Amino acid dipepetide frequency for Roseomonas deserti

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	26.038AlaAla: 26.038 ± 0.213	1.231AlaCys: 1.231 ± 0.031	6.652AlaAsp: 6.652 ± 0.072	10.245AlaGlu: 10.245 ± 0.115	4.296AlaPhe: 4.296 ± 0.057	14.283AlaGly: 14.283 ± 0.111	2.327AlaHis: 2.327 ± 0.04	5.845AlaIle: 5.845 ± 0.063	2.668AlaLys: 2.668 ± 0.05	18.437AlaLeu: 18.437 ± 0.131	4.154AlaMet: 4.154 ± 0.044	2.337AlaAsn: 2.337 ± 0.04	8.162AlaPro: 8.162 ± 0.079	4.995AlaGln: 4.995 ± 0.059	11.949AlaArg: 11.949 ± 0.1	6.286AlaSer: 6.286 ± 0.074	6.812AlaThr: 6.812 ± 0.065	10.087AlaVal: 10.087 ± 0.068	2.104AlaTrp: 2.104 ± 0.033	2.27AlaTyr: 2.27 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	1.075CysAla: 1.075 ± 0.028	0.108CysCys: 0.108 ± 0.008	0.463CysAsp: 0.463 ± 0.019	0.33CysGlu: 0.33 ± 0.016	0.305CysPhe: 0.305 ± 0.014	0.888CysGly: 0.888 ± 0.024	0.21CysHis: 0.21 ± 0.012	0.344CysIle: 0.344 ± 0.014	0.101CysLys: 0.101 ± 0.007	0.867CysLeu: 0.867 ± 0.02	0.15CysMet: 0.15 ± 0.011	0.16CysAsn: 0.16 ± 0.011	0.433CysPro: 0.433 ± 0.015	0.217CysGln: 0.217 ± 0.012	0.669CysArg: 0.669 ± 0.022	0.386CysSer: 0.386 ± 0.016	0.364CysThr: 0.364 ± 0.015	0.521CysVal: 0.521 ± 0.016	0.123CysTrp: 0.123 ± 0.009	0.164CysTyr: 0.164 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.109AspAla: 7.109 ± 0.067	0.409AspCys: 0.409 ± 0.015	2.3AspAsp: 2.3 ± 0.048	2.333AspGlu: 2.333 ± 0.038	2.015AspPhe: 2.015 ± 0.031	5.096AspGly: 5.096 ± 0.063	1.013AspHis: 1.013 ± 0.027	2.169AspIle: 2.169 ± 0.037	0.907AspLys: 0.907 ± 0.022	5.4AspLeu: 5.4 ± 0.057	1.057AspMet: 1.057 ± 0.023	0.889AspAsn: 0.889 ± 0.024	3.805AspPro: 3.805 ± 0.047	1.501AspGln: 1.501 ± 0.029	4.332AspArg: 4.332 ± 0.054	2.103AspSer: 2.103 ± 0.035	2.175AspThr: 2.175 ± 0.048	3.263AspVal: 3.263 ± 0.043	1.06AspTrp: 1.06 ± 0.028	1.193AspTyr: 1.193 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	9.89GluAla: 9.89 ± 0.097	0.267GluCys: 0.267 ± 0.013	2.414GluAsp: 2.414 ± 0.041	3.058GluGlu: 3.058 ± 0.053	1.449GluPhe: 1.449 ± 0.031	4.955GluGly: 4.955 ± 0.062	1.006GluHis: 1.006 ± 0.024	2.566GluIle: 2.566 ± 0.045	1.457GluLys: 1.457 ± 0.036	5.327GluLeu: 5.327 ± 0.053	1.367GluMet: 1.367 ± 0.031	1.079GluAsn: 1.079 ± 0.023	2.609GluPro: 2.609 ± 0.038	2.004GluGln: 2.004 ± 0.04	4.571GluArg: 4.571 ± 0.059	1.963GluSer: 1.963 ± 0.035	2.844GluThr: 2.844 ± 0.041	3.788GluVal: 3.788 ± 0.053	0.655GluTrp: 0.655 ± 0.022	0.705GluTyr: 0.705 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	4.663PheAla: 4.663 ± 0.06	0.39PheCys: 0.39 ± 0.013	2.209PheAsp: 2.209 ± 0.043	1.674PheGlu: 1.674 ± 0.033	1.235PhePhe: 1.235 ± 0.034	3.481PheGly: 3.481 ± 0.052	0.712PheHis: 0.712 ± 0.019	1.182PheIle: 1.182 ± 0.028	0.547PheLys: 0.547 ± 0.018	3.508PheLeu: 3.508 ± 0.054	0.606PheMet: 0.606 ± 0.022	0.827PheAsn: 0.827 ± 0.022	1.697PhePro: 1.697 ± 0.037	0.952PheGln: 0.952 ± 0.02	2.38PheArg: 2.38 ± 0.04	1.947PheSer: 1.947 ± 0.038	1.733PheThr: 1.733 ± 0.029	2.223PheVal: 2.223 ± 0.043	0.535PheTrp: 0.535 ± 0.019	0.67PheTyr: 0.67 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	11.75GlyAla: 11.75 ± 0.098	0.862GlyCys: 0.862 ± 0.023	4.117GlyAsp: 4.117 ± 0.068	4.637GlyGlu: 4.637 ± 0.051	3.935GlyPhe: 3.935 ± 0.054	8.782GlyGly: 8.782 ± 0.108	2.057GlyHis: 2.057 ± 0.039	4.304GlyIle: 4.304 ± 0.058	2.223GlyLys: 2.223 ± 0.042	11.427GlyLeu: 11.427 ± 0.095	2.675GlyMet: 2.675 ± 0.043	1.99GlyAsn: 1.99 ± 0.047	4.41GlyPro: 4.41 ± 0.058	3.611GlyGln: 3.611 ± 0.052	7.581GlyArg: 7.581 ± 0.066	4.715GlySer: 4.715 ± 0.053	4.54GlyThr: 4.54 ± 0.06	6.11GlyVal: 6.11 ± 0.063	1.765GlyTrp: 1.765 ± 0.037	2.013GlyTyr: 2.013 ± 0.033	0.0GlyXaa: 0.0 ± 0.0
His	2.695HisAla: 2.695 ± 0.045	0.214HisCys: 0.214 ± 0.012	1.156HisAsp: 1.156 ± 0.023	0.8HisGlu: 0.8 ± 0.019	0.732HisPhe: 0.732 ± 0.017	2.085HisGly: 2.085 ± 0.038	0.529HisHis: 0.529 ± 0.021	0.628HisIle: 0.628 ± 0.018	0.291HisLys: 0.291 ± 0.014	2.162HisLeu: 2.162 ± 0.036	0.359HisMet: 0.359 ± 0.016	0.361HisAsn: 0.361 ± 0.014	1.476HisPro: 1.476 ± 0.035	0.556HisGln: 0.556 ± 0.017	1.599HisArg: 1.599 ± 0.03	0.804HisSer: 0.804 ± 0.026	0.688HisThr: 0.688 ± 0.019	1.351HisVal: 1.351 ± 0.026	0.364HisTrp: 0.364 ± 0.014	0.436HisTyr: 0.436 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	6.687IleAla: 6.687 ± 0.068	0.384IleCys: 0.384 ± 0.015	2.497IleAsp: 2.497 ± 0.038	2.531IleGlu: 2.531 ± 0.039	1.243IlePhe: 1.243 ± 0.03	4.562IleGly: 4.562 ± 0.052	0.695IleHis: 0.695 ± 0.022	1.382IleIle: 1.382 ± 0.031	0.687IleLys: 0.687 ± 0.023	4.011IleLeu: 4.011 ± 0.054	0.701IleMet: 0.701 ± 0.024	0.904IleAsn: 0.904 ± 0.024	2.186IlePro: 2.186 ± 0.037	1.013IleGln: 1.013 ± 0.024	3.161IleArg: 3.161 ± 0.043	1.884IleSer: 1.884 ± 0.039	2.143IleThr: 2.143 ± 0.038	2.778IleVal: 2.778 ± 0.044	0.449IleTrp: 0.449 ± 0.018	0.691IleTyr: 0.691 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	2.829LysAla: 2.829 ± 0.051	0.075LysCys: 0.075 ± 0.007	0.937LysAsp: 0.937 ± 0.027	0.914LysGlu: 0.914 ± 0.028	0.514LysPhe: 0.514 ± 0.019	1.655LysGly: 1.655 ± 0.031	0.374LysHis: 0.374 ± 0.015	0.928LysIle: 0.928 ± 0.026	0.682LysLys: 0.682 ± 0.027	2.496LysLeu: 2.496 ± 0.044	0.465LysMet: 0.465 ± 0.018	0.415LysAsn: 0.415 ± 0.016	1.494LysPro: 1.494 ± 0.033	0.679LysGln: 0.679 ± 0.021	1.714LysArg: 1.714 ± 0.03	0.941LysSer: 0.941 ± 0.025	1.015LysThr: 1.015 ± 0.027	1.6LysVal: 1.6 ± 0.034	0.186LysTrp: 0.186 ± 0.011	0.304LysTyr: 0.304 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	19.121LeuAla: 19.121 ± 0.158	0.982LeuCys: 0.982 ± 0.023	6.171LeuAsp: 6.171 ± 0.07	5.709LeuGlu: 5.709 ± 0.062	3.282LeuPhe: 3.282 ± 0.054	10.347LeuGly: 10.347 ± 0.086	2.141LeuHis: 2.141 ± 0.04	3.825LeuIle: 3.825 ± 0.05	2.446LeuLys: 2.446 ± 0.043	13.632LeuLeu: 13.632 ± 0.124	2.248LeuMet: 2.248 ± 0.036	2.094LeuAsn: 2.094 ± 0.043	7.893LeuPro: 7.893 ± 0.076	3.848LeuGln: 3.848 ± 0.053	9.859LeuArg: 9.859 ± 0.086	6.051LeuSer: 6.051 ± 0.054	5.555LeuThr: 5.555 ± 0.063	8.119LeuVal: 8.119 ± 0.081	1.432LeuTrp: 1.432 ± 0.03	1.803LeuTyr: 1.803 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	3.635MetAla: 3.635 ± 0.047	0.111MetCys: 0.111 ± 0.008	1.016MetAsp: 1.016 ± 0.024	1.052MetGlu: 1.052 ± 0.03	0.511MetPhe: 0.511 ± 0.02	1.764MetGly: 1.764 ± 0.031	0.35MetHis: 0.35 ± 0.013	0.953MetIle: 0.953 ± 0.025	0.559MetLys: 0.559 ± 0.018	2.866MetLeu: 2.866 ± 0.048	0.534MetMet: 0.534 ± 0.021	0.567MetAsn: 0.567 ± 0.019	1.762MetPro: 1.762 ± 0.034	0.933MetGln: 0.933 ± 0.022	1.848MetArg: 1.848 ± 0.03	1.255MetSer: 1.255 ± 0.027	1.606MetThr: 1.606 ± 0.035	1.672MetVal: 1.672 ± 0.03	0.195MetTrp: 0.195 ± 0.011	0.224MetTyr: 0.224 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.704AsnAla: 2.704 ± 0.046	0.169AsnCys: 0.169 ± 0.011	1.034AsnAsp: 1.034 ± 0.037	0.717AsnGlu: 0.717 ± 0.021	0.684AsnPhe: 0.684 ± 0.022	1.783AsnGly: 1.783 ± 0.037	0.417AsnHis: 0.417 ± 0.018	0.899AsnIle: 0.899 ± 0.022	0.386AsnLys: 0.386 ± 0.015	2.234AsnLeu: 2.234 ± 0.041	0.432AsnMet: 0.432 ± 0.015	0.503AsnAsn: 0.503 ± 0.018	1.645AsnPro: 1.645 ± 0.037	0.587AsnGln: 0.587 ± 0.021	1.564AsnArg: 1.564 ± 0.031	0.856AsnSer: 0.856 ± 0.025	0.964AsnThr: 0.964 ± 0.023	1.358AsnVal: 1.358 ± 0.029	0.291AsnTrp: 0.291 ± 0.013	0.433AsnTyr: 0.433 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	9.314ProAla: 9.314 ± 0.089	0.355ProCys: 0.355 ± 0.014	3.548ProAsp: 3.548 ± 0.052	4.284ProGlu: 4.284 ± 0.06	1.984ProPhe: 1.984 ± 0.042	6.526ProGly: 6.526 ± 0.069	1.179ProHis: 1.179 ± 0.027	1.881ProIle: 1.881 ± 0.034	1.162ProLys: 1.162 ± 0.027	6.316ProLeu: 6.316 ± 0.07	1.363ProMet: 1.363 ± 0.029	1.101ProAsn: 1.101 ± 0.029	4.076ProPro: 4.076 ± 0.073	1.959ProGln: 1.959 ± 0.035	4.23ProArg: 4.23 ± 0.053	2.622ProSer: 2.622 ± 0.045	2.361ProThr: 2.361 ± 0.036	4.629ProVal: 4.629 ± 0.052	0.896ProTrp: 0.896 ± 0.025	1.119ProTyr: 1.119 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	5.712GlnAla: 5.712 ± 0.078	0.151GlnCys: 0.151 ± 0.009	1.625GlnAsp: 1.625 ± 0.031	1.633GlnGlu: 1.633 ± 0.032	0.831GlnPhe: 0.831 ± 0.024	3.313GlnGly: 3.313 ± 0.047	0.669GlnHis: 0.669 ± 0.024	1.43GlnIle: 1.43 ± 0.033	0.798GlnLys: 0.798 ± 0.024	3.267GlnLeu: 3.267 ± 0.042	0.809GlnMet: 0.809 ± 0.024	0.636GlnAsn: 0.636 ± 0.02	2.249GlnPro: 2.249 ± 0.038	1.464GlnGln: 1.464 ± 0.038	3.057GlnArg: 3.057 ± 0.049	1.551GlnSer: 1.551 ± 0.03	1.407GlnThr: 1.407 ± 0.031	2.471GlnVal: 2.471 ± 0.043	0.353GlnTrp: 0.353 ± 0.015	0.436GlnTyr: 0.436 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	10.891ArgAla: 10.891 ± 0.09	0.616ArgCys: 0.616 ± 0.019	4.484ArgAsp: 4.484 ± 0.053	3.941ArgGlu: 3.941 ± 0.049	3.146ArgPhe: 3.146 ± 0.048	6.183ArgGly: 6.183 ± 0.057	1.991ArgHis: 1.991 ± 0.037	3.935ArgIle: 3.935 ± 0.055	1.457ArgLys: 1.457 ± 0.036	10.568ArgLeu: 10.568 ± 0.107	1.995ArgMet: 1.995 ± 0.031	1.586ArgAsn: 1.586 ± 0.033	4.716ArgPro: 4.716 ± 0.056	3.28ArgGln: 3.28 ± 0.049	7.429ArgArg: 7.429 ± 0.078	3.486ArgSer: 3.486 ± 0.055	2.678ArgThr: 2.678 ± 0.036	5.031ArgVal: 5.031 ± 0.05	1.237ArgTrp: 1.237 ± 0.03	1.522ArgTyr: 1.522 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.017SerAla: 6.017 ± 0.057	0.375SerCys: 0.375 ± 0.015	2.097SerAsp: 2.097 ± 0.036	2.034SerGlu: 2.034 ± 0.034	2.089SerPhe: 2.089 ± 0.039	5.027SerGly: 5.027 ± 0.061	0.918SerHis: 0.918 ± 0.022	2.104SerIle: 2.104 ± 0.037	0.853SerLys: 0.853 ± 0.024	5.696SerLeu: 5.696 ± 0.049	1.09SerMet: 1.09 ± 0.025	0.94SerAsn: 0.94 ± 0.022	2.745SerPro: 2.745 ± 0.041	1.356SerGln: 1.356 ± 0.029	3.483SerArg: 3.483 ± 0.038	2.277SerSer: 2.277 ± 0.043	2.227SerThr: 2.227 ± 0.038	3.184SerVal: 3.184 ± 0.046	0.774SerTrp: 0.774 ± 0.022	1.016SerTyr: 1.016 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	6.549ThrAla: 6.549 ± 0.056	0.3ThrCys: 0.3 ± 0.013	2.283ThrAsp: 2.283 ± 0.036	2.351ThrGlu: 2.351 ± 0.037	1.429ThrPhe: 1.429 ± 0.032	4.793ThrGly: 4.793 ± 0.067	0.869ThrHis: 0.869 ± 0.023	2.024ThrIle: 2.024 ± 0.04	0.815ThrLys: 0.815 ± 0.024	6.218ThrLeu: 6.218 ± 0.066	0.969ThrMet: 0.969 ± 0.023	0.905ThrAsn: 0.905 ± 0.027	3.624ThrPro: 3.624 ± 0.051	1.319ThrGln: 1.319 ± 0.025	3.373ThrArg: 3.373 ± 0.047	2.063ThrSer: 2.063 ± 0.039	2.494ThrThr: 2.494 ± 0.042	3.696ThrVal: 3.696 ± 0.048	0.569ThrTrp: 0.569 ± 0.019	0.889ThrTyr: 0.889 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	10.495ValAla: 10.495 ± 0.085	0.552ValCys: 0.552 ± 0.018	3.314ValAsp: 3.314 ± 0.044	4.322ValGlu: 4.322 ± 0.049	2.425ValPhe: 2.425 ± 0.043	5.052ValGly: 5.052 ± 0.059	1.115ValHis: 1.115 ± 0.023	3.062ValIle: 3.062 ± 0.047	1.507ValLys: 1.507 ± 0.035	8.327ValLeu: 8.327 ± 0.078	1.752ValMet: 1.752 ± 0.033	1.59ValAsn: 1.59 ± 0.03	4.095ValPro: 4.095 ± 0.053	2.29ValGln: 2.29 ± 0.046	4.32ValArg: 4.32 ± 0.052	3.496ValSer: 3.496 ± 0.042	4.3ValThr: 4.3 ± 0.051	5.846ValVal: 5.846 ± 0.062	0.829ValTrp: 0.829 ± 0.023	1.048ValTyr: 1.048 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.472TrpAla: 1.472 ± 0.032	0.143TrpCys: 0.143 ± 0.01	0.676TrpAsp: 0.676 ± 0.021	0.586TrpGlu: 0.586 ± 0.019	0.488TrpPhe: 0.488 ± 0.016	1.096TrpGly: 1.096 ± 0.027	0.364TrpHis: 0.364 ± 0.015	0.57TrpIle: 0.57 ± 0.019	0.352TrpLys: 0.352 ± 0.016	1.943TrpLeu: 1.943 ± 0.034	0.374TrpMet: 0.374 ± 0.014	0.364TrpAsn: 0.364 ± 0.016	0.884TrpPro: 0.884 ± 0.023	0.732TrpGln: 0.732 ± 0.02	1.469TrpArg: 1.469 ± 0.031	0.785TrpSer: 0.785 ± 0.021	0.787TrpThr: 0.787 ± 0.023	0.767TrpVal: 0.767 ± 0.02	0.249TrpTrp: 0.249 ± 0.012	0.249TrpTyr: 0.249 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.532TyrAla: 2.532 ± 0.037	0.184TyrCys: 0.184 ± 0.009	1.134TyrAsp: 1.134 ± 0.026	0.823TyrGlu: 0.823 ± 0.023	0.577TyrPhe: 0.577 ± 0.02	1.836TyrGly: 1.836 ± 0.033	0.349TyrHis: 0.349 ± 0.013	0.559TyrIle: 0.559 ± 0.02	0.32TyrLys: 0.32 ± 0.014	1.855TyrLeu: 1.855 ± 0.035	0.309TyrMet: 0.309 ± 0.013	0.408TyrAsn: 0.408 ± 0.014	0.947TyrPro: 0.947 ± 0.022	0.566TyrGln: 0.566 ± 0.017	1.586TyrArg: 1.586 ± 0.033	0.831TyrSer: 0.831 ± 0.026	0.84TyrThr: 0.84 ± 0.025	1.242TyrVal: 1.242 ± 0.031	0.284TyrTrp: 0.284 ± 0.014	0.401TyrTyr: 0.401 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5405 proteins (1725895 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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