558HisIle: 1.558 ± 0.043	1.132HisLys: 1.132 ± 0.038	2.753HisLeu: 2.753 ± 0.059	0.505HisMet: 0.505 ± 0.021	1.042HisAsn: 1.042 ± 0.035	1.414HisPro: 1.414 ± 0.045	1.365HisGln: 1.365 ± 0.042	1.364HisArg: 1.364 ± 0.04	1.463HisSer: 1.463 ± 0.039	1.181HisThr: 1.181 ± 0.042	1.443HisVal: 1.443 ± 0.041	0.419HisTrp: 0.419 ± 0.025	1.241HisTyr: 1.241 ± 0.042	0.001HisXaa: 0.001 ± 0.001
Ile	6.362IleAla: 6.362 ± 0.078	0.738IleCys: 0.738 ± 0.027	4.116IleAsp: 4.116 ± 0.068	4.221IleGlu: 4.221 ± 0.075	2.448IlePhe: 2.448 ± 0.057	4.431IleGly: 4.431 ± 0.077	1.796IleHis: 1.796 ± 0.047	4.735IleIle: 4.735 ± 0.077	4.061IleLys: 4.061 ± 0.073	6.623IleLeu: 6.623 ± 0.095	1.448IleMet: 1.448 ± 0.042	3.709IleAsn: 3.709 ± 0.059	3.377IlePro: 3.377 ± 0.065	2.497IleGln: 2.497 ± 0.05	3.501IleArg: 3.501 ± 0.06	4.474IleSer: 4.474 ± 0.069	3.997IleThr: 3.997 ± 0.064	4.094IleVal: 4.094 ± 0.078	0.674IleTrp: 0.674 ± 0.031	2.079IleTyr: 2.079 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	4.406LysAla: 4.406 ± 0.077	0.355LysCys: 0.355 ± 0.021	2.912LysAsp: 2.912 ± 0.055	3.539LysGlu: 3.539 ± 0.072	1.429LysPhe: 1.429 ± 0.041	2.952LysGly: 2.952 ± 0.052	1.387LysHis: 1.387 ± 0.04	4.045LysIle: 4.045 ± 0.076	4.401LysLys: 4.401 ± 0.086	5.301LysLeu: 5.301 ± 0.079	1.376LysMet: 1.376 ± 0.037	3.025LysAsn: 3.025 ± 0.067	2.805LysPro: 2.805 ± 0.056	2.982LysGln: 2.982 ± 0.059	2.982LysArg: 2.982 ± 0.057	3.518LysSer: 3.518 ± 0.066	3.617LysThr: 3.617 ± 0.058	2.691LysVal: 2.691 ± 0.06	0.537LysTrp: 0.537 ± 0.024	1.49LysTyr: 1.49 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	9.798LeuAla: 9.798 ± 0.122	1.37LeuCys: 1.37 ± 0.042	5.422LeuAsp: 5.422 ± 0.077	5.38LeuGlu: 5.38 ± 0.085	5.096LeuPhe: 5.096 ± 0.076	6.502LeuGly: 6.502 ± 0.086	2.638LeuHis: 2.638 ± 0.055	7.353LeuIle: 7.353 ± 0.103	5.893LeuLys: 5.893 ± 0.09	12.381LeuLeu: 12.381 ± 0.161	2.617LeuMet: 2.617 ± 0.058	4.801LeuAsn: 4.801 ± 0.075	5.177LeuPro: 5.177 ± 0.079	4.967LeuGln: 4.967 ± 0.087	5.044LeuArg: 5.044 ± 0.086	7.864LeuSer: 7.864 ± 0.1	6.048LeuThr: 6.048 ± 0.082	6.4LeuVal: 6.4 ± 0.085	1.089LeuTrp: 1.089 ± 0.037	3.195LeuTyr: 3.195 ± 0.062	0.002LeuXaa: 0.002 ± 0.001
Met	2.434MetAla: 2.434 ± 0.05	0.19MetCys: 0.19 ± 0.015	1.316MetAsp: 1.316 ± 0.031	1.297MetGlu: 1.297 ± 0.036	0.726MetPhe: 0.726 ± 0.029	1.556MetGly: 1.556 ± 0.043	0.443MetHis: 0.443 ± 0.026	1.756MetIle: 1.756 ± 0.043	1.559MetLys: 1.559 ± 0.042	2.528MetLeu: 2.528 ± 0.056	0.737MetMet: 0.737 ± 0.033	1.229MetAsn: 1.229 ± 0.031	1.196MetPro: 1.196 ± 0.033	1.103MetGln: 1.103 ± 0.037	1.323MetArg: 1.323 ± 0.043	1.659MetSer: 1.659 ± 0.044	1.713MetThr: 1.713 ± 0.04	1.705MetVal: 1.705 ± 0.053	0.177MetTrp: 0.177 ± 0.014	0.587MetTyr: 0.587 ± 0.025	0.001MetXaa: 0.001 ± 0.001
Asn	3.255AsnAla: 3.255 ± 0.053	0.452AsnCys: 0.452 ± 0.022	2.445AsnAsp: 2.445 ± 0.052	2.534AsnGlu: 2.534 ± 0.057	1.631AsnPhe: 1.631 ± 0.05	2.548AsnGly: 2.548 ± 0.052	1.379AsnHis: 1.379 ± 0.041	3.07AsnIle: 3.07 ± 0.061	2.595AsnLys: 2.595 ± 0.058	4.156AsnLeu: 4.156 ± 0.071	0.931AsnMet: 0.931 ± 0.033	2.39AsnAsn: 2.39 ± 0.062	2.577AsnPro: 2.577 ± 0.055	2.349AsnGln: 2.349 ± 0.06	2.458AsnArg: 2.458 ± 0.058	2.47AsnSer: 2.47 ± 0.061	2.472AsnThr: 2.472 ± 0.055	2.304AsnVal: 2.304 ± 0.059	0.543AsnTrp: 0.543 ± 0.022	1.694AsnTyr: 1.694 ± 0.048	0.0AsnXaa: 0.0 ± 0.0
Pro	3.369ProAla: 3.369 ± 0.062	0.483ProCys: 0.483 ± 0.024	3.027ProAsp: 3.027 ± 0.062	3.289ProGlu: 3.289 ± 0.072	1.944ProPhe: 1.944 ± 0.041	3.125ProGly: 3.125 ± 0.056	0.995ProHis: 0.995 ± 0.03	2.191ProIle: 2.191 ± 0.055	1.846ProLys: 1.846 ± 0.042	4.433ProLeu: 4.433 ± 0.058	1.03ProMet: 1.03 ± 0.037	1.516ProAsn: 1.516 ± 0.039	1.614ProPro: 1.614 ± 0.043	1.694ProGln: 1.694 ± 0.037	1.636ProArg: 1.636 ± 0.039	2.419ProSer: 2.419 ± 0.047	1.777ProThr: 1.777 ± 0.044	3.865ProVal: 3.865 ± 0.071	0.53ProTrp: 0.53 ± 0.027	1.44ProTyr: 1.44 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	4.173GlnAla: 4.173 ± 0.072	0.501GlnCys: 0.501 ± 0.024	2.131GlnAsp: 2.131 ± 0.055	2.563GlnGlu: 2.563 ± 0.064	1.971GlnPhe: 1.971 ± 0.04	2.817GlnGly: 2.817 ± 0.048	1.21GlnHis: 1.21 ± 0.036	2.75GlnIle: 2.75 ± 0.061	2.488GlnLys: 2.488 ± 0.054	4.979GlnLeu: 4.979 ± 0.091	0.977GlnMet: 0.977 ± 0.03	1.839GlnAsn: 1.839 ± 0.048	1.819GlnPro: 1.819 ± 0.051	2.946GlnGln: 2.946 ± 0.081	2.339GlnArg: 2.339 ± 0.049	2.822GlnSer: 2.822 ± 0.057	2.428GlnThr: 2.428 ± 0.047	2.628GlnVal: 2.628 ± 0.051	0.703GlnTrp: 0.703 ± 0.031	1.643GlnTyr: 1.643 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	3.485ArgAla: 3.485 ± 0.07	0.586ArgCys: 0.586 ± 0.025	2.736ArgAsp: 2.736 ± 0.05	3.312ArgGlu: 3.312 ± 0.062	2.581ArgPhe: 2.581 ± 0.058	2.501ArgGly: 2.501 ± 0.054	1.676ArgHis: 1.676 ± 0.045	3.588ArgIle: 3.588 ± 0.063	2.758ArgLys: 2.758 ± 0.055	6.077ArgLeu: 6.077 ± 0.087	1.226ArgMet: 1.226 ± 0.037	2.12ArgAsn: 2.12 ± 0.044	1.66ArgPro: 1.66 ± 0.048	2.842ArgGln: 2.842 ± 0.058	2.626ArgArg: 2.626 ± 0.065	2.543ArgSer: 2.543 ± 0.046	2.303ArgThr: 2.303 ± 0.052	3.024ArgVal: 3.024 ± 0.063	0.662ArgTrp: 0.662 ± 0.025	2.081ArgTyr: 2.081 ± 0.045	0.002ArgXaa: 0.002 ± 0.001
Ser	4.414SerAla: 4.414 ± 0.068	0.805SerCys: 0.805 ± 0.03	3.3SerAsp: 3.3 ± 0.054	3.645SerGlu: 3.645 ± 0.062	2.82SerPhe: 2.82 ± 0.056	4.886SerGly: 4.886 ± 0.087	1.729SerHis: 1.729 ± 0.043	3.909SerIle: 3.909 ± 0.069	3.037SerLys: 3.037 ± 0.053	7.448SerLeu: 7.448 ± 0.098	1.671SerMet: 1.671 ± 0.039	2.428SerAsn: 2.428 ± 0.054	2.829SerPro: 2.829 ± 0.054	2.683SerGln: 2.683 ± 0.058	3.347SerArg: 3.347 ± 0.06	4.319SerSer: 4.319 ± 0.095	2.915SerThr: 2.915 ± 0.057	3.861SerVal: 3.861 ± 0.074	0.747SerTrp: 0.747 ± 0.029	2.02SerTyr: 2.02 ± 0.047	0.001SerXaa: 0.001 ± 0.001
Thr	4.249ThrAla: 4.249 ± 0.073	0.599ThrCys: 0.599 ± 0.031	2.577ThrAsp: 2.577 ± 0.051	2.561ThrGlu: 2.561 ± 0.056	2.113ThrPhe: 2.113 ± 0.054	4.171ThrGly: 4.171 ± 0.07	1.359ThrHis: 1.359 ± 0.038	3.93ThrIle: 3.93 ± 0.071	2.075ThrLys: 2.075 ± 0.048	6.237ThrLeu: 6.237 ± 0.077	1.371ThrMet: 1.371 ± 0.036	2.0ThrAsn: 2.0 ± 0.051	2.744ThrPro: 2.744 ± 0.054	1.918ThrGln: 1.918 ± 0.045	2.872ThrArg: 2.872 ± 0.064	3.163ThrSer: 3.163 ± 0.061	2.874ThrThr: 2.874 ± 0.061	3.594ThrVal: 3.594 ± 0.069	0.539ThrTrp: 0.539 ± 0.023	1.486ThrTyr: 1.486 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	5.098ValAla: 5.098 ± 0.089	0.791ValCys: 0.791 ± 0.03	3.415ValAsp: 3.415 ± 0.069	3.327ValGlu: 3.327 ± 0.072	2.97ValPhe: 2.97 ± 0.061	3.543ValGly: 3.543 ± 0.07	1.369ValHis: 1.369 ± 0.038	4.752ValIle: 4.752 ± 0.086	3.247ValLys: 3.247 ± 0.055	6.718ValLeu: 6.718 ± 0.102	1.748ValMet: 1.748 ± 0.046	2.84ValAsn: 2.84 ± 0.061	2.374ValPro: 2.374 ± 0.053	2.015ValGln: 2.015 ± 0.053	2.891ValArg: 2.891 ± 0.059	4.254ValSer: 4.254 ± 0.071	3.547ValThr: 3.547 ± 0.064	4.398ValVal: 4.398 ± 0.083	0.656ValTrp: 0.656 ± 0.029	1.956ValTyr: 1.956 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.703TrpAla: 0.703 ± 0.027	0.148TrpCys: 0.148 ± 0.012	0.531TrpAsp: 0.531 ± 0.023	0.532TrpGlu: 0.532 ± 0.024	0.632TrpPhe: 0.632 ± 0.028	0.672TrpGly: 0.672 ± 0.026	0.393TrpHis: 0.393 ± 0.02	0.756TrpIle: 0.756 ± 0.029	0.432TrpLys: 0.432 ± 0.02	1.704TrpLeu: 1.704 ± 0.05	0.331TrpMet: 0.331 ± 0.019	0.449TrpAsn: 0.449 ± 0.021	0.479TrpPro: 0.479 ± 0.02	0.894TrpGln: 0.894 ± 0.033	0.684TrpArg: 0.684 ± 0.026	0.71TrpSer: 0.71 ± 0.029	0.504TrpThr: 0.504 ± 0.022	0.703TrpVal: 0.703 ± 0.031	0.18TrpTrp: 0.18 ± 0.015	0.418TrpTyr: 0.418 ± 0.022	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.455TyrAla: 2.455 ± 0.054	0.523TyrCys: 0.523 ± 0.027	1.745TyrAsp: 1.745 ± 0.041	1.779TyrGlu: 1.779 ± 0.043	1.738TyrPhe: 1.738 ± 0.049	2.161TyrGly: 2.161 ± 0.046	0.994TyrHis: 0.994 ± 0.037	1.798TyrIle: 1.798 ± 0.04	1.606TyrLys: 1.606 ± 0.044	4.137TyrLeu: 4.137 ± 0.078	0.69TyrMet: 0.69 ± 0.023	1.324TyrAsn: 1.324 ± 0.042	1.598TyrPro: 1.598 ± 0.045	2.05TyrGln: 2.05 ± 0.054	2.008TyrArg: 2.008 ± 0.048	2.085TyrSer: 2.085 ± 0.054	1.549TyrThr: 1.549 ± 0.037	1.716TyrVal: 1.716 ± 0.039	0.517TyrTrp: 0.517 ± 0.022	1.401TyrTyr: 1.401 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.002XaaPhe: 0.002 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.003XaaArg: 0.003 ± 0.002	0.001XaaSer: 0.001 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.027XaaXaa: 0.027 ± 0.009

Statistics based on 2908 proteins (978053 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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