Amino acid dipepetide frequency for Dyadobacter jejuensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.819AlaAla: 5.819 ± 0.086	0.676AlaCys: 0.676 ± 0.026	4.179AlaAsp: 4.179 ± 0.055	4.297AlaGlu: 4.297 ± 0.05	3.369AlaPhe: 3.369 ± 0.049	5.559AlaGly: 5.559 ± 0.073	1.474AlaHis: 1.474 ± 0.03	5.007AlaIle: 5.007 ± 0.068	4.025AlaLys: 4.025 ± 0.057	7.593AlaLeu: 7.593 ± 0.083	1.902AlaMet: 1.902 ± 0.041	3.406AlaAsn: 3.406 ± 0.05	2.804AlaPro: 2.804 ± 0.041	3.48AlaGln: 3.48 ± 0.047	2.734AlaArg: 2.734 ± 0.049	5.088AlaSer: 5.088 ± 0.057	4.285AlaThr: 4.285 ± 0.07	4.521AlaVal: 4.521 ± 0.054	0.917AlaTrp: 0.917 ± 0.025	3.056AlaTyr: 3.056 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.477CysAla: 0.477 ± 0.02	0.101CysCys: 0.101 ± 0.008	0.385CysAsp: 0.385 ± 0.017	0.405CysGlu: 0.405 ± 0.017	0.375CysPhe: 0.375 ± 0.014	0.584CysGly: 0.584 ± 0.021	0.217CysHis: 0.217 ± 0.012	0.487CysIle: 0.487 ± 0.019	0.392CysLys: 0.392 ± 0.015	0.741CysLeu: 0.741 ± 0.022	0.182CysMet: 0.182 ± 0.01	0.342CysAsn: 0.342 ± 0.014	0.327CysPro: 0.327 ± 0.017	0.314CysGln: 0.314 ± 0.013	0.302CysArg: 0.302 ± 0.012	0.538CysSer: 0.538 ± 0.02	0.428CysThr: 0.428 ± 0.015	0.427CysVal: 0.427 ± 0.016	0.096CysTrp: 0.096 ± 0.008	0.304CysTyr: 0.304 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.838AspAla: 3.838 ± 0.045	0.367AspCys: 0.367 ± 0.016	2.51AspAsp: 2.51 ± 0.041	2.96AspGlu: 2.96 ± 0.04	3.061AspPhe: 3.061 ± 0.051	4.214AspGly: 4.214 ± 0.065	1.187AspHis: 1.187 ± 0.03	3.624AspIle: 3.624 ± 0.051	3.099AspLys: 3.099 ± 0.052	5.685AspLeu: 5.685 ± 0.058	1.222AspMet: 1.222 ± 0.027	2.257AspAsn: 2.257 ± 0.042	2.546AspPro: 2.546 ± 0.043	2.436AspGln: 2.436 ± 0.034	2.756AspArg: 2.756 ± 0.041	3.137AspSer: 3.137 ± 0.047	2.584AspThr: 2.584 ± 0.039	3.013AspVal: 3.013 ± 0.046	0.887AspTrp: 0.887 ± 0.024	2.541AspTyr: 2.541 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	4.884GluAla: 4.884 ± 0.057	0.327GluCys: 0.327 ± 0.013	2.806GluAsp: 2.806 ± 0.038	3.852GluGlu: 3.852 ± 0.062	2.234GluPhe: 2.234 ± 0.038	3.999GluGly: 3.999 ± 0.05	1.051GluHis: 1.051 ± 0.026	4.118GluIle: 4.118 ± 0.053	4.297GluLys: 4.297 ± 0.056	5.805GluLeu: 5.805 ± 0.062	1.578GluMet: 1.578 ± 0.029	3.079GluAsn: 3.079 ± 0.045	1.94GluPro: 1.94 ± 0.039	2.445GluGln: 2.445 ± 0.043	2.892GluArg: 2.892 ± 0.047	3.432GluSer: 3.432 ± 0.043	2.893GluThr: 2.893 ± 0.04	4.198GluVal: 4.198 ± 0.055	0.764GluTrp: 0.764 ± 0.021	2.086GluTyr: 2.086 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.004PheAla: 3.004 ± 0.047	0.425PheCys: 0.425 ± 0.015	2.945PheAsp: 2.945 ± 0.039	2.84PheGlu: 2.84 ± 0.042	2.277PhePhe: 2.277 ± 0.045	3.509PheGly: 3.509 ± 0.05	0.799PheHis: 0.799 ± 0.022	2.916PheIle: 2.916 ± 0.045	2.599PheLys: 2.599 ± 0.044	4.436PheLeu: 4.436 ± 0.064	1.15PheMet: 1.15 ± 0.026	2.382PheAsn: 2.382 ± 0.039	1.827PhePro: 1.827 ± 0.032	1.72PheGln: 1.72 ± 0.031	2.01PheArg: 2.01 ± 0.037	3.517PheSer: 3.517 ± 0.048	2.802PheThr: 2.802 ± 0.042	2.931PheVal: 2.931 ± 0.043	0.638PheTrp: 0.638 ± 0.024	1.862PheTyr: 1.862 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	5.091GlyAla: 5.091 ± 0.065	0.644GlyCys: 0.644 ± 0.02	3.49GlyAsp: 3.49 ± 0.05	3.627GlyGlu: 3.627 ± 0.05	3.512GlyPhe: 3.512 ± 0.046	5.221GlyGly: 5.221 ± 0.064	1.459GlyHis: 1.459 ± 0.031	5.158GlyIle: 5.158 ± 0.058	4.821GlyLys: 4.821 ± 0.059	7.022GlyLeu: 7.022 ± 0.07	1.91GlyMet: 1.91 ± 0.036	3.475GlyAsn: 3.475 ± 0.055	2.058GlyPro: 2.058 ± 0.036	2.956GlyGln: 2.956 ± 0.042	3.054GlyArg: 3.054 ± 0.044	4.916GlySer: 4.916 ± 0.065	4.477GlyThr: 4.477 ± 0.057	4.965GlyVal: 4.965 ± 0.061	1.097GlyTrp: 1.097 ± 0.029	3.303GlyTyr: 3.303 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.258HisAla: 1.258 ± 0.031	0.184HisCys: 0.184 ± 0.011	0.925HisAsp: 0.925 ± 0.023	0.973HisGlu: 0.973 ± 0.027	1.19HisPhe: 1.19 ± 0.028	1.332HisGly: 1.332 ± 0.028	0.611HisHis: 0.611 ± 0.02	1.374HisIle: 1.374 ± 0.03	0.918HisLys: 0.918 ± 0.023	2.038HisLeu: 2.038 ± 0.038	0.439HisMet: 0.439 ± 0.016	0.825HisAsn: 0.825 ± 0.024	1.132HisPro: 1.132 ± 0.028	1.029HisGln: 1.029 ± 0.026	0.982HisArg: 0.982 ± 0.023	1.203HisSer: 1.203 ± 0.028	1.101HisThr: 1.101 ± 0.027	0.963HisVal: 0.963 ± 0.024	0.33HisTrp: 0.33 ± 0.015	0.951HisTyr: 0.951 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.179IleAla: 5.179 ± 0.066	0.614IleCys: 0.614 ± 0.019	4.056IleAsp: 4.056 ± 0.046	4.099IleGlu: 4.099 ± 0.057	2.808IlePhe: 2.808 ± 0.052	4.944IleGly: 4.944 ± 0.067	1.355IleHis: 1.355 ± 0.027	4.019IleIle: 4.019 ± 0.064	3.772IleLys: 3.772 ± 0.045	6.082IleLeu: 6.082 ± 0.066	1.244IleMet: 1.244 ± 0.027	3.202IleAsn: 3.202 ± 0.053	3.186IlePro: 3.186 ± 0.045	2.621IleGln: 2.621 ± 0.042	3.236IleArg: 3.236 ± 0.045	4.603IleSer: 4.603 ± 0.063	3.872IleThr: 3.872 ± 0.057	3.988IleVal: 3.988 ± 0.063	0.806IleTrp: 0.806 ± 0.022	2.358IleTyr: 2.358 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.725LysAla: 4.725 ± 0.062	0.268LysCys: 0.268 ± 0.014	3.437LysAsp: 3.437 ± 0.049	4.291LysGlu: 4.291 ± 0.06	2.095LysPhe: 2.095 ± 0.04	4.418LysGly: 4.418 ± 0.059	1.074LysHis: 1.074 ± 0.027	4.123LysIle: 4.123 ± 0.051	4.44LysLys: 4.44 ± 0.064	5.339LysLeu: 5.339 ± 0.068	1.623LysMet: 1.623 ± 0.028	3.432LysAsn: 3.432 ± 0.05	2.5LysPro: 2.5 ± 0.045	2.13LysGln: 2.13 ± 0.036	2.692LysArg: 2.692 ± 0.041	3.692LysSer: 3.692 ± 0.049	3.526LysThr: 3.526 ± 0.051	3.992LysVal: 3.992 ± 0.05	0.814LysTrp: 0.814 ± 0.024	2.32LysTyr: 2.32 ± 0.04	0.0LysXaa: 0.0 ± 0.0
Leu	7.543LeuAla: 7.543 ± 0.092	0.771LeuCys: 0.771 ± 0.025	4.991LeuAsp: 4.991 ± 0.054	5.651LeuGlu: 5.651 ± 0.062	4.551LeuPhe: 4.551 ± 0.064	6.689LeuGly: 6.689 ± 0.065	1.812LeuHis: 1.812 ± 0.039	5.986LeuIle: 5.986 ± 0.073	6.442LeuLys: 6.442 ± 0.067	10.23LeuLeu: 10.23 ± 0.124	2.395LeuMet: 2.395 ± 0.042	4.822LeuAsn: 4.822 ± 0.063	4.565LeuPro: 4.565 ± 0.05	3.931LeuGln: 3.931 ± 0.055	4.162LeuArg: 4.162 ± 0.042	7.277LeuSer: 7.277 ± 0.067	5.742LeuThr: 5.742 ± 0.055	6.11LeuVal: 6.11 ± 0.065	1.16LeuTrp: 1.16 ± 0.03	3.426LeuTyr: 3.426 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.259MetAla: 2.259 ± 0.038	0.121MetCys: 0.121 ± 0.008	1.407MetAsp: 1.407 ± 0.031	1.537MetGlu: 1.537 ± 0.031	0.748MetPhe: 0.748 ± 0.022	1.837MetGly: 1.837 ± 0.037	0.455MetHis: 0.455 ± 0.018	1.447MetIle: 1.447 ± 0.033	1.87MetLys: 1.87 ± 0.03	2.197MetLeu: 2.197 ± 0.04	0.628MetMet: 0.628 ± 0.018	1.232MetAsn: 1.232 ± 0.026	1.073MetPro: 1.073 ± 0.024	0.88MetGln: 0.88 ± 0.023	1.016MetArg: 1.016 ± 0.025	1.405MetSer: 1.405 ± 0.026	1.247MetThr: 1.247 ± 0.028	1.707MetVal: 1.707 ± 0.041	0.191MetTrp: 0.191 ± 0.013	0.699MetTyr: 0.699 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.316AsnAla: 3.316 ± 0.049	0.321AsnCys: 0.321 ± 0.015	2.461AsnAsp: 2.461 ± 0.044	2.599AsnGlu: 2.599 ± 0.043	2.36AsnPhe: 2.36 ± 0.043	3.793AsnGly: 3.793 ± 0.062	0.97AsnHis: 0.97 ± 0.026	3.359AsnIle: 3.359 ± 0.049	2.836AsnLys: 2.836 ± 0.043	4.641AsnLeu: 4.641 ± 0.051	1.095AsnMet: 1.095 ± 0.026	2.59AsnAsn: 2.59 ± 0.05	2.711AsnPro: 2.711 ± 0.043	2.146AsnGln: 2.146 ± 0.036	2.56AsnArg: 2.56 ± 0.046	3.102AsnSer: 3.102 ± 0.049	2.99AsnThr: 2.99 ± 0.054	2.676AsnVal: 2.676 ± 0.044	0.742AsnTrp: 0.742 ± 0.022	2.18AsnTyr: 2.18 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	3.105ProAla: 3.105 ± 0.049	0.231ProCys: 0.231 ± 0.012	2.702ProAsp: 2.702 ± 0.043	3.033ProGlu: 3.033 ± 0.038	2.013ProPhe: 2.013 ± 0.039	2.858ProGly: 2.858 ± 0.042	0.878ProHis: 0.878 ± 0.025	2.818ProIle: 2.818 ± 0.047	2.278ProLys: 2.278 ± 0.043	3.699ProLeu: 3.699 ± 0.054	0.994ProMet: 0.994 ± 0.023	2.227ProAsn: 2.227 ± 0.038	1.175ProPro: 1.175 ± 0.036	1.598ProGln: 1.598 ± 0.034	1.349ProArg: 1.349 ± 0.031	2.899ProSer: 2.899 ± 0.046	2.646ProThr: 2.646 ± 0.043	2.962ProVal: 2.962 ± 0.042	0.522ProTrp: 0.522 ± 0.02	1.753ProTyr: 1.753 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	3.27GlnAla: 3.27 ± 0.047	0.198GlnCys: 0.198 ± 0.012	1.964GlnAsp: 1.964 ± 0.038	2.695GlnGlu: 2.695 ± 0.042	1.759GlnPhe: 1.759 ± 0.033	2.739GlnGly: 2.739 ± 0.044	0.814GlnHis: 0.814 ± 0.022	2.755GlnIle: 2.755 ± 0.04	2.8GlnLys: 2.8 ± 0.047	3.959GlnLeu: 3.959 ± 0.064	1.005GlnMet: 1.005 ± 0.025	2.107GlnAsn: 2.107 ± 0.041	1.629GlnPro: 1.629 ± 0.033	2.192GlnGln: 2.192 ± 0.039	1.85GlnArg: 1.85 ± 0.035	2.455GlnSer: 2.455 ± 0.041	2.179GlnThr: 2.179 ± 0.044	2.736GlnVal: 2.736 ± 0.042	0.569GlnTrp: 0.569 ± 0.022	1.764GlnTyr: 1.764 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.889ArgAla: 2.889 ± 0.045	0.27ArgCys: 0.27 ± 0.013	2.017ArgAsp: 2.017 ± 0.034	2.464ArgGlu: 2.464 ± 0.044	2.329ArgPhe: 2.329 ± 0.036	2.518ArgGly: 2.518 ± 0.043	0.86ArgHis: 0.86 ± 0.023	3.265ArgIle: 3.265 ± 0.044	2.798ArgLys: 2.798 ± 0.041	4.67ArgLeu: 4.67 ± 0.052	1.22ArgMet: 1.22 ± 0.027	2.338ArgAsn: 2.338 ± 0.04	1.751ArgPro: 1.751 ± 0.033	1.929ArgGln: 1.929 ± 0.034	1.982ArgArg: 1.982 ± 0.032	2.733ArgSer: 2.733 ± 0.042	2.385ArgThr: 2.385 ± 0.04	2.867ArgVal: 2.867 ± 0.038	0.658ArgTrp: 0.658 ± 0.02	2.128ArgTyr: 2.128 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	4.449SerAla: 4.449 ± 0.056	0.572SerCys: 0.572 ± 0.016	3.501SerAsp: 3.501 ± 0.045	3.725SerGlu: 3.725 ± 0.047	3.548SerPhe: 3.548 ± 0.048	5.086SerGly: 5.086 ± 0.068	1.233SerHis: 1.233 ± 0.033	4.556SerIle: 4.556 ± 0.05	3.806SerLys: 3.806 ± 0.05	6.75SerLeu: 6.75 ± 0.068	1.539SerMet: 1.539 ± 0.032	3.116SerAsn: 3.116 ± 0.053	2.814SerPro: 2.814 ± 0.044	2.62SerGln: 2.62 ± 0.038	2.834SerArg: 2.834 ± 0.049	4.414SerSer: 4.414 ± 0.064	3.8SerThr: 3.8 ± 0.062	4.202SerVal: 4.202 ± 0.049	0.906SerTrp: 0.906 ± 0.027	2.843SerTyr: 2.843 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	4.315ThrAla: 4.315 ± 0.068	0.339ThrCys: 0.339 ± 0.013	3.398ThrAsp: 3.398 ± 0.051	3.112ThrGlu: 3.112 ± 0.04	2.711ThrPhe: 2.711 ± 0.046	4.552ThrGly: 4.552 ± 0.063	1.14ThrHis: 1.14 ± 0.024	3.961ThrIle: 3.961 ± 0.059	2.944ThrLys: 2.944 ± 0.042	5.62ThrLeu: 5.62 ± 0.063	1.138ThrMet: 1.138 ± 0.026	2.695ThrAsn: 2.695 ± 0.052	2.782ThrPro: 2.782 ± 0.049	2.139ThrGln: 2.139 ± 0.038	2.083ThrArg: 2.083 ± 0.033	3.795ThrSer: 3.795 ± 0.055	3.535ThrThr: 3.535 ± 0.066	3.866ThrVal: 3.866 ± 0.06	0.69ThrTrp: 0.69 ± 0.022	2.309ThrTyr: 2.309 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	5.022ValAla: 5.022 ± 0.064	0.53ValCys: 0.53 ± 0.019	3.66ValAsp: 3.66 ± 0.047	3.616ValGlu: 3.616 ± 0.051	2.926ValPhe: 2.926 ± 0.045	4.457ValGly: 4.457 ± 0.06	1.18ValHis: 1.18 ± 0.027	3.993ValIle: 3.993 ± 0.058	3.669ValLys: 3.669 ± 0.05	6.367ValLeu: 6.367 ± 0.075	1.5ValMet: 1.5 ± 0.031	3.121ValAsn: 3.121 ± 0.046	2.714ValPro: 2.714 ± 0.039	2.281ValGln: 2.281 ± 0.035	2.802ValArg: 2.802 ± 0.042	4.508ValSer: 4.508 ± 0.056	3.608ValThr: 3.608 ± 0.055	4.692ValVal: 4.692 ± 0.073	0.745ValTrp: 0.745 ± 0.024	2.415ValTyr: 2.415 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	0.938TrpAla: 0.938 ± 0.027	0.115TrpCys: 0.115 ± 0.008	0.735TrpAsp: 0.735 ± 0.025	0.806TrpGlu: 0.806 ± 0.022	0.557TrpPhe: 0.557 ± 0.02	0.991TrpGly: 0.991 ± 0.026	0.307TrpHis: 0.307 ± 0.014	0.796TrpIle: 0.796 ± 0.022	0.907TrpLys: 0.907 ± 0.025	1.326TrpLeu: 1.326 ± 0.035	0.373TrpMet: 0.373 ± 0.017	0.731TrpAsn: 0.731 ± 0.022	0.449TrpPro: 0.449 ± 0.017	0.576TrpGln: 0.576 ± 0.018	0.586TrpArg: 0.586 ± 0.019	0.859TrpSer: 0.859 ± 0.027	0.731TrpThr: 0.731 ± 0.022	0.836TrpVal: 0.836 ± 0.025	0.209TrpTrp: 0.209 ± 0.013	0.506TrpTyr: 0.506 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.808TyrAla: 2.808 ± 0.041	0.348TyrCys: 0.348 ± 0.016	2.354TyrAsp: 2.354 ± 0.042	2.097TyrGlu: 2.097 ± 0.033	2.163TyrPhe: 2.163 ± 0.035	2.956TyrGly: 2.956 ± 0.045	0.884TyrHis: 0.884 ± 0.025	2.28TyrIle: 2.28 ± 0.04	2.217TyrLys: 2.217 ± 0.037	4.058TyrLeu: 4.058 ± 0.064	0.816TyrMet: 0.816 ± 0.022	2.07TyrAsn: 2.07 ± 0.045	1.762TyrPro: 1.762 ± 0.033	2.021TyrGln: 2.021 ± 0.034	2.187TyrArg: 2.187 ± 0.037	2.745TyrSer: 2.745 ± 0.043	2.294TyrThr: 2.294 ± 0.038	2.155TyrVal: 2.155 ± 0.037	0.591TyrTrp: 0.591 ± 0.019	1.917TyrTyr: 1.917 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4730 proteins (1682925 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---