Amino acid dipepetide frequency for Circo-like virus-Brazil hs2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.044AlaAla: 1.044 ± 0.939
0.0AlaCys: 0.0 ± 0.0
0.0AlaAsp: 0.0 ± 0.0
1.044AlaGlu: 1.044 ± 0.889
2.088AlaPhe: 2.088 ± 1.031
1.044AlaGly: 1.044 ± 0.889
1.044AlaHis: 1.044 ± 0.975
1.044AlaIle: 1.044 ± 0.975
2.088AlaLys: 2.088 ± 1.031
3.132AlaLeu: 3.132 ± 0.802
1.044AlaMet: 1.044 ± 0.889
2.088AlaAsn: 2.088 ± 1.878
1.044AlaPro: 1.044 ± 0.889
0.0AlaGln: 0.0 ± 0.0
2.088AlaArg: 2.088 ± 1.101
3.132AlaSer: 3.132 ± 1.896
3.132AlaThr: 3.132 ± 1.799
1.044AlaVal: 1.044 ± 0.889
0.0AlaTrp: 0.0 ± 0.0
2.088AlaTyr: 2.088 ± 1.135
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
1.044CysPhe: 1.044 ± 0.889
3.132CysGly: 3.132 ± 1.661
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
1.044CysLeu: 1.044 ± 0.889
1.044CysMet: 1.044 ± 0.889
0.0CysAsn: 0.0 ± 0.0
1.044CysPro: 1.044 ± 0.889
1.044CysGln: 1.044 ± 0.889
1.044CysArg: 1.044 ± 0.889
1.044CysSer: 1.044 ± 0.939
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.088AspAla: 2.088 ± 1.021
0.0AspCys: 0.0 ± 0.0
4.175AspAsp: 4.175 ± 2.457
4.175AspGlu: 4.175 ± 1.52
4.175AspPhe: 4.175 ± 2.493
4.175AspGly: 4.175 ± 1.4
0.0AspHis: 0.0 ± 0.0
4.175AspIle: 4.175 ± 1.707
1.044AspLys: 1.044 ± 0.939
5.219AspLeu: 5.219 ± 3.301
1.044AspMet: 1.044 ± 0.939
3.132AspAsn: 3.132 ± 1.768
0.0AspPro: 0.0 ± 0.0
3.132AspGln: 3.132 ± 2.108
4.175AspArg: 4.175 ± 2.062
2.088AspSer: 2.088 ± 1.779
6.263AspThr: 6.263 ± 2.308
3.132AspVal: 3.132 ± 1.629
3.132AspTrp: 3.132 ± 0.802
5.219AspTyr: 5.219 ± 1.182
0.0AspXaa: 0.0 ± 0.0
Glu
3.132GluAla: 3.132 ± 1.014
1.044GluCys: 1.044 ± 0.889
4.175GluAsp: 4.175 ± 1.497
8.351GluGlu: 8.351 ± 4.085
3.132GluPhe: 3.132 ± 1.824
2.088GluGly: 2.088 ± 1.779
1.044GluHis: 1.044 ± 1.008
3.132GluIle: 3.132 ± 0.898
7.307GluLys: 7.307 ± 2.664
12.526GluLeu: 12.526 ± 1.924
1.044GluMet: 1.044 ± 1.008
3.132GluAsn: 3.132 ± 2.108
2.088GluPro: 2.088 ± 1.779
2.088GluGln: 2.088 ± 2.016
4.175GluArg: 4.175 ± 1.38
7.307GluSer: 7.307 ± 1.935
7.307GluThr: 7.307 ± 2.697
2.088GluVal: 2.088 ± 1.135
4.175GluTrp: 4.175 ± 2.417
6.263GluTyr: 6.263 ± 3.38
0.0GluXaa: 0.0 ± 0.0
Phe
1.044PheAla: 1.044 ± 0.889
1.044PheCys: 1.044 ± 0.939
3.132PheAsp: 3.132 ± 1.629
1.044PheGlu: 1.044 ± 0.939
1.044PhePhe: 1.044 ± 0.939
3.132PheGly: 3.132 ± 0.802
0.0PheHis: 0.0 ± 0.0
6.263PheIle: 6.263 ± 1.237
7.307PheLys: 7.307 ± 2.926
1.044PheLeu: 1.044 ± 0.975
1.044PheMet: 1.044 ± 0.975
3.132PheAsn: 3.132 ± 1.69
1.044PhePro: 1.044 ± 0.939
3.132PheGln: 3.132 ± 1.78
1.044PheArg: 1.044 ± 0.889
2.088PheSer: 2.088 ± 1.038
3.132PheThr: 3.132 ± 1.69
1.044PheVal: 1.044 ± 0.889
1.044PheTrp: 1.044 ± 0.889
2.088PheTyr: 2.088 ± 1.031
0.0PheXaa: 0.0 ± 0.0
Gly
1.044GlyAla: 1.044 ± 0.889
0.0GlyCys: 0.0 ± 0.0
1.044GlyAsp: 1.044 ± 0.889
6.263GlyGlu: 6.263 ± 1.529
5.219GlyPhe: 5.219 ± 2.266
2.088GlyGly: 2.088 ± 1.021
0.0GlyHis: 0.0 ± 0.0
4.175GlyIle: 4.175 ± 2.076
4.175GlyLys: 4.175 ± 1.497
2.088GlyLeu: 2.088 ± 1.021
2.088GlyMet: 2.088 ± 1.101
1.044GlyAsn: 1.044 ± 0.939
1.044GlyPro: 1.044 ± 0.889
1.044GlyGln: 1.044 ± 0.889
5.219GlyArg: 5.219 ± 2.142
4.175GlySer: 4.175 ± 1.417
4.175GlyThr: 4.175 ± 1.288
3.132GlyVal: 3.132 ± 1.629
4.175GlyTrp: 4.175 ± 2.704
4.175GlyTyr: 4.175 ± 2.076
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
1.044HisPhe: 1.044 ± 0.939
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
1.044HisIle: 1.044 ± 0.889
1.044HisLys: 1.044 ± 0.939
4.175HisLeu: 4.175 ± 1.497
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
1.044HisArg: 1.044 ± 0.889
1.044HisSer: 1.044 ± 0.889
1.044HisThr: 1.044 ± 0.939
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
1.044HisTyr: 1.044 ± 0.975
0.0HisXaa: 0.0 ± 0.0
Ile
3.132IleAla: 3.132 ± 1.799
1.044IleCys: 1.044 ± 0.889
4.175IleAsp: 4.175 ± 2.062
7.307IleGlu: 7.307 ± 1.161
2.088IlePhe: 2.088 ± 1.135
3.132IleGly: 3.132 ± 1.891
0.0IleHis: 0.0 ± 0.0
5.219IleIle: 5.219 ± 2.142
9.395IleLys: 9.395 ± 3.235
1.044IleLeu: 1.044 ± 0.975
1.044IleMet: 1.044 ± 0.975
1.044IleAsn: 1.044 ± 0.939
4.175IlePro: 4.175 ± 2.693
2.088IleGln: 2.088 ± 1.021
2.088IleArg: 2.088 ± 1.038
2.088IleSer: 2.088 ± 1.031
3.132IleThr: 3.132 ± 1.824
5.219IleVal: 5.219 ± 0.951
3.132IleTrp: 3.132 ± 0.802
4.175IleTyr: 4.175 ± 1.846
0.0IleXaa: 0.0 ± 0.0
Lys
4.175LysAla: 4.175 ± 1.56
1.044LysCys: 1.044 ± 0.889
6.263LysAsp: 6.263 ± 3.696
7.307LysGlu: 7.307 ± 3.429
4.175LysPhe: 4.175 ± 2.693
5.219LysGly: 5.219 ± 1.843
2.088LysHis: 2.088 ± 1.021
6.263LysIle: 6.263 ± 2.161
16.701LysLys: 16.701 ± 4.764
3.132LysLeu: 3.132 ± 1.896
1.044LysMet: 1.044 ± 0.975
4.175LysAsn: 4.175 ± 1.846
2.088LysPro: 2.088 ± 1.021
2.088LysGln: 2.088 ± 1.878
8.351LysArg: 8.351 ± 1.345
4.175LysSer: 4.175 ± 0.292
5.219LysThr: 5.219 ± 1.843
4.175LysVal: 4.175 ± 1.52
1.044LysTrp: 1.044 ± 0.975
7.307LysTyr: 7.307 ± 2.098
0.0LysXaa: 0.0 ± 0.0
Leu
1.044LeuAla: 1.044 ± 0.939
1.044LeuCys: 1.044 ± 0.975
8.351LeuAsp: 8.351 ± 2.761
8.351LeuGlu: 8.351 ± 1.843
1.044LeuPhe: 1.044 ± 0.889
3.132LeuGly: 3.132 ± 1.629
2.088LeuHis: 2.088 ± 1.038
4.175LeuIle: 4.175 ± 1.707
5.219LeuLys: 5.219 ± 2.969
3.132LeuLeu: 3.132 ± 1.69
5.219LeuMet: 5.219 ± 1.331
4.175LeuAsn: 4.175 ± 0.292
2.088LeuPro: 2.088 ± 1.101
2.088LeuGln: 2.088 ± 1.101
4.175LeuArg: 4.175 ± 1.4
4.175LeuSer: 4.175 ± 1.846
3.132LeuThr: 3.132 ± 3.024
7.307LeuVal: 7.307 ± 2.047
0.0LeuTrp: 0.0 ± 0.0
1.044LeuTyr: 1.044 ± 0.975
0.0LeuXaa: 0.0 ± 0.0
Met
1.044MetAla: 1.044 ± 0.975
0.0MetCys: 0.0 ± 0.0
2.088MetAsp: 2.088 ± 2.016
3.132MetGlu: 3.132 ± 1.629
0.0MetPhe: 0.0 ± 0.0
2.088MetGly: 2.088 ± 1.031
0.0MetHis: 0.0 ± 0.0
2.088MetIle: 2.088 ± 1.101
1.044MetLys: 1.044 ± 0.939
0.0MetLeu: 0.0 ± 0.0
2.088MetMet: 2.088 ± 1.101
1.044MetAsn: 1.044 ± 1.008
2.088MetPro: 2.088 ± 1.135
1.044MetGln: 1.044 ± 0.939
2.088MetArg: 2.088 ± 1.296
3.132MetSer: 3.132 ± 0.898
1.044MetThr: 1.044 ± 1.008
3.132MetVal: 3.132 ± 1.014
1.044MetTrp: 1.044 ± 0.939
1.044MetTyr: 1.044 ± 1.008
0.0MetXaa: 0.0 ± 0.0
Asn
3.132AsnAla: 3.132 ± 1.841
0.0AsnCys: 0.0 ± 0.0
2.088AsnAsp: 2.088 ± 1.878
2.088AsnGlu: 2.088 ± 1.038
1.044AsnPhe: 1.044 ± 0.889
6.263AsnGly: 6.263 ± 1.605
0.0AsnHis: 0.0 ± 0.0
2.088AsnIle: 2.088 ± 1.038
3.132AsnLys: 3.132 ± 1.799
8.351AsnLeu: 8.351 ± 3.357
2.088AsnMet: 2.088 ± 1.101
0.0AsnAsn: 0.0 ± 0.0
0.0AsnPro: 0.0 ± 0.0
1.044AsnGln: 1.044 ± 1.008
4.175AsnArg: 4.175 ± 1.288
3.132AsnSer: 3.132 ± 1.014
7.307AsnThr: 7.307 ± 3.181
5.219AsnVal: 5.219 ± 1.182
1.044AsnTrp: 1.044 ± 0.939
4.175AsnTyr: 4.175 ± 0.292
0.0AsnXaa: 0.0 ± 0.0
Pro
0.0ProAla: 0.0 ± 0.0
0.0ProCys: 0.0 ± 0.0
4.175ProAsp: 4.175 ± 1.56
3.132ProGlu: 3.132 ± 0.802
0.0ProPhe: 0.0 ± 0.0
3.132ProGly: 3.132 ± 1.768
0.0ProHis: 0.0 ± 0.0
2.088ProIle: 2.088 ± 1.038
2.088ProLys: 2.088 ± 1.135
3.132ProLeu: 3.132 ± 0.802
0.0ProMet: 0.0 ± 0.782
3.132ProAsn: 3.132 ± 0.898
1.044ProPro: 1.044 ± 0.975
1.044ProGln: 1.044 ± 0.939
1.044ProArg: 1.044 ± 0.889
0.0ProSer: 0.0 ± 0.0
2.088ProThr: 2.088 ± 1.296
2.088ProVal: 2.088 ± 1.296
0.0ProTrp: 0.0 ± 0.0
2.088ProTyr: 2.088 ± 1.135
0.0ProXaa: 0.0 ± 0.0
Gln
1.044GlnAla: 1.044 ± 0.889
0.0GlnCys: 0.0 ± 0.0
2.088GlnAsp: 2.088 ± 1.878
4.175GlnGlu: 4.175 ± 4.032
0.0GlnPhe: 0.0 ± 0.0
1.044GlnGly: 1.044 ± 0.889
0.0GlnHis: 0.0 ± 0.0
3.132GlnIle: 3.132 ± 1.78
7.307GlnLys: 7.307 ± 2.76
0.0GlnLeu: 0.0 ± 0.0
2.088GlnMet: 2.088 ± 1.806
4.175GlnAsn: 4.175 ± 1.417
2.088GlnPro: 2.088 ± 1.031
0.0GlnGln: 0.0 ± 0.0
2.088GlnArg: 2.088 ± 1.038
0.0GlnSer: 0.0 ± 0.0
1.044GlnThr: 1.044 ± 0.889
0.0GlnVal: 0.0 ± 0.0
2.088GlnTrp: 2.088 ± 1.101
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
2.088ArgAla: 2.088 ± 1.779
2.088ArgCys: 2.088 ± 1.779
3.132ArgAsp: 3.132 ± 1.661
6.263ArgGlu: 6.263 ± 2.975
5.219ArgPhe: 5.219 ± 2.66
1.044ArgGly: 1.044 ± 0.889
1.044ArgHis: 1.044 ± 0.939
1.044ArgIle: 1.044 ± 0.889
9.395ArgLys: 9.395 ± 1.92
6.263ArgLeu: 6.263 ± 3.321
1.044ArgMet: 1.044 ± 0.889
4.175ArgAsn: 4.175 ± 1.831
2.088ArgPro: 2.088 ± 1.101
2.088ArgGln: 2.088 ± 1.038
5.219ArgArg: 5.219 ± 2.115
2.088ArgSer: 2.088 ± 1.021
5.219ArgThr: 5.219 ± 2.434
1.044ArgVal: 1.044 ± 0.889
3.132ArgTrp: 3.132 ± 2.108
3.132ArgTyr: 3.132 ± 1.69
0.0ArgXaa: 0.0 ± 0.0
Ser
1.044SerAla: 1.044 ± 0.975
0.0SerCys: 0.0 ± 0.0
4.175SerAsp: 4.175 ± 0.292
5.219SerGlu: 5.219 ± 1.787
2.088SerPhe: 2.088 ± 1.95
4.175SerGly: 4.175 ± 2.634
1.044SerHis: 1.044 ± 0.939
0.0SerIle: 0.0 ± 0.0
4.175SerLys: 4.175 ± 0.292
6.263SerLeu: 6.263 ± 3.696
3.132SerMet: 3.132 ± 1.891
4.175SerAsn: 4.175 ± 2.062
1.044SerPro: 1.044 ± 0.939
2.088SerGln: 2.088 ± 1.021
4.175SerArg: 4.175 ± 1.38
1.044SerSer: 1.044 ± 0.975
4.175SerThr: 4.175 ± 1.497
1.044SerVal: 1.044 ± 0.889
1.044SerTrp: 1.044 ± 0.975
1.044SerTyr: 1.044 ± 0.889
0.0SerXaa: 0.0 ± 0.0
Thr
1.044ThrAla: 1.044 ± 0.939
0.0ThrCys: 0.0 ± 0.0
2.088ThrAsp: 2.088 ± 1.296
8.351ThrGlu: 8.351 ± 1.843
1.044ThrPhe: 1.044 ± 0.939
5.219ThrGly: 5.219 ± 1.558
1.044ThrHis: 1.044 ± 0.889
8.351ThrIle: 8.351 ± 2.429
3.132ThrLys: 3.132 ± 1.824
6.263ThrLeu: 6.263 ± 2.574
0.0ThrMet: 0.0 ± 0.0
4.175ThrAsn: 4.175 ± 1.846
4.175ThrPro: 4.175 ± 2.794
2.088ThrGln: 2.088 ± 2.016
2.088ThrArg: 2.088 ± 1.038
6.263ThrSer: 6.263 ± 2.542
5.219ThrThr: 5.219 ± 2.434
3.132ThrVal: 3.132 ± 1.891
1.044ThrTrp: 1.044 ± 1.008
2.088ThrTyr: 2.088 ± 1.031
0.0ThrXaa: 0.0 ± 0.0
Val
1.044ValAla: 1.044 ± 0.975
0.0ValCys: 0.0 ± 0.0
4.175ValAsp: 4.175 ± 1.846
4.175ValGlu: 4.175 ± 2.457
3.132ValPhe: 3.132 ± 1.014
3.132ValGly: 3.132 ± 0.802
1.044ValHis: 1.044 ± 0.889
3.132ValIle: 3.132 ± 1.841
2.088ValLys: 2.088 ± 1.296
1.044ValLeu: 1.044 ± 0.939
2.088ValMet: 2.088 ± 1.135
6.263ValAsn: 6.263 ± 3.397
3.132ValPro: 3.132 ± 0.802
3.132ValGln: 3.132 ± 1.629
7.307ValArg: 7.307 ± 0.876
1.044ValSer: 1.044 ± 1.008
1.044ValThr: 1.044 ± 0.939
2.088ValVal: 2.088 ± 1.779
1.044ValTrp: 1.044 ± 1.008
3.132ValTyr: 3.132 ± 1.661
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
2.088TrpCys: 2.088 ± 1.779
3.132TrpAsp: 3.132 ± 1.799
1.044TrpGlu: 1.044 ± 1.008
1.044TrpPhe: 1.044 ± 0.889
1.044TrpGly: 1.044 ± 0.889
1.044TrpHis: 1.044 ± 0.939
2.088TrpIle: 2.088 ± 1.021
4.175TrpLys: 4.175 ± 1.846
2.088TrpLeu: 2.088 ± 1.038
0.0TrpMet: 0.0 ± 0.0
1.044TrpAsn: 1.044 ± 1.008
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
1.044TrpArg: 1.044 ± 0.939
2.088TrpSer: 2.088 ± 1.296
0.0TrpThr: 0.0 ± 0.0
4.175TrpVal: 4.175 ± 1.831
2.088TrpTrp: 2.088 ± 1.031
2.088TrpTyr: 2.088 ± 1.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.044TyrAla: 1.044 ± 0.939
1.044TyrCys: 1.044 ± 0.889
2.088TyrAsp: 2.088 ± 1.779
4.175TyrGlu: 4.175 ± 1.38
5.219TyrPhe: 5.219 ± 0.951
2.088TyrGly: 2.088 ± 1.038
0.0TyrHis: 0.0 ± 0.0
5.219TyrIle: 5.219 ± 2.151
5.219TyrLys: 5.219 ± 2.151
1.044TyrLeu: 1.044 ± 0.939
1.044TyrMet: 1.044 ± 0.83
6.263TyrAsn: 6.263 ± 1.529
1.044TyrPro: 1.044 ± 0.975
3.132TyrGln: 3.132 ± 2.816
4.175TyrArg: 4.175 ± 2.457
1.044TyrSer: 1.044 ± 1.008
3.132TyrThr: 3.132 ± 1.896
4.175TyrVal: 4.175 ± 0.292
1.044TyrTrp: 1.044 ± 0.889
3.132TyrTyr: 3.132 ± 1.841
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (959 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski