Amino acid dipepetide frequency for Haliangium ochraceum (strain DSM 14365 / JCM 11303 / SMP-2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.401AlaAla: 20.401 ± 0.193	1.742AlaCys: 1.742 ± 0.037	7.682AlaAsp: 7.682 ± 0.068	9.487AlaGlu: 9.487 ± 0.089	3.73AlaPhe: 3.73 ± 0.044	11.084AlaGly: 11.084 ± 0.09	2.949AlaHis: 2.949 ± 0.036	4.625AlaIle: 4.625 ± 0.048	2.668AlaLys: 2.668 ± 0.046	16.185AlaLeu: 16.185 ± 0.147	2.506AlaMet: 2.506 ± 0.034	2.254AlaAsn: 2.254 ± 0.035	7.695AlaPro: 7.695 ± 0.09	4.71AlaGln: 4.71 ± 0.056	11.492AlaArg: 11.492 ± 0.091	7.656AlaSer: 7.656 ± 0.07	5.874AlaThr: 5.874 ± 0.049	8.8AlaVal: 8.8 ± 0.064	1.691AlaTrp: 1.691 ± 0.031	2.491AlaTyr: 2.491 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	1.497CysAla: 1.497 ± 0.031	0.137CysCys: 0.137 ± 0.009	0.909CysAsp: 0.909 ± 0.045	0.823CysGlu: 0.823 ± 0.02	0.342CysPhe: 0.342 ± 0.011	1.241CysGly: 1.241 ± 0.04	0.344CysHis: 0.344 ± 0.022	0.356CysIle: 0.356 ± 0.013	0.199CysLys: 0.199 ± 0.009	0.89CysLeu: 0.89 ± 0.019	0.202CysMet: 0.202 ± 0.008	0.274CysAsn: 0.274 ± 0.016	0.638CysPro: 0.638 ± 0.023	0.341CysGln: 0.341 ± 0.013	0.766CysArg: 0.766 ± 0.021	0.714CysSer: 0.714 ± 0.023	0.598CysThr: 0.598 ± 0.022	0.803CysVal: 0.803 ± 0.021	0.159CysTrp: 0.159 ± 0.011	0.243CysTyr: 0.243 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	9.338AspAla: 9.338 ± 0.084	0.72AspCys: 0.72 ± 0.038	5.035AspAsp: 5.035 ± 0.062	5.342AspGlu: 5.342 ± 0.052	1.979AspPhe: 1.979 ± 0.032	6.398AspGly: 6.398 ± 0.104	1.135AspHis: 1.135 ± 0.021	2.751AspIle: 2.751 ± 0.033	1.303AspLys: 1.303 ± 0.027	5.503AspLeu: 5.503 ± 0.054	1.073AspMet: 1.073 ± 0.02	1.347AspAsn: 1.347 ± 0.03	3.542AspPro: 3.542 ± 0.041	1.638AspGln: 1.638 ± 0.025	3.714AspArg: 3.714 ± 0.045	3.292AspSer: 3.292 ± 0.039	2.919AspThr: 2.919 ± 0.033	4.008AspVal: 4.008 ± 0.043	0.845AspTrp: 0.845 ± 0.021	1.357AspTyr: 1.357 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	8.386GluAla: 8.386 ± 0.069	0.574GluCys: 0.574 ± 0.023	3.7GluAsp: 3.7 ± 0.049	3.539GluGlu: 3.539 ± 0.053	1.739GluPhe: 1.739 ± 0.029	4.578GluGly: 4.578 ± 0.047	1.922GluHis: 1.922 ± 0.029	2.971GluIle: 2.971 ± 0.033	1.276GluLys: 1.276 ± 0.03	8.272GluLeu: 8.272 ± 0.071	1.316GluMet: 1.316 ± 0.024	1.413GluAsn: 1.413 ± 0.026	3.704GluPro: 3.704 ± 0.046	2.996GluGln: 2.996 ± 0.033	7.773GluArg: 7.773 ± 0.074	3.293GluSer: 3.293 ± 0.037	2.868GluThr: 2.868 ± 0.04	4.912GluVal: 4.912 ± 0.048	0.587GluTrp: 0.587 ± 0.015	1.217GluTyr: 1.217 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	4.033PheAla: 4.033 ± 0.043	0.381PheCys: 0.381 ± 0.012	2.561PheAsp: 2.561 ± 0.032	2.263PheGlu: 2.263 ± 0.031	1.14PhePhe: 1.14 ± 0.02	2.977PheGly: 2.977 ± 0.04	0.73PheHis: 0.73 ± 0.017	0.995PheIle: 0.995 ± 0.019	0.552PheLys: 0.552 ± 0.016	2.939PheLeu: 2.939 ± 0.039	0.511PheMet: 0.511 ± 0.017	0.646PheAsn: 0.646 ± 0.019	1.301PhePro: 1.301 ± 0.019	0.917PheGln: 0.917 ± 0.019	2.181PheArg: 2.181 ± 0.031	1.872PheSer: 1.872 ± 0.031	1.604PheThr: 1.604 ± 0.028	2.374PheVal: 2.374 ± 0.03	0.398PheTrp: 0.398 ± 0.012	0.778PheTyr: 0.778 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	10.844GlyAla: 10.844 ± 0.096	1.175GlyCys: 1.175 ± 0.029	6.183GlyAsp: 6.183 ± 0.068	6.127GlyGlu: 6.127 ± 0.054	2.941GlyPhe: 2.941 ± 0.038	8.033GlyGly: 8.033 ± 0.122	1.907GlyHis: 1.907 ± 0.03	3.214GlyIle: 3.214 ± 0.04	2.298GlyLys: 2.298 ± 0.034	7.37GlyLeu: 7.37 ± 0.064	1.788GlyMet: 1.788 ± 0.027	2.03GlyAsn: 2.03 ± 0.042	3.605GlyPro: 3.605 ± 0.042	2.808GlyGln: 2.808 ± 0.041	6.54GlyArg: 6.54 ± 0.055	4.957GlySer: 4.957 ± 0.053	4.273GlyThr: 4.273 ± 0.05	6.3GlyVal: 6.3 ± 0.057	1.123GlyTrp: 1.123 ± 0.022	2.111GlyTyr: 2.111 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.894HisAla: 2.894 ± 0.037	0.261HisCys: 0.261 ± 0.01	1.211HisAsp: 1.211 ± 0.023	1.449HisGlu: 1.449 ± 0.024	0.737HisPhe: 0.737 ± 0.016	2.007HisGly: 2.007 ± 0.034	0.597HisHis: 0.597 ± 0.016	0.832HisIle: 0.832 ± 0.018	0.427HisLys: 0.427 ± 0.013	2.438HisLeu: 2.438 ± 0.032	0.372HisMet: 0.372 ± 0.011	0.425HisAsn: 0.425 ± 0.013	1.438HisPro: 1.438 ± 0.025	0.668HisGln: 0.668 ± 0.018	1.887HisArg: 1.887 ± 0.029	1.1HisSer: 1.1 ± 0.019	1.113HisThr: 1.113 ± 0.024	1.593HisVal: 1.593 ± 0.025	0.304HisTrp: 0.304 ± 0.011	0.59HisTyr: 0.59 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	5.409IleAla: 5.409 ± 0.05	0.351IleCys: 0.351 ± 0.012	3.386IleAsp: 3.386 ± 0.044	3.249IleGlu: 3.249 ± 0.043	1.065IlePhe: 1.065 ± 0.025	3.308IleGly: 3.308 ± 0.035	0.845IleHis: 0.845 ± 0.018	1.34IleIle: 1.34 ± 0.023	0.824IleLys: 0.824 ± 0.022	3.11IleLeu: 3.11 ± 0.044	0.513IleMet: 0.513 ± 0.016	0.833IleAsn: 0.833 ± 0.019	1.751IlePro: 1.751 ± 0.028	0.98IleGln: 0.98 ± 0.018	2.385IleArg: 2.385 ± 0.029	1.879IleSer: 1.879 ± 0.027	1.861IleThr: 1.861 ± 0.029	2.786IleVal: 2.786 ± 0.035	0.397IleTrp: 0.397 ± 0.014	0.874IleTyr: 0.874 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	2.29LysAla: 2.29 ± 0.046	0.136LysCys: 0.136 ± 0.008	0.985LysAsp: 0.985 ± 0.022	1.006LysGlu: 1.006 ± 0.026	0.536LysPhe: 0.536 ± 0.015	1.386LysGly: 1.386 ± 0.029	0.526LysHis: 0.526 ± 0.014	0.885LysIle: 0.885 ± 0.022	0.876LysLys: 0.876 ± 0.033	2.504LysLeu: 2.504 ± 0.04	0.406LysMet: 0.406 ± 0.014	0.567LysAsn: 0.567 ± 0.015	1.318LysPro: 1.318 ± 0.029	0.847LysGln: 0.847 ± 0.021	2.19LysArg: 2.19 ± 0.033	1.28LysSer: 1.28 ± 0.026	1.136LysThr: 1.136 ± 0.023	1.495LysVal: 1.495 ± 0.029	0.185LysTrp: 0.185 ± 0.009	0.46LysTyr: 0.46 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	15.23LeuAla: 15.23 ± 0.127	1.186LeuCys: 1.186 ± 0.02	6.781LeuAsp: 6.781 ± 0.052	6.615LeuGlu: 6.615 ± 0.069	3.053LeuPhe: 3.053 ± 0.04	9.365LeuGly: 9.365 ± 0.073	2.157LeuHis: 2.157 ± 0.035	3.338LeuIle: 3.338 ± 0.039	1.79LeuLys: 1.79 ± 0.034	10.729LeuLeu: 10.729 ± 0.09	1.645LeuMet: 1.645 ± 0.025	1.563LeuAsn: 1.563 ± 0.029	5.534LeuPro: 5.534 ± 0.058	2.621LeuGln: 2.621 ± 0.034	9.478LeuArg: 9.478 ± 0.081	6.971LeuSer: 6.971 ± 0.053	4.381LeuThr: 4.381 ± 0.041	7.768LeuVal: 7.768 ± 0.064	1.301LeuTrp: 1.301 ± 0.025	2.134LeuTyr: 2.134 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.3MetAla: 2.3 ± 0.028	0.157MetCys: 0.157 ± 0.008	0.927MetAsp: 0.927 ± 0.02	0.849MetGlu: 0.849 ± 0.018	0.552MetPhe: 0.552 ± 0.015	1.357MetGly: 1.357 ± 0.024	0.474MetHis: 0.474 ± 0.013	0.622MetIle: 0.622 ± 0.017	0.532MetLys: 0.532 ± 0.016	1.993MetLeu: 1.993 ± 0.024	0.36MetMet: 0.36 ± 0.012	0.517MetAsn: 0.517 ± 0.013	1.243MetPro: 1.243 ± 0.021	0.643MetGln: 0.643 ± 0.014	1.778MetArg: 1.778 ± 0.026	1.655MetSer: 1.655 ± 0.024	0.911MetThr: 0.911 ± 0.018	1.3MetVal: 1.3 ± 0.024	0.192MetTrp: 0.192 ± 0.008	0.335MetTyr: 0.335 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.465AsnAla: 2.465 ± 0.033	0.252AsnCys: 0.252 ± 0.012	1.175AsnAsp: 1.175 ± 0.028	1.099AsnGlu: 1.099 ± 0.022	0.665AsnPhe: 0.665 ± 0.017	1.775AsnGly: 1.775 ± 0.041	0.44AsnHis: 0.44 ± 0.012	0.92AsnIle: 0.92 ± 0.021	0.458AsnLys: 0.458 ± 0.014	2.061AsnLeu: 2.061 ± 0.031	0.348AsnMet: 0.348 ± 0.013	0.551AsnAsn: 0.551 ± 0.021	1.43AsnPro: 1.43 ± 0.025	0.731AsnGln: 0.731 ± 0.019	1.509AsnArg: 1.509 ± 0.026	1.021AsnSer: 1.021 ± 0.023	1.035AsnThr: 1.035 ± 0.022	1.342AsnVal: 1.342 ± 0.021	0.233AsnTrp: 0.233 ± 0.01	0.507AsnTyr: 0.507 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.037ProAla: 8.037 ± 0.079	0.456ProCys: 0.456 ± 0.015	3.57ProAsp: 3.57 ± 0.05	4.436ProGlu: 4.436 ± 0.046	1.553ProPhe: 1.553 ± 0.027	5.178ProGly: 5.178 ± 0.053	1.085ProHis: 1.085 ± 0.023	1.601ProIle: 1.601 ± 0.022	1.057ProLys: 1.057 ± 0.021	5.097ProLeu: 5.097 ± 0.05	1.13ProMet: 1.13 ± 0.019	1.044ProAsn: 1.044 ± 0.021	3.858ProPro: 3.858 ± 0.06	1.647ProGln: 1.647 ± 0.031	3.85ProArg: 3.85 ± 0.044	3.597ProSer: 3.597 ± 0.042	2.487ProThr: 2.487 ± 0.034	3.922ProVal: 3.922 ± 0.039	0.75ProTrp: 0.75 ± 0.016	1.115ProTyr: 1.115 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	4.403GlnAla: 4.403 ± 0.059	0.325GlnCys: 0.325 ± 0.015	1.305GlnAsp: 1.305 ± 0.023	1.586GlnGlu: 1.586 ± 0.025	0.863GlnPhe: 0.863 ± 0.02	2.31GlnGly: 2.31 ± 0.029	0.803GlnHis: 0.803 ± 0.018	1.305GlnIle: 1.305 ± 0.023	0.621GlnLys: 0.621 ± 0.018	3.26GlnLeu: 3.26 ± 0.036	0.69GlnMet: 0.69 ± 0.014	0.66GlnAsn: 0.66 ± 0.018	2.161GlnPro: 2.161 ± 0.036	1.459GlnGln: 1.459 ± 0.037	3.643GlnArg: 3.643 ± 0.042	1.782GlnSer: 1.782 ± 0.028	1.583GlnThr: 1.583 ± 0.025	2.594GlnVal: 2.594 ± 0.032	0.377GlnTrp: 0.377 ± 0.013	0.543GlnTyr: 0.543 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	11.625ArgAla: 11.625 ± 0.111	0.963ArgCys: 0.963 ± 0.023	4.923ArgAsp: 4.923 ± 0.053	5.628ArgGlu: 5.628 ± 0.058	3.068ArgPhe: 3.068 ± 0.031	6.432ArgGly: 6.432 ± 0.061	1.707ArgHis: 1.707 ± 0.027	3.508ArgIle: 3.508 ± 0.038	1.785ArgLys: 1.785 ± 0.033	8.335ArgLeu: 8.335 ± 0.069	1.833ArgMet: 1.833 ± 0.032	1.487ArgAsn: 1.487 ± 0.027	4.059ArgPro: 4.059 ± 0.045	2.509ArgGln: 2.509 ± 0.035	7.235ArgArg: 7.235 ± 0.067	4.631ArgSer: 4.631 ± 0.048	3.575ArgThr: 3.575 ± 0.038	6.602ArgVal: 6.602 ± 0.059	1.271ArgTrp: 1.271 ± 0.026	2.183ArgTyr: 2.183 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	8.028SerAla: 8.028 ± 0.066	0.691SerCys: 0.691 ± 0.022	3.857SerAsp: 3.857 ± 0.038	4.083SerGlu: 4.083 ± 0.041	2.114SerPhe: 2.114 ± 0.031	5.712SerGly: 5.712 ± 0.061	1.053SerHis: 1.053 ± 0.02	2.013SerIle: 2.013 ± 0.032	1.295SerLys: 1.295 ± 0.026	5.697SerLeu: 5.697 ± 0.058	1.216SerMet: 1.216 ± 0.021	1.232SerAsn: 1.232 ± 0.025	3.253SerPro: 3.253 ± 0.042	1.668SerGln: 1.668 ± 0.024	3.799SerArg: 3.799 ± 0.043	3.826SerSer: 3.826 ± 0.044	2.582SerThr: 2.582 ± 0.036	4.014SerVal: 4.014 ± 0.042	0.81SerTrp: 0.81 ± 0.019	1.485SerTyr: 1.485 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	5.453ThrAla: 5.453 ± 0.047	0.645ThrCys: 0.645 ± 0.026	2.259ThrAsp: 2.259 ± 0.034	2.563ThrGlu: 2.563 ± 0.032	1.32ThrPhe: 1.32 ± 0.023	4.331ThrGly: 4.331 ± 0.047	0.969ThrHis: 0.969 ± 0.017	1.81ThrIle: 1.81 ± 0.029	0.967ThrLys: 0.967 ± 0.027	5.337ThrLeu: 5.337 ± 0.046	0.87ThrMet: 0.87 ± 0.018	0.926ThrAsn: 0.926 ± 0.022	3.382ThrPro: 3.382 ± 0.039	1.481ThrGln: 1.481 ± 0.024	3.661ThrArg: 3.661 ± 0.038	2.708ThrSer: 2.708 ± 0.035	2.255ThrThr: 2.255 ± 0.031	3.514ThrVal: 3.514 ± 0.036	0.721ThrTrp: 0.721 ± 0.016	0.956ThrTyr: 0.956 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	9.433ValAla: 9.433 ± 0.067	0.921ValCys: 0.921 ± 0.027	4.641ValAsp: 4.641 ± 0.043	4.682ValGlu: 4.682 ± 0.046	2.447ValPhe: 2.447 ± 0.034	5.429ValGly: 5.429 ± 0.056	1.843ValHis: 1.843 ± 0.023	2.823ValIle: 2.823 ± 0.038	1.361ValLys: 1.361 ± 0.025	7.776ValLeu: 7.776 ± 0.063	1.214ValMet: 1.214 ± 0.022	1.43ValAsn: 1.43 ± 0.024	3.879ValPro: 3.879 ± 0.039	2.146ValGln: 2.146 ± 0.029	6.115ValArg: 6.115 ± 0.052	4.31ValSer: 4.31 ± 0.047	3.418ValThr: 3.418 ± 0.04	5.927ValVal: 5.927 ± 0.057	0.895ValTrp: 0.895 ± 0.022	1.752ValTyr: 1.752 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.163TrpAla: 1.163 ± 0.022	0.14TrpCys: 0.14 ± 0.008	0.718TrpAsp: 0.718 ± 0.019	0.608TrpGlu: 0.608 ± 0.017	0.468TrpPhe: 0.468 ± 0.012	0.849TrpGly: 0.849 ± 0.021	0.327TrpHis: 0.327 ± 0.011	0.479TrpIle: 0.479 ± 0.014	0.29TrpLys: 0.29 ± 0.009	1.66TrpLeu: 1.66 ± 0.027	0.306TrpMet: 0.306 ± 0.01	0.382TrpAsn: 0.382 ± 0.013	0.644TrpPro: 0.644 ± 0.017	0.615TrpGln: 0.615 ± 0.015	1.254TrpArg: 1.254 ± 0.022	0.862TrpSer: 0.862 ± 0.02	0.692TrpThr: 0.692 ± 0.017	0.817TrpVal: 0.817 ± 0.018	0.205TrpTrp: 0.205 ± 0.008	0.286TrpTyr: 0.286 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.491TyrAla: 2.491 ± 0.032	0.262TyrCys: 0.262 ± 0.011	1.429TyrAsp: 1.429 ± 0.028	1.601TyrGlu: 1.601 ± 0.03	0.84TyrPhe: 0.84 ± 0.019	1.878TyrGly: 1.878 ± 0.03	0.532TyrHis: 0.532 ± 0.013	0.758TyrIle: 0.758 ± 0.016	0.437TyrLys: 0.437 ± 0.013	2.486TyrLeu: 2.486 ± 0.033	0.398TyrMet: 0.398 ± 0.014	0.434TyrAsn: 0.434 ± 0.015	1.033TyrPro: 1.033 ± 0.021	0.848TyrGln: 0.848 ± 0.021	2.111TyrArg: 2.111 ± 0.031	1.021TyrSer: 1.021 ± 0.023	0.964TyrThr: 0.964 ± 0.02	1.57TyrVal: 1.57 ± 0.03	0.322TyrTrp: 0.322 ± 0.013	0.613TyrTyr: 0.613 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6684 proteins (2756058 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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