Amino acid dipepetide frequency for Caldilinea aerophila (strain DSM 14535 / JCM 11387 / NBRC 104270 / STL-6-O1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.401AlaAla: 14.401 ± 0.142
1.009AlaCys: 1.009 ± 0.029
5.113AlaAsp: 5.113 ± 0.076
7.074AlaGlu: 7.074 ± 0.089
3.936AlaPhe: 3.936 ± 0.056
8.711AlaGly: 8.711 ± 0.081
2.204AlaHis: 2.204 ± 0.046
6.092AlaIle: 6.092 ± 0.068
2.157AlaLys: 2.157 ± 0.047
13.799AlaLeu: 13.799 ± 0.146
2.742AlaMet: 2.742 ± 0.04
2.866AlaAsn: 2.866 ± 0.044
5.804AlaPro: 5.804 ± 0.08
4.834AlaGln: 4.834 ± 0.065
7.087AlaArg: 7.087 ± 0.084
5.374AlaSer: 5.374 ± 0.066
5.92AlaThr: 5.92 ± 0.107
8.343AlaVal: 8.343 ± 0.09
1.786AlaTrp: 1.786 ± 0.037
2.968AlaTyr: 2.968 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.881CysAla: 0.881 ± 0.022
0.115CysCys: 0.115 ± 0.011
0.459CysAsp: 0.459 ± 0.018
0.481CysGlu: 0.481 ± 0.019
0.31CysPhe: 0.31 ± 0.015
0.844CysGly: 0.844 ± 0.026
0.222CysHis: 0.222 ± 0.016
0.454CysIle: 0.454 ± 0.017
0.187CysLys: 0.187 ± 0.011
0.673CysLeu: 0.673 ± 0.024
0.149CysMet: 0.149 ± 0.011
0.28CysAsn: 0.28 ± 0.014
0.505CysPro: 0.505 ± 0.021
0.268CysGln: 0.268 ± 0.016
0.573CysArg: 0.573 ± 0.021
0.443CysSer: 0.443 ± 0.017
0.532CysThr: 0.532 ± 0.021
0.565CysVal: 0.565 ± 0.02
0.142CysTrp: 0.142 ± 0.01
0.239CysTyr: 0.239 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
5.738AspAla: 5.738 ± 0.069
0.37AspCys: 0.37 ± 0.016
2.337AspAsp: 2.337 ± 0.045
3.373AspGlu: 3.373 ± 0.052
2.097AspPhe: 2.097 ± 0.039
4.198AspGly: 4.198 ± 0.073
0.915AspHis: 0.915 ± 0.025
2.433AspIle: 2.433 ± 0.046
1.105AspLys: 1.105 ± 0.029
5.437AspLeu: 5.437 ± 0.064
0.867AspMet: 0.867 ± 0.025
1.296AspAsn: 1.296 ± 0.038
3.483AspPro: 3.483 ± 0.051
1.439AspGln: 1.439 ± 0.03
3.278AspArg: 3.278 ± 0.043
1.948AspSer: 1.948 ± 0.045
2.013AspThr: 2.013 ± 0.043
3.952AspVal: 3.952 ± 0.053
0.966AspTrp: 0.966 ± 0.028
1.52AspTyr: 1.52 ± 0.03
0.0AspXaa: 0.0 ± 0.0
Glu
7.433GluAla: 7.433 ± 0.088
0.355GluCys: 0.355 ± 0.018
2.411GluAsp: 2.411 ± 0.046
4.641GluGlu: 4.641 ± 0.078
1.91GluPhe: 1.91 ± 0.04
4.296GluGly: 4.296 ± 0.062
1.414GluHis: 1.414 ± 0.033
3.536GluIle: 3.536 ± 0.046
1.816GluLys: 1.816 ± 0.044
6.209GluLeu: 6.209 ± 0.074
1.689GluMet: 1.689 ± 0.036
1.705GluAsn: 1.705 ± 0.033
3.098GluPro: 3.098 ± 0.054
3.043GluGln: 3.043 ± 0.048
5.618GluArg: 5.618 ± 0.086
2.682GluSer: 2.682 ± 0.047
3.322GluThr: 3.322 ± 0.053
4.465GluVal: 4.465 ± 0.059
0.999GluTrp: 0.999 ± 0.027
1.421GluTyr: 1.421 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
3.954PheAla: 3.954 ± 0.054
0.388PheCys: 0.388 ± 0.017
2.325PheAsp: 2.325 ± 0.037
1.979PheGlu: 1.979 ± 0.041
1.71PhePhe: 1.71 ± 0.041
3.221PheGly: 3.221 ± 0.055
0.738PheHis: 0.738 ± 0.021
2.018PheIle: 2.018 ± 0.041
0.76PheLys: 0.76 ± 0.029
3.872PheLeu: 3.872 ± 0.062
0.726PheMet: 0.726 ± 0.023
1.184PheAsn: 1.184 ± 0.027
1.823PhePro: 1.823 ± 0.032
1.284PheGln: 1.284 ± 0.027
2.182PheArg: 2.182 ± 0.04
2.095PheSer: 2.095 ± 0.044
2.34PheThr: 2.34 ± 0.048
2.982PheVal: 2.982 ± 0.044
0.77PheTrp: 0.77 ± 0.027
1.26PheTyr: 1.26 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
8.169GlyAla: 8.169 ± 0.097
0.834GlyCys: 0.834 ± 0.025
3.921GlyAsp: 3.921 ± 0.063
5.005GlyGlu: 5.005 ± 0.059
3.039GlyPhe: 3.039 ± 0.046
6.147GlyGly: 6.147 ± 0.108
1.539GlyHis: 1.539 ± 0.036
3.997GlyIle: 3.997 ± 0.055
2.569GlyLys: 2.569 ± 0.04
8.034GlyLeu: 8.034 ± 0.103
2.03GlyMet: 2.03 ± 0.043
2.117GlyAsn: 2.117 ± 0.055
3.078GlyPro: 3.078 ± 0.055
2.844GlyGln: 2.844 ± 0.055
5.21GlyArg: 5.21 ± 0.063
3.807GlySer: 3.807 ± 0.059
3.479GlyThr: 3.479 ± 0.052
7.015GlyVal: 7.015 ± 0.079
1.736GlyTrp: 1.736 ± 0.041
2.686GlyTyr: 2.686 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
2.041HisAla: 2.041 ± 0.038
0.264HisCys: 0.264 ± 0.013
0.971HisAsp: 0.971 ± 0.025
1.12HisGlu: 1.12 ± 0.028
0.893HisPhe: 0.893 ± 0.024
1.666HisGly: 1.666 ± 0.037
0.631HisHis: 0.631 ± 0.025
1.149HisIle: 1.149 ± 0.032
0.455HisLys: 0.455 ± 0.02
2.452HisLeu: 2.452 ± 0.046
0.404HisMet: 0.404 ± 0.017
0.608HisAsn: 0.608 ± 0.019
1.632HisPro: 1.632 ± 0.034
0.73HisGln: 0.73 ± 0.023
1.631HisArg: 1.631 ± 0.032
0.953HisSer: 0.953 ± 0.027
1.083HisThr: 1.083 ± 0.026
1.475HisVal: 1.475 ± 0.032
0.375HisTrp: 0.375 ± 0.017
0.732HisTyr: 0.732 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
6.365IleAla: 6.365 ± 0.074
0.505IleCys: 0.505 ± 0.017
3.415IleAsp: 3.415 ± 0.047
3.871IleGlu: 3.871 ± 0.053
2.184IlePhe: 2.184 ± 0.043
4.607IleGly: 4.607 ± 0.068
1.127IleHis: 1.127 ± 0.027
2.387IleIle: 2.387 ± 0.05
1.166IleLys: 1.166 ± 0.03
5.06IleLeu: 5.06 ± 0.073
0.887IleMet: 0.887 ± 0.025
1.474IleAsn: 1.474 ± 0.035
2.921IlePro: 2.921 ± 0.054
1.732IleGln: 1.732 ± 0.036
2.974IleArg: 2.974 ± 0.045
2.58IleSer: 2.58 ± 0.047
2.9IleThr: 2.9 ± 0.05
4.787IleVal: 4.787 ± 0.059
0.882IleTrp: 0.882 ± 0.033
1.691IleTyr: 1.691 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
2.674LysAla: 2.674 ± 0.048
0.129LysCys: 0.129 ± 0.011
1.003LysAsp: 1.003 ± 0.03
1.592LysGlu: 1.592 ± 0.041
0.711LysPhe: 0.711 ± 0.023
1.782LysGly: 1.782 ± 0.041
0.502LysHis: 0.502 ± 0.02
1.317LysIle: 1.317 ± 0.03
0.7LysLys: 0.7 ± 0.024
2.554LysLeu: 2.554 ± 0.041
0.614LysMet: 0.614 ± 0.022
0.643LysAsn: 0.643 ± 0.021
1.539LysPro: 1.539 ± 0.033
1.003LysGln: 1.003 ± 0.027
1.877LysArg: 1.877 ± 0.044
1.13LysSer: 1.13 ± 0.03
1.447LysThr: 1.447 ± 0.037
1.815LysVal: 1.815 ± 0.038
0.332LysTrp: 0.332 ± 0.018
0.63LysTyr: 0.63 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
13.145LeuAla: 13.145 ± 0.135
0.954LeuCys: 0.954 ± 0.027
5.522LeuAsp: 5.522 ± 0.062
6.122LeuGlu: 6.122 ± 0.077
4.196LeuPhe: 4.196 ± 0.059
7.674LeuGly: 7.674 ± 0.084
2.404LeuHis: 2.404 ± 0.048
5.839LeuIle: 5.839 ± 0.07
2.557LeuLys: 2.557 ± 0.048
12.626LeuLeu: 12.626 ± 0.146
2.245LeuMet: 2.245 ± 0.038
3.114LeuAsn: 3.114 ± 0.044
6.595LeuPro: 6.595 ± 0.072
4.029LeuGln: 4.029 ± 0.056
8.151LeuArg: 8.151 ± 0.087
5.986LeuSer: 5.986 ± 0.075
6.32LeuThr: 6.32 ± 0.08
7.53LeuVal: 7.53 ± 0.089
1.808LeuTrp: 1.808 ± 0.045
3.061LeuTyr: 3.061 ± 0.055
0.0LeuXaa: 0.0 ± 0.0
Met
2.709MetAla: 2.709 ± 0.043
0.112MetCys: 0.112 ± 0.008
0.93MetAsp: 0.93 ± 0.024
1.262MetGlu: 1.262 ± 0.029
0.581MetPhe: 0.581 ± 0.019
1.598MetGly: 1.598 ± 0.035
0.501MetHis: 0.501 ± 0.018
1.198MetIle: 1.198 ± 0.03
0.687MetLys: 0.687 ± 0.023
2.463MetLeu: 2.463 ± 0.046
0.594MetMet: 0.594 ± 0.021
0.757MetAsn: 0.757 ± 0.025
1.258MetPro: 1.258 ± 0.025
0.986MetGln: 0.986 ± 0.022
1.749MetArg: 1.749 ± 0.036
1.205MetSer: 1.205 ± 0.025
1.461MetThr: 1.461 ± 0.034
1.681MetVal: 1.681 ± 0.035
0.252MetTrp: 0.252 ± 0.013
0.462MetTyr: 0.462 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.039AsnAla: 3.039 ± 0.046
0.234AsnCys: 0.234 ± 0.012
1.39AsnAsp: 1.39 ± 0.034
1.589AsnGlu: 1.589 ± 0.035
1.083AsnPhe: 1.083 ± 0.031
2.582AsnGly: 2.582 ± 0.064
0.59AsnHis: 0.59 ± 0.019
1.427AsnIle: 1.427 ± 0.032
0.584AsnLys: 0.584 ± 0.028
3.172AsnLeu: 3.172 ± 0.048
0.525AsnMet: 0.525 ± 0.02
0.968AsnAsn: 0.968 ± 0.039
2.182AsnPro: 2.182 ± 0.049
1.059AsnGln: 1.059 ± 0.028
2.02AsnArg: 2.02 ± 0.04
1.341AsnSer: 1.341 ± 0.04
1.476AsnThr: 1.476 ± 0.052
2.18AsnVal: 2.18 ± 0.046
0.57AsnTrp: 0.57 ± 0.02
0.877AsnTyr: 0.877 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
6.423ProAla: 6.423 ± 0.075
0.341ProCys: 0.341 ± 0.016
3.568ProAsp: 3.568 ± 0.054
4.186ProGlu: 4.186 ± 0.058
2.166ProPhe: 2.166 ± 0.038
4.702ProGly: 4.702 ± 0.062
1.193ProHis: 1.193 ± 0.03
2.75ProIle: 2.75 ± 0.042
1.203ProLys: 1.203 ± 0.03
5.946ProLeu: 5.946 ± 0.066
1.16ProMet: 1.16 ± 0.023
1.712ProAsn: 1.712 ± 0.042
3.487ProPro: 3.487 ± 0.066
2.039ProGln: 2.039 ± 0.037
2.741ProArg: 2.741 ± 0.044
2.94ProSer: 2.94 ± 0.054
4.041ProThr: 4.041 ± 0.146
4.425ProVal: 4.425 ± 0.067
0.924ProTrp: 0.924 ± 0.026
1.608ProTyr: 1.608 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
4.638GlnAla: 4.638 ± 0.063
0.255GlnCys: 0.255 ± 0.014
1.355GlnAsp: 1.355 ± 0.033
2.499GlnGlu: 2.499 ± 0.042
1.211GlnPhe: 1.211 ± 0.028
2.633GlnGly: 2.633 ± 0.04
0.739GlnHis: 0.739 ± 0.026
2.257GlnIle: 2.257 ± 0.042
1.039GlnLys: 1.039 ± 0.029
3.722GlnLeu: 3.722 ± 0.053
1.066GlnMet: 1.066 ± 0.026
1.026GlnAsn: 1.026 ± 0.031
2.615GlnPro: 2.615 ± 0.046
1.843GlnGln: 1.843 ± 0.048
3.543GlnArg: 3.543 ± 0.057
1.699GlnSer: 1.699 ± 0.036
2.002GlnThr: 2.002 ± 0.036
2.913GlnVal: 2.913 ± 0.045
0.636GlnTrp: 0.636 ± 0.02
0.865GlnTyr: 0.865 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
6.542ArgAla: 6.542 ± 0.082
0.639ArgCys: 0.639 ± 0.024
2.653ArgAsp: 2.653 ± 0.041
4.014ArgGlu: 4.014 ± 0.061
2.943ArgPhe: 2.943 ± 0.047
4.299ArgGly: 4.299 ± 0.062
1.568ArgHis: 1.568 ± 0.033
4.222ArgIle: 4.222 ± 0.048
1.901ArgLys: 1.901 ± 0.04
8.277ArgLeu: 8.277 ± 0.085
1.823ArgMet: 1.823 ± 0.031
2.259ArgAsn: 2.259 ± 0.036
3.618ArgPro: 3.618 ± 0.055
2.921ArgGln: 2.921 ± 0.05
6.272ArgArg: 6.272 ± 0.093
3.731ArgSer: 3.731 ± 0.055
3.661ArgThr: 3.661 ± 0.046
4.867ArgVal: 4.867 ± 0.062
1.584ArgTrp: 1.584 ± 0.037
2.435ArgTyr: 2.435 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
5.385SerAla: 5.385 ± 0.073
0.358SerCys: 0.358 ± 0.015
2.445SerAsp: 2.445 ± 0.046
2.786SerGlu: 2.786 ± 0.044
1.954SerPhe: 1.954 ± 0.038
4.506SerGly: 4.506 ± 0.067
1.042SerHis: 1.042 ± 0.027
2.614SerIle: 2.614 ± 0.042
1.113SerLys: 1.113 ± 0.027
5.34SerLeu: 5.34 ± 0.07
1.152SerMet: 1.152 ± 0.028
1.382SerAsn: 1.382 ± 0.037
3.198SerPro: 3.198 ± 0.062
1.76SerGln: 1.76 ± 0.038
2.954SerArg: 2.954 ± 0.053
2.76SerSer: 2.76 ± 0.059
2.813SerThr: 2.813 ± 0.052
3.652SerVal: 3.652 ± 0.05
0.812SerTrp: 0.812 ± 0.027
1.331SerTyr: 1.331 ± 0.033
0.0SerXaa: 0.0 ± 0.0
Thr
5.83ThrAla: 5.83 ± 0.096
0.391ThrCys: 0.391 ± 0.016
2.414ThrAsp: 2.414 ± 0.042
2.69ThrGlu: 2.69 ± 0.049
2.223ThrPhe: 2.223 ± 0.049
4.486ThrGly: 4.486 ± 0.056
1.191ThrHis: 1.191 ± 0.031
2.996ThrIle: 2.996 ± 0.048
0.98ThrLys: 0.98 ± 0.027
6.822ThrLeu: 6.822 ± 0.087
1.084ThrMet: 1.084 ± 0.029
1.542ThrAsn: 1.542 ± 0.061
4.9ThrPro: 4.9 ± 0.146
1.84ThrGln: 1.84 ± 0.037
2.903ThrArg: 2.903 ± 0.05
2.644ThrSer: 2.644 ± 0.055
2.984ThrThr: 2.984 ± 0.065
4.587ThrVal: 4.587 ± 0.085
0.922ThrTrp: 0.922 ± 0.025
1.551ThrTyr: 1.551 ± 0.042
0.0ThrXaa: 0.0 ± 0.0
Val
8.339ValAla: 8.339 ± 0.086
0.642ValCys: 0.642 ± 0.019
4.15ValAsp: 4.15 ± 0.058
5.172ValGlu: 5.172 ± 0.061
2.657ValPhe: 2.657 ± 0.048
5.663ValGly: 5.663 ± 0.069
1.699ValHis: 1.699 ± 0.038
4.603ValIle: 4.603 ± 0.056
1.98ValLys: 1.98 ± 0.039
8.05ValLeu: 8.05 ± 0.094
1.686ValMet: 1.686 ± 0.035
2.378ValAsn: 2.378 ± 0.045
3.337ValPro: 3.337 ± 0.05
2.954ValGln: 2.954 ± 0.046
5.518ValArg: 5.518 ± 0.067
3.799ValSer: 3.799 ± 0.051
4.553ValThr: 4.553 ± 0.108
6.064ValVal: 6.064 ± 0.088
1.162ValTrp: 1.162 ± 0.026
2.196ValTyr: 2.196 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.435TrpAla: 1.435 ± 0.034
0.131TrpCys: 0.131 ± 0.009
0.73TrpAsp: 0.73 ± 0.025
1.026TrpGlu: 1.026 ± 0.026
0.646TrpPhe: 0.646 ± 0.023
1.198TrpGly: 1.198 ± 0.032
0.36TrpHis: 0.36 ± 0.017
0.883TrpIle: 0.883 ± 0.027
0.461TrpLys: 0.461 ± 0.019
2.334TrpLeu: 2.334 ± 0.054
0.507TrpMet: 0.507 ± 0.016
0.6TrpAsn: 0.6 ± 0.022
0.885TrpPro: 0.885 ± 0.026
0.893TrpGln: 0.893 ± 0.026
1.655TrpArg: 1.655 ± 0.038
0.974TrpSer: 0.974 ± 0.027
0.856TrpThr: 0.856 ± 0.027
1.204TrpVal: 1.204 ± 0.03
0.406TrpTrp: 0.406 ± 0.017
0.413TrpTyr: 0.413 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.08TyrAla: 3.08 ± 0.05
0.295TyrCys: 0.295 ± 0.015
1.652TyrAsp: 1.652 ± 0.04
1.582TyrGlu: 1.582 ± 0.03
1.162TyrPhe: 1.162 ± 0.032
2.442TyrGly: 2.442 ± 0.045
0.688TyrHis: 0.688 ± 0.024
1.343TyrIle: 1.343 ± 0.037
0.573TyrLys: 0.573 ± 0.022
3.036TyrLeu: 3.036 ± 0.048
0.495TyrMet: 0.495 ± 0.018
0.98TyrAsn: 0.98 ± 0.029
1.596TyrPro: 1.596 ± 0.033
1.058TyrGln: 1.058 ± 0.03
2.293TyrArg: 2.293 ± 0.045
1.264TyrSer: 1.264 ± 0.034
1.777TyrThr: 1.777 ± 0.04
2.095TyrVal: 2.095 ± 0.04
0.535TyrTrp: 0.535 ± 0.023
0.962TyrTyr: 0.962 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4097 proteins (1491047 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski