Amino acid dipepetide frequency for Streptococcus sp. sy004

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.581AlaAla: 5.581 ± 0.16
0.516AlaCys: 0.516 ± 0.034
4.649AlaAsp: 4.649 ± 0.119
4.972AlaGlu: 4.972 ± 0.131
3.062AlaPhe: 3.062 ± 0.084
5.358AlaGly: 5.358 ± 0.155
1.162AlaHis: 1.162 ± 0.057
5.86AlaIle: 5.86 ± 0.127
5.722AlaLys: 5.722 ± 0.134
7.866AlaLeu: 7.866 ± 0.166
2.003AlaMet: 2.003 ± 0.067
3.46AlaAsn: 3.46 ± 0.105
1.909AlaPro: 1.909 ± 0.079
3.457AlaGln: 3.457 ± 0.109
3.032AlaArg: 3.032 ± 0.097
5.035AlaSer: 5.035 ± 0.135
4.442AlaThr: 4.442 ± 0.134
5.129AlaVal: 5.129 ± 0.134
0.571AlaTrp: 0.571 ± 0.044
2.977AlaTyr: 2.977 ± 0.095
0.0AlaXaa: 0.0 ± 0.0
Cys
0.223CysAla: 0.223 ± 0.026
0.044CysCys: 0.044 ± 0.013
0.279CysAsp: 0.279 ± 0.033
0.237CysGlu: 0.237 ± 0.029
0.248CysPhe: 0.248 ± 0.025
0.422CysGly: 0.422 ± 0.037
0.16CysHis: 0.16 ± 0.023
0.226CysIle: 0.226 ± 0.025
0.168CysLys: 0.168 ± 0.024
0.632CysLeu: 0.632 ± 0.045
0.08CysMet: 0.08 ± 0.012
0.174CysAsn: 0.174 ± 0.026
0.223CysPro: 0.223 ± 0.028
0.475CysGln: 0.475 ± 0.04
0.196CysArg: 0.196 ± 0.024
0.303CysSer: 0.303 ± 0.029
0.168CysThr: 0.168 ± 0.022
0.254CysVal: 0.254 ± 0.028
0.039CysTrp: 0.039 ± 0.01
0.207CysTyr: 0.207 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
3.429AspAla: 3.429 ± 0.113
0.317AspCys: 0.317 ± 0.032
3.004AspAsp: 3.004 ± 0.116
3.893AspGlu: 3.893 ± 0.125
3.242AspPhe: 3.242 ± 0.103
3.656AspGly: 3.656 ± 0.105
0.814AspHis: 0.814 ± 0.045
3.851AspIle: 3.851 ± 0.112
4.329AspLys: 4.329 ± 0.117
6.718AspLeu: 6.718 ± 0.161
1.553AspMet: 1.553 ± 0.071
2.483AspAsn: 2.483 ± 0.085
1.504AspPro: 1.504 ± 0.068
2.604AspGln: 2.604 ± 0.089
2.108AspArg: 2.108 ± 0.076
2.985AspSer: 2.985 ± 0.094
2.798AspThr: 2.798 ± 0.103
4.13AspVal: 4.13 ± 0.121
0.577AspTrp: 0.577 ± 0.044
2.971AspTyr: 2.971 ± 0.094
0.0AspXaa: 0.0 ± 0.0
Glu
5.41GluAla: 5.41 ± 0.144
0.19GluCys: 0.19 ± 0.026
3.407GluAsp: 3.407 ± 0.095
5.598GluGlu: 5.598 ± 0.165
2.53GluPhe: 2.53 ± 0.085
3.393GluGly: 3.393 ± 0.112
1.15GluHis: 1.15 ± 0.061
5.013GluIle: 5.013 ± 0.116
5.452GluLys: 5.452 ± 0.136
7.088GluLeu: 7.088 ± 0.178
1.796GluMet: 1.796 ± 0.069
3.327GluAsn: 3.327 ± 0.099
1.647GluPro: 1.647 ± 0.078
3.791GluGln: 3.791 ± 0.116
3.211GluArg: 3.211 ± 0.096
3.239GluSer: 3.239 ± 0.117
4.097GluThr: 4.097 ± 0.133
5.132GluVal: 5.132 ± 0.146
0.472GluTrp: 0.472 ± 0.035
1.661GluTyr: 1.661 ± 0.083
0.0GluXaa: 0.0 ± 0.0
Phe
3.33PheAla: 3.33 ± 0.109
0.179PheCys: 0.179 ± 0.021
3.027PheAsp: 3.027 ± 0.115
2.795PheGlu: 2.795 ± 0.093
1.997PhePhe: 1.997 ± 0.083
3.029PheGly: 3.029 ± 0.091
0.698PheHis: 0.698 ± 0.046
2.958PheIle: 2.958 ± 0.106
2.331PheLys: 2.331 ± 0.071
4.514PheLeu: 4.514 ± 0.167
0.971PheMet: 0.971 ± 0.056
1.934PheAsn: 1.934 ± 0.073
1.537PhePro: 1.537 ± 0.074
1.512PheGln: 1.512 ± 0.066
1.517PheArg: 1.517 ± 0.063
3.129PheSer: 3.129 ± 0.107
2.409PheThr: 2.409 ± 0.084
3.148PheVal: 3.148 ± 0.105
0.414PheTrp: 0.414 ± 0.034
1.763PheTyr: 1.763 ± 0.081
0.0PheXaa: 0.0 ± 0.0
Gly
4.406GlyAla: 4.406 ± 0.13
0.284GlyCys: 0.284 ± 0.029
3.198GlyAsp: 3.198 ± 0.107
3.44GlyGlu: 3.44 ± 0.107
3.118GlyPhe: 3.118 ± 0.1
4.069GlyGly: 4.069 ± 0.132
1.305GlyHis: 1.305 ± 0.059
4.698GlyIle: 4.698 ± 0.14
4.127GlyLys: 4.127 ± 0.109
7.422GlyLeu: 7.422 ± 0.191
1.807GlyMet: 1.807 ± 0.073
2.513GlyAsn: 2.513 ± 0.106
1.327GlyPro: 1.327 ± 0.055
3.915GlyGln: 3.915 ± 0.105
2.935GlyArg: 2.935 ± 0.106
3.683GlySer: 3.683 ± 0.109
3.702GlyThr: 3.702 ± 0.144
4.704GlyVal: 4.704 ± 0.112
0.568GlyTrp: 0.568 ± 0.043
2.646GlyTyr: 2.646 ± 0.087
0.0GlyXaa: 0.0 ± 0.0
His
1.123HisAla: 1.123 ± 0.055
0.154HisCys: 0.154 ± 0.02
0.944HisAsp: 0.944 ± 0.047
1.07HisGlu: 1.07 ± 0.053
0.897HisPhe: 0.897 ± 0.051
1.076HisGly: 1.076 ± 0.064
0.535HisHis: 0.535 ± 0.039
1.156HisIle: 1.156 ± 0.059
0.88HisLys: 0.88 ± 0.052
2.155HisLeu: 2.155 ± 0.089
0.323HisMet: 0.323 ± 0.03
0.607HisAsn: 0.607 ± 0.047
0.797HisPro: 0.797 ± 0.055
1.173HisGln: 1.173 ± 0.052
0.83HisArg: 0.83 ± 0.052
0.869HisSer: 0.869 ± 0.049
0.792HisThr: 0.792 ± 0.048
1.07HisVal: 1.07 ± 0.061
0.099HisTrp: 0.099 ± 0.015
0.927HisTyr: 0.927 ± 0.051
0.0HisXaa: 0.0 ± 0.0
Ile
5.521IleAla: 5.521 ± 0.137
0.513IleCys: 0.513 ± 0.04
4.141IleAsp: 4.141 ± 0.104
4.585IleGlu: 4.585 ± 0.121
3.087IlePhe: 3.087 ± 0.097
4.605IleGly: 4.605 ± 0.126
1.035IleHis: 1.035 ± 0.063
4.726IleIle: 4.726 ± 0.123
4.701IleLys: 4.701 ± 0.109
6.999IleLeu: 6.999 ± 0.159
1.722IleMet: 1.722 ± 0.074
3.04IleAsn: 3.04 ± 0.096
2.505IlePro: 2.505 ± 0.096
2.472IleGln: 2.472 ± 0.089
2.775IleArg: 2.775 ± 0.094
4.762IleSer: 4.762 ± 0.125
3.796IleThr: 3.796 ± 0.117
4.453IleVal: 4.453 ± 0.112
0.535IleTrp: 0.535 ± 0.04
2.519IleTyr: 2.519 ± 0.09
0.0IleXaa: 0.0 ± 0.0
Lys
5.192LysAla: 5.192 ± 0.128
0.141LysCys: 0.141 ± 0.019
3.645LysAsp: 3.645 ± 0.115
5.667LysGlu: 5.667 ± 0.128
1.94LysPhe: 1.94 ± 0.077
3.851LysGly: 3.851 ± 0.108
1.093LysHis: 1.093 ± 0.059
4.627LysIle: 4.627 ± 0.118
5.126LysLys: 5.126 ± 0.13
5.819LysLeu: 5.819 ± 0.131
1.934LysMet: 1.934 ± 0.067
3.173LysAsn: 3.173 ± 0.102
2.061LysPro: 2.061 ± 0.088
3.2LysGln: 3.2 ± 0.106
3.004LysArg: 3.004 ± 0.108
3.898LysSer: 3.898 ± 0.089
4.268LysThr: 4.268 ± 0.109
4.516LysVal: 4.516 ± 0.127
0.524LysTrp: 0.524 ± 0.039
1.893LysTyr: 1.893 ± 0.073
0.0LysXaa: 0.0 ± 0.0
Leu
10.363LeuAla: 10.363 ± 0.197
0.43LeuCys: 0.43 ± 0.033
6.329LeuAsp: 6.329 ± 0.162
7.088LeuGlu: 7.088 ± 0.178
4.24LeuPhe: 4.24 ± 0.138
6.875LeuGly: 6.875 ± 0.167
1.501LeuHis: 1.501 ± 0.072
6.881LeuIle: 6.881 ± 0.186
6.097LeuLys: 6.097 ± 0.132
11.196LeuLeu: 11.196 ± 0.261
2.433LeuMet: 2.433 ± 0.084
4.265LeuAsn: 4.265 ± 0.098
4.348LeuPro: 4.348 ± 0.107
3.556LeuGln: 3.556 ± 0.102
3.835LeuArg: 3.835 ± 0.108
8.108LeuSer: 8.108 ± 0.176
7.422LeuThr: 7.422 ± 0.17
7.827LeuVal: 7.827 ± 0.165
0.695LeuTrp: 0.695 ± 0.047
3.027LeuTyr: 3.027 ± 0.098
0.0LeuXaa: 0.0 ± 0.0
Met
2.21MetAla: 2.21 ± 0.088
0.108MetCys: 0.108 ± 0.018
1.368MetAsp: 1.368 ± 0.065
1.379MetGlu: 1.379 ± 0.063
0.833MetPhe: 0.833 ± 0.047
1.57MetGly: 1.57 ± 0.074
0.24MetHis: 0.24 ± 0.028
1.975MetIle: 1.975 ± 0.088
1.826MetLys: 1.826 ± 0.072
2.265MetLeu: 2.265 ± 0.082
0.742MetMet: 0.742 ± 0.046
1.076MetAsn: 1.076 ± 0.055
0.759MetPro: 0.759 ± 0.047
0.935MetGln: 0.935 ± 0.047
0.988MetArg: 0.988 ± 0.057
1.708MetSer: 1.708 ± 0.072
2.359MetThr: 2.359 ± 0.071
1.711MetVal: 1.711 ± 0.067
0.149MetTrp: 0.149 ± 0.019
0.557MetTyr: 0.557 ± 0.041
0.0MetXaa: 0.0 ± 0.0
Asn
2.665AsnAla: 2.665 ± 0.086
0.182AsnCys: 0.182 ± 0.021
2.315AsnAsp: 2.315 ± 0.07
2.249AsnGlu: 2.249 ± 0.081
1.962AsnPhe: 1.962 ± 0.076
2.869AsnGly: 2.869 ± 0.107
1.026AsnHis: 1.026 ± 0.052
2.748AsnIle: 2.748 ± 0.105
2.77AsnLys: 2.77 ± 0.09
4.886AsnLeu: 4.886 ± 0.123
1.101AsnMet: 1.101 ± 0.059
1.835AsnAsn: 1.835 ± 0.084
2.204AsnPro: 2.204 ± 0.073
3.024AsnGln: 3.024 ± 0.102
2.072AsnArg: 2.072 ± 0.08
2.309AsnSer: 2.309 ± 0.088
2.05AsnThr: 2.05 ± 0.1
2.643AsnVal: 2.643 ± 0.075
0.513AsnTrp: 0.513 ± 0.045
1.887AsnTyr: 1.887 ± 0.075
0.0AsnXaa: 0.0 ± 0.0
Pro
2.271ProAla: 2.271 ± 0.089
0.157ProCys: 0.157 ± 0.022
2.047ProAsp: 2.047 ± 0.08
2.577ProGlu: 2.577 ± 0.095
1.426ProPhe: 1.426 ± 0.068
1.567ProGly: 1.567 ± 0.067
0.662ProHis: 0.662 ± 0.048
2.431ProIle: 2.431 ± 0.088
2.196ProLys: 2.196 ± 0.085
2.947ProLeu: 2.947 ± 0.09
0.717ProMet: 0.717 ± 0.049
1.851ProAsn: 1.851 ± 0.083
0.505ProPro: 0.505 ± 0.04
1.357ProGln: 1.357 ± 0.061
1.024ProArg: 1.024 ± 0.058
2.249ProSer: 2.249 ± 0.072
2.086ProThr: 2.086 ± 0.09
2.891ProVal: 2.891 ± 0.135
0.27ProTrp: 0.27 ± 0.028
1.363ProTyr: 1.363 ± 0.067
0.0ProXaa: 0.0 ± 0.0
Gln
4.632GlnAla: 4.632 ± 0.128
0.13GlnCys: 0.13 ± 0.017
2.541GlnAsp: 2.541 ± 0.087
4.014GlnGlu: 4.014 ± 0.117
1.851GlnPhe: 1.851 ± 0.08
2.853GlnGly: 2.853 ± 0.088
0.709GlnHis: 0.709 ± 0.045
3.189GlnIle: 3.189 ± 0.101
2.977GlnLys: 2.977 ± 0.102
5.581GlnLeu: 5.581 ± 0.194
1.17GlnMet: 1.17 ± 0.057
1.793GlnAsn: 1.793 ± 0.087
1.437GlnPro: 1.437 ± 0.063
1.904GlnGln: 1.904 ± 0.081
1.686GlnArg: 1.686 ± 0.073
2.511GlnSer: 2.511 ± 0.089
3.118GlnThr: 3.118 ± 0.097
4.271GlnVal: 4.271 ± 0.122
0.312GlnTrp: 0.312 ± 0.034
1.322GlnTyr: 1.322 ± 0.067
0.0GlnXaa: 0.0 ± 0.0
Arg
2.571ArgAla: 2.571 ± 0.085
0.19ArgCys: 0.19 ± 0.023
2.174ArgAsp: 2.174 ± 0.088
2.858ArgGlu: 2.858 ± 0.093
2.072ArgPhe: 2.072 ± 0.084
2.315ArgGly: 2.315 ± 0.089
0.963ArgHis: 0.963 ± 0.049
2.555ArgIle: 2.555 ± 0.084
2.447ArgLys: 2.447 ± 0.081
4.908ArgLeu: 4.908 ± 0.12
1.004ArgMet: 1.004 ± 0.05
1.493ArgAsn: 1.493 ± 0.069
1.355ArgPro: 1.355 ± 0.077
2.853ArgGln: 2.853 ± 0.116
2.149ArgArg: 2.149 ± 0.093
2.102ArgSer: 2.102 ± 0.079
1.989ArgThr: 1.989 ± 0.082
2.861ArgVal: 2.861 ± 0.098
0.301ArgTrp: 0.301 ± 0.028
1.644ArgTyr: 1.644 ± 0.065
0.0ArgXaa: 0.0 ± 0.0
Ser
4.064SerAla: 4.064 ± 0.114
0.317SerCys: 0.317 ± 0.033
3.371SerAsp: 3.371 ± 0.098
3.642SerGlu: 3.642 ± 0.125
2.911SerPhe: 2.911 ± 0.096
4.42SerGly: 4.42 ± 0.135
1.327SerHis: 1.327 ± 0.06
3.923SerIle: 3.923 ± 0.118
3.805SerLys: 3.805 ± 0.109
7.212SerLeu: 7.212 ± 0.171
1.402SerMet: 1.402 ± 0.064
2.571SerAsn: 2.571 ± 0.082
2.025SerPro: 2.025 ± 0.077
3.934SerGln: 3.934 ± 0.137
2.53SerArg: 2.53 ± 0.095
4.839SerSer: 4.839 ± 0.247
3.336SerThr: 3.336 ± 0.135
4.097SerVal: 4.097 ± 0.113
0.599SerTrp: 0.599 ± 0.042
2.665SerTyr: 2.665 ± 0.082
0.0SerXaa: 0.0 ± 0.0
Thr
4.367ThrAla: 4.367 ± 0.111
0.29ThrCys: 0.29 ± 0.03
3.603ThrAsp: 3.603 ± 0.117
3.68ThrGlu: 3.68 ± 0.125
2.61ThrPhe: 2.61 ± 0.081
4.32ThrGly: 4.32 ± 0.14
0.99ThrHis: 0.99 ± 0.054
4.207ThrIle: 4.207 ± 0.103
3.796ThrLys: 3.796 ± 0.11
5.783ThrLeu: 5.783 ± 0.145
1.247ThrMet: 1.247 ± 0.06
2.571ThrAsn: 2.571 ± 0.09
2.497ThrPro: 2.497 ± 0.118
2.337ThrGln: 2.337 ± 0.078
2.033ThrArg: 2.033 ± 0.078
4.078ThrSer: 4.078 ± 0.127
3.686ThrThr: 3.686 ± 0.146
4.522ThrVal: 4.522 ± 0.142
0.521ThrTrp: 0.521 ± 0.036
2.599ThrTyr: 2.599 ± 0.11
0.0ThrXaa: 0.0 ± 0.0
Val
6.321ValAla: 6.321 ± 0.148
0.375ValCys: 0.375 ± 0.03
4.141ValAsp: 4.141 ± 0.112
5.115ValGlu: 5.115 ± 0.161
2.93ValPhe: 2.93 ± 0.088
4.635ValGly: 4.635 ± 0.13
1.046ValHis: 1.046 ± 0.056
4.947ValIle: 4.947 ± 0.133
4.87ValLys: 4.87 ± 0.12
6.881ValLeu: 6.881 ± 0.165
1.782ValMet: 1.782 ± 0.084
3.305ValAsn: 3.305 ± 0.079
2.417ValPro: 2.417 ± 0.088
2.204ValGln: 2.204 ± 0.08
2.682ValArg: 2.682 ± 0.101
4.607ValSer: 4.607 ± 0.123
4.933ValThr: 4.933 ± 0.156
5.692ValVal: 5.692 ± 0.178
0.538ValTrp: 0.538 ± 0.04
2.262ValTyr: 2.262 ± 0.081
0.0ValXaa: 0.0 ± 0.0
Trp
0.527TrpAla: 0.527 ± 0.034
0.041TrpCys: 0.041 ± 0.011
0.425TrpAsp: 0.425 ± 0.035
0.486TrpGlu: 0.486 ± 0.037
0.436TrpPhe: 0.436 ± 0.045
0.532TrpGly: 0.532 ± 0.044
0.149TrpHis: 0.149 ± 0.02
0.497TrpIle: 0.497 ± 0.037
0.361TrpLys: 0.361 ± 0.038
1.181TrpLeu: 1.181 ± 0.067
0.196TrpMet: 0.196 ± 0.023
0.386TrpAsn: 0.386 ± 0.035
0.168TrpPro: 0.168 ± 0.023
0.599TrpGln: 0.599 ± 0.04
0.359TrpArg: 0.359 ± 0.04
0.626TrpSer: 0.626 ± 0.043
0.339TrpThr: 0.339 ± 0.032
0.45TrpVal: 0.45 ± 0.044
0.127TrpTrp: 0.127 ± 0.02
0.259TrpTyr: 0.259 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.555TyrAla: 2.555 ± 0.087
0.199TyrCys: 0.199 ± 0.024
2.359TyrAsp: 2.359 ± 0.096
2.262TyrGlu: 2.262 ± 0.087
1.799TyrPhe: 1.799 ± 0.08
2.453TyrGly: 2.453 ± 0.08
0.913TyrHis: 0.913 ± 0.059
2.025TyrIle: 2.025 ± 0.073
1.589TyrLys: 1.589 ± 0.074
4.467TyrLeu: 4.467 ± 0.107
0.772TyrMet: 0.772 ± 0.049
1.451TyrAsn: 1.451 ± 0.07
1.368TyrPro: 1.368 ± 0.055
2.698TyrGln: 2.698 ± 0.109
1.837TyrArg: 1.837 ± 0.071
1.948TyrSer: 1.948 ± 0.08
1.951TyrThr: 1.951 ± 0.089
2.182TyrVal: 2.182 ± 0.074
0.32TyrTrp: 0.32 ± 0.029
1.619TyrTyr: 1.619 ± 0.077
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1182 proteins (362461 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski