Amino acid dipepetide frequency for Lutibacter sp. Hel_I_33_5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.843AlaAla: 3.843 ± 0.109
0.513AlaCys: 0.513 ± 0.031
3.182AlaAsp: 3.182 ± 0.089
3.278AlaGlu: 3.278 ± 0.072
3.014AlaPhe: 3.014 ± 0.066
3.995AlaGly: 3.995 ± 0.096
0.894AlaHis: 0.894 ± 0.035
5.362AlaIle: 5.362 ± 0.095
4.684AlaLys: 4.684 ± 0.099
5.171AlaLeu: 5.171 ± 0.087
1.23AlaMet: 1.23 ± 0.046
3.729AlaAsn: 3.729 ± 0.108
1.666AlaPro: 1.666 ± 0.072
1.945AlaGln: 1.945 ± 0.048
1.724AlaArg: 1.724 ± 0.055
4.214AlaSer: 4.214 ± 0.096
4.008AlaThr: 4.008 ± 0.14
3.681AlaVal: 3.681 ± 0.086
0.469AlaTrp: 0.469 ± 0.02
2.004AlaTyr: 2.004 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.39CysAla: 0.39 ± 0.021
0.078CysCys: 0.078 ± 0.009
0.47CysAsp: 0.47 ± 0.044
0.411CysGlu: 0.411 ± 0.023
0.425CysPhe: 0.425 ± 0.023
0.573CysGly: 0.573 ± 0.032
0.156CysHis: 0.156 ± 0.015
0.532CysIle: 0.532 ± 0.03
0.51CysLys: 0.51 ± 0.026
0.56CysLeu: 0.56 ± 0.025
0.132CysMet: 0.132 ± 0.011
0.432CysAsn: 0.432 ± 0.022
0.301CysPro: 0.301 ± 0.027
0.175CysGln: 0.175 ± 0.015
0.17CysArg: 0.17 ± 0.013
0.565CysSer: 0.565 ± 0.025
0.455CysThr: 0.455 ± 0.041
0.424CysVal: 0.424 ± 0.027
0.065CysTrp: 0.065 ± 0.008
0.225CysTyr: 0.225 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
3.829AspAla: 3.829 ± 0.129
0.388AspCys: 0.388 ± 0.025
3.503AspAsp: 3.503 ± 0.278
3.542AspGlu: 3.542 ± 0.071
3.579AspPhe: 3.579 ± 0.073
4.968AspGly: 4.968 ± 0.581
0.677AspHis: 0.677 ± 0.027
4.707AspIle: 4.707 ± 0.08
4.502AspLys: 4.502 ± 0.088
5.094AspLeu: 5.094 ± 0.074
0.916AspMet: 0.916 ± 0.033
3.69AspAsn: 3.69 ± 0.169
1.533AspPro: 1.533 ± 0.121
1.146AspGln: 1.146 ± 0.036
1.57AspArg: 1.57 ± 0.046
3.559AspSer: 3.559 ± 0.164
3.569AspThr: 3.569 ± 0.297
3.923AspVal: 3.923 ± 0.083
0.666AspTrp: 0.666 ± 0.027
2.501AspTyr: 2.501 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
3.66GluAla: 3.66 ± 0.079
0.278GluCys: 0.278 ± 0.019
3.485GluAsp: 3.485 ± 0.099
4.444GluGlu: 4.444 ± 0.1
3.014GluPhe: 3.014 ± 0.056
3.269GluGly: 3.269 ± 0.079
0.972GluHis: 0.972 ± 0.039
5.661GluIle: 5.661 ± 0.102
6.21GluLys: 6.21 ± 0.145
5.659GluLeu: 5.659 ± 0.101
1.293GluMet: 1.293 ± 0.042
5.08GluAsn: 5.08 ± 0.104
1.237GluPro: 1.237 ± 0.036
1.81GluGln: 1.81 ± 0.05
2.072GluArg: 2.072 ± 0.064
3.137GluSer: 3.137 ± 0.066
3.416GluThr: 3.416 ± 0.07
4.04GluVal: 4.04 ± 0.067
0.514GluTrp: 0.514 ± 0.024
2.273GluTyr: 2.273 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
2.757PheAla: 2.757 ± 0.063
0.438PheCys: 0.438 ± 0.021
3.326PheAsp: 3.326 ± 0.069
2.951PheGlu: 2.951 ± 0.076
2.951PhePhe: 2.951 ± 0.081
3.694PheGly: 3.694 ± 0.083
0.757PheHis: 0.757 ± 0.03
4.354PheIle: 4.354 ± 0.103
4.244PheLys: 4.244 ± 0.102
4.79PheLeu: 4.79 ± 0.11
1.009PheMet: 1.009 ± 0.04
3.865PheAsn: 3.865 ± 0.085
1.607PhePro: 1.607 ± 0.043
1.364PheGln: 1.364 ± 0.045
1.459PheArg: 1.459 ± 0.043
4.512PheSer: 4.512 ± 0.077
3.416PheThr: 3.416 ± 0.069
2.904PheVal: 2.904 ± 0.07
0.569PheTrp: 0.569 ± 0.024
2.301PheTyr: 2.301 ± 0.063
0.0PheXaa: 0.0 ± 0.0
Gly
3.959GlyAla: 3.959 ± 0.085
0.556GlyCys: 0.556 ± 0.038
3.707GlyAsp: 3.707 ± 0.238
3.333GlyGlu: 3.333 ± 0.065
3.791GlyPhe: 3.791 ± 0.082
4.636GlyGly: 4.636 ± 0.119
0.971GlyHis: 0.971 ± 0.037
5.684GlyIle: 5.684 ± 0.108
5.193GlyLys: 5.193 ± 0.113
5.527GlyLeu: 5.527 ± 0.093
1.441GlyMet: 1.441 ± 0.043
3.993GlyAsn: 3.993 ± 0.105
1.129GlyPro: 1.129 ± 0.04
1.534GlyGln: 1.534 ± 0.046
1.856GlyArg: 1.856 ± 0.051
4.082GlySer: 4.082 ± 0.115
4.784GlyThr: 4.784 ± 0.298
4.446GlyVal: 4.446 ± 0.109
0.666GlyTrp: 0.666 ± 0.029
2.651GlyTyr: 2.651 ± 0.066
0.0GlyXaa: 0.0 ± 0.0
His
0.847HisAla: 0.847 ± 0.031
0.162HisCys: 0.162 ± 0.013
0.718HisAsp: 0.718 ± 0.029
0.789HisGlu: 0.789 ± 0.035
1.082HisPhe: 1.082 ± 0.041
0.953HisGly: 0.953 ± 0.035
0.433HisHis: 0.433 ± 0.024
1.289HisIle: 1.289 ± 0.046
1.248HisLys: 1.248 ± 0.044
1.599HisLeu: 1.599 ± 0.047
0.241HisMet: 0.241 ± 0.017
0.953HisAsn: 0.953 ± 0.035
0.784HisPro: 0.784 ± 0.032
0.81HisGln: 0.81 ± 0.033
0.59HisArg: 0.59 ± 0.026
0.97HisSer: 0.97 ± 0.036
0.924HisThr: 0.924 ± 0.031
0.823HisVal: 0.823 ± 0.029
0.181HisTrp: 0.181 ± 0.014
0.677HisTyr: 0.677 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
5.391IleAla: 5.391 ± 0.098
0.636IleCys: 0.636 ± 0.028
5.375IleAsp: 5.375 ± 0.094
5.535IleGlu: 5.535 ± 0.11
3.865IlePhe: 3.865 ± 0.089
5.123IleGly: 5.123 ± 0.094
1.394IleHis: 1.394 ± 0.044
6.835IleIle: 6.835 ± 0.142
7.041IleLys: 7.041 ± 0.125
7.19IleLeu: 7.19 ± 0.121
1.242IleMet: 1.242 ± 0.041
6.037IleAsn: 6.037 ± 0.106
3.286IlePro: 3.286 ± 0.068
2.458IleGln: 2.458 ± 0.059
2.379IleArg: 2.379 ± 0.071
6.409IleSer: 6.409 ± 0.105
5.493IleThr: 5.493 ± 0.125
4.814IleVal: 4.814 ± 0.082
0.66IleTrp: 0.66 ± 0.027
3.014IleTyr: 3.014 ± 0.084
0.0IleXaa: 0.0 ± 0.0
Lys
4.796LysAla: 4.796 ± 0.101
0.323LysCys: 0.323 ± 0.018
4.864LysAsp: 4.864 ± 0.093
7.085LysGlu: 7.085 ± 0.149
3.3LysPhe: 3.3 ± 0.075
4.837LysGly: 4.837 ± 0.105
1.486LysHis: 1.486 ± 0.047
7.354LysIle: 7.354 ± 0.152
9.068LysLys: 9.068 ± 0.182
6.955LysLeu: 6.955 ± 0.142
2.013LysMet: 2.013 ± 0.06
6.63LysAsn: 6.63 ± 0.152
2.344LysPro: 2.344 ± 0.063
2.648LysGln: 2.648 ± 0.064
2.967LysArg: 2.967 ± 0.08
5.161LysSer: 5.161 ± 0.109
5.282LysThr: 5.282 ± 0.08
5.229LysVal: 5.229 ± 0.098
0.802LysTrp: 0.802 ± 0.031
3.326LysTyr: 3.326 ± 0.086
0.0LysXaa: 0.0 ± 0.0
Leu
4.997LeuAla: 4.997 ± 0.096
0.557LeuCys: 0.557 ± 0.025
5.17LeuAsp: 5.17 ± 0.154
5.864LeuGlu: 5.864 ± 0.096
4.824LeuPhe: 4.824 ± 0.121
5.573LeuGly: 5.573 ± 0.099
1.461LeuHis: 1.461 ± 0.049
7.153LeuIle: 7.153 ± 0.138
8.137LeuLys: 8.137 ± 0.173
8.395LeuLeu: 8.395 ± 0.164
1.692LeuMet: 1.692 ± 0.054
5.728LeuAsn: 5.728 ± 0.091
3.228LeuPro: 3.228 ± 0.062
2.971LeuGln: 2.971 ± 0.074
2.664LeuArg: 2.664 ± 0.072
6.638LeuSer: 6.638 ± 0.111
5.403LeuThr: 5.403 ± 0.154
5.129LeuVal: 5.129 ± 0.08
0.762LeuTrp: 0.762 ± 0.042
3.0LeuTyr: 3.0 ± 0.067
0.0LeuXaa: 0.0 ± 0.0
Met
1.202MetAla: 1.202 ± 0.039
0.118MetCys: 0.118 ± 0.011
0.895MetAsp: 0.895 ± 0.033
1.005MetGlu: 1.005 ± 0.04
0.828MetPhe: 0.828 ± 0.037
1.1MetGly: 1.1 ± 0.044
0.332MetHis: 0.332 ± 0.02
1.557MetIle: 1.557 ± 0.043
2.047MetLys: 2.047 ± 0.063
1.688MetLeu: 1.688 ± 0.054
0.492MetMet: 0.492 ± 0.026
1.253MetAsn: 1.253 ± 0.041
0.663MetPro: 0.663 ± 0.029
0.66MetGln: 0.66 ± 0.027
0.679MetArg: 0.679 ± 0.03
1.29MetSer: 1.29 ± 0.042
0.989MetThr: 0.989 ± 0.033
1.108MetVal: 1.108 ± 0.039
0.137MetTrp: 0.137 ± 0.013
0.673MetTyr: 0.673 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
3.935AsnAla: 3.935 ± 0.09
0.574AsnCys: 0.574 ± 0.04
4.25AsnAsp: 4.25 ± 0.273
3.69AsnGlu: 3.69 ± 0.071
3.429AsnPhe: 3.429 ± 0.074
4.493AsnGly: 4.493 ± 0.141
1.17AsnHis: 1.17 ± 0.041
5.55AsnIle: 5.55 ± 0.104
5.596AsnLys: 5.596 ± 0.123
5.993AsnLeu: 5.993 ± 0.126
1.195AsnMet: 1.195 ± 0.038
5.405AsnAsn: 5.405 ± 0.127
3.05AsnPro: 3.05 ± 0.087
2.488AsnGln: 2.488 ± 0.064
2.041AsnArg: 2.041 ± 0.062
4.943AsnSer: 4.943 ± 0.101
4.434AsnThr: 4.434 ± 0.121
3.868AsnVal: 3.868 ± 0.06
0.776AsnTrp: 0.776 ± 0.036
3.242AsnTyr: 3.242 ± 0.066
0.0AsnXaa: 0.0 ± 0.0
Pro
1.671ProAla: 1.671 ± 0.075
0.219ProCys: 0.219 ± 0.021
1.926ProAsp: 1.926 ± 0.124
2.241ProGlu: 2.241 ± 0.062
1.679ProPhe: 1.679 ± 0.051
1.605ProGly: 1.605 ± 0.046
0.531ProHis: 0.531 ± 0.024
2.76ProIle: 2.76 ± 0.056
2.716ProLys: 2.716 ± 0.064
2.629ProLeu: 2.629 ± 0.056
0.581ProMet: 0.581 ± 0.026
2.408ProAsn: 2.408 ± 0.085
0.681ProPro: 0.681 ± 0.038
0.949ProGln: 0.949 ± 0.038
0.801ProArg: 0.801 ± 0.028
2.11ProSer: 2.11 ± 0.061
2.311ProThr: 2.311 ± 0.143
1.994ProVal: 1.994 ± 0.092
0.315ProTrp: 0.315 ± 0.019
1.158ProTyr: 1.158 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
1.496GlnAla: 1.496 ± 0.039
0.172GlnCys: 0.172 ± 0.014
1.417GlnAsp: 1.417 ± 0.046
2.067GlnGlu: 2.067 ± 0.055
1.696GlnPhe: 1.696 ± 0.05
1.571GlnGly: 1.571 ± 0.045
0.536GlnHis: 0.536 ± 0.025
2.513GlnIle: 2.513 ± 0.05
2.909GlnLys: 2.909 ± 0.073
3.234GlnLeu: 3.234 ± 0.059
0.613GlnMet: 0.613 ± 0.027
2.294GlnAsn: 2.294 ± 0.051
0.913GlnPro: 0.913 ± 0.031
1.306GlnGln: 1.306 ± 0.05
1.013GlnArg: 1.013 ± 0.04
1.729GlnSer: 1.729 ± 0.041
1.749GlnThr: 1.749 ± 0.05
1.764GlnVal: 1.764 ± 0.048
0.27GlnTrp: 0.27 ± 0.016
1.156GlnTyr: 1.156 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
1.824ArgAla: 1.824 ± 0.055
0.154ArgCys: 0.154 ± 0.012
1.506ArgAsp: 1.506 ± 0.045
1.806ArgGlu: 1.806 ± 0.061
1.781ArgPhe: 1.781 ± 0.046
1.762ArgGly: 1.762 ± 0.05
0.466ArgHis: 0.466 ± 0.026
2.683ArgIle: 2.683 ± 0.07
2.927ArgLys: 2.927 ± 0.066
2.741ArgLeu: 2.741 ± 0.065
0.679ArgMet: 0.679 ± 0.031
2.1ArgAsn: 2.1 ± 0.061
0.83ArgPro: 0.83 ± 0.034
0.885ArgGln: 0.885 ± 0.039
1.12ArgArg: 1.12 ± 0.045
1.643ArgSer: 1.643 ± 0.054
1.672ArgThr: 1.672 ± 0.048
1.886ArgVal: 1.886 ± 0.054
0.319ArgTrp: 0.319 ± 0.02
1.241ArgTyr: 1.241 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
3.568SerAla: 3.568 ± 0.075
0.63SerCys: 0.63 ± 0.025
3.872SerAsp: 3.872 ± 0.131
4.045SerGlu: 4.045 ± 0.077
4.205SerPhe: 4.205 ± 0.093
4.782SerGly: 4.782 ± 0.12
0.945SerHis: 0.945 ± 0.034
5.865SerIle: 5.865 ± 0.092
5.839SerLys: 5.839 ± 0.103
6.323SerLeu: 6.323 ± 0.101
1.143SerMet: 1.143 ± 0.039
4.599SerAsn: 4.599 ± 0.112
2.022SerPro: 2.022 ± 0.063
1.97SerGln: 1.97 ± 0.053
1.89SerArg: 1.89 ± 0.055
4.729SerSer: 4.729 ± 0.107
4.131SerThr: 4.131 ± 0.129
4.05SerVal: 4.05 ± 0.086
0.7SerTrp: 0.7 ± 0.025
2.863SerTyr: 2.863 ± 0.077
0.0SerXaa: 0.0 ± 0.0
Thr
3.817ThrAla: 3.817 ± 0.146
0.407ThrCys: 0.407 ± 0.032
3.859ThrAsp: 3.859 ± 0.29
3.464ThrGlu: 3.464 ± 0.067
3.275ThrPhe: 3.275 ± 0.07
4.212ThrGly: 4.212 ± 0.18
1.004ThrHis: 1.004 ± 0.028
5.947ThrIle: 5.947 ± 0.165
4.607ThrLys: 4.607 ± 0.093
5.518ThrLeu: 5.518 ± 0.128
0.851ThrMet: 0.851 ± 0.033
4.477ThrAsn: 4.477 ± 0.166
2.64ThrPro: 2.64 ± 0.142
1.813ThrGln: 1.813 ± 0.057
1.525ThrArg: 1.525 ± 0.048
4.5ThrSer: 4.5 ± 0.126
4.134ThrThr: 4.134 ± 0.202
4.316ThrVal: 4.316 ± 0.259
0.612ThrTrp: 0.612 ± 0.026
2.374ThrTyr: 2.374 ± 0.087
0.0ThrXaa: 0.0 ± 0.0
Val
3.948ValAla: 3.948 ± 0.088
0.472ValCys: 0.472 ± 0.021
3.784ValAsp: 3.784 ± 0.148
3.605ValGlu: 3.605 ± 0.068
3.377ValPhe: 3.377 ± 0.058
3.848ValGly: 3.848 ± 0.075
0.906ValHis: 0.906 ± 0.034
4.9ValIle: 4.9 ± 0.082
4.536ValLys: 4.536 ± 0.082
5.709ValLeu: 5.709 ± 0.091
1.104ValMet: 1.104 ± 0.039
3.976ValAsn: 3.976 ± 0.096
1.91ValPro: 1.91 ± 0.077
1.549ValGln: 1.549 ± 0.042
1.841ValArg: 1.841 ± 0.057
4.7ValSer: 4.7 ± 0.085
4.06ValThr: 4.06 ± 0.198
3.988ValVal: 3.988 ± 0.082
0.596ValTrp: 0.596 ± 0.024
2.217ValTyr: 2.217 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
0.506TrpAla: 0.506 ± 0.024
0.077TrpCys: 0.077 ± 0.009
0.515TrpAsp: 0.515 ± 0.023
0.558TrpGlu: 0.558 ± 0.032
0.586TrpPhe: 0.586 ± 0.025
0.577TrpGly: 0.577 ± 0.025
0.217TrpHis: 0.217 ± 0.014
0.707TrpIle: 0.707 ± 0.03
0.869TrpLys: 0.869 ± 0.03
0.863TrpLeu: 0.863 ± 0.032
0.268TrpMet: 0.268 ± 0.015
0.738TrpAsn: 0.738 ± 0.032
0.158TrpPro: 0.158 ± 0.012
0.357TrpGln: 0.357 ± 0.02
0.343TrpArg: 0.343 ± 0.022
0.615TrpSer: 0.615 ± 0.032
0.558TrpThr: 0.558 ± 0.031
0.548TrpVal: 0.548 ± 0.024
0.145TrpTrp: 0.145 ± 0.013
0.412TrpTyr: 0.412 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.169TyrAla: 2.169 ± 0.059
0.299TyrCys: 0.299 ± 0.02
2.042TyrAsp: 2.042 ± 0.054
1.81TyrGlu: 1.81 ± 0.048
2.567TyrPhe: 2.567 ± 0.076
2.369TyrGly: 2.369 ± 0.068
0.764TyrHis: 0.764 ± 0.034
2.766TyrIle: 2.766 ± 0.069
3.585TyrLys: 3.585 ± 0.086
3.706TyrLeu: 3.706 ± 0.083
0.579TyrMet: 0.579 ± 0.024
2.734TyrAsn: 2.734 ± 0.062
1.3TyrPro: 1.3 ± 0.037
1.576TyrGln: 1.576 ± 0.045
1.321TyrArg: 1.321 ± 0.039
2.667TyrSer: 2.667 ± 0.06
2.564TyrThr: 2.564 ± 0.095
2.092TyrVal: 2.092 ± 0.049
0.394TyrTrp: 0.394 ± 0.022
1.643TyrTyr: 1.643 ± 0.046
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2634 proteins (952811 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski