Amino acid dipepetide frequency for Ascidiaceihabitans donghaensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.565AlaAla: 14.565 ± 0.161	1.169AlaCys: 1.169 ± 0.033	7.144AlaAsp: 7.144 ± 0.087	6.431AlaGlu: 6.431 ± 0.094	4.419AlaPhe: 4.419 ± 0.061	9.735AlaGly: 9.735 ± 0.107	2.437AlaHis: 2.437 ± 0.05	5.653AlaIle: 5.653 ± 0.074	4.495AlaLys: 4.495 ± 0.075	12.524AlaLeu: 12.524 ± 0.142	3.825AlaMet: 3.825 ± 0.054	3.039AlaAsn: 3.039 ± 0.05	5.391AlaPro: 5.391 ± 0.088	5.115AlaGln: 5.115 ± 0.068	6.75AlaArg: 6.75 ± 0.088	5.972AlaSer: 5.972 ± 0.083	6.222AlaThr: 6.222 ± 0.073	8.028AlaVal: 8.028 ± 0.112	1.446AlaTrp: 1.446 ± 0.034	2.511AlaTyr: 2.511 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.188CysAla: 1.188 ± 0.033	0.113CysCys: 0.113 ± 0.009	0.663CysAsp: 0.663 ± 0.026	0.452CysGlu: 0.452 ± 0.018	0.359CysPhe: 0.359 ± 0.016	0.934CysGly: 0.934 ± 0.028	0.292CysHis: 0.292 ± 0.017	0.475CysIle: 0.475 ± 0.021	0.286CysLys: 0.286 ± 0.015	0.828CysLeu: 0.828 ± 0.029	0.201CysMet: 0.201 ± 0.012	0.259CysAsn: 0.259 ± 0.015	0.509CysPro: 0.509 ± 0.02	0.271CysGln: 0.271 ± 0.016	0.436CysArg: 0.436 ± 0.021	0.45CysSer: 0.45 ± 0.021	0.53CysThr: 0.53 ± 0.024	0.806CysVal: 0.806 ± 0.028	0.106CysTrp: 0.106 ± 0.011	0.247CysTyr: 0.247 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.34AspAla: 8.34 ± 0.092	0.539AspCys: 0.539 ± 0.024	4.003AspAsp: 4.003 ± 0.095	3.241AspGlu: 3.241 ± 0.049	2.523AspPhe: 2.523 ± 0.051	5.803AspGly: 5.803 ± 0.099	1.53AspHis: 1.53 ± 0.04	3.497AspIle: 3.497 ± 0.052	1.973AspLys: 1.973 ± 0.042	6.408AspLeu: 6.408 ± 0.068	2.047AspMet: 2.047 ± 0.04	1.632AspAsn: 1.632 ± 0.051	3.435AspPro: 3.435 ± 0.056	2.179AspGln: 2.179 ± 0.044	3.723AspArg: 3.723 ± 0.056	2.251AspSer: 2.251 ± 0.052	3.918AspThr: 3.918 ± 0.098	5.531AspVal: 5.531 ± 0.069	1.103AspTrp: 1.103 ± 0.029	1.543AspTyr: 1.543 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	6.545GluAla: 6.545 ± 0.088	0.352GluCys: 0.352 ± 0.02	3.387GluAsp: 3.387 ± 0.063	2.764GluGlu: 2.764 ± 0.055	1.757GluPhe: 1.757 ± 0.041	4.206GluGly: 4.206 ± 0.069	1.122GluHis: 1.122 ± 0.032	3.206GluIle: 3.206 ± 0.054	2.207GluLys: 2.207 ± 0.048	4.583GluLeu: 4.583 ± 0.067	1.825GluMet: 1.825 ± 0.04	1.964GluAsn: 1.964 ± 0.042	2.075GluPro: 2.075 ± 0.045	1.814GluGln: 1.814 ± 0.039	3.311GluArg: 3.311 ± 0.064	1.91GluSer: 1.91 ± 0.042	3.726GluThr: 3.726 ± 0.052	3.768GluVal: 3.768 ± 0.052	0.671GluTrp: 0.671 ± 0.024	1.037GluTyr: 1.037 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.573PheAla: 4.573 ± 0.064	0.486PheCys: 0.486 ± 0.022	3.193PheAsp: 3.193 ± 0.045	2.416PheGlu: 2.416 ± 0.04	1.54PhePhe: 1.54 ± 0.038	3.889PheGly: 3.889 ± 0.06	0.785PheHis: 0.785 ± 0.025	1.738PheIle: 1.738 ± 0.043	1.285PheLys: 1.285 ± 0.04	3.361PheLeu: 3.361 ± 0.055	1.005PheMet: 1.005 ± 0.031	1.206PheAsn: 1.206 ± 0.027	1.528PhePro: 1.528 ± 0.033	1.222PheGln: 1.222 ± 0.024	1.855PheArg: 1.855 ± 0.035	2.357PheSer: 2.357 ± 0.047	2.203PheThr: 2.203 ± 0.048	2.959PheVal: 2.959 ± 0.046	0.623PheTrp: 0.623 ± 0.023	0.987PheTyr: 0.987 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	9.559GlyAla: 9.559 ± 0.105	0.875GlyCys: 0.875 ± 0.031	5.121GlyAsp: 5.121 ± 0.113	3.935GlyGlu: 3.935 ± 0.066	3.829GlyPhe: 3.829 ± 0.067	7.41GlyGly: 7.41 ± 0.138	2.02GlyHis: 2.02 ± 0.043	4.45GlyIle: 4.45 ± 0.061	3.32GlyLys: 3.32 ± 0.055	8.575GlyLeu: 8.575 ± 0.11	2.571GlyMet: 2.571 ± 0.045	2.533GlyAsn: 2.533 ± 0.091	3.449GlyPro: 3.449 ± 0.052	3.249GlyGln: 3.249 ± 0.049	4.913GlyArg: 4.913 ± 0.074	4.262GlySer: 4.262 ± 0.071	5.05GlyThr: 5.05 ± 0.115	6.504GlyVal: 6.504 ± 0.084	1.374GlyTrp: 1.374 ± 0.03	2.318GlyTyr: 2.318 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.422HisAla: 2.422 ± 0.044	0.249HisCys: 0.249 ± 0.013	1.385HisAsp: 1.385 ± 0.035	0.979HisGlu: 0.979 ± 0.028	0.926HisPhe: 0.926 ± 0.029	1.946HisGly: 1.946 ± 0.044	0.604HisHis: 0.604 ± 0.027	1.174HisIle: 1.174 ± 0.031	0.724HisLys: 0.724 ± 0.021	2.179HisLeu: 2.179 ± 0.047	0.661HisMet: 0.661 ± 0.024	0.574HisAsn: 0.574 ± 0.022	1.365HisPro: 1.365 ± 0.038	0.632HisGln: 0.632 ± 0.025	1.214HisArg: 1.214 ± 0.031	1.064HisSer: 1.064 ± 0.032	1.064HisThr: 1.064 ± 0.028	1.636HisVal: 1.636 ± 0.035	0.361HisTrp: 0.361 ± 0.016	0.587HisTyr: 0.587 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.658IleAla: 6.658 ± 0.078	0.591IleCys: 0.591 ± 0.02	3.662IleAsp: 3.662 ± 0.059	3.569IleGlu: 3.569 ± 0.059	1.871IlePhe: 1.871 ± 0.043	4.838IleGly: 4.838 ± 0.067	0.944IleHis: 0.944 ± 0.028	2.475IleIle: 2.475 ± 0.05	1.871IleLys: 1.871 ± 0.038	4.615IleLeu: 4.615 ± 0.066	1.266IleMet: 1.266 ± 0.034	1.633IleAsn: 1.633 ± 0.043	2.258IlePro: 2.258 ± 0.05	1.365IleGln: 1.365 ± 0.035	2.656IleArg: 2.656 ± 0.042	3.132IleSer: 3.132 ± 0.048	3.231IleThr: 3.231 ± 0.052	3.94IleVal: 3.94 ± 0.064	0.786IleTrp: 0.786 ± 0.024	1.217IleTyr: 1.217 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.498LysAla: 4.498 ± 0.072	0.245LysCys: 0.245 ± 0.013	2.371LysAsp: 2.371 ± 0.038	1.6LysGlu: 1.6 ± 0.045	1.191LysPhe: 1.191 ± 0.033	3.17LysGly: 3.17 ± 0.057	0.806LysHis: 0.806 ± 0.029	1.926LysIle: 1.926 ± 0.044	1.416LysLys: 1.416 ± 0.04	3.272LysLeu: 3.272 ± 0.051	1.129LysMet: 1.129 ± 0.033	1.08LysAsn: 1.08 ± 0.031	2.01LysPro: 2.01 ± 0.051	1.139LysGln: 1.139 ± 0.028	2.528LysArg: 2.528 ± 0.046	2.162LysSer: 2.162 ± 0.042	2.497LysThr: 2.497 ± 0.05	2.521LysVal: 2.521 ± 0.053	0.471LysTrp: 0.471 ± 0.019	0.781LysTyr: 0.781 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	11.064LeuAla: 11.064 ± 0.104	0.998LeuCys: 0.998 ± 0.036	6.066LeuAsp: 6.066 ± 0.075	4.889LeuGlu: 4.889 ± 0.073	3.486LeuPhe: 3.486 ± 0.056	8.012LeuGly: 8.012 ± 0.093	1.947LeuHis: 1.947 ± 0.038	5.045LeuIle: 5.045 ± 0.08	3.577LeuLys: 3.577 ± 0.055	7.893LeuLeu: 7.893 ± 0.107	2.817LeuMet: 2.817 ± 0.049	3.167LeuAsn: 3.167 ± 0.059	5.03LeuPro: 5.03 ± 0.078	3.137LeuGln: 3.137 ± 0.047	6.2LeuArg: 6.2 ± 0.081	6.393LeuSer: 6.393 ± 0.07	6.004LeuThr: 6.004 ± 0.083	6.411LeuVal: 6.411 ± 0.082	1.248LeuTrp: 1.248 ± 0.033	1.92LeuTyr: 1.92 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.506MetAla: 3.506 ± 0.055	0.259MetCys: 0.259 ± 0.014	1.713MetAsp: 1.713 ± 0.037	1.36MetGlu: 1.36 ± 0.033	0.937MetPhe: 0.937 ± 0.026	2.526MetGly: 2.526 ± 0.054	0.565MetHis: 0.565 ± 0.021	1.686MetIle: 1.686 ± 0.042	1.266MetLys: 1.266 ± 0.034	2.643MetLeu: 2.643 ± 0.048	0.909MetMet: 0.909 ± 0.031	0.968MetAsn: 0.968 ± 0.031	1.578MetPro: 1.578 ± 0.037	1.267MetGln: 1.267 ± 0.029	1.98MetArg: 1.98 ± 0.038	1.959MetSer: 1.959 ± 0.041	2.265MetThr: 2.265 ± 0.042	1.962MetVal: 1.962 ± 0.041	0.295MetTrp: 0.295 ± 0.016	0.414MetTyr: 0.414 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.729AsnAla: 3.729 ± 0.06	0.311AsnCys: 0.311 ± 0.016	2.014AsnAsp: 2.014 ± 0.085	1.356AsnGlu: 1.356 ± 0.036	1.137AsnPhe: 1.137 ± 0.029	2.859AsnGly: 2.859 ± 0.07	0.602AsnHis: 0.602 ± 0.022	1.661AsnIle: 1.661 ± 0.041	0.933AsnLys: 0.933 ± 0.034	2.741AsnLeu: 2.741 ± 0.05	0.849AsnMet: 0.849 ± 0.026	0.948AsnAsn: 0.948 ± 0.037	1.944AsnPro: 1.944 ± 0.042	0.889AsnGln: 0.889 ± 0.029	1.755AsnArg: 1.755 ± 0.039	1.426AsnSer: 1.426 ± 0.049	1.796AsnThr: 1.796 ± 0.041	2.152AsnVal: 2.152 ± 0.054	0.501AsnTrp: 0.501 ± 0.02	0.732AsnTyr: 0.732 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	5.026ProAla: 5.026 ± 0.066	0.356ProCys: 0.356 ± 0.017	3.916ProAsp: 3.916 ± 0.071	3.295ProGlu: 3.295 ± 0.063	2.036ProPhe: 2.036 ± 0.046	3.521ProGly: 3.521 ± 0.054	1.102ProHis: 1.102 ± 0.031	2.26ProIle: 2.26 ± 0.045	2.09ProLys: 2.09 ± 0.053	4.304ProLeu: 4.304 ± 0.055	1.424ProMet: 1.424 ± 0.033	1.621ProAsn: 1.621 ± 0.038	1.858ProPro: 1.858 ± 0.043	1.807ProGln: 1.807 ± 0.044	2.378ProArg: 2.378 ± 0.046	2.674ProSer: 2.674 ± 0.048	2.56ProThr: 2.56 ± 0.048	3.938ProVal: 3.938 ± 0.06	0.616ProTrp: 0.616 ± 0.021	1.131ProTyr: 1.131 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.368GlnAla: 4.368 ± 0.072	0.246GlnCys: 0.246 ± 0.014	2.198GlnAsp: 2.198 ± 0.048	1.518GlnGlu: 1.518 ± 0.031	1.251GlnPhe: 1.251 ± 0.032	2.802GlnGly: 2.802 ± 0.053	0.711GlnHis: 0.711 ± 0.027	2.231GlnIle: 2.231 ± 0.045	1.347GlnLys: 1.347 ± 0.033	3.014GlnLeu: 3.014 ± 0.054	1.26GlnMet: 1.26 ± 0.034	1.297GlnAsn: 1.297 ± 0.031	1.577GlnPro: 1.577 ± 0.038	1.213GlnGln: 1.213 ± 0.036	2.113GlnArg: 2.113 ± 0.044	2.249GlnSer: 2.249 ± 0.038	2.345GlnThr: 2.345 ± 0.044	2.41GlnVal: 2.41 ± 0.045	0.45GlnTrp: 0.45 ± 0.02	0.675GlnTyr: 0.675 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	6.299ArgAla: 6.299 ± 0.073	0.468ArgCys: 0.468 ± 0.02	3.996ArgAsp: 3.996 ± 0.049	2.982ArgGlu: 2.982 ± 0.056	2.549ArgPhe: 2.549 ± 0.049	3.869ArgGly: 3.869 ± 0.064	1.399ArgHis: 1.399 ± 0.035	3.363ArgIle: 3.363 ± 0.059	2.475ArgLys: 2.475 ± 0.045	5.997ArgLeu: 5.997 ± 0.098	1.872ArgMet: 1.872 ± 0.033	1.757ArgAsn: 1.757 ± 0.037	2.729ArgPro: 2.729 ± 0.053	2.064ArgGln: 2.064 ± 0.039	3.773ArgArg: 3.773 ± 0.074	3.054ArgSer: 3.054 ± 0.048	2.892ArgThr: 2.892 ± 0.05	4.254ArgVal: 4.254 ± 0.065	0.844ArgTrp: 0.844 ± 0.028	1.429ArgTyr: 1.429 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	5.83SerAla: 5.83 ± 0.077	0.495SerCys: 0.495 ± 0.022	3.8SerAsp: 3.8 ± 0.05	2.803SerGlu: 2.803 ± 0.053	2.41SerPhe: 2.41 ± 0.047	5.503SerGly: 5.503 ± 0.082	1.146SerHis: 1.146 ± 0.033	2.754SerIle: 2.754 ± 0.06	1.991SerLys: 1.991 ± 0.04	4.965SerLeu: 4.965 ± 0.062	1.591SerMet: 1.591 ± 0.041	1.687SerAsn: 1.687 ± 0.037	2.4SerPro: 2.4 ± 0.049	1.761SerGln: 1.761 ± 0.043	2.909SerArg: 2.909 ± 0.055	2.762SerSer: 2.762 ± 0.054	2.864SerThr: 2.864 ± 0.06	4.019SerVal: 4.019 ± 0.055	0.632SerTrp: 0.632 ± 0.023	1.441SerTyr: 1.441 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.383ThrAla: 6.383 ± 0.091	0.548ThrCys: 0.548 ± 0.022	3.602ThrAsp: 3.602 ± 0.058	2.837ThrGlu: 2.837 ± 0.055	2.269ThrPhe: 2.269 ± 0.045	5.491ThrGly: 5.491 ± 0.087	1.401ThrHis: 1.401 ± 0.032	3.039ThrIle: 3.039 ± 0.07	1.963ThrLys: 1.963 ± 0.042	6.346ThrLeu: 6.346 ± 0.08	1.494ThrMet: 1.494 ± 0.036	1.636ThrAsn: 1.636 ± 0.05	3.493ThrPro: 3.493 ± 0.056	2.301ThrGln: 2.301 ± 0.042	3.317ThrArg: 3.317 ± 0.052	3.208ThrSer: 3.208 ± 0.063	3.237ThrThr: 3.237 ± 0.075	4.532ThrVal: 4.532 ± 0.088	0.792ThrTrp: 0.792 ± 0.028	1.451ThrTyr: 1.451 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	8.341ValAla: 8.341 ± 0.091	0.725ValCys: 0.725 ± 0.022	4.439ValAsp: 4.439 ± 0.071	3.976ValGlu: 3.976 ± 0.061	3.136ValPhe: 3.136 ± 0.055	5.533ValGly: 5.533 ± 0.079	1.45ValHis: 1.45 ± 0.039	4.196ValIle: 4.196 ± 0.066	2.386ValLys: 2.386 ± 0.055	7.392ValLeu: 7.392 ± 0.1	2.321ValMet: 2.321 ± 0.043	2.142ValAsn: 2.142 ± 0.053	3.583ValPro: 3.583 ± 0.052	2.586ValGln: 2.586 ± 0.05	3.969ValArg: 3.969 ± 0.061	4.481ValSer: 4.481 ± 0.063	4.808ValThr: 4.808 ± 0.069	5.856ValVal: 5.856 ± 0.084	1.007ValTrp: 1.007 ± 0.03	1.502ValTyr: 1.502 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.386TrpAla: 1.386 ± 0.035	0.151TrpCys: 0.151 ± 0.01	0.877TrpAsp: 0.877 ± 0.03	0.596TrpGlu: 0.596 ± 0.022	0.589TrpPhe: 0.589 ± 0.022	1.056TrpGly: 1.056 ± 0.032	0.367TrpHis: 0.367 ± 0.019	0.709TrpIle: 0.709 ± 0.026	0.467TrpLys: 0.467 ± 0.017	1.498TrpLeu: 1.498 ± 0.037	0.467TrpMet: 0.467 ± 0.019	0.482TrpAsn: 0.482 ± 0.02	0.659TrpPro: 0.659 ± 0.023	0.553TrpGln: 0.553 ± 0.024	0.939TrpArg: 0.939 ± 0.034	0.8TrpSer: 0.8 ± 0.023	0.813TrpThr: 0.813 ± 0.026	0.996TrpVal: 0.996 ± 0.028	0.224TrpTrp: 0.224 ± 0.016	0.286TrpTyr: 0.286 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.59TyrAla: 2.59 ± 0.044	0.227TyrCys: 0.227 ± 0.013	1.668TyrAsp: 1.668 ± 0.037	1.23TyrGlu: 1.23 ± 0.032	0.998TyrPhe: 0.998 ± 0.03	2.215TyrGly: 2.215 ± 0.042	0.517TyrHis: 0.517 ± 0.019	1.04TyrIle: 1.04 ± 0.026	0.748TyrLys: 0.748 ± 0.026	2.169TyrLeu: 2.169 ± 0.046	0.525TyrMet: 0.525 ± 0.019	0.71TyrAsn: 0.71 ± 0.023	1.042TyrPro: 1.042 ± 0.028	0.707TyrGln: 0.707 ± 0.025	1.347TyrArg: 1.347 ± 0.034	1.196TyrSer: 1.196 ± 0.036	1.315TyrThr: 1.315 ± 0.038	1.604TyrVal: 1.604 ± 0.036	0.363TyrTrp: 0.363 ± 0.019	0.606TyrTyr: 0.606 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4027 proteins (1246692 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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