Amino acid dipepetide frequency for Podoviridae sp. ct2cs2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.915AlaAla: 7.915 ± 1.281
0.344AlaCys: 0.344 ± 0.204
3.614AlaAsp: 3.614 ± 0.557
4.99AlaGlu: 4.99 ± 0.995
2.495AlaPhe: 2.495 ± 0.551
8.087AlaGly: 8.087 ± 1.278
1.377AlaHis: 1.377 ± 0.481
5.334AlaIle: 5.334 ± 0.718
4.818AlaLys: 4.818 ± 0.542
5.85AlaLeu: 5.85 ± 0.759
2.323AlaMet: 2.323 ± 0.381
3.786AlaAsn: 3.786 ± 0.695
3.269AlaPro: 3.269 ± 0.767
3.097AlaGln: 3.097 ± 0.852
2.839AlaArg: 2.839 ± 0.551
7.485AlaSer: 7.485 ± 1.199
6.797AlaThr: 6.797 ± 1.203
4.56AlaVal: 4.56 ± 0.647
0.946AlaTrp: 0.946 ± 0.256
3.872AlaTyr: 3.872 ± 0.706
0.0AlaXaa: 0.0 ± 0.0
Cys
0.172CysAla: 0.172 ± 0.113
0.258CysCys: 0.258 ± 0.14
0.86CysAsp: 0.86 ± 0.275
0.774CysGlu: 0.774 ± 0.276
0.43CysPhe: 0.43 ± 0.231
0.946CysGly: 0.946 ± 0.329
0.258CysHis: 0.258 ± 0.18
0.344CysIle: 0.344 ± 0.171
0.688CysLys: 0.688 ± 0.211
0.43CysLeu: 0.43 ± 0.186
0.43CysMet: 0.43 ± 0.204
0.602CysAsn: 0.602 ± 0.264
0.688CysPro: 0.688 ± 0.263
0.516CysGln: 0.516 ± 0.233
0.258CysArg: 0.258 ± 0.152
0.774CysSer: 0.774 ± 0.239
0.602CysThr: 0.602 ± 0.291
0.43CysVal: 0.43 ± 0.285
0.258CysTrp: 0.258 ± 0.112
0.946CysTyr: 0.946 ± 0.239
0.0CysXaa: 0.0 ± 0.0
Asp
4.474AspAla: 4.474 ± 0.435
0.602AspCys: 0.602 ± 0.204
2.925AspAsp: 2.925 ± 0.636
2.753AspGlu: 2.753 ± 0.563
2.065AspPhe: 2.065 ± 0.435
4.13AspGly: 4.13 ± 0.668
0.172AspHis: 0.172 ± 0.137
4.388AspIle: 4.388 ± 0.743
2.753AspLys: 2.753 ± 0.479
3.441AspLeu: 3.441 ± 0.534
1.549AspMet: 1.549 ± 0.478
2.753AspAsn: 2.753 ± 0.536
2.323AspPro: 2.323 ± 0.415
1.463AspGln: 1.463 ± 0.313
1.979AspArg: 1.979 ± 0.409
2.925AspSer: 2.925 ± 0.508
3.786AspThr: 3.786 ± 0.601
3.7AspVal: 3.7 ± 0.645
0.516AspTrp: 0.516 ± 0.206
2.667AspTyr: 2.667 ± 0.56
0.0AspXaa: 0.0 ± 0.0
Glu
5.42GluAla: 5.42 ± 0.931
0.688GluCys: 0.688 ± 0.261
3.527GluAsp: 3.527 ± 0.629
3.786GluGlu: 3.786 ± 0.901
2.753GluPhe: 2.753 ± 0.404
3.614GluGly: 3.614 ± 0.584
0.602GluHis: 0.602 ± 0.23
4.216GluIle: 4.216 ± 0.651
3.011GluLys: 3.011 ± 0.55
5.764GluLeu: 5.764 ± 0.994
1.893GluMet: 1.893 ± 0.445
2.667GluAsn: 2.667 ± 0.542
1.118GluPro: 1.118 ± 0.353
3.269GluGln: 3.269 ± 1.001
2.409GluArg: 2.409 ± 0.545
3.441GluSer: 3.441 ± 0.59
4.044GluThr: 4.044 ± 0.745
3.786GluVal: 3.786 ± 0.773
0.774GluTrp: 0.774 ± 0.219
2.581GluTyr: 2.581 ± 0.455
0.0GluXaa: 0.0 ± 0.0
Phe
2.667PheAla: 2.667 ± 0.435
0.688PheCys: 0.688 ± 0.248
1.721PheAsp: 1.721 ± 0.366
1.721PheGlu: 1.721 ± 0.431
0.86PhePhe: 0.86 ± 0.285
2.753PheGly: 2.753 ± 0.583
0.516PheHis: 0.516 ± 0.196
2.409PheIle: 2.409 ± 0.433
3.269PheLys: 3.269 ± 0.428
2.925PheLeu: 2.925 ± 0.464
1.807PheMet: 1.807 ± 0.431
2.151PheAsn: 2.151 ± 0.527
0.774PhePro: 0.774 ± 0.264
1.807PheGln: 1.807 ± 0.375
1.291PheArg: 1.291 ± 0.326
1.893PheSer: 1.893 ± 0.51
3.269PheThr: 3.269 ± 0.533
3.011PheVal: 3.011 ± 0.452
0.43PheTrp: 0.43 ± 0.177
1.377PheTyr: 1.377 ± 0.27
0.0PheXaa: 0.0 ± 0.0
Gly
6.195GlyAla: 6.195 ± 0.864
0.774GlyCys: 0.774 ± 0.22
3.097GlyAsp: 3.097 ± 0.521
3.441GlyGlu: 3.441 ± 0.683
3.786GlyPhe: 3.786 ± 0.584
7.055GlyGly: 7.055 ± 2.133
0.946GlyHis: 0.946 ± 0.253
4.216GlyIle: 4.216 ± 0.508
5.42GlyLys: 5.42 ± 0.955
4.302GlyLeu: 4.302 ± 0.56
1.291GlyMet: 1.291 ± 0.302
4.388GlyAsn: 4.388 ± 0.877
0.516GlyPro: 0.516 ± 0.206
2.581GlyGln: 2.581 ± 0.538
1.721GlyArg: 1.721 ± 0.275
7.743GlySer: 7.743 ± 1.156
8.776GlyThr: 8.776 ± 1.366
4.646GlyVal: 4.646 ± 0.68
0.946GlyTrp: 0.946 ± 0.325
3.441GlyTyr: 3.441 ± 0.676
0.0GlyXaa: 0.0 ± 0.0
His
0.602HisAla: 0.602 ± 0.217
0.086HisCys: 0.086 ± 0.095
1.205HisAsp: 1.205 ± 0.41
1.118HisGlu: 1.118 ± 0.381
0.774HisPhe: 0.774 ± 0.27
0.946HisGly: 0.946 ± 0.299
0.344HisHis: 0.344 ± 0.208
1.205HisIle: 1.205 ± 0.377
0.946HisLys: 0.946 ± 0.312
0.602HisLeu: 0.602 ± 0.255
0.258HisMet: 0.258 ± 0.134
1.291HisAsn: 1.291 ± 0.373
0.258HisPro: 0.258 ± 0.155
0.258HisGln: 0.258 ± 0.145
0.774HisArg: 0.774 ± 0.236
0.774HisSer: 0.774 ± 0.261
0.774HisThr: 0.774 ± 0.26
0.774HisVal: 0.774 ± 0.276
0.172HisTrp: 0.172 ± 0.117
0.774HisTyr: 0.774 ± 0.243
0.0HisXaa: 0.0 ± 0.0
Ile
4.646IleAla: 4.646 ± 0.622
0.688IleCys: 0.688 ± 0.258
4.044IleAsp: 4.044 ± 0.641
4.56IleGlu: 4.56 ± 0.662
1.205IlePhe: 1.205 ± 0.283
4.474IleGly: 4.474 ± 0.766
0.688IleHis: 0.688 ± 0.28
3.786IleIle: 3.786 ± 0.564
4.818IleLys: 4.818 ± 0.907
4.646IleLeu: 4.646 ± 0.684
0.774IleMet: 0.774 ± 0.262
4.818IleAsn: 4.818 ± 0.569
2.839IlePro: 2.839 ± 0.407
2.065IleGln: 2.065 ± 0.466
2.581IleArg: 2.581 ± 0.479
4.732IleSer: 4.732 ± 0.461
4.99IleThr: 4.99 ± 0.78
3.183IleVal: 3.183 ± 0.45
0.86IleTrp: 0.86 ± 0.244
1.979IleTyr: 1.979 ± 0.373
0.0IleXaa: 0.0 ± 0.0
Lys
4.732LysAla: 4.732 ± 0.852
0.946LysCys: 0.946 ± 0.306
3.355LysAsp: 3.355 ± 0.513
4.904LysGlu: 4.904 ± 0.782
2.667LysPhe: 2.667 ± 0.397
3.011LysGly: 3.011 ± 0.555
1.377LysHis: 1.377 ± 0.454
3.958LysIle: 3.958 ± 0.702
3.269LysLys: 3.269 ± 0.889
4.646LysLeu: 4.646 ± 0.719
2.237LysMet: 2.237 ± 0.454
2.065LysAsn: 2.065 ± 0.544
1.635LysPro: 1.635 ± 0.396
3.355LysGln: 3.355 ± 0.546
2.839LysArg: 2.839 ± 0.484
4.99LysSer: 4.99 ± 0.748
3.786LysThr: 3.786 ± 0.551
3.355LysVal: 3.355 ± 0.568
1.032LysTrp: 1.032 ± 0.243
1.893LysTyr: 1.893 ± 0.364
0.0LysXaa: 0.0 ± 0.0
Leu
6.281LeuAla: 6.281 ± 0.668
1.118LeuCys: 1.118 ± 0.276
4.388LeuAsp: 4.388 ± 0.617
5.248LeuGlu: 5.248 ± 0.855
2.839LeuPhe: 2.839 ± 0.482
4.646LeuGly: 4.646 ± 0.654
1.635LeuHis: 1.635 ± 0.386
4.216LeuIle: 4.216 ± 0.646
3.958LeuLys: 3.958 ± 0.535
6.367LeuLeu: 6.367 ± 0.966
2.065LeuMet: 2.065 ± 0.426
4.904LeuAsn: 4.904 ± 0.868
2.409LeuPro: 2.409 ± 0.407
4.216LeuGln: 4.216 ± 0.686
3.786LeuArg: 3.786 ± 0.57
5.42LeuSer: 5.42 ± 0.62
5.334LeuThr: 5.334 ± 0.698
3.786LeuVal: 3.786 ± 0.566
0.946LeuTrp: 0.946 ± 0.301
2.581LeuTyr: 2.581 ± 0.489
0.0LeuXaa: 0.0 ± 0.0
Met
2.323MetAla: 2.323 ± 0.429
0.172MetCys: 0.172 ± 0.127
0.86MetAsp: 0.86 ± 0.285
1.807MetGlu: 1.807 ± 0.415
0.946MetPhe: 0.946 ± 0.269
1.549MetGly: 1.549 ± 0.466
0.344MetHis: 0.344 ± 0.171
1.635MetIle: 1.635 ± 0.403
1.205MetLys: 1.205 ± 0.261
2.151MetLeu: 2.151 ± 0.424
0.43MetMet: 0.43 ± 0.184
1.549MetAsn: 1.549 ± 0.327
0.602MetPro: 0.602 ± 0.211
1.291MetGln: 1.291 ± 0.349
0.946MetArg: 0.946 ± 0.283
2.237MetSer: 2.237 ± 0.516
1.807MetThr: 1.807 ± 0.379
1.118MetVal: 1.118 ± 0.381
0.258MetTrp: 0.258 ± 0.143
0.688MetTyr: 0.688 ± 0.257
0.0MetXaa: 0.0 ± 0.0
Asn
6.023AsnAla: 6.023 ± 0.823
0.946AsnCys: 0.946 ± 0.237
2.581AsnAsp: 2.581 ± 0.455
2.667AsnGlu: 2.667 ± 0.478
1.291AsnPhe: 1.291 ± 0.307
4.56AsnGly: 4.56 ± 1.409
0.602AsnHis: 0.602 ± 0.264
3.097AsnIle: 3.097 ± 0.517
2.839AsnLys: 2.839 ± 0.618
4.646AsnLeu: 4.646 ± 0.618
1.291AsnMet: 1.291 ± 0.311
4.13AsnAsn: 4.13 ± 0.757
3.269AsnPro: 3.269 ± 0.49
1.979AsnGln: 1.979 ± 0.347
3.527AsnArg: 3.527 ± 0.509
3.097AsnSer: 3.097 ± 0.821
5.42AsnThr: 5.42 ± 1.138
3.614AsnVal: 3.614 ± 0.639
0.774AsnTrp: 0.774 ± 0.237
3.097AsnTyr: 3.097 ± 0.469
0.0AsnXaa: 0.0 ± 0.0
Pro
3.527ProAla: 3.527 ± 0.612
0.0ProCys: 0.0 ± 0.0
2.495ProAsp: 2.495 ± 0.446
2.151ProGlu: 2.151 ± 0.385
1.893ProPhe: 1.893 ± 0.446
0.0ProGly: 0.0 ± 0.0
0.43ProHis: 0.43 ± 0.187
1.893ProIle: 1.893 ± 0.387
2.667ProLys: 2.667 ± 0.642
2.581ProLeu: 2.581 ± 0.386
1.291ProMet: 1.291 ± 0.361
1.721ProAsn: 1.721 ± 0.511
1.807ProPro: 1.807 ± 0.416
1.377ProGln: 1.377 ± 0.332
1.118ProArg: 1.118 ± 0.403
3.011ProSer: 3.011 ± 0.54
3.355ProThr: 3.355 ± 0.679
2.323ProVal: 2.323 ± 0.484
0.0ProTrp: 0.0 ± 0.0
1.205ProTyr: 1.205 ± 0.366
0.0ProXaa: 0.0 ± 0.0
Gln
4.044GlnAla: 4.044 ± 0.795
0.172GlnCys: 0.172 ± 0.111
2.065GlnAsp: 2.065 ± 0.493
3.097GlnGlu: 3.097 ± 0.654
1.721GlnPhe: 1.721 ± 0.371
2.753GlnGly: 2.753 ± 0.425
0.344GlnHis: 0.344 ± 0.16
2.581GlnIle: 2.581 ± 0.448
3.097GlnLys: 3.097 ± 0.496
3.7GlnLeu: 3.7 ± 0.696
0.86GlnMet: 0.86 ± 0.37
2.495GlnAsn: 2.495 ± 0.505
1.635GlnPro: 1.635 ± 0.546
2.065GlnGln: 2.065 ± 0.41
2.065GlnArg: 2.065 ± 0.4
2.409GlnSer: 2.409 ± 0.483
3.183GlnThr: 3.183 ± 0.607
2.151GlnVal: 2.151 ± 0.416
0.516GlnTrp: 0.516 ± 0.21
0.86GlnTyr: 0.86 ± 0.313
0.0GlnXaa: 0.0 ± 0.0
Arg
1.893ArgAla: 1.893 ± 0.45
0.516ArgCys: 0.516 ± 0.233
1.463ArgAsp: 1.463 ± 0.37
2.237ArgGlu: 2.237 ± 0.57
1.893ArgPhe: 1.893 ± 0.387
2.237ArgGly: 2.237 ± 0.424
0.946ArgHis: 0.946 ± 0.329
2.925ArgIle: 2.925 ± 0.437
2.237ArgLys: 2.237 ± 0.419
3.786ArgLeu: 3.786 ± 0.515
0.946ArgMet: 0.946 ± 0.341
3.011ArgAsn: 3.011 ± 0.593
1.979ArgPro: 1.979 ± 0.521
1.635ArgGln: 1.635 ± 0.356
2.925ArgArg: 2.925 ± 0.505
2.839ArgSer: 2.839 ± 0.55
2.667ArgThr: 2.667 ± 0.433
1.893ArgVal: 1.893 ± 0.414
0.688ArgTrp: 0.688 ± 0.259
1.979ArgTyr: 1.979 ± 0.388
0.0ArgXaa: 0.0 ± 0.0
Ser
7.055SerAla: 7.055 ± 1.395
0.602SerCys: 0.602 ± 0.252
3.011SerAsp: 3.011 ± 0.475
3.441SerGlu: 3.441 ± 0.606
1.807SerPhe: 1.807 ± 0.42
7.485SerGly: 7.485 ± 1.296
0.688SerHis: 0.688 ± 0.215
5.764SerIle: 5.764 ± 0.891
3.7SerLys: 3.7 ± 0.534
5.076SerLeu: 5.076 ± 0.642
1.377SerMet: 1.377 ± 0.343
4.732SerAsn: 4.732 ± 1.061
3.097SerPro: 3.097 ± 0.605
3.269SerGln: 3.269 ± 0.472
3.183SerArg: 3.183 ± 0.551
5.678SerSer: 5.678 ± 1.263
6.281SerThr: 6.281 ± 0.764
4.474SerVal: 4.474 ± 0.681
1.032SerTrp: 1.032 ± 0.359
2.409SerTyr: 2.409 ± 0.42
0.0SerXaa: 0.0 ± 0.0
Thr
7.055ThrAla: 7.055 ± 0.93
0.602ThrCys: 0.602 ± 0.31
4.646ThrAsp: 4.646 ± 0.557
4.646ThrGlu: 4.646 ± 0.941
3.183ThrPhe: 3.183 ± 0.678
8.087ThrGly: 8.087 ± 1.094
1.032ThrHis: 1.032 ± 0.309
4.99ThrIle: 4.99 ± 0.844
4.56ThrLys: 4.56 ± 0.639
5.85ThrLeu: 5.85 ± 0.623
0.86ThrMet: 0.86 ± 0.216
4.302ThrAsn: 4.302 ± 0.809
3.355ThrPro: 3.355 ± 0.532
2.495ThrGln: 2.495 ± 0.393
1.893ThrArg: 1.893 ± 0.459
6.453ThrSer: 6.453 ± 1.716
7.055ThrThr: 7.055 ± 1.204
4.904ThrVal: 4.904 ± 0.885
1.721ThrTrp: 1.721 ± 0.566
4.044ThrTyr: 4.044 ± 0.774
0.0ThrXaa: 0.0 ± 0.0
Val
4.646ValAla: 4.646 ± 0.605
0.602ValCys: 0.602 ± 0.201
2.581ValAsp: 2.581 ± 0.396
3.872ValGlu: 3.872 ± 0.829
2.667ValPhe: 2.667 ± 0.577
4.732ValGly: 4.732 ± 0.562
0.774ValHis: 0.774 ± 0.242
2.409ValIle: 2.409 ± 0.485
3.7ValLys: 3.7 ± 0.649
4.216ValLeu: 4.216 ± 0.603
1.205ValMet: 1.205 ± 0.325
3.7ValAsn: 3.7 ± 0.58
1.893ValPro: 1.893 ± 0.386
2.495ValGln: 2.495 ± 0.497
2.409ValArg: 2.409 ± 0.495
4.56ValSer: 4.56 ± 0.68
5.937ValThr: 5.937 ± 0.896
3.786ValVal: 3.786 ± 0.763
0.516ValTrp: 0.516 ± 0.225
2.151ValTyr: 2.151 ± 0.387
0.0ValXaa: 0.0 ± 0.0
Trp
0.946TrpAla: 0.946 ± 0.281
0.344TrpCys: 0.344 ± 0.178
0.602TrpAsp: 0.602 ± 0.221
0.86TrpGlu: 0.86 ± 0.375
0.688TrpPhe: 0.688 ± 0.219
0.86TrpGly: 0.86 ± 0.281
0.172TrpHis: 0.172 ± 0.117
0.516TrpIle: 0.516 ± 0.187
1.118TrpLys: 1.118 ± 0.248
1.291TrpLeu: 1.291 ± 0.3
0.086TrpMet: 0.086 ± 0.085
1.032TrpAsn: 1.032 ± 0.27
0.0TrpPro: 0.0 ± 0.0
0.258TrpGln: 0.258 ± 0.133
0.344TrpArg: 0.344 ± 0.144
1.118TrpSer: 1.118 ± 0.316
0.774TrpThr: 0.774 ± 0.326
1.205TrpVal: 1.205 ± 0.239
0.172TrpTrp: 0.172 ± 0.119
0.774TrpTyr: 0.774 ± 0.256
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.183TyrAla: 3.183 ± 0.483
0.516TyrCys: 0.516 ± 0.227
2.323TyrAsp: 2.323 ± 0.432
1.291TyrGlu: 1.291 ± 0.335
1.377TyrPhe: 1.377 ± 0.341
3.355TyrGly: 3.355 ± 0.613
0.688TyrHis: 0.688 ± 0.241
2.495TyrIle: 2.495 ± 0.494
1.979TyrLys: 1.979 ± 0.42
3.872TyrLeu: 3.872 ± 0.631
0.86TyrMet: 0.86 ± 0.261
3.355TyrAsn: 3.355 ± 0.422
1.377TyrPro: 1.377 ± 0.338
2.323TyrGln: 2.323 ± 0.486
1.807TyrArg: 1.807 ± 0.4
2.581TyrSer: 2.581 ± 0.499
3.097TyrThr: 3.097 ± 0.515
2.237TyrVal: 2.237 ± 0.411
0.602TyrTrp: 0.602 ± 0.224
1.721TyrTyr: 1.721 ± 0.356
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 68 proteins (11624 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski