Amino acid dipepetide frequency for Streptococcus satellite phage Javan725

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.337AlaCys: 0.337 ± 0.257
3.705AlaAsp: 3.705 ± 1.0
7.41AlaGlu: 7.41 ± 1.83
4.042AlaPhe: 4.042 ± 1.418
3.368AlaGly: 3.368 ± 0.863
0.674AlaHis: 0.674 ± 0.506
4.042AlaIle: 4.042 ± 1.164
4.379AlaLys: 4.379 ± 0.854
4.379AlaLeu: 4.379 ± 1.284
3.368AlaMet: 3.368 ± 1.377
3.031AlaAsn: 3.031 ± 0.75
1.01AlaPro: 1.01 ± 0.519
1.347AlaGln: 1.347 ± 0.583
2.695AlaArg: 2.695 ± 0.937
2.695AlaSer: 2.695 ± 0.835
3.705AlaThr: 3.705 ± 0.844
2.695AlaVal: 2.695 ± 0.723
0.674AlaTrp: 0.674 ± 0.368
2.358AlaTyr: 2.358 ± 0.786
0.0AlaXaa: 0.0 ± 0.0
Cys
0.337CysAla: 0.337 ± 0.301
0.0CysCys: 0.0 ± 0.0
0.674CysAsp: 0.674 ± 0.437
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
1.01CysGly: 1.01 ± 0.748
0.0CysHis: 0.0 ± 0.0
0.337CysIle: 0.337 ± 0.311
1.01CysLys: 1.01 ± 0.491
1.347CysLeu: 1.347 ± 0.67
0.337CysMet: 0.337 ± 0.371
1.684CysAsn: 1.684 ± 0.748
0.337CysPro: 0.337 ± 0.359
0.337CysGln: 0.337 ± 0.359
0.674CysArg: 0.674 ± 0.431
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
0.337AspAla: 0.337 ± 0.332
1.01AspCys: 1.01 ± 0.514
1.684AspAsp: 1.684 ± 0.617
3.705AspGlu: 3.705 ± 0.925
4.379AspPhe: 4.379 ± 0.941
2.358AspGly: 2.358 ± 0.734
0.337AspHis: 0.337 ± 0.315
4.715AspIle: 4.715 ± 1.394
5.389AspLys: 5.389 ± 1.418
6.063AspLeu: 6.063 ± 1.048
1.347AspMet: 1.347 ± 0.532
3.031AspAsn: 3.031 ± 1.318
0.337AspPro: 0.337 ± 0.311
1.684AspGln: 1.684 ± 0.808
4.379AspArg: 4.379 ± 1.13
3.031AspSer: 3.031 ± 0.826
2.695AspThr: 2.695 ± 0.96
3.368AspVal: 3.368 ± 1.077
0.337AspTrp: 0.337 ± 0.257
4.042AspTyr: 4.042 ± 1.326
0.0AspXaa: 0.0 ± 0.0
Glu
7.073GluAla: 7.073 ± 1.364
0.337GluCys: 0.337 ± 0.301
3.705GluAsp: 3.705 ± 0.966
7.073GluGlu: 7.073 ± 1.818
3.031GluPhe: 3.031 ± 1.253
1.684GluGly: 1.684 ± 0.701
1.684GluHis: 1.684 ± 0.563
6.063GluIle: 6.063 ± 1.261
6.736GluLys: 6.736 ± 1.43
9.768GluLeu: 9.768 ± 1.066
2.358GluMet: 2.358 ± 0.963
5.389GluAsn: 5.389 ± 1.305
2.695GluPro: 2.695 ± 1.055
2.358GluGln: 2.358 ± 0.867
5.052GluArg: 5.052 ± 1.252
4.715GluSer: 4.715 ± 0.877
6.063GluThr: 6.063 ± 1.088
3.368GluVal: 3.368 ± 1.113
1.01GluTrp: 1.01 ± 0.613
4.715GluTyr: 4.715 ± 1.066
0.0GluXaa: 0.0 ± 0.0
Phe
1.684PheAla: 1.684 ± 0.687
0.0PheCys: 0.0 ± 0.0
2.358PheAsp: 2.358 ± 0.742
6.063PheGlu: 6.063 ± 1.574
2.021PhePhe: 2.021 ± 1.154
1.684PheGly: 1.684 ± 0.729
1.347PheHis: 1.347 ± 0.629
3.705PheIle: 3.705 ± 0.875
4.042PheLys: 4.042 ± 0.935
4.379PheLeu: 4.379 ± 1.147
0.674PheMet: 0.674 ± 0.44
3.031PheAsn: 3.031 ± 1.109
0.674PhePro: 0.674 ± 0.4
2.358PheGln: 2.358 ± 0.731
2.021PheArg: 2.021 ± 0.768
3.368PheSer: 3.368 ± 0.836
4.042PheThr: 4.042 ± 1.447
1.01PheVal: 1.01 ± 0.572
1.01PheTrp: 1.01 ± 0.514
1.347PheTyr: 1.347 ± 0.584
0.0PheXaa: 0.0 ± 0.0
Gly
3.368GlyAla: 3.368 ± 1.41
0.337GlyCys: 0.337 ± 0.315
3.031GlyAsp: 3.031 ± 0.981
3.031GlyGlu: 3.031 ± 0.737
1.684GlyPhe: 1.684 ± 0.821
3.031GlyGly: 3.031 ± 1.203
1.347GlyHis: 1.347 ± 0.622
4.715GlyIle: 4.715 ± 1.126
3.031GlyLys: 3.031 ± 0.875
4.379GlyLeu: 4.379 ± 1.53
1.01GlyMet: 1.01 ± 0.566
1.347GlyAsn: 1.347 ± 0.785
0.0GlyPro: 0.0 ± 0.0
1.684GlyGln: 1.684 ± 0.668
3.031GlyArg: 3.031 ± 0.839
1.347GlySer: 1.347 ± 0.685
3.705GlyThr: 3.705 ± 1.337
3.368GlyVal: 3.368 ± 1.101
1.01GlyTrp: 1.01 ± 0.568
2.358GlyTyr: 2.358 ± 0.79
0.0GlyXaa: 0.0 ± 0.0
His
2.021HisAla: 2.021 ± 0.665
0.0HisCys: 0.0 ± 0.0
0.337HisAsp: 0.337 ± 0.301
1.347HisGlu: 1.347 ± 0.611
1.347HisPhe: 1.347 ± 0.66
1.347HisGly: 1.347 ± 0.601
0.337HisHis: 0.337 ± 0.301
0.674HisIle: 0.674 ± 0.418
1.684HisLys: 1.684 ± 0.962
1.347HisLeu: 1.347 ± 0.57
0.0HisMet: 0.0 ± 0.0
0.674HisAsn: 0.674 ± 0.433
1.01HisPro: 1.01 ± 0.545
0.337HisGln: 0.337 ± 0.399
0.674HisArg: 0.674 ± 0.509
1.684HisSer: 1.684 ± 0.521
1.347HisThr: 1.347 ± 0.6
0.674HisVal: 0.674 ± 0.418
0.0HisTrp: 0.0 ± 0.0
1.347HisTyr: 1.347 ± 0.527
0.0HisXaa: 0.0 ± 0.0
Ile
5.389IleAla: 5.389 ± 1.263
1.01IleCys: 1.01 ± 0.582
4.379IleAsp: 4.379 ± 1.419
7.073IleGlu: 7.073 ± 2.215
3.705IlePhe: 3.705 ± 0.915
3.031IleGly: 3.031 ± 0.737
1.347IleHis: 1.347 ± 0.74
4.042IleIle: 4.042 ± 1.06
7.41IleLys: 7.41 ± 1.397
4.379IleLeu: 4.379 ± 0.921
0.674IleMet: 0.674 ± 0.411
4.042IleAsn: 4.042 ± 1.461
3.031IlePro: 3.031 ± 1.132
2.695IleGln: 2.695 ± 0.866
2.021IleArg: 2.021 ± 0.998
5.389IleSer: 5.389 ± 1.345
4.379IleThr: 4.379 ± 1.016
2.358IleVal: 2.358 ± 0.899
0.337IleTrp: 0.337 ± 0.409
3.705IleTyr: 3.705 ± 0.96
0.0IleXaa: 0.0 ± 0.0
Lys
8.084LysAla: 8.084 ± 2.424
0.337LysCys: 0.337 ± 0.365
1.684LysAsp: 1.684 ± 0.964
9.431LysGlu: 9.431 ± 1.812
4.379LysPhe: 4.379 ± 1.094
4.715LysGly: 4.715 ± 1.408
3.031LysHis: 3.031 ± 1.033
8.084LysIle: 8.084 ± 1.418
6.063LysLys: 6.063 ± 1.672
6.736LysLeu: 6.736 ± 1.234
1.684LysMet: 1.684 ± 0.663
4.379LysAsn: 4.379 ± 0.842
5.052LysPro: 5.052 ± 1.095
3.705LysGln: 3.705 ± 0.918
6.736LysArg: 6.736 ± 1.326
3.705LysSer: 3.705 ± 0.957
6.063LysThr: 6.063 ± 1.165
7.41LysVal: 7.41 ± 1.237
0.674LysTrp: 0.674 ± 0.528
2.358LysTyr: 2.358 ± 0.922
0.0LysXaa: 0.0 ± 0.0
Leu
6.063LeuAla: 6.063 ± 1.48
1.01LeuCys: 1.01 ± 0.565
10.441LeuAsp: 10.441 ± 1.927
9.431LeuGlu: 9.431 ± 1.781
4.042LeuPhe: 4.042 ± 1.424
3.031LeuGly: 3.031 ± 1.282
1.01LeuHis: 1.01 ± 0.501
6.399LeuIle: 6.399 ± 1.437
9.768LeuLys: 9.768 ± 1.889
11.788LeuLeu: 11.788 ± 1.848
1.684LeuMet: 1.684 ± 0.763
5.389LeuAsn: 5.389 ± 1.445
3.031LeuPro: 3.031 ± 1.022
3.368LeuGln: 3.368 ± 0.983
3.705LeuArg: 3.705 ± 0.979
5.389LeuSer: 5.389 ± 1.081
4.715LeuThr: 4.715 ± 1.079
4.715LeuVal: 4.715 ± 1.285
1.01LeuTrp: 1.01 ± 0.521
3.031LeuTyr: 3.031 ± 0.88
0.0LeuXaa: 0.0 ± 0.0
Met
2.021MetAla: 2.021 ± 1.012
0.0MetCys: 0.0 ± 0.0
1.684MetAsp: 1.684 ± 0.531
2.021MetGlu: 2.021 ± 0.702
1.01MetPhe: 1.01 ± 0.662
1.01MetGly: 1.01 ± 0.589
0.337MetHis: 0.337 ± 0.332
2.021MetIle: 2.021 ± 0.914
2.695MetLys: 2.695 ± 1.098
1.347MetLeu: 1.347 ± 0.592
0.0MetMet: 0.0 ± 0.0
2.021MetAsn: 2.021 ± 0.878
0.337MetPro: 0.337 ± 0.365
1.347MetGln: 1.347 ± 0.52
2.358MetArg: 2.358 ± 0.993
1.684MetSer: 1.684 ± 0.645
2.695MetThr: 2.695 ± 1.418
1.684MetVal: 1.684 ± 0.618
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.695AsnAla: 2.695 ± 0.829
0.337AsnCys: 0.337 ± 0.359
3.031AsnAsp: 3.031 ± 1.153
4.042AsnGlu: 4.042 ± 0.782
0.674AsnPhe: 0.674 ± 0.504
3.368AsnGly: 3.368 ± 1.035
1.01AsnHis: 1.01 ± 0.51
3.705AsnIle: 3.705 ± 1.057
5.389AsnLys: 5.389 ± 1.231
7.747AsnLeu: 7.747 ± 1.093
1.01AsnMet: 1.01 ± 0.697
2.695AsnAsn: 2.695 ± 1.045
1.347AsnPro: 1.347 ± 0.594
2.695AsnGln: 2.695 ± 0.733
2.695AsnArg: 2.695 ± 0.932
3.705AsnSer: 3.705 ± 0.782
3.031AsnThr: 3.031 ± 1.102
1.347AsnVal: 1.347 ± 0.575
0.0AsnTrp: 0.0 ± 0.0
1.347AsnTyr: 1.347 ± 0.5
0.0AsnXaa: 0.0 ± 0.0
Pro
2.021ProAla: 2.021 ± 0.641
0.0ProCys: 0.0 ± 0.0
1.347ProAsp: 1.347 ± 0.666
1.684ProGlu: 1.684 ± 0.899
2.358ProPhe: 2.358 ± 1.004
0.674ProGly: 0.674 ± 0.511
0.0ProHis: 0.0 ± 0.0
2.021ProIle: 2.021 ± 0.699
3.705ProLys: 3.705 ± 1.215
1.684ProLeu: 1.684 ± 0.663
1.347ProMet: 1.347 ± 0.63
2.358ProAsn: 2.358 ± 1.064
0.674ProPro: 0.674 ± 0.413
1.01ProGln: 1.01 ± 0.77
2.695ProArg: 2.695 ± 0.898
2.695ProSer: 2.695 ± 0.814
1.01ProThr: 1.01 ± 0.49
2.358ProVal: 2.358 ± 0.704
0.337ProTrp: 0.337 ± 0.257
1.01ProTyr: 1.01 ± 0.424
0.0ProXaa: 0.0 ± 0.0
Gln
4.042GlnAla: 4.042 ± 1.208
0.0GlnCys: 0.0 ± 0.0
1.684GlnAsp: 1.684 ± 0.763
4.042GlnGlu: 4.042 ± 1.267
1.347GlnPhe: 1.347 ± 0.633
1.347GlnGly: 1.347 ± 1.019
0.337GlnHis: 0.337 ± 0.257
2.695GlnIle: 2.695 ± 1.054
3.368GlnLys: 3.368 ± 1.601
3.705GlnLeu: 3.705 ± 1.017
0.674GlnMet: 0.674 ± 0.555
1.01GlnAsn: 1.01 ± 0.656
0.674GlnPro: 0.674 ± 0.531
2.021GlnGln: 2.021 ± 0.71
2.695GlnArg: 2.695 ± 0.757
1.684GlnSer: 1.684 ± 0.643
2.021GlnThr: 2.021 ± 0.744
2.021GlnVal: 2.021 ± 0.952
0.0GlnTrp: 0.0 ± 0.0
2.021GlnTyr: 2.021 ± 0.884
0.0GlnXaa: 0.0 ± 0.0
Arg
2.358ArgAla: 2.358 ± 0.808
0.337ArgCys: 0.337 ± 0.359
3.368ArgAsp: 3.368 ± 1.092
4.042ArgGlu: 4.042 ± 1.102
2.021ArgPhe: 2.021 ± 0.724
3.031ArgGly: 3.031 ± 0.916
1.01ArgHis: 1.01 ± 0.542
4.042ArgIle: 4.042 ± 0.817
4.715ArgLys: 4.715 ± 1.02
7.41ArgLeu: 7.41 ± 1.926
1.684ArgMet: 1.684 ± 0.883
2.695ArgAsn: 2.695 ± 0.821
1.684ArgPro: 1.684 ± 0.598
1.684ArgGln: 1.684 ± 0.877
3.705ArgArg: 3.705 ± 1.22
2.021ArgSer: 2.021 ± 0.608
2.695ArgThr: 2.695 ± 0.807
3.031ArgVal: 3.031 ± 0.724
0.337ArgTrp: 0.337 ± 0.337
4.379ArgTyr: 4.379 ± 1.414
0.0ArgXaa: 0.0 ± 0.0
Ser
1.684SerAla: 1.684 ± 0.719
0.674SerCys: 0.674 ± 0.511
4.379SerAsp: 4.379 ± 1.104
3.368SerGlu: 3.368 ± 0.887
1.684SerPhe: 1.684 ± 0.833
3.705SerGly: 3.705 ± 1.086
0.337SerHis: 0.337 ± 0.315
4.379SerIle: 4.379 ± 1.095
6.063SerLys: 6.063 ± 1.372
5.389SerLeu: 5.389 ± 0.998
2.021SerMet: 2.021 ± 0.758
4.042SerAsn: 4.042 ± 1.336
2.021SerPro: 2.021 ± 0.659
1.347SerGln: 1.347 ± 0.741
1.01SerArg: 1.01 ± 0.527
3.368SerSer: 3.368 ± 1.02
4.042SerThr: 4.042 ± 0.924
1.01SerVal: 1.01 ± 0.468
0.674SerTrp: 0.674 ± 0.368
3.705SerTyr: 3.705 ± 1.139
0.0SerXaa: 0.0 ± 0.0
Thr
2.695ThrAla: 2.695 ± 0.655
0.674ThrCys: 0.674 ± 0.516
1.347ThrAsp: 1.347 ± 0.574
2.358ThrGlu: 2.358 ± 0.629
5.726ThrPhe: 5.726 ± 1.873
4.379ThrGly: 4.379 ± 0.938
1.684ThrHis: 1.684 ± 0.647
4.042ThrIle: 4.042 ± 0.855
5.726ThrLys: 5.726 ± 1.243
7.747ThrLeu: 7.747 ± 0.881
2.021ThrMet: 2.021 ± 0.641
2.695ThrAsn: 2.695 ± 1.117
2.358ThrPro: 2.358 ± 0.717
2.695ThrGln: 2.695 ± 1.303
3.705ThrArg: 3.705 ± 0.737
2.695ThrSer: 2.695 ± 1.0
2.695ThrThr: 2.695 ± 0.864
3.705ThrVal: 3.705 ± 0.848
0.674ThrTrp: 0.674 ± 0.408
2.358ThrTyr: 2.358 ± 0.899
0.0ThrXaa: 0.0 ± 0.0
Val
3.031ValAla: 3.031 ± 1.016
1.01ValCys: 1.01 ± 0.491
3.705ValAsp: 3.705 ± 1.531
3.368ValGlu: 3.368 ± 1.489
1.347ValPhe: 1.347 ± 0.497
1.684ValGly: 1.684 ± 0.703
0.337ValHis: 0.337 ± 0.315
1.684ValIle: 1.684 ± 0.59
5.726ValLys: 5.726 ± 1.215
4.379ValLeu: 4.379 ± 1.223
1.684ValMet: 1.684 ± 0.972
1.347ValAsn: 1.347 ± 0.629
2.695ValPro: 2.695 ± 0.945
1.347ValGln: 1.347 ± 0.647
3.031ValArg: 3.031 ± 0.792
2.695ValSer: 2.695 ± 0.788
5.052ValThr: 5.052 ± 1.158
3.705ValVal: 3.705 ± 1.118
0.0ValTrp: 0.0 ± 0.0
1.684ValTyr: 1.684 ± 0.512
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.337TrpAsp: 0.337 ± 0.257
1.347TrpGlu: 1.347 ± 0.683
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.337TrpHis: 0.337 ± 0.257
0.674TrpIle: 0.674 ± 0.401
0.674TrpLys: 0.674 ± 0.49
1.684TrpLeu: 1.684 ± 0.636
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.337TrpPro: 0.337 ± 0.257
0.674TrpGln: 0.674 ± 0.406
0.337TrpArg: 0.337 ± 0.257
1.01TrpSer: 1.01 ± 0.476
0.0TrpThr: 0.0 ± 0.0
0.674TrpVal: 0.674 ± 0.343
0.0TrpTrp: 0.0 ± 0.0
0.337TrpTyr: 0.337 ± 0.257
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.01TyrAla: 1.01 ± 0.544
0.674TyrCys: 0.674 ± 0.485
1.347TyrAsp: 1.347 ± 0.405
4.042TyrGlu: 4.042 ± 1.436
2.021TyrPhe: 2.021 ± 1.025
2.358TyrGly: 2.358 ± 0.922
1.684TyrHis: 1.684 ± 0.652
2.358TyrIle: 2.358 ± 0.872
6.736TyrLys: 6.736 ± 1.511
3.368TyrLeu: 3.368 ± 0.774
2.358TyrMet: 2.358 ± 0.906
1.01TyrAsn: 1.01 ± 0.53
1.684TyrPro: 1.684 ± 0.983
2.695TyrGln: 2.695 ± 0.693
3.368TyrArg: 3.368 ± 1.114
2.021TyrSer: 2.021 ± 0.566
2.021TyrThr: 2.021 ± 0.657
1.01TyrVal: 1.01 ± 0.472
0.337TyrTrp: 0.337 ± 0.359
1.684TyrTyr: 1.684 ± 0.791
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 19 proteins (2970 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski