Amino acid dipepetide frequency for Dendrosporobacter quercicolus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.062AlaAla: 13.062 ± 0.174	1.128AlaCys: 1.128 ± 0.038	5.119AlaAsp: 5.119 ± 0.076	6.468AlaGlu: 6.468 ± 0.077	3.434AlaPhe: 3.434 ± 0.061	10.03AlaGly: 10.03 ± 0.182	1.445AlaHis: 1.445 ± 0.032	6.395AlaIle: 6.395 ± 0.094	5.007AlaLys: 5.007 ± 0.072	9.752AlaLeu: 9.752 ± 0.108	2.456AlaMet: 2.456 ± 0.046	3.221AlaAsn: 3.221 ± 0.064	3.019AlaPro: 3.019 ± 0.061	3.577AlaGln: 3.577 ± 0.068	4.807AlaArg: 4.807 ± 0.069	4.355AlaSer: 4.355 ± 0.062	4.125AlaThr: 4.125 ± 0.107	8.879AlaVal: 8.879 ± 0.104	0.78AlaTrp: 0.78 ± 0.029	2.762AlaTyr: 2.762 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.913CysAla: 0.913 ± 0.03	0.217CysCys: 0.217 ± 0.016	0.534CysAsp: 0.534 ± 0.023	0.547CysGlu: 0.547 ± 0.026	0.479CysPhe: 0.479 ± 0.022	1.177CysGly: 1.177 ± 0.039	0.26CysHis: 0.26 ± 0.015	0.722CysIle: 0.722 ± 0.022	0.51CysLys: 0.51 ± 0.021	1.207CysLeu: 1.207 ± 0.033	0.287CysMet: 0.287 ± 0.017	0.425CysAsn: 0.425 ± 0.019	0.639CysPro: 0.639 ± 0.029	0.447CysGln: 0.447 ± 0.02	0.794CysArg: 0.794 ± 0.024	0.78CysSer: 0.78 ± 0.027	0.563CysThr: 0.563 ± 0.024	0.66CysVal: 0.66 ± 0.028	0.124CysTrp: 0.124 ± 0.01	0.413CysTyr: 0.413 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.891AspAla: 3.891 ± 0.067	0.653AspCys: 0.653 ± 0.027	2.123AspAsp: 2.123 ± 0.047	3.103AspGlu: 3.103 ± 0.058	2.132AspPhe: 2.132 ± 0.047	3.594AspGly: 3.594 ± 0.061	0.948AspHis: 0.948 ± 0.031	4.14AspIle: 4.14 ± 0.076	2.87AspLys: 2.87 ± 0.059	4.713AspLeu: 4.713 ± 0.066	1.207AspMet: 1.207 ± 0.032	1.832AspAsn: 1.832 ± 0.056	1.854AspPro: 1.854 ± 0.046	1.876AspGln: 1.876 ± 0.039	2.565AspArg: 2.565 ± 0.042	2.541AspSer: 2.541 ± 0.045	2.341AspThr: 2.341 ± 0.052	3.297AspVal: 3.297 ± 0.058	0.595AspTrp: 0.595 ± 0.022	1.956AspTyr: 1.956 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	5.573GluAla: 5.573 ± 0.088	0.533GluCys: 0.533 ± 0.021	2.471GluAsp: 2.471 ± 0.055	3.894GluGlu: 3.894 ± 0.066	2.268GluPhe: 2.268 ± 0.049	3.226GluGly: 3.226 ± 0.054	1.225GluHis: 1.225 ± 0.035	4.75GluIle: 4.75 ± 0.075	3.868GluLys: 3.868 ± 0.074	6.865GluLeu: 6.865 ± 0.081	1.618GluMet: 1.618 ± 0.034	2.503GluAsn: 2.503 ± 0.058	1.912GluPro: 1.912 ± 0.044	3.534GluGln: 3.534 ± 0.06	3.483GluArg: 3.483 ± 0.054	2.479GluSer: 2.479 ± 0.043	3.107GluThr: 3.107 ± 0.054	4.146GluVal: 4.146 ± 0.06	0.6GluTrp: 0.6 ± 0.024	2.001GluTyr: 2.001 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.577PheAla: 3.577 ± 0.059	0.559PheCys: 0.559 ± 0.02	2.107PheAsp: 2.107 ± 0.05	1.847PheGlu: 1.847 ± 0.04	1.762PhePhe: 1.762 ± 0.05	3.138PheGly: 3.138 ± 0.056	0.718PheHis: 0.718 ± 0.025	2.835PheIle: 2.835 ± 0.049	1.784PheLys: 1.784 ± 0.046	3.594PheLeu: 3.594 ± 0.064	0.97PheMet: 0.97 ± 0.034	1.564PheAsn: 1.564 ± 0.041	1.438PhePro: 1.438 ± 0.034	1.269PheGln: 1.269 ± 0.035	1.734PheArg: 1.734 ± 0.041	2.747PheSer: 2.747 ± 0.057	2.396PheThr: 2.396 ± 0.048	2.529PheVal: 2.529 ± 0.053	0.473PheTrp: 0.473 ± 0.023	1.273PheTyr: 1.273 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	6.766GlyAla: 6.766 ± 0.137	1.143GlyCys: 1.143 ± 0.034	3.326GlyAsp: 3.326 ± 0.05	4.202GlyGlu: 4.202 ± 0.062	3.121GlyPhe: 3.121 ± 0.054	6.04GlyGly: 6.04 ± 0.12	1.456GlyHis: 1.456 ± 0.034	6.134GlyIle: 6.134 ± 0.071	4.588GlyLys: 4.588 ± 0.071	8.226GlyLeu: 8.226 ± 0.091	2.197GlyMet: 2.197 ± 0.047	2.852GlyAsn: 2.852 ± 0.064	2.194GlyPro: 2.194 ± 0.047	3.356GlyGln: 3.356 ± 0.091	4.336GlyArg: 4.336 ± 0.069	4.361GlySer: 4.361 ± 0.074	4.027GlyThr: 4.027 ± 0.075	5.669GlyVal: 5.669 ± 0.078	0.812GlyTrp: 0.812 ± 0.026	2.793GlyTyr: 2.793 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	1.369HisAla: 1.369 ± 0.031	0.343HisCys: 0.343 ± 0.019	0.87HisAsp: 0.87 ± 0.028	0.939HisGlu: 0.939 ± 0.029	0.791HisPhe: 0.791 ± 0.029	1.397HisGly: 1.397 ± 0.036	0.523HisHis: 0.523 ± 0.022	1.38HisIle: 1.38 ± 0.034	0.876HisLys: 0.876 ± 0.027	1.864HisLeu: 1.864 ± 0.05	0.444HisMet: 0.444 ± 0.015	0.696HisAsn: 0.696 ± 0.024	1.002HisPro: 1.002 ± 0.031	0.797HisGln: 0.797 ± 0.025	0.986HisArg: 0.986 ± 0.031	1.181HisSer: 1.181 ± 0.033	0.995HisThr: 0.995 ± 0.029	1.088HisVal: 1.088 ± 0.031	0.211HisTrp: 0.211 ± 0.012	0.75HisTyr: 0.75 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	7.733IleAla: 7.733 ± 0.086	0.88IleCys: 0.88 ± 0.031	3.914IleAsp: 3.914 ± 0.061	4.245IleGlu: 4.245 ± 0.054	2.475IlePhe: 2.475 ± 0.051	5.559IleGly: 5.559 ± 0.071	1.353IleHis: 1.353 ± 0.036	4.99IleIle: 4.99 ± 0.087	3.764IleLys: 3.764 ± 0.068	6.396IleLeu: 6.396 ± 0.089	1.616IleMet: 1.616 ± 0.037	2.838IleAsn: 2.838 ± 0.051	3.167IlePro: 3.167 ± 0.059	2.243IleGln: 2.243 ± 0.042	3.467IleArg: 3.467 ± 0.057	4.175IleSer: 4.175 ± 0.071	4.123IleThr: 4.123 ± 0.064	5.147IleVal: 5.147 ± 0.074	0.554IleTrp: 0.554 ± 0.023	2.034IleTyr: 2.034 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	4.964LysAla: 4.964 ± 0.069	0.409LysCys: 0.409 ± 0.02	2.365LysAsp: 2.365 ± 0.05	3.466LysGlu: 3.466 ± 0.069	1.6LysPhe: 1.6 ± 0.034	3.072LysGly: 3.072 ± 0.053	0.936LysHis: 0.936 ± 0.029	4.025LysIle: 4.025 ± 0.064	3.25LysLys: 3.25 ± 0.065	5.445LysLeu: 5.445 ± 0.072	1.492LysMet: 1.492 ± 0.034	2.399LysAsn: 2.399 ± 0.046	2.224LysPro: 2.224 ± 0.04	2.489LysGln: 2.489 ± 0.05	2.559LysArg: 2.559 ± 0.043	2.703LysSer: 2.703 ± 0.05	3.158LysThr: 3.158 ± 0.052	3.765LysVal: 3.765 ± 0.063	0.533LysTrp: 0.533 ± 0.023	1.76LysTyr: 1.76 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	11.704LeuAla: 11.704 ± 0.129	1.096LeuCys: 1.096 ± 0.034	4.902LeuAsp: 4.902 ± 0.077	5.97LeuGlu: 5.97 ± 0.09	3.918LeuPhe: 3.918 ± 0.068	7.465LeuGly: 7.465 ± 0.103	1.772LeuHis: 1.772 ± 0.04	6.377LeuIle: 6.377 ± 0.089	5.479LeuLys: 5.479 ± 0.075	11.041LeuLeu: 11.041 ± 0.117	2.399LeuMet: 2.399 ± 0.056	4.155LeuAsn: 4.155 ± 0.063	4.815LeuPro: 4.815 ± 0.062	4.111LeuGln: 4.111 ± 0.067	4.869LeuArg: 4.869 ± 0.059	6.406LeuSer: 6.406 ± 0.089	6.309LeuThr: 6.309 ± 0.099	6.716LeuVal: 6.716 ± 0.075	0.889LeuTrp: 0.889 ± 0.027	2.817LeuTyr: 2.817 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.583MetAla: 2.583 ± 0.045	0.188MetCys: 0.188 ± 0.014	1.228MetAsp: 1.228 ± 0.033	1.427MetGlu: 1.427 ± 0.035	0.778MetPhe: 0.778 ± 0.029	1.726MetGly: 1.726 ± 0.045	0.405MetHis: 0.405 ± 0.019	1.833MetIle: 1.833 ± 0.04	1.498MetLys: 1.498 ± 0.031	2.767MetLeu: 2.767 ± 0.051	0.664MetMet: 0.664 ± 0.024	1.138MetAsn: 1.138 ± 0.028	1.127MetPro: 1.127 ± 0.032	1.059MetGln: 1.059 ± 0.032	1.227MetArg: 1.227 ± 0.033	1.445MetSer: 1.445 ± 0.036	1.44MetThr: 1.44 ± 0.036	1.766MetVal: 1.766 ± 0.039	0.156MetTrp: 0.156 ± 0.012	0.569MetTyr: 0.569 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.173AsnAla: 3.173 ± 0.054	0.5AsnCys: 0.5 ± 0.024	1.729AsnAsp: 1.729 ± 0.042	2.095AsnGlu: 2.095 ± 0.042	1.556AsnPhe: 1.556 ± 0.039	2.792AsnGly: 2.792 ± 0.052	0.808AsnHis: 0.808 ± 0.028	3.177AsnIle: 3.177 ± 0.058	2.071AsnLys: 2.071 ± 0.047	3.735AsnLeu: 3.735 ± 0.065	0.964AsnMet: 0.964 ± 0.028	1.525AsnAsn: 1.525 ± 0.046	1.996AsnPro: 1.996 ± 0.041	1.647AsnGln: 1.647 ± 0.041	2.031AsnArg: 2.031 ± 0.041	2.185AsnSer: 2.185 ± 0.045	2.137AsnThr: 2.137 ± 0.043	2.528AsnVal: 2.528 ± 0.047	0.444AsnTrp: 0.444 ± 0.021	1.354AsnTyr: 1.354 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	4.587ProAla: 4.587 ± 0.098	0.411ProCys: 0.411 ± 0.019	2.445ProAsp: 2.445 ± 0.048	3.212ProGlu: 3.212 ± 0.058	1.625ProPhe: 1.625 ± 0.041	3.561ProGly: 3.561 ± 0.063	0.745ProHis: 0.745 ± 0.028	1.997ProIle: 1.997 ± 0.043	1.584ProLys: 1.584 ± 0.037	3.918ProLeu: 3.918 ± 0.055	0.802ProMet: 0.802 ± 0.025	1.261ProAsn: 1.261 ± 0.038	1.557ProPro: 1.557 ± 0.044	1.567ProGln: 1.567 ± 0.038	1.687ProArg: 1.687 ± 0.045	1.872ProSer: 1.872 ± 0.046	1.695ProThr: 1.695 ± 0.042	3.971ProVal: 3.971 ± 0.06	0.461ProTrp: 0.461 ± 0.018	1.272ProTyr: 1.272 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	4.92GlnAla: 4.92 ± 0.104	0.418GlnCys: 0.418 ± 0.022	1.785GlnAsp: 1.785 ± 0.038	2.698GlnGlu: 2.698 ± 0.06	1.427GlnPhe: 1.427 ± 0.035	2.752GlnGly: 2.752 ± 0.057	0.725GlnHis: 0.725 ± 0.024	2.657GlnIle: 2.657 ± 0.048	2.054GlnLys: 2.054 ± 0.045	4.449GlnLeu: 4.449 ± 0.06	1.041GlnMet: 1.041 ± 0.028	1.591GlnAsn: 1.591 ± 0.041	1.896GlnPro: 1.896 ± 0.043	2.382GlnGln: 2.382 ± 0.057	1.998GlnArg: 1.998 ± 0.047	2.161GlnSer: 2.161 ± 0.048	2.198GlnThr: 2.198 ± 0.048	2.819GlnVal: 2.819 ± 0.055	0.376GlnTrp: 0.376 ± 0.019	1.392GlnTyr: 1.392 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	3.671ArgAla: 3.671 ± 0.062	0.591ArgCys: 0.591 ± 0.027	2.437ArgAsp: 2.437 ± 0.049	3.66ArgGlu: 3.66 ± 0.065	1.946ArgPhe: 1.946 ± 0.045	3.028ArgGly: 3.028 ± 0.048	1.08ArgHis: 1.08 ± 0.031	3.681ArgIle: 3.681 ± 0.052	2.699ArgLys: 2.699 ± 0.042	5.905ArgLeu: 5.905 ± 0.076	1.413ArgMet: 1.413 ± 0.037	2.056ArgAsn: 2.056 ± 0.045	2.117ArgPro: 2.117 ± 0.048	3.109ArgGln: 3.109 ± 0.053	3.12ArgArg: 3.12 ± 0.058	2.612ArgSer: 2.612 ± 0.046	2.421ArgThr: 2.421 ± 0.047	3.19ArgVal: 3.19 ± 0.052	0.525ArgTrp: 0.525 ± 0.022	1.868ArgTyr: 1.868 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.053SerAla: 5.053 ± 0.08	0.668SerCys: 0.668 ± 0.029	2.452SerAsp: 2.452 ± 0.045	2.834SerGlu: 2.834 ± 0.047	2.402SerPhe: 2.402 ± 0.051	5.354SerGly: 5.354 ± 0.103	1.063SerHis: 1.063 ± 0.028	3.737SerIle: 3.737 ± 0.066	2.483SerLys: 2.483 ± 0.046	5.927SerLeu: 5.927 ± 0.077	1.487SerMet: 1.487 ± 0.033	1.902SerAsn: 1.902 ± 0.045	2.231SerPro: 2.231 ± 0.049	2.01SerGln: 2.01 ± 0.045	2.963SerArg: 2.963 ± 0.055	3.395SerSer: 3.395 ± 0.058	2.728SerThr: 2.728 ± 0.048	3.853SerVal: 3.853 ± 0.061	0.591SerTrp: 0.591 ± 0.027	1.809SerTyr: 1.809 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	6.157ThrAla: 6.157 ± 0.083	0.488ThrCys: 0.488 ± 0.022	2.568ThrAsp: 2.568 ± 0.051	2.872ThrGlu: 2.872 ± 0.048	1.866ThrPhe: 1.866 ± 0.041	5.627ThrGly: 5.627 ± 0.141	0.84ThrHis: 0.84 ± 0.027	3.768ThrIle: 3.768 ± 0.064	2.349ThrLys: 2.349 ± 0.042	5.014ThrLeu: 5.014 ± 0.071	1.173ThrMet: 1.173 ± 0.034	1.81ThrAsn: 1.81 ± 0.042	2.398ThrPro: 2.398 ± 0.052	1.543ThrGln: 1.543 ± 0.042	2.208ThrArg: 2.208 ± 0.037	2.615ThrSer: 2.615 ± 0.056	2.819ThrThr: 2.819 ± 0.056	4.866ThrVal: 4.866 ± 0.092	0.414ThrTrp: 0.414 ± 0.019	1.534ThrTyr: 1.534 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	6.868ValAla: 6.868 ± 0.099	0.907ValCys: 0.907 ± 0.024	3.613ValAsp: 3.613 ± 0.065	4.32ValGlu: 4.32 ± 0.062	2.939ValPhe: 2.939 ± 0.056	4.792ValGly: 4.792 ± 0.067	1.243ValHis: 1.243 ± 0.033	5.454ValIle: 5.454 ± 0.078	4.023ValLys: 4.023 ± 0.068	7.639ValLeu: 7.639 ± 0.085	1.958ValMet: 1.958 ± 0.041	3.088ValAsn: 3.088 ± 0.051	2.811ValPro: 2.811 ± 0.051	2.52ValGln: 2.52 ± 0.051	3.621ValArg: 3.621 ± 0.054	4.425ValSer: 4.425 ± 0.071	4.174ValThr: 4.174 ± 0.065	5.636ValVal: 5.636 ± 0.083	0.643ValTrp: 0.643 ± 0.026	2.284ValTyr: 2.284 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.665TrpAla: 0.665 ± 0.023	0.097TrpCys: 0.097 ± 0.01	0.47TrpAsp: 0.47 ± 0.019	0.558TrpGlu: 0.558 ± 0.022	0.37TrpPhe: 0.37 ± 0.019	0.726TrpGly: 0.726 ± 0.027	0.189TrpHis: 0.189 ± 0.012	0.566TrpIle: 0.566 ± 0.022	0.494TrpLys: 0.494 ± 0.024	1.287TrpLeu: 1.287 ± 0.044	0.215TrpMet: 0.215 ± 0.014	0.45TrpAsn: 0.45 ± 0.019	0.402TrpPro: 0.402 ± 0.02	0.596TrpGln: 0.596 ± 0.023	0.651TrpArg: 0.651 ± 0.026	0.546TrpSer: 0.546 ± 0.022	0.423TrpThr: 0.423 ± 0.017	0.581TrpVal: 0.581 ± 0.023	0.134TrpTrp: 0.134 ± 0.01	0.298TrpTyr: 0.298 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.594TyrAla: 2.594 ± 0.052	0.468TyrCys: 0.468 ± 0.021	1.769TyrAsp: 1.769 ± 0.054	1.698TyrGlu: 1.698 ± 0.037	1.423TyrPhe: 1.423 ± 0.037	2.545TyrGly: 2.545 ± 0.042	0.768TyrHis: 0.768 ± 0.027	2.058TyrIle: 2.058 ± 0.046	1.364TyrLys: 1.364 ± 0.034	3.466TyrLeu: 3.466 ± 0.051	0.621TyrMet: 0.621 ± 0.023	1.143TyrAsn: 1.143 ± 0.031	1.427TyrPro: 1.427 ± 0.034	1.608TyrGln: 1.608 ± 0.043	2.024TyrArg: 2.024 ± 0.046	1.957TyrSer: 1.957 ± 0.048	1.751TyrThr: 1.751 ± 0.038	1.853TyrVal: 1.853 ± 0.041	0.406TyrTrp: 0.406 ± 0.02	1.217TyrTyr: 1.217 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3747 proteins (1190279 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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