Amino acid dipepetide frequency for Streptococcus phage Javan188

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.545AlaAla: 4.545 ± 1.034
0.313AlaCys: 0.313 ± 0.119
5.251AlaAsp: 5.251 ± 0.779
6.661AlaGlu: 6.661 ± 0.765
2.978AlaPhe: 2.978 ± 0.583
4.389AlaGly: 4.389 ± 0.95
0.47AlaHis: 0.47 ± 0.202
6.113AlaIle: 6.113 ± 0.657
7.288AlaLys: 7.288 ± 0.778
6.897AlaLeu: 6.897 ± 0.952
2.038AlaMet: 2.038 ± 0.549
5.408AlaAsn: 5.408 ± 0.946
1.332AlaPro: 1.332 ± 0.309
3.762AlaGln: 3.762 ± 0.737
2.665AlaArg: 2.665 ± 0.44
4.389AlaSer: 4.389 ± 1.039
5.486AlaThr: 5.486 ± 1.167
4.389AlaVal: 4.389 ± 0.989
0.392AlaTrp: 0.392 ± 0.149
3.37AlaTyr: 3.37 ± 0.661
0.0AlaXaa: 0.0 ± 0.0
Cys
0.078CysAla: 0.078 ± 0.067
0.078CysCys: 0.078 ± 0.067
0.078CysAsp: 0.078 ± 0.067
0.705CysGlu: 0.705 ± 0.248
0.078CysPhe: 0.078 ± 0.087
0.157CysGly: 0.157 ± 0.093
0.078CysHis: 0.078 ± 0.076
0.235CysIle: 0.235 ± 0.113
0.47CysLys: 0.47 ± 0.185
0.392CysLeu: 0.392 ± 0.176
0.078CysMet: 0.078 ± 0.081
0.157CysAsn: 0.157 ± 0.102
0.157CysPro: 0.157 ± 0.114
0.392CysGln: 0.392 ± 0.153
0.47CysArg: 0.47 ± 0.185
0.078CysSer: 0.078 ± 0.067
0.235CysThr: 0.235 ± 0.158
0.078CysVal: 0.078 ± 0.079
0.157CysTrp: 0.157 ± 0.108
0.078CysTyr: 0.078 ± 0.086
0.0CysXaa: 0.0 ± 0.0
Asp
3.448AspAla: 3.448 ± 0.409
0.157AspCys: 0.157 ± 0.103
3.448AspAsp: 3.448 ± 0.652
4.937AspGlu: 4.937 ± 0.82
3.448AspPhe: 3.448 ± 0.577
3.84AspGly: 3.84 ± 0.649
0.549AspHis: 0.549 ± 0.223
5.486AspIle: 5.486 ± 0.857
6.661AspLys: 6.661 ± 0.985
5.799AspLeu: 5.799 ± 0.87
1.646AspMet: 1.646 ± 0.268
3.292AspAsn: 3.292 ± 0.492
1.567AspPro: 1.567 ± 0.337
1.254AspGln: 1.254 ± 0.29
2.665AspArg: 2.665 ± 0.51
3.292AspSer: 3.292 ± 0.46
3.056AspThr: 3.056 ± 0.478
3.135AspVal: 3.135 ± 0.591
1.019AspTrp: 1.019 ± 0.315
3.448AspTyr: 3.448 ± 0.707
0.0AspXaa: 0.0 ± 0.0
Glu
5.878GluAla: 5.878 ± 0.696
0.313GluCys: 0.313 ± 0.147
3.056GluAsp: 3.056 ± 0.58
5.486GluGlu: 5.486 ± 0.814
2.273GluPhe: 2.273 ± 0.433
3.762GluGly: 3.762 ± 0.559
1.489GluHis: 1.489 ± 0.487
4.937GluIle: 4.937 ± 0.59
6.348GluLys: 6.348 ± 0.879
8.386GluLeu: 8.386 ± 1.054
2.038GluMet: 2.038 ± 0.411
3.762GluAsn: 3.762 ± 0.56
1.959GluPro: 1.959 ± 0.449
2.821GluGln: 2.821 ± 0.528
4.31GluArg: 4.31 ± 0.743
3.37GluSer: 3.37 ± 0.455
3.292GluThr: 3.292 ± 0.564
4.467GluVal: 4.467 ± 0.692
1.019GluTrp: 1.019 ± 0.232
3.683GluTyr: 3.683 ± 0.601
0.0GluXaa: 0.0 ± 0.0
Phe
2.821PheAla: 2.821 ± 0.817
0.078PheCys: 0.078 ± 0.073
2.586PheAsp: 2.586 ± 0.385
2.351PheGlu: 2.351 ± 0.454
1.176PhePhe: 1.176 ± 0.363
2.821PheGly: 2.821 ± 0.602
0.392PheHis: 0.392 ± 0.16
2.743PheIle: 2.743 ± 0.571
3.84PheLys: 3.84 ± 0.601
2.978PheLeu: 2.978 ± 0.609
0.94PheMet: 0.94 ± 0.242
2.821PheAsn: 2.821 ± 0.329
0.47PhePro: 0.47 ± 0.161
0.627PheGln: 0.627 ± 0.232
1.411PheArg: 1.411 ± 0.283
2.586PheSer: 2.586 ± 0.347
2.665PheThr: 2.665 ± 0.449
2.194PheVal: 2.194 ± 0.289
0.705PheTrp: 0.705 ± 0.22
1.489PheTyr: 1.489 ± 0.35
0.0PheXaa: 0.0 ± 0.0
Gly
4.859GlyAla: 4.859 ± 0.885
0.078GlyCys: 0.078 ± 0.076
3.762GlyAsp: 3.762 ± 0.524
3.37GlyGlu: 3.37 ± 0.57
2.508GlyPhe: 2.508 ± 0.554
4.389GlyGly: 4.389 ± 0.607
0.94GlyHis: 0.94 ± 0.326
4.702GlyIle: 4.702 ± 1.331
6.113GlyLys: 6.113 ± 0.762
6.505GlyLeu: 6.505 ± 0.981
1.881GlyMet: 1.881 ± 0.448
2.194GlyAsn: 2.194 ± 0.429
1.176GlyPro: 1.176 ± 0.533
1.803GlyGln: 1.803 ± 0.286
2.586GlyArg: 2.586 ± 0.476
3.135GlySer: 3.135 ± 0.391
4.467GlyThr: 4.467 ± 0.61
4.31GlyVal: 4.31 ± 0.675
0.47GlyTrp: 0.47 ± 0.207
2.821GlyTyr: 2.821 ± 0.537
0.0GlyXaa: 0.0 ± 0.0
His
0.94HisAla: 0.94 ± 0.26
0.078HisCys: 0.078 ± 0.079
0.705HisAsp: 0.705 ± 0.264
0.862HisGlu: 0.862 ± 0.302
0.784HisPhe: 0.784 ± 0.261
0.784HisGly: 0.784 ± 0.276
0.392HisHis: 0.392 ± 0.187
1.097HisIle: 1.097 ± 0.336
0.862HisLys: 0.862 ± 0.273
0.94HisLeu: 0.94 ± 0.276
0.078HisMet: 0.078 ± 0.076
0.392HisAsn: 0.392 ± 0.152
0.784HisPro: 0.784 ± 0.277
0.47HisGln: 0.47 ± 0.205
0.784HisArg: 0.784 ± 0.232
0.784HisSer: 0.784 ± 0.256
0.862HisThr: 0.862 ± 0.318
0.784HisVal: 0.784 ± 0.238
0.078HisTrp: 0.078 ± 0.089
0.47HisTyr: 0.47 ± 0.191
0.0HisXaa: 0.0 ± 0.0
Ile
5.564IleAla: 5.564 ± 1.051
0.313IleCys: 0.313 ± 0.15
6.818IleAsp: 6.818 ± 0.716
4.624IleGlu: 4.624 ± 0.737
2.351IlePhe: 2.351 ± 0.434
3.683IleGly: 3.683 ± 0.569
0.862IleHis: 0.862 ± 0.312
5.016IleIle: 5.016 ± 0.819
7.445IleLys: 7.445 ± 0.886
5.172IleLeu: 5.172 ± 0.688
1.489IleMet: 1.489 ± 0.252
4.389IleAsn: 4.389 ± 0.646
2.194IlePro: 2.194 ± 0.423
2.821IleGln: 2.821 ± 0.657
1.881IleArg: 1.881 ± 0.374
4.467IleSer: 4.467 ± 0.707
3.997IleThr: 3.997 ± 0.61
4.389IleVal: 4.389 ± 0.474
0.627IleTrp: 0.627 ± 0.217
3.527IleTyr: 3.527 ± 0.68
0.0IleXaa: 0.0 ± 0.0
Lys
6.348LysAla: 6.348 ± 0.56
0.235LysCys: 0.235 ± 0.109
5.486LysAsp: 5.486 ± 0.814
6.505LysGlu: 6.505 ± 0.771
2.194LysPhe: 2.194 ± 0.461
4.781LysGly: 4.781 ± 0.507
1.097LysHis: 1.097 ± 0.404
7.602LysIle: 7.602 ± 0.852
7.288LysLys: 7.288 ± 1.077
6.505LysLeu: 6.505 ± 0.814
2.743LysMet: 2.743 ± 0.437
4.937LysAsn: 4.937 ± 0.706
3.527LysPro: 3.527 ± 0.579
4.075LysGln: 4.075 ± 0.64
4.075LysArg: 4.075 ± 0.77
4.389LysSer: 4.389 ± 0.588
4.624LysThr: 4.624 ± 0.618
5.486LysVal: 5.486 ± 0.774
1.254LysTrp: 1.254 ± 0.349
3.683LysTyr: 3.683 ± 0.697
0.0LysXaa: 0.0 ± 0.0
Leu
6.505LeuAla: 6.505 ± 0.896
0.392LeuCys: 0.392 ± 0.178
6.505LeuAsp: 6.505 ± 0.671
7.21LeuGlu: 7.21 ± 1.044
2.508LeuPhe: 2.508 ± 0.359
5.251LeuGly: 5.251 ± 0.802
0.862LeuHis: 0.862 ± 0.249
5.016LeuIle: 5.016 ± 0.626
8.464LeuLys: 8.464 ± 0.975
6.818LeuLeu: 6.818 ± 0.925
1.724LeuMet: 1.724 ± 0.419
5.329LeuAsn: 5.329 ± 0.599
3.918LeuPro: 3.918 ± 0.822
3.918LeuGln: 3.918 ± 0.488
3.84LeuArg: 3.84 ± 0.6
6.975LeuSer: 6.975 ± 0.804
5.094LeuThr: 5.094 ± 0.607
5.408LeuVal: 5.408 ± 0.567
0.784LeuTrp: 0.784 ± 0.206
2.351LeuTyr: 2.351 ± 0.554
0.0LeuXaa: 0.0 ± 0.0
Met
3.056MetAla: 3.056 ± 0.707
0.078MetCys: 0.078 ± 0.067
1.176MetAsp: 1.176 ± 0.27
1.646MetGlu: 1.646 ± 0.302
0.862MetPhe: 0.862 ± 0.205
1.254MetGly: 1.254 ± 0.309
0.235MetHis: 0.235 ± 0.128
1.332MetIle: 1.332 ± 0.262
0.94MetLys: 0.94 ± 0.299
1.803MetLeu: 1.803 ± 0.357
0.47MetMet: 0.47 ± 0.221
1.567MetAsn: 1.567 ± 0.419
0.784MetPro: 0.784 ± 0.212
0.94MetGln: 0.94 ± 0.257
1.959MetArg: 1.959 ± 0.42
2.978MetSer: 2.978 ± 0.786
1.019MetThr: 1.019 ± 0.273
0.862MetVal: 0.862 ± 0.3
0.078MetTrp: 0.078 ± 0.078
0.392MetTyr: 0.392 ± 0.177
0.0MetXaa: 0.0 ± 0.0
Asn
5.094AsnAla: 5.094 ± 0.649
0.235AsnCys: 0.235 ± 0.125
2.665AsnAsp: 2.665 ± 0.445
3.135AsnGlu: 3.135 ± 0.691
2.116AsnPhe: 2.116 ± 0.484
3.683AsnGly: 3.683 ± 0.466
0.862AsnHis: 0.862 ± 0.249
4.467AsnIle: 4.467 ± 0.673
3.84AsnLys: 3.84 ± 0.607
5.408AsnLeu: 5.408 ± 0.605
1.019AsnMet: 1.019 ± 0.252
2.429AsnAsn: 2.429 ± 0.496
2.194AsnPro: 2.194 ± 0.363
1.567AsnGln: 1.567 ± 0.304
2.665AsnArg: 2.665 ± 0.445
5.016AsnSer: 5.016 ± 0.876
2.9AsnThr: 2.9 ± 0.572
2.978AsnVal: 2.978 ± 0.432
0.627AsnTrp: 0.627 ± 0.203
1.803AsnTyr: 1.803 ± 0.451
0.0AsnXaa: 0.0 ± 0.0
Pro
1.489ProAla: 1.489 ± 0.384
0.313ProCys: 0.313 ± 0.184
1.567ProAsp: 1.567 ± 0.328
2.508ProGlu: 2.508 ± 0.618
1.019ProPhe: 1.019 ± 0.396
1.803ProGly: 1.803 ± 0.354
0.313ProHis: 0.313 ± 0.216
1.803ProIle: 1.803 ± 0.327
2.665ProLys: 2.665 ± 0.469
2.038ProLeu: 2.038 ± 0.422
0.627ProMet: 0.627 ± 0.256
2.038ProAsn: 2.038 ± 0.448
0.47ProPro: 0.47 ± 0.221
1.489ProGln: 1.489 ± 0.451
1.176ProArg: 1.176 ± 0.374
1.881ProSer: 1.881 ± 0.367
1.803ProThr: 1.803 ± 0.407
2.351ProVal: 2.351 ± 0.468
0.157ProTrp: 0.157 ± 0.121
0.784ProTyr: 0.784 ± 0.342
0.0ProXaa: 0.0 ± 0.0
Gln
3.84GlnAla: 3.84 ± 0.703
0.235GlnCys: 0.235 ± 0.138
1.646GlnAsp: 1.646 ± 0.324
3.213GlnGlu: 3.213 ± 0.63
1.803GlnPhe: 1.803 ± 0.339
2.665GlnGly: 2.665 ± 0.56
0.313GlnHis: 0.313 ± 0.151
3.213GlnIle: 3.213 ± 0.737
3.762GlnLys: 3.762 ± 0.595
3.683GlnLeu: 3.683 ± 0.686
1.097GlnMet: 1.097 ± 0.331
2.038GlnAsn: 2.038 ± 0.458
0.392GlnPro: 0.392 ± 0.154
1.489GlnGln: 1.489 ± 0.413
1.567GlnArg: 1.567 ± 0.338
3.056GlnSer: 3.056 ± 0.678
2.038GlnThr: 2.038 ± 0.335
1.097GlnVal: 1.097 ± 0.231
0.392GlnTrp: 0.392 ± 0.188
0.94GlnTyr: 0.94 ± 0.343
0.0GlnXaa: 0.0 ± 0.0
Arg
3.056ArgAla: 3.056 ± 0.502
0.235ArgCys: 0.235 ± 0.131
2.194ArgAsp: 2.194 ± 0.566
3.448ArgGlu: 3.448 ± 0.474
2.351ArgPhe: 2.351 ± 0.444
2.429ArgGly: 2.429 ± 0.505
0.784ArgHis: 0.784 ± 0.244
3.762ArgIle: 3.762 ± 0.553
3.135ArgLys: 3.135 ± 0.579
5.643ArgLeu: 5.643 ± 0.958
1.097ArgMet: 1.097 ± 0.273
2.429ArgAsn: 2.429 ± 0.51
0.94ArgPro: 0.94 ± 0.267
1.724ArgGln: 1.724 ± 0.323
1.254ArgArg: 1.254 ± 0.337
1.959ArgSer: 1.959 ± 0.428
2.273ArgThr: 2.273 ± 0.573
2.508ArgVal: 2.508 ± 0.478
0.47ArgTrp: 0.47 ± 0.235
1.803ArgTyr: 1.803 ± 0.427
0.0ArgXaa: 0.0 ± 0.0
Ser
6.426SerAla: 6.426 ± 1.503
0.235SerCys: 0.235 ± 0.143
3.683SerAsp: 3.683 ± 0.675
3.84SerGlu: 3.84 ± 0.499
2.194SerPhe: 2.194 ± 0.462
5.408SerGly: 5.408 ± 1.046
1.019SerHis: 1.019 ± 0.385
4.31SerIle: 4.31 ± 0.64
4.937SerLys: 4.937 ± 0.59
5.251SerLeu: 5.251 ± 1.665
1.567SerMet: 1.567 ± 0.511
3.605SerAsn: 3.605 ± 0.652
1.646SerPro: 1.646 ± 0.316
2.351SerGln: 2.351 ± 0.508
3.056SerArg: 3.056 ± 0.453
5.408SerSer: 5.408 ± 1.585
3.683SerThr: 3.683 ± 0.713
4.702SerVal: 4.702 ± 0.685
0.549SerTrp: 0.549 ± 0.204
2.665SerTyr: 2.665 ± 0.517
0.0SerXaa: 0.0 ± 0.0
Thr
4.781ThrAla: 4.781 ± 0.829
0.313ThrCys: 0.313 ± 0.162
3.683ThrAsp: 3.683 ± 0.55
2.978ThrGlu: 2.978 ± 0.474
2.743ThrPhe: 2.743 ± 0.572
4.624ThrGly: 4.624 ± 0.735
0.784ThrHis: 0.784 ± 0.254
3.448ThrIle: 3.448 ± 0.423
4.232ThrLys: 4.232 ± 0.58
6.034ThrLeu: 6.034 ± 0.738
1.019ThrMet: 1.019 ± 0.328
2.586ThrAsn: 2.586 ± 0.566
1.803ThrPro: 1.803 ± 0.531
2.273ThrGln: 2.273 ± 0.454
1.959ThrArg: 1.959 ± 0.456
4.702ThrSer: 4.702 ± 1.639
4.467ThrThr: 4.467 ± 0.709
3.448ThrVal: 3.448 ± 0.448
0.627ThrTrp: 0.627 ± 0.332
2.038ThrTyr: 2.038 ± 0.449
0.0ThrXaa: 0.0 ± 0.0
Val
5.094ValAla: 5.094 ± 0.577
0.078ValCys: 0.078 ± 0.067
4.075ValAsp: 4.075 ± 0.647
4.624ValGlu: 4.624 ± 0.718
2.586ValPhe: 2.586 ± 0.384
3.997ValGly: 3.997 ± 0.58
0.94ValHis: 0.94 ± 0.245
3.997ValIle: 3.997 ± 0.481
4.781ValLys: 4.781 ± 0.524
4.154ValLeu: 4.154 ± 0.571
1.411ValMet: 1.411 ± 0.328
2.978ValAsn: 2.978 ± 0.432
1.567ValPro: 1.567 ± 0.389
2.116ValGln: 2.116 ± 0.732
2.586ValArg: 2.586 ± 0.433
3.762ValSer: 3.762 ± 0.609
4.232ValThr: 4.232 ± 0.543
3.918ValVal: 3.918 ± 0.398
0.549ValTrp: 0.549 ± 0.203
2.116ValTyr: 2.116 ± 0.466
0.0ValXaa: 0.0 ± 0.0
Trp
0.784TrpAla: 0.784 ± 0.202
0.0TrpCys: 0.0 ± 0.0
0.862TrpAsp: 0.862 ± 0.211
1.332TrpGlu: 1.332 ± 0.277
0.392TrpPhe: 0.392 ± 0.162
0.392TrpGly: 0.392 ± 0.146
0.078TrpHis: 0.078 ± 0.076
0.784TrpIle: 0.784 ± 0.192
0.627TrpLys: 0.627 ± 0.178
0.862TrpLeu: 0.862 ± 0.254
0.078TrpMet: 0.078 ± 0.076
0.549TrpAsn: 0.549 ± 0.192
0.47TrpPro: 0.47 ± 0.223
0.705TrpGln: 0.705 ± 0.228
0.549TrpArg: 0.549 ± 0.203
0.47TrpSer: 0.47 ± 0.221
0.078TrpThr: 0.078 ± 0.065
0.94TrpVal: 0.94 ± 0.323
0.157TrpTrp: 0.157 ± 0.109
0.235TrpTyr: 0.235 ± 0.128
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.527TyrAla: 3.527 ± 0.441
0.47TyrCys: 0.47 ± 0.192
2.9TyrAsp: 2.9 ± 0.609
3.213TyrGlu: 3.213 ± 0.608
1.332TyrPhe: 1.332 ± 0.295
1.959TyrGly: 1.959 ± 0.465
0.47TyrHis: 0.47 ± 0.222
1.567TyrIle: 1.567 ± 0.377
3.135TyrLys: 3.135 ± 0.576
3.683TyrLeu: 3.683 ± 0.728
0.313TyrMet: 0.313 ± 0.138
1.803TyrAsn: 1.803 ± 0.465
0.94TyrPro: 0.94 ± 0.373
1.881TyrGln: 1.881 ± 0.437
2.038TyrArg: 2.038 ± 0.497
3.84TyrSer: 3.84 ± 0.648
2.273TyrThr: 2.273 ± 0.432
2.116TyrVal: 2.116 ± 0.417
0.235TyrTrp: 0.235 ± 0.115
1.724TyrTyr: 1.724 ± 0.438
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 55 proteins (12761 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski