Amino acid dipepetide frequency for Pseudogymnoascus sp. 23342-1-I1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.131AlaAla: 10.131 ± 0.082	1.021AlaCys: 1.021 ± 0.018	4.424AlaAsp: 4.424 ± 0.028	5.526AlaGlu: 5.526 ± 0.053	3.143AlaPhe: 3.143 ± 0.026	6.226AlaGly: 6.226 ± 0.044	1.717AlaHis: 1.717 ± 0.019	4.494AlaIle: 4.494 ± 0.037	4.402AlaLys: 4.402 ± 0.041	7.983AlaLeu: 7.983 ± 0.053	1.973AlaMet: 1.973 ± 0.021	3.087AlaAsn: 3.087 ± 0.028	5.311AlaPro: 5.311 ± 0.05	3.409AlaGln: 3.409 ± 0.03	4.926AlaArg: 4.926 ± 0.039	7.209AlaSer: 7.209 ± 0.042	5.666AlaThr: 5.666 ± 0.033	5.607AlaVal: 5.607 ± 0.045	1.141AlaTrp: 1.141 ± 0.016	2.207AlaTyr: 2.207 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.928CysAla: 0.928 ± 0.017	0.231CysCys: 0.231 ± 0.007	0.625CysAsp: 0.625 ± 0.013	0.591CysGlu: 0.591 ± 0.013	0.503CysPhe: 0.503 ± 0.009	0.944CysGly: 0.944 ± 0.018	0.291CysHis: 0.291 ± 0.008	0.686CysIle: 0.686 ± 0.014	0.488CysLys: 0.488 ± 0.01	1.148CysLeu: 1.148 ± 0.015	0.263CysMet: 0.263 ± 0.007	0.414CysAsn: 0.414 ± 0.011	0.597CysPro: 0.597 ± 0.012	0.392CysGln: 0.392 ± 0.009	0.645CysArg: 0.645 ± 0.012	0.837CysSer: 0.837 ± 0.013	0.653CysThr: 0.653 ± 0.014	0.725CysVal: 0.725 ± 0.013	0.185CysTrp: 0.185 ± 0.006	0.338CysTyr: 0.338 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.919AspAla: 4.919 ± 0.033	0.572AspCys: 0.572 ± 0.012	4.139AspAsp: 4.139 ± 0.046	4.562AspGlu: 4.562 ± 0.041	2.211AspPhe: 2.211 ± 0.02	4.254AspGly: 4.254 ± 0.034	1.096AspHis: 1.096 ± 0.016	3.189AspIle: 3.189 ± 0.029	2.445AspLys: 2.445 ± 0.024	4.916AspLeu: 4.916 ± 0.029	1.251AspMet: 1.251 ± 0.017	1.967AspAsn: 1.967 ± 0.021	3.067AspPro: 3.067 ± 0.026	1.724AspGln: 1.724 ± 0.022	2.856AspArg: 2.856 ± 0.028	4.106AspSer: 4.106 ± 0.032	3.008AspThr: 3.008 ± 0.027	3.727AspVal: 3.727 ± 0.025	0.828AspTrp: 0.828 ± 0.012	1.599AspTyr: 1.599 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	5.892GluAla: 5.892 ± 0.049	0.603GluCys: 0.603 ± 0.01	4.266GluAsp: 4.266 ± 0.039	5.994GluGlu: 5.994 ± 0.062	1.984GluPhe: 1.984 ± 0.019	4.528GluGly: 4.528 ± 0.039	1.265GluHis: 1.265 ± 0.016	3.16GluIle: 3.16 ± 0.024	3.837GluLys: 3.837 ± 0.04	5.229GluLeu: 5.229 ± 0.038	1.531GluMet: 1.531 ± 0.018	2.27GluAsn: 2.27 ± 0.024	2.756GluPro: 2.756 ± 0.041	2.292GluGln: 2.292 ± 0.027	4.074GluArg: 4.074 ± 0.04	4.276GluSer: 4.276 ± 0.033	3.423GluThr: 3.423 ± 0.031	3.989GluVal: 3.989 ± 0.032	0.913GluTrp: 0.913 ± 0.014	1.723GluTyr: 1.723 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.055PheAla: 3.055 ± 0.027	0.523PheCys: 0.523 ± 0.011	2.221PheAsp: 2.221 ± 0.024	2.208PheGlu: 2.208 ± 0.022	1.527PhePhe: 1.527 ± 0.021	2.962PheGly: 2.962 ± 0.033	0.802PheHis: 0.802 ± 0.013	1.817PheIle: 1.817 ± 0.021	1.573PheLys: 1.573 ± 0.016	3.308PheLeu: 3.308 ± 0.028	0.788PheMet: 0.788 ± 0.013	1.416PheAsn: 1.416 ± 0.018	1.876PhePro: 1.876 ± 0.022	1.335PheGln: 1.335 ± 0.017	1.819PheArg: 1.819 ± 0.021	2.885PheSer: 2.885 ± 0.028	2.118PheThr: 2.118 ± 0.023	2.351PheVal: 2.351 ± 0.02	0.623PheTrp: 0.623 ± 0.011	1.096PheTyr: 1.096 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	5.97GlyAla: 5.97 ± 0.045	0.852GlyCys: 0.852 ± 0.016	3.864GlyAsp: 3.864 ± 0.033	4.327GlyGlu: 4.327 ± 0.034	2.859GlyPhe: 2.859 ± 0.029	7.193GlyGly: 7.193 ± 0.072	1.639GlyHis: 1.639 ± 0.019	3.681GlyIle: 3.681 ± 0.028	3.823GlyLys: 3.823 ± 0.033	6.147GlyLeu: 6.147 ± 0.039	1.74GlyMet: 1.74 ± 0.02	2.735GlyAsn: 2.735 ± 0.028	3.348GlyPro: 3.348 ± 0.03	2.559GlyGln: 2.559 ± 0.029	4.326GlyArg: 4.326 ± 0.034	5.879GlySer: 5.879 ± 0.04	4.134GlyThr: 4.134 ± 0.034	4.755GlyVal: 4.755 ± 0.035	1.227GlyTrp: 1.227 ± 0.019	2.183GlyTyr: 2.183 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	1.731HisAla: 1.731 ± 0.019	0.291HisCys: 0.291 ± 0.008	1.201HisAsp: 1.201 ± 0.018	1.226HisGlu: 1.226 ± 0.017	0.857HisPhe: 0.857 ± 0.013	1.614HisGly: 1.614 ± 0.019	0.73HisHis: 0.73 ± 0.014	1.203HisIle: 1.203 ± 0.016	0.905HisLys: 0.905 ± 0.013	2.057HisLeu: 2.057 ± 0.02	0.447HisMet: 0.447 ± 0.01	0.822HisAsn: 0.822 ± 0.013	1.532HisPro: 1.532 ± 0.021	0.881HisGln: 0.881 ± 0.015	1.335HisArg: 1.335 ± 0.017	1.655HisSer: 1.655 ± 0.018	1.26HisThr: 1.26 ± 0.018	1.307HisVal: 1.307 ± 0.017	0.297HisTrp: 0.297 ± 0.008	0.651HisTyr: 0.651 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.394IleAla: 4.394 ± 0.031	0.738IleCys: 0.738 ± 0.013	2.946IleAsp: 2.946 ± 0.028	3.003IleGlu: 3.003 ± 0.026	2.028IlePhe: 2.028 ± 0.021	3.349IleGly: 3.349 ± 0.031	1.122IleHis: 1.122 ± 0.016	2.68IleIle: 2.68 ± 0.027	2.325IleLys: 2.325 ± 0.026	4.589IleLeu: 4.589 ± 0.038	1.038IleMet: 1.038 ± 0.014	1.885IleAsn: 1.885 ± 0.019	3.03IlePro: 3.03 ± 0.025	1.859IleGln: 1.859 ± 0.02	2.688IleArg: 2.688 ± 0.022	3.991IleSer: 3.991 ± 0.031	3.042IleThr: 3.042 ± 0.025	3.24IleVal: 3.24 ± 0.028	0.711IleTrp: 0.711 ± 0.014	1.447IleTyr: 1.447 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.563LysAla: 4.563 ± 0.04	0.499LysCys: 0.499 ± 0.011	2.826LysAsp: 2.826 ± 0.028	3.597LysGlu: 3.597 ± 0.041	1.512LysPhe: 1.512 ± 0.02	3.306LysGly: 3.306 ± 0.031	1.062LysHis: 1.062 ± 0.016	2.38LysIle: 2.38 ± 0.024	3.447LysLys: 3.447 ± 0.056	4.223LysLeu: 4.223 ± 0.032	1.042LysMet: 1.042 ± 0.016	1.778LysAsn: 1.778 ± 0.019	2.707LysPro: 2.707 ± 0.029	1.757LysGln: 1.757 ± 0.02	3.378LysArg: 3.378 ± 0.028	3.662LysSer: 3.662 ± 0.03	2.87LysThr: 2.87 ± 0.03	2.961LysVal: 2.961 ± 0.027	0.678LysTrp: 0.678 ± 0.012	1.427LysTyr: 1.427 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	7.922LeuAla: 7.922 ± 0.049	1.103LeuCys: 1.103 ± 0.014	5.048LeuAsp: 5.048 ± 0.038	5.559LeuGlu: 5.559 ± 0.047	3.183LeuPhe: 3.183 ± 0.025	6.075LeuGly: 6.075 ± 0.036	2.093LeuHis: 2.093 ± 0.022	3.936LeuIle: 3.936 ± 0.032	4.308LeuLys: 4.308 ± 0.037	8.374LeuLeu: 8.374 ± 0.062	1.769LeuMet: 1.769 ± 0.02	3.088LeuAsn: 3.088 ± 0.027	5.404LeuPro: 5.404 ± 0.038	3.634LeuGln: 3.634 ± 0.032	5.483LeuArg: 5.483 ± 0.038	7.175LeuSer: 7.175 ± 0.044	4.841LeuThr: 4.841 ± 0.029	5.298LeuVal: 5.298 ± 0.038	1.173LeuTrp: 1.173 ± 0.017	2.296LeuTyr: 2.296 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.264MetAla: 2.264 ± 0.023	0.22MetCys: 0.22 ± 0.007	1.269MetAsp: 1.269 ± 0.014	1.358MetGlu: 1.358 ± 0.017	0.748MetPhe: 0.748 ± 0.012	1.618MetGly: 1.618 ± 0.021	0.464MetHis: 0.464 ± 0.009	0.968MetIle: 0.968 ± 0.014	1.052MetLys: 1.052 ± 0.016	1.797MetLeu: 1.797 ± 0.019	0.577MetMet: 0.577 ± 0.012	0.768MetAsn: 0.768 ± 0.014	1.203MetPro: 1.203 ± 0.018	0.793MetGln: 0.793 ± 0.015	1.257MetArg: 1.257 ± 0.015	1.875MetSer: 1.875 ± 0.02	1.202MetThr: 1.202 ± 0.016	1.342MetVal: 1.342 ± 0.014	0.266MetTrp: 0.266 ± 0.007	0.505MetTyr: 0.505 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.202AsnAla: 3.202 ± 0.027	0.446AsnCys: 0.446 ± 0.009	1.973AsnAsp: 1.973 ± 0.02	2.051AsnGlu: 2.051 ± 0.023	1.401AsnPhe: 1.401 ± 0.016	3.155AsnGly: 3.155 ± 0.033	0.806AsnHis: 0.806 ± 0.013	2.125AsnIle: 2.125 ± 0.022	1.58AsnLys: 1.58 ± 0.019	3.172AsnLeu: 3.172 ± 0.025	0.824AsnMet: 0.824 ± 0.014	1.537AsnAsn: 1.537 ± 0.024	2.406AsnPro: 2.406 ± 0.023	1.261AsnGln: 1.261 ± 0.015	1.849AsnArg: 1.849 ± 0.021	2.811AsnSer: 2.811 ± 0.027	2.217AsnThr: 2.217 ± 0.023	2.286AsnVal: 2.286 ± 0.022	0.545AsnTrp: 0.545 ± 0.012	1.088AsnTyr: 1.088 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	5.346ProAla: 5.346 ± 0.049	0.452ProCys: 0.452 ± 0.011	2.939ProAsp: 2.939 ± 0.028	3.694ProGlu: 3.694 ± 0.033	1.942ProPhe: 1.942 ± 0.021	3.886ProGly: 3.886 ± 0.033	1.243ProHis: 1.243 ± 0.019	2.619ProIle: 2.619 ± 0.024	2.761ProLys: 2.761 ± 0.031	4.759ProLeu: 4.759 ± 0.038	1.027ProMet: 1.027 ± 0.015	2.143ProAsn: 2.143 ± 0.025	5.246ProPro: 5.246 ± 0.067	2.419ProGln: 2.419 ± 0.036	3.318ProArg: 3.318 ± 0.029	5.872ProSer: 5.872 ± 0.047	4.272ProThr: 4.272 ± 0.032	3.521ProVal: 3.521 ± 0.036	0.689ProTrp: 0.689 ± 0.012	1.485ProTyr: 1.485 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.327GlnAla: 3.327 ± 0.035	0.404GlnCys: 0.404 ± 0.009	1.935GlnAsp: 1.935 ± 0.022	2.266GlnGlu: 2.266 ± 0.026	1.223GlnPhe: 1.223 ± 0.015	2.501GlnGly: 2.501 ± 0.029	0.941GlnHis: 0.941 ± 0.016	1.826GlnIle: 1.826 ± 0.016	1.904GlnLys: 1.904 ± 0.021	3.327GlnLeu: 3.327 ± 0.03	0.858GlnMet: 0.858 ± 0.014	1.506GlnAsn: 1.506 ± 0.018	2.367GlnPro: 2.367 ± 0.03	2.444GlnGln: 2.444 ± 0.061	2.447GlnArg: 2.447 ± 0.024	2.891GlnSer: 2.891 ± 0.029	2.23GlnThr: 2.23 ± 0.024	2.06GlnVal: 2.06 ± 0.021	0.533GlnTrp: 0.533 ± 0.01	1.137GlnTyr: 1.137 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	4.786ArgAla: 4.786 ± 0.032	0.637ArgCys: 0.637 ± 0.013	3.276ArgAsp: 3.276 ± 0.033	3.967ArgGlu: 3.967 ± 0.035	1.987ArgPhe: 1.987 ± 0.019	4.034ArgGly: 4.034 ± 0.036	1.397ArgHis: 1.397 ± 0.015	2.81ArgIle: 2.81 ± 0.024	3.361ArgLys: 3.361 ± 0.03	5.107ArgLeu: 5.107 ± 0.036	1.285ArgMet: 1.285 ± 0.016	2.165ArgAsn: 2.165 ± 0.024	3.243ArgPro: 3.243 ± 0.032	2.436ArgGln: 2.436 ± 0.027	4.831ArgArg: 4.831 ± 0.045	4.451ArgSer: 4.451 ± 0.037	3.17ArgThr: 3.17 ± 0.028	3.355ArgVal: 3.355 ± 0.031	0.848ArgTrp: 0.848 ± 0.015	1.544ArgTyr: 1.544 ± 0.017	0.0ArgXaa: 0.0 ± 0.0
Ser	6.737SerAla: 6.737 ± 0.044	0.827SerCys: 0.827 ± 0.014	4.204SerAsp: 4.204 ± 0.035	4.135SerGlu: 4.135 ± 0.031	2.92SerPhe: 2.92 ± 0.029	5.748SerGly: 5.748 ± 0.038	1.795SerHis: 1.795 ± 0.02	4.139SerIle: 4.139 ± 0.034	3.777SerLys: 3.777 ± 0.032	7.077SerLeu: 7.077 ± 0.048	1.649SerMet: 1.649 ± 0.021	2.975SerAsn: 2.975 ± 0.027	5.466SerPro: 5.466 ± 0.055	3.121SerGln: 3.121 ± 0.03	4.684SerArg: 4.684 ± 0.043	8.215SerSer: 8.215 ± 0.061	5.608SerThr: 5.608 ± 0.041	4.484SerVal: 4.484 ± 0.032	1.065SerTrp: 1.065 ± 0.015	2.074SerTyr: 2.074 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	5.443ThrAla: 5.443 ± 0.031	0.729ThrCys: 0.729 ± 0.013	2.941ThrAsp: 2.941 ± 0.026	3.19ThrGlu: 3.19 ± 0.029	2.22ThrPhe: 2.22 ± 0.023	4.313ThrGly: 4.313 ± 0.037	1.268ThrHis: 1.268 ± 0.015	3.241ThrIle: 3.241 ± 0.027	2.739ThrLys: 2.739 ± 0.022	5.24ThrLeu: 5.24 ± 0.04	1.168ThrMet: 1.168 ± 0.015	2.168ThrAsn: 2.168 ± 0.02	4.523ThrPro: 4.523 ± 0.039	2.033ThrGln: 2.033 ± 0.021	3.031ThrArg: 3.031 ± 0.025	5.365ThrSer: 5.365 ± 0.04	4.684ThrThr: 4.684 ± 0.04	3.684ThrVal: 3.684 ± 0.033	0.848ThrTrp: 0.848 ± 0.014	1.655ThrTyr: 1.655 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.634ValAla: 5.634 ± 0.039	0.758ValCys: 0.758 ± 0.012	3.806ValAsp: 3.806 ± 0.027	4.285ValGlu: 4.285 ± 0.04	2.373ValPhe: 2.373 ± 0.021	4.395ValGly: 4.395 ± 0.033	1.262ValHis: 1.262 ± 0.016	2.984ValIle: 2.984 ± 0.024	3.044ValLys: 3.044 ± 0.027	5.478ValLeu: 5.478 ± 0.041	1.347ValMet: 1.347 ± 0.017	2.217ValAsn: 2.217 ± 0.025	3.53ValPro: 3.53 ± 0.029	2.212ValGln: 2.212 ± 0.022	3.339ValArg: 3.339 ± 0.028	4.466ValSer: 4.466 ± 0.029	3.531ValThr: 3.531 ± 0.032	4.661ValVal: 4.661 ± 0.042	0.862ValTrp: 0.862 ± 0.013	1.687ValTyr: 1.687 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	1.165TrpAla: 1.165 ± 0.017	0.188TrpCys: 0.188 ± 0.005	0.878TrpAsp: 0.878 ± 0.016	0.886TrpGlu: 0.886 ± 0.013	0.519TrpPhe: 0.519 ± 0.01	0.987TrpGly: 0.987 ± 0.017	0.317TrpHis: 0.317 ± 0.009	0.714TrpIle: 0.714 ± 0.012	0.761TrpLys: 0.761 ± 0.011	1.251TrpLeu: 1.251 ± 0.018	0.367TrpMet: 0.367 ± 0.009	0.601TrpAsn: 0.601 ± 0.011	0.576TrpPro: 0.576 ± 0.01	0.497TrpGln: 0.497 ± 0.011	0.911TrpArg: 0.911 ± 0.014	1.005TrpSer: 1.005 ± 0.016	0.898TrpThr: 0.898 ± 0.015	0.92TrpVal: 0.92 ± 0.014	0.264TrpTrp: 0.264 ± 0.008	0.406TrpTyr: 0.406 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.197TyrAla: 2.197 ± 0.021	0.389TyrCys: 0.389 ± 0.01	1.659TyrAsp: 1.659 ± 0.021	1.579TyrGlu: 1.579 ± 0.021	1.165TyrPhe: 1.165 ± 0.018	2.15TyrGly: 2.15 ± 0.028	0.692TyrHis: 0.692 ± 0.013	1.455TyrIle: 1.455 ± 0.016	1.141TyrLys: 1.141 ± 0.014	2.578TyrLeu: 2.578 ± 0.027	0.602TyrMet: 0.602 ± 0.012	1.191TyrAsn: 1.191 ± 0.017	1.445TyrPro: 1.445 ± 0.021	1.072TyrGln: 1.072 ± 0.016	1.492TyrArg: 1.492 ± 0.017	2.072TyrSer: 2.072 ± 0.023	1.659TyrThr: 1.659 ± 0.019	1.597TyrVal: 1.597 ± 0.019	0.416TyrTrp: 0.416 ± 0.009	0.93TyrTyr: 0.93 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10680 proteins (5193933 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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