Amino acid dipepetide frequency for Vibrio virus K139

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.413AlaAla: 9.413 ± 1.63
0.392AlaCys: 0.392 ± 0.211
4.804AlaAsp: 4.804 ± 0.652
7.06AlaGlu: 7.06 ± 0.996
4.118AlaPhe: 4.118 ± 0.71
6.373AlaGly: 6.373 ± 1.03
1.569AlaHis: 1.569 ± 0.407
5.589AlaIle: 5.589 ± 0.844
5.687AlaLys: 5.687 ± 0.658
7.942AlaLeu: 7.942 ± 0.831
3.628AlaMet: 3.628 ± 0.725
4.314AlaAsn: 4.314 ± 0.691
1.961AlaPro: 1.961 ± 0.468
4.216AlaGln: 4.216 ± 0.649
3.726AlaArg: 3.726 ± 0.733
6.079AlaSer: 6.079 ± 0.896
5.981AlaThr: 5.981 ± 0.677
5.295AlaVal: 5.295 ± 0.631
1.569AlaTrp: 1.569 ± 0.309
2.745AlaTyr: 2.745 ± 0.522
0.0AlaXaa: 0.0 ± 0.0
Cys
0.882CysAla: 0.882 ± 0.364
0.392CysCys: 0.392 ± 0.27
0.784CysAsp: 0.784 ± 0.28
1.177CysGlu: 1.177 ± 0.324
0.196CysPhe: 0.196 ± 0.166
0.588CysGly: 0.588 ± 0.303
0.294CysHis: 0.294 ± 0.168
0.294CysIle: 0.294 ± 0.177
0.588CysLys: 0.588 ± 0.256
0.882CysLeu: 0.882 ± 0.299
0.196CysMet: 0.196 ± 0.135
0.294CysAsn: 0.294 ± 0.235
0.49CysPro: 0.49 ± 0.21
0.882CysGln: 0.882 ± 0.377
0.588CysArg: 0.588 ± 0.264
0.98CysSer: 0.98 ± 0.327
0.49CysThr: 0.49 ± 0.216
0.588CysVal: 0.588 ± 0.221
0.196CysTrp: 0.196 ± 0.12
0.686CysTyr: 0.686 ± 0.255
0.0CysXaa: 0.0 ± 0.0
Asp
3.824AspAla: 3.824 ± 0.458
0.588AspCys: 0.588 ± 0.218
2.059AspAsp: 2.059 ± 0.482
4.706AspGlu: 4.706 ± 0.768
2.157AspPhe: 2.157 ± 0.514
4.412AspGly: 4.412 ± 0.6
0.882AspHis: 0.882 ± 0.227
4.706AspIle: 4.706 ± 0.588
3.236AspLys: 3.236 ± 0.584
3.628AspLeu: 3.628 ± 0.704
1.863AspMet: 1.863 ± 0.344
2.451AspAsn: 2.451 ± 0.45
3.138AspPro: 3.138 ± 0.631
2.157AspGln: 2.157 ± 0.451
2.157AspArg: 2.157 ± 0.448
2.745AspSer: 2.745 ± 0.36
2.353AspThr: 2.353 ± 0.473
4.412AspVal: 4.412 ± 0.681
0.686AspTrp: 0.686 ± 0.24
2.549AspTyr: 2.549 ± 0.438
0.0AspXaa: 0.0 ± 0.0
Glu
6.373GluAla: 6.373 ± 0.793
1.471GluCys: 1.471 ± 0.481
3.432GluAsp: 3.432 ± 0.713
3.236GluGlu: 3.236 ± 0.578
2.745GluPhe: 2.745 ± 0.394
2.941GluGly: 2.941 ± 0.67
1.961GluHis: 1.961 ± 0.546
3.53GluIle: 3.53 ± 0.564
4.314GluLys: 4.314 ± 0.897
9.315GluLeu: 9.315 ± 0.88
1.863GluMet: 1.863 ± 0.48
2.549GluAsn: 2.549 ± 0.569
2.157GluPro: 2.157 ± 0.575
5.099GluGln: 5.099 ± 0.566
4.804GluArg: 4.804 ± 0.801
4.706GluSer: 4.706 ± 0.727
3.236GluThr: 3.236 ± 0.711
4.902GluVal: 4.902 ± 0.602
1.275GluTrp: 1.275 ± 0.386
1.569GluTyr: 1.569 ± 0.326
0.0GluXaa: 0.0 ± 0.0
Phe
4.02PheAla: 4.02 ± 0.576
0.392PheCys: 0.392 ± 0.208
2.549PheAsp: 2.549 ± 0.483
3.236PheGlu: 3.236 ± 0.507
1.373PhePhe: 1.373 ± 0.408
2.451PheGly: 2.451 ± 0.607
0.098PheHis: 0.098 ± 0.086
1.765PheIle: 1.765 ± 0.495
2.745PheLys: 2.745 ± 0.532
2.157PheLeu: 2.157 ± 0.34
1.275PheMet: 1.275 ± 0.354
1.765PheAsn: 1.765 ± 0.435
0.882PhePro: 0.882 ± 0.279
1.569PheGln: 1.569 ± 0.38
1.569PheArg: 1.569 ± 0.395
3.04PheSer: 3.04 ± 0.778
2.647PheThr: 2.647 ± 0.346
2.941PheVal: 2.941 ± 0.595
0.882PheTrp: 0.882 ± 0.347
0.98PheTyr: 0.98 ± 0.349
0.0PheXaa: 0.0 ± 0.0
Gly
4.51GlyAla: 4.51 ± 0.68
0.784GlyCys: 0.784 ± 0.292
3.824GlyAsp: 3.824 ± 0.47
4.51GlyGlu: 4.51 ± 0.596
2.157GlyPhe: 2.157 ± 0.441
4.216GlyGly: 4.216 ± 0.704
1.863GlyHis: 1.863 ± 0.45
4.118GlyIle: 4.118 ± 0.626
4.706GlyLys: 4.706 ± 0.594
5.099GlyLeu: 5.099 ± 0.683
1.765GlyMet: 1.765 ± 0.558
2.353GlyAsn: 2.353 ± 0.519
0.686GlyPro: 0.686 ± 0.254
2.941GlyGln: 2.941 ± 0.601
3.824GlyArg: 3.824 ± 0.648
3.726GlySer: 3.726 ± 0.435
2.745GlyThr: 2.745 ± 0.417
4.118GlyVal: 4.118 ± 0.778
0.98GlyTrp: 0.98 ± 0.257
1.863GlyTyr: 1.863 ± 0.473
0.0GlyXaa: 0.0 ± 0.0
His
1.373HisAla: 1.373 ± 0.461
0.294HisCys: 0.294 ± 0.169
0.686HisAsp: 0.686 ± 0.305
1.471HisGlu: 1.471 ± 0.307
0.882HisPhe: 0.882 ± 0.322
1.863HisGly: 1.863 ± 0.381
0.588HisHis: 0.588 ± 0.234
1.079HisIle: 1.079 ± 0.411
1.177HisLys: 1.177 ± 0.397
1.471HisLeu: 1.471 ± 0.364
0.686HisMet: 0.686 ± 0.287
0.686HisAsn: 0.686 ± 0.21
0.882HisPro: 0.882 ± 0.331
1.177HisGln: 1.177 ± 0.309
0.49HisArg: 0.49 ± 0.191
1.177HisSer: 1.177 ± 0.331
1.275HisThr: 1.275 ± 0.339
1.275HisVal: 1.275 ± 0.309
0.392HisTrp: 0.392 ± 0.215
0.686HisTyr: 0.686 ± 0.276
0.0HisXaa: 0.0 ± 0.0
Ile
7.55IleAla: 7.55 ± 0.911
0.686IleCys: 0.686 ± 0.273
4.216IleAsp: 4.216 ± 0.618
5.785IleGlu: 5.785 ± 0.806
2.451IlePhe: 2.451 ± 0.502
2.941IleGly: 2.941 ± 0.546
0.98IleHis: 0.98 ± 0.333
2.941IleIle: 2.941 ± 0.666
3.628IleLys: 3.628 ± 0.74
3.04IleLeu: 3.04 ± 0.646
1.765IleMet: 1.765 ± 0.456
3.334IleAsn: 3.334 ± 0.677
3.236IlePro: 3.236 ± 0.668
2.157IleGln: 2.157 ± 0.372
2.745IleArg: 2.745 ± 0.715
4.804IleSer: 4.804 ± 0.798
4.314IleThr: 4.314 ± 0.688
2.255IleVal: 2.255 ± 0.412
0.784IleTrp: 0.784 ± 0.263
1.569IleTyr: 1.569 ± 0.395
0.0IleXaa: 0.0 ± 0.0
Lys
6.863LysAla: 6.863 ± 0.984
0.098LysCys: 0.098 ± 0.113
2.647LysAsp: 2.647 ± 0.599
4.216LysGlu: 4.216 ± 0.677
1.961LysPhe: 1.961 ± 0.483
3.628LysGly: 3.628 ± 0.674
1.079LysHis: 1.079 ± 0.314
3.628LysIle: 3.628 ± 0.56
3.432LysLys: 3.432 ± 0.692
5.393LysLeu: 5.393 ± 0.656
1.569LysMet: 1.569 ± 0.323
3.138LysAsn: 3.138 ± 0.622
3.138LysPro: 3.138 ± 0.498
3.53LysGln: 3.53 ± 0.459
5.0LysArg: 5.0 ± 0.695
3.236LysSer: 3.236 ± 0.527
3.628LysThr: 3.628 ± 0.571
4.02LysVal: 4.02 ± 0.564
0.882LysTrp: 0.882 ± 0.271
2.059LysTyr: 2.059 ± 0.492
0.0LysXaa: 0.0 ± 0.0
Leu
7.844LeuAla: 7.844 ± 0.843
0.98LeuCys: 0.98 ± 0.329
4.314LeuAsp: 4.314 ± 0.516
6.177LeuGlu: 6.177 ± 0.721
3.04LeuPhe: 3.04 ± 0.494
5.295LeuGly: 5.295 ± 0.643
0.882LeuHis: 0.882 ± 0.302
5.491LeuIle: 5.491 ± 0.634
6.667LeuLys: 6.667 ± 0.991
6.177LeuLeu: 6.177 ± 0.783
2.353LeuMet: 2.353 ± 0.476
4.51LeuAsn: 4.51 ± 0.742
5.0LeuPro: 5.0 ± 0.787
3.432LeuGln: 3.432 ± 0.432
4.608LeuArg: 4.608 ± 0.497
7.256LeuSer: 7.256 ± 1.06
5.589LeuThr: 5.589 ± 0.755
3.922LeuVal: 3.922 ± 0.496
0.686LeuTrp: 0.686 ± 0.229
1.667LeuTyr: 1.667 ± 0.418
0.0LeuXaa: 0.0 ± 0.0
Met
3.726MetAla: 3.726 ± 0.594
0.49MetCys: 0.49 ± 0.189
0.882MetAsp: 0.882 ± 0.334
0.98MetGlu: 0.98 ± 0.376
0.882MetPhe: 0.882 ± 0.281
1.569MetGly: 1.569 ± 0.466
0.686MetHis: 0.686 ± 0.222
1.471MetIle: 1.471 ± 0.416
0.98MetLys: 0.98 ± 0.315
2.647MetLeu: 2.647 ± 0.504
0.882MetMet: 0.882 ± 0.297
1.569MetAsn: 1.569 ± 0.399
0.784MetPro: 0.784 ± 0.292
1.373MetGln: 1.373 ± 0.378
1.471MetArg: 1.471 ± 0.304
2.843MetSer: 2.843 ± 0.486
1.863MetThr: 1.863 ± 0.506
2.157MetVal: 2.157 ± 0.335
0.392MetTrp: 0.392 ± 0.173
0.49MetTyr: 0.49 ± 0.171
0.0MetXaa: 0.0 ± 0.0
Asn
4.118AsnAla: 4.118 ± 0.733
0.49AsnCys: 0.49 ± 0.205
2.451AsnAsp: 2.451 ± 0.377
2.843AsnGlu: 2.843 ± 0.494
1.275AsnPhe: 1.275 ± 0.339
3.236AsnGly: 3.236 ± 0.672
0.98AsnHis: 0.98 ± 0.307
2.941AsnIle: 2.941 ± 0.446
2.941AsnLys: 2.941 ± 0.642
3.824AsnLeu: 3.824 ± 0.541
1.373AsnMet: 1.373 ± 0.301
1.667AsnAsn: 1.667 ± 0.365
2.549AsnPro: 2.549 ± 0.325
2.745AsnGln: 2.745 ± 0.55
2.549AsnArg: 2.549 ± 0.449
2.157AsnSer: 2.157 ± 0.514
1.961AsnThr: 1.961 ± 0.47
1.863AsnVal: 1.863 ± 0.431
0.49AsnTrp: 0.49 ± 0.18
1.079AsnTyr: 1.079 ± 0.317
0.0AsnXaa: 0.0 ± 0.0
Pro
3.824ProAla: 3.824 ± 0.531
0.294ProCys: 0.294 ± 0.161
3.04ProAsp: 3.04 ± 0.436
4.51ProGlu: 4.51 ± 0.811
1.863ProPhe: 1.863 ± 0.5
1.667ProGly: 1.667 ± 0.421
0.882ProHis: 0.882 ± 0.32
2.549ProIle: 2.549 ± 0.543
1.961ProLys: 1.961 ± 0.481
3.334ProLeu: 3.334 ± 0.491
1.079ProMet: 1.079 ± 0.345
1.765ProAsn: 1.765 ± 0.428
1.275ProPro: 1.275 ± 0.297
2.255ProGln: 2.255 ± 0.431
2.353ProArg: 2.353 ± 0.434
2.157ProSer: 2.157 ± 0.511
1.863ProThr: 1.863 ± 0.453
2.647ProVal: 2.647 ± 0.539
0.49ProTrp: 0.49 ± 0.25
1.569ProTyr: 1.569 ± 0.381
0.0ProXaa: 0.0 ± 0.0
Gln
4.314GlnAla: 4.314 ± 0.601
0.49GlnCys: 0.49 ± 0.206
2.157GlnAsp: 2.157 ± 0.425
2.353GlnGlu: 2.353 ± 0.571
1.765GlnPhe: 1.765 ± 0.355
3.236GlnGly: 3.236 ± 0.526
0.882GlnHis: 0.882 ± 0.312
2.843GlnIle: 2.843 ± 0.555
2.941GlnLys: 2.941 ± 0.513
4.902GlnLeu: 4.902 ± 0.591
1.667GlnMet: 1.667 ± 0.392
1.961GlnAsn: 1.961 ± 0.499
2.451GlnPro: 2.451 ± 0.425
4.314GlnGln: 4.314 ± 0.739
3.04GlnArg: 3.04 ± 0.508
2.647GlnSer: 2.647 ± 0.43
2.745GlnThr: 2.745 ± 0.575
3.824GlnVal: 3.824 ± 0.635
0.882GlnTrp: 0.882 ± 0.433
1.471GlnTyr: 1.471 ± 0.276
0.0GlnXaa: 0.0 ± 0.0
Arg
3.628ArgAla: 3.628 ± 0.547
0.882ArgCys: 0.882 ± 0.338
2.745ArgAsp: 2.745 ± 0.475
4.118ArgGlu: 4.118 ± 0.659
2.549ArgPhe: 2.549 ± 0.45
1.961ArgGly: 1.961 ± 0.55
1.079ArgHis: 1.079 ± 0.288
3.53ArgIle: 3.53 ± 0.493
4.902ArgLys: 4.902 ± 0.868
6.569ArgLeu: 6.569 ± 0.703
0.588ArgMet: 0.588 ± 0.212
2.353ArgAsn: 2.353 ± 0.476
1.471ArgPro: 1.471 ± 0.337
1.961ArgGln: 1.961 ± 0.435
2.157ArgArg: 2.157 ± 0.464
2.941ArgSer: 2.941 ± 0.494
2.647ArgThr: 2.647 ± 0.562
2.647ArgVal: 2.647 ± 0.421
0.98ArgTrp: 0.98 ± 0.38
1.373ArgTyr: 1.373 ± 0.326
0.0ArgXaa: 0.0 ± 0.0
Ser
6.373SerAla: 6.373 ± 0.691
0.686SerCys: 0.686 ± 0.281
4.51SerAsp: 4.51 ± 0.783
5.295SerGlu: 5.295 ± 0.846
2.451SerPhe: 2.451 ± 0.503
5.099SerGly: 5.099 ± 0.732
1.177SerHis: 1.177 ± 0.302
4.216SerIle: 4.216 ± 0.735
3.138SerLys: 3.138 ± 0.542
4.902SerLeu: 4.902 ± 0.784
1.373SerMet: 1.373 ± 0.363
2.255SerAsn: 2.255 ± 0.512
3.236SerPro: 3.236 ± 0.479
2.941SerGln: 2.941 ± 0.502
2.549SerArg: 2.549 ± 0.349
3.726SerSer: 3.726 ± 0.591
4.02SerThr: 4.02 ± 0.645
3.824SerVal: 3.824 ± 0.642
0.784SerTrp: 0.784 ± 0.212
2.157SerTyr: 2.157 ± 0.537
0.0SerXaa: 0.0 ± 0.0
Thr
5.0ThrAla: 5.0 ± 0.517
0.882ThrCys: 0.882 ± 0.354
3.726ThrAsp: 3.726 ± 0.598
3.53ThrGlu: 3.53 ± 0.568
2.353ThrPhe: 2.353 ± 0.475
3.824ThrGly: 3.824 ± 0.739
1.373ThrHis: 1.373 ± 0.344
3.236ThrIle: 3.236 ± 0.488
4.118ThrLys: 4.118 ± 0.689
4.216ThrLeu: 4.216 ± 0.691
1.177ThrMet: 1.177 ± 0.244
2.255ThrAsn: 2.255 ± 0.392
3.53ThrPro: 3.53 ± 0.604
3.236ThrGln: 3.236 ± 0.673
1.961ThrArg: 1.961 ± 0.521
3.138ThrSer: 3.138 ± 0.562
3.432ThrThr: 3.432 ± 0.513
3.138ThrVal: 3.138 ± 0.691
1.471ThrTrp: 1.471 ± 0.321
1.177ThrTyr: 1.177 ± 0.364
0.0ThrXaa: 0.0 ± 0.0
Val
5.687ValAla: 5.687 ± 0.729
0.588ValCys: 0.588 ± 0.217
3.432ValAsp: 3.432 ± 0.536
3.628ValGlu: 3.628 ± 0.612
1.863ValPhe: 1.863 ± 0.367
3.53ValGly: 3.53 ± 0.697
0.98ValHis: 0.98 ± 0.296
4.314ValIle: 4.314 ± 0.631
3.04ValLys: 3.04 ± 0.588
5.295ValLeu: 5.295 ± 0.707
1.667ValMet: 1.667 ± 0.312
2.549ValAsn: 2.549 ± 0.453
2.353ValPro: 2.353 ± 0.454
1.961ValGln: 1.961 ± 0.354
2.843ValArg: 2.843 ± 0.547
5.197ValSer: 5.197 ± 0.559
4.118ValThr: 4.118 ± 0.737
3.824ValVal: 3.824 ± 0.737
0.686ValTrp: 0.686 ± 0.203
2.549ValTyr: 2.549 ± 0.442
0.0ValXaa: 0.0 ± 0.0
Trp
1.275TrpAla: 1.275 ± 0.37
0.294TrpCys: 0.294 ± 0.157
1.275TrpAsp: 1.275 ± 0.347
0.392TrpGlu: 0.392 ± 0.161
0.686TrpPhe: 0.686 ± 0.305
0.196TrpGly: 0.196 ± 0.125
0.686TrpHis: 0.686 ± 0.275
0.98TrpIle: 0.98 ± 0.263
0.686TrpLys: 0.686 ± 0.272
1.569TrpLeu: 1.569 ± 0.344
0.49TrpMet: 0.49 ± 0.212
0.686TrpAsn: 0.686 ± 0.242
0.784TrpPro: 0.784 ± 0.223
1.275TrpGln: 1.275 ± 0.297
0.98TrpArg: 0.98 ± 0.447
0.588TrpSer: 0.588 ± 0.233
0.686TrpThr: 0.686 ± 0.281
1.275TrpVal: 1.275 ± 0.364
0.392TrpTrp: 0.392 ± 0.147
0.294TrpTyr: 0.294 ± 0.157
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.863TyrAla: 1.863 ± 0.411
0.294TyrCys: 0.294 ± 0.183
1.177TyrAsp: 1.177 ± 0.335
2.255TyrGlu: 2.255 ± 0.56
1.569TyrPhe: 1.569 ± 0.294
1.863TyrGly: 1.863 ± 0.368
0.686TyrHis: 0.686 ± 0.254
1.961TyrIle: 1.961 ± 0.521
2.255TyrLys: 2.255 ± 0.395
3.53TyrLeu: 3.53 ± 0.646
0.784TyrMet: 0.784 ± 0.254
1.079TyrAsn: 1.079 ± 0.319
1.373TyrPro: 1.373 ± 0.402
1.667TyrGln: 1.667 ± 0.363
1.667TyrArg: 1.667 ± 0.296
1.569TyrSer: 1.569 ± 0.46
1.177TyrThr: 1.177 ± 0.362
1.177TyrVal: 1.177 ± 0.335
0.588TyrTrp: 0.588 ± 0.22
0.294TyrTyr: 0.294 ± 0.212
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 44 proteins (10200 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski