Amino acid dipepetide frequency for Mesotoga prima MesG1.Ag.4.2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.182AlaAla: 5.182 ± 0.099
0.513AlaCys: 0.513 ± 0.026
3.043AlaAsp: 3.043 ± 0.06
4.235AlaGlu: 4.235 ± 0.077
3.54AlaPhe: 3.54 ± 0.077
5.259AlaGly: 5.259 ± 0.101
0.903AlaHis: 0.903 ± 0.031
5.625AlaIle: 5.625 ± 0.096
3.68AlaLys: 3.68 ± 0.079
7.259AlaLeu: 7.259 ± 0.104
1.912AlaMet: 1.912 ± 0.053
2.193AlaAsn: 2.193 ± 0.056
1.795AlaPro: 1.795 ± 0.049
1.467AlaGln: 1.467 ± 0.043
3.668AlaArg: 3.668 ± 0.076
4.569AlaSer: 4.569 ± 0.085
3.014AlaThr: 3.014 ± 0.076
5.632AlaVal: 5.632 ± 0.085
0.578AlaTrp: 0.578 ± 0.025
2.112AlaTyr: 2.112 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.444CysAla: 0.444 ± 0.026
0.083CysCys: 0.083 ± 0.011
0.524CysAsp: 0.524 ± 0.029
0.554CysGlu: 0.554 ± 0.029
0.377CysPhe: 0.377 ± 0.025
0.797CysGly: 0.797 ± 0.035
0.165CysHis: 0.165 ± 0.015
0.446CysIle: 0.446 ± 0.027
0.416CysLys: 0.416 ± 0.025
0.637CysLeu: 0.637 ± 0.03
0.15CysMet: 0.15 ± 0.014
0.313CysAsn: 0.313 ± 0.023
0.476CysPro: 0.476 ± 0.028
0.155CysGln: 0.155 ± 0.015
0.482CysArg: 0.482 ± 0.028
0.649CysSer: 0.649 ± 0.029
0.415CysThr: 0.415 ± 0.023
0.483CysVal: 0.483 ± 0.026
0.123CysTrp: 0.123 ± 0.013
0.228CysTyr: 0.228 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
3.053AspAla: 3.053 ± 0.064
0.504AspCys: 0.504 ± 0.03
2.591AspAsp: 2.591 ± 0.065
4.298AspGlu: 4.298 ± 0.079
3.139AspPhe: 3.139 ± 0.066
4.038AspGly: 4.038 ± 0.087
0.861AspHis: 0.861 ± 0.031
3.98AspIle: 3.98 ± 0.068
2.56AspLys: 2.56 ± 0.06
6.002AspLeu: 6.002 ± 0.089
1.225AspMet: 1.225 ± 0.041
2.003AspAsn: 2.003 ± 0.045
2.571AspPro: 2.571 ± 0.063
1.136AspGln: 1.136 ± 0.037
3.091AspArg: 3.091 ± 0.071
3.924AspSer: 3.924 ± 0.072
2.283AspThr: 2.283 ± 0.057
3.732AspVal: 3.732 ± 0.07
0.721AspTrp: 0.721 ± 0.037
2.323AspTyr: 2.323 ± 0.049
0.0AspXaa: 0.0 ± 0.0
Glu
5.052GluAla: 5.052 ± 0.076
0.382GluCys: 0.382 ± 0.024
3.916GluAsp: 3.916 ± 0.073
7.159GluGlu: 7.159 ± 0.114
3.298GluPhe: 3.298 ± 0.064
4.95GluGly: 4.95 ± 0.082
0.961GluHis: 0.961 ± 0.033
7.082GluIle: 7.082 ± 0.097
5.745GluLys: 5.745 ± 0.104
7.325GluLeu: 7.325 ± 0.116
2.271GluMet: 2.271 ± 0.06
3.424GluAsn: 3.424 ± 0.067
2.133GluPro: 2.133 ± 0.064
1.461GluGln: 1.461 ± 0.039
4.787GluArg: 4.787 ± 0.087
4.717GluSer: 4.717 ± 0.086
3.618GluThr: 3.618 ± 0.08
5.429GluVal: 5.429 ± 0.088
0.676GluTrp: 0.676 ± 0.033
2.426GluTyr: 2.426 ± 0.054
0.0GluXaa: 0.0 ± 0.0
Phe
3.35PheAla: 3.35 ± 0.079
0.429PheCys: 0.429 ± 0.023
3.114PheAsp: 3.114 ± 0.06
3.74PheGlu: 3.74 ± 0.083
2.653PhePhe: 2.653 ± 0.071
3.923PheGly: 3.923 ± 0.074
0.75PheHis: 0.75 ± 0.03
3.13PheIle: 3.13 ± 0.068
2.401PheLys: 2.401 ± 0.054
5.115PheLeu: 5.115 ± 0.082
1.299PheMet: 1.299 ± 0.039
1.662PheAsn: 1.662 ± 0.048
2.027PhePro: 2.027 ± 0.053
1.104PheGln: 1.104 ± 0.039
2.453PheArg: 2.453 ± 0.057
4.511PheSer: 4.511 ± 0.086
2.392PheThr: 2.392 ± 0.056
3.907PheVal: 3.907 ± 0.077
0.598PheTrp: 0.598 ± 0.027
1.63PheTyr: 1.63 ± 0.046
0.0PheXaa: 0.0 ± 0.0
Gly
4.744GlyAla: 4.744 ± 0.085
0.689GlyCys: 0.689 ± 0.034
3.709GlyAsp: 3.709 ± 0.088
5.238GlyGlu: 5.238 ± 0.088
4.033GlyPhe: 4.033 ± 0.087
5.29GlyGly: 5.29 ± 0.103
1.159GlyHis: 1.159 ± 0.042
6.4GlyIle: 6.4 ± 0.087
5.044GlyLys: 5.044 ± 0.085
7.024GlyLeu: 7.024 ± 0.116
2.153GlyMet: 2.153 ± 0.047
2.807GlyAsn: 2.807 ± 0.055
1.984GlyPro: 1.984 ± 0.057
1.609GlyGln: 1.609 ± 0.045
3.943GlyArg: 3.943 ± 0.08
5.186GlySer: 5.186 ± 0.099
3.86GlyThr: 3.86 ± 0.069
5.434GlyVal: 5.434 ± 0.086
0.886GlyTrp: 0.886 ± 0.04
2.85GlyTyr: 2.85 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
0.85HisAla: 0.85 ± 0.032
0.166HisCys: 0.166 ± 0.013
0.792HisAsp: 0.792 ± 0.031
1.026HisGlu: 1.026 ± 0.036
0.843HisPhe: 0.843 ± 0.032
1.207HisGly: 1.207 ± 0.041
0.294HisHis: 0.294 ± 0.017
1.044HisIle: 1.044 ± 0.038
0.674HisLys: 0.674 ± 0.031
1.401HisLeu: 1.401 ± 0.044
0.333HisMet: 0.333 ± 0.02
0.568HisAsn: 0.568 ± 0.026
0.854HisPro: 0.854 ± 0.033
0.346HisGln: 0.346 ± 0.019
0.782HisArg: 0.782 ± 0.03
1.097HisSer: 1.097 ± 0.038
0.648HisThr: 0.648 ± 0.029
0.984HisVal: 0.984 ± 0.035
0.164HisTrp: 0.164 ± 0.015
0.617HisTyr: 0.617 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
5.86IleAla: 5.86 ± 0.1
0.637IleCys: 0.637 ± 0.029
4.983IleAsp: 4.983 ± 0.077
6.142IleGlu: 6.142 ± 0.102
3.555IlePhe: 3.555 ± 0.082
5.521IleGly: 5.521 ± 0.088
1.039IleHis: 1.039 ± 0.038
5.026IleIle: 5.026 ± 0.095
3.513IleLys: 3.513 ± 0.072
7.261IleLeu: 7.261 ± 0.112
1.891IleMet: 1.891 ± 0.053
2.616IleAsn: 2.616 ± 0.055
3.537IlePro: 3.537 ± 0.062
1.613IleGln: 1.613 ± 0.046
3.652IleArg: 3.652 ± 0.075
6.224IleSer: 6.224 ± 0.11
3.831IleThr: 3.831 ± 0.072
6.285IleVal: 6.285 ± 0.1
0.689IleTrp: 0.689 ± 0.031
2.307IleTyr: 2.307 ± 0.056
0.0IleXaa: 0.0 ± 0.0
Lys
4.267LysAla: 4.267 ± 0.072
0.408LysCys: 0.408 ± 0.026
3.185LysAsp: 3.185 ± 0.065
5.239LysGlu: 5.239 ± 0.09
1.896LysPhe: 1.896 ± 0.054
4.155LysGly: 4.155 ± 0.074
0.869LysHis: 0.869 ± 0.039
4.619LysIle: 4.619 ± 0.079
4.359LysLys: 4.359 ± 0.084
5.253LysLeu: 5.253 ± 0.098
1.684LysMet: 1.684 ± 0.049
2.546LysAsn: 2.546 ± 0.052
2.07LysPro: 2.07 ± 0.054
1.259LysGln: 1.259 ± 0.041
3.73LysArg: 3.73 ± 0.081
4.007LysSer: 4.007 ± 0.067
3.333LysThr: 3.333 ± 0.063
4.036LysVal: 4.036 ± 0.072
0.588LysTrp: 0.588 ± 0.027
2.006LysTyr: 2.006 ± 0.048
0.0LysXaa: 0.0 ± 0.0
Leu
6.503LeuAla: 6.503 ± 0.101
0.807LeuCys: 0.807 ± 0.034
5.301LeuAsp: 5.301 ± 0.088
7.536LeuGlu: 7.536 ± 0.117
5.094LeuPhe: 5.094 ± 0.085
6.975LeuGly: 6.975 ± 0.109
1.352LeuHis: 1.352 ± 0.042
7.047LeuIle: 7.047 ± 0.098
6.742LeuLys: 6.742 ± 0.089
10.18LeuLeu: 10.18 ± 0.148
2.542LeuMet: 2.542 ± 0.061
3.838LeuAsn: 3.838 ± 0.067
4.094LeuPro: 4.094 ± 0.064
2.539LeuGln: 2.539 ± 0.052
5.266LeuArg: 5.266 ± 0.097
8.669LeuSer: 8.669 ± 0.12
4.861LeuThr: 4.861 ± 0.089
6.861LeuVal: 6.861 ± 0.092
0.907LeuTrp: 0.907 ± 0.035
2.873LeuTyr: 2.873 ± 0.065
0.0LeuXaa: 0.0 ± 0.0
Met
1.946MetAla: 1.946 ± 0.049
0.133MetCys: 0.133 ± 0.013
1.396MetAsp: 1.396 ± 0.046
1.801MetGlu: 1.801 ± 0.056
0.866MetPhe: 0.866 ± 0.032
1.881MetGly: 1.881 ± 0.048
0.301MetHis: 0.301 ± 0.022
2.24MetIle: 2.24 ± 0.054
2.543MetLys: 2.543 ± 0.057
2.361MetLeu: 2.361 ± 0.06
0.726MetMet: 0.726 ± 0.034
1.354MetAsn: 1.354 ± 0.041
0.911MetPro: 0.911 ± 0.032
0.514MetGln: 0.514 ± 0.025
1.546MetArg: 1.546 ± 0.046
1.737MetSer: 1.737 ± 0.047
1.429MetThr: 1.429 ± 0.046
1.784MetVal: 1.784 ± 0.044
0.184MetTrp: 0.184 ± 0.014
0.716MetTyr: 0.716 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
2.342AsnAla: 2.342 ± 0.054
0.368AsnCys: 0.368 ± 0.021
1.914AsnAsp: 1.914 ± 0.055
2.664AsnGlu: 2.664 ± 0.061
1.783AsnPhe: 1.783 ± 0.055
3.001AsnGly: 3.001 ± 0.069
0.654AsnHis: 0.654 ± 0.029
2.706AsnIle: 2.706 ± 0.065
1.84AsnLys: 1.84 ± 0.046
3.94AsnLeu: 3.94 ± 0.075
0.939AsnMet: 0.939 ± 0.037
1.317AsnAsn: 1.317 ± 0.042
2.109AsnPro: 2.109 ± 0.046
0.833AsnGln: 0.833 ± 0.034
2.045AsnArg: 2.045 ± 0.054
2.824AsnSer: 2.824 ± 0.065
1.81AsnThr: 1.81 ± 0.051
2.701AsnVal: 2.701 ± 0.063
0.493AsnTrp: 0.493 ± 0.029
1.545AsnTyr: 1.545 ± 0.049
0.0AsnXaa: 0.0 ± 0.0
Pro
2.295ProAla: 2.295 ± 0.062
0.229ProCys: 0.229 ± 0.02
2.474ProAsp: 2.474 ± 0.061
3.57ProGlu: 3.57 ± 0.078
2.16ProPhe: 2.16 ± 0.049
2.934ProGly: 2.934 ± 0.067
0.59ProHis: 0.59 ± 0.028
2.475ProIle: 2.475 ± 0.057
1.649ProLys: 1.649 ± 0.045
3.507ProLeu: 3.507 ± 0.072
0.846ProMet: 0.846 ± 0.031
1.305ProAsn: 1.305 ± 0.042
1.233ProPro: 1.233 ± 0.043
0.93ProGln: 0.93 ± 0.033
1.496ProArg: 1.496 ± 0.043
2.738ProSer: 2.738 ± 0.063
1.817ProThr: 1.817 ± 0.046
3.402ProVal: 3.402 ± 0.056
0.432ProTrp: 0.432 ± 0.023
1.49ProTyr: 1.49 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
1.406GlnAla: 1.406 ± 0.04
0.155GlnCys: 0.155 ± 0.014
1.098GlnAsp: 1.098 ± 0.041
1.737GlnGlu: 1.737 ± 0.05
0.962GlnPhe: 0.962 ± 0.035
1.424GlnGly: 1.424 ± 0.042
0.308GlnHis: 0.308 ± 0.019
1.858GlnIle: 1.858 ± 0.05
1.534GlnLys: 1.534 ± 0.043
2.231GlnLeu: 2.231 ± 0.046
0.743GlnMet: 0.743 ± 0.031
0.948GlnAsn: 0.948 ± 0.031
0.734GlnPro: 0.734 ± 0.03
0.589GlnGln: 0.589 ± 0.03
1.296GlnArg: 1.296 ± 0.046
1.528GlnSer: 1.528 ± 0.046
1.113GlnThr: 1.113 ± 0.037
1.442GlnVal: 1.442 ± 0.04
0.297GlnTrp: 0.297 ± 0.02
0.781GlnTyr: 0.781 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
3.125ArgAla: 3.125 ± 0.064
0.407ArgCys: 0.407 ± 0.027
2.956ArgAsp: 2.956 ± 0.057
4.74ArgGlu: 4.74 ± 0.087
2.703ArgPhe: 2.703 ± 0.056
3.255ArgGly: 3.255 ± 0.064
0.743ArgHis: 0.743 ± 0.031
4.59ArgIle: 4.59 ± 0.074
3.855ArgLys: 3.855 ± 0.068
5.333ArgLeu: 5.333 ± 0.101
1.48ArgMet: 1.48 ± 0.042
2.392ArgAsn: 2.392 ± 0.051
1.647ArgPro: 1.647 ± 0.042
1.248ArgGln: 1.248 ± 0.036
3.109ArgArg: 3.109 ± 0.069
3.401ArgSer: 3.401 ± 0.076
2.485ArgThr: 2.485 ± 0.05
3.9ArgVal: 3.9 ± 0.076
0.534ArgTrp: 0.534 ± 0.026
1.886ArgTyr: 1.886 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
4.465SerAla: 4.465 ± 0.079
0.631SerCys: 0.631 ± 0.03
3.802SerAsp: 3.802 ± 0.077
5.303SerGlu: 5.303 ± 0.084
4.146SerPhe: 4.146 ± 0.073
6.326SerGly: 6.326 ± 0.108
1.104SerHis: 1.104 ± 0.034
5.492SerIle: 5.492 ± 0.093
4.182SerLys: 4.182 ± 0.069
8.026SerLeu: 8.026 ± 0.11
1.99SerMet: 1.99 ± 0.051
2.551SerAsn: 2.551 ± 0.056
2.761SerPro: 2.761 ± 0.061
1.597SerGln: 1.597 ± 0.046
3.972SerArg: 3.972 ± 0.076
5.675SerSer: 5.675 ± 0.111
3.356SerThr: 3.356 ± 0.073
5.711SerVal: 5.711 ± 0.084
0.835SerTrp: 0.835 ± 0.033
2.511SerTyr: 2.511 ± 0.059
0.0SerXaa: 0.0 ± 0.0
Thr
3.518ThrAla: 3.518 ± 0.074
0.346ThrCys: 0.346 ± 0.024
2.425ThrAsp: 2.425 ± 0.055
3.143ThrGlu: 3.143 ± 0.064
2.445ThrPhe: 2.445 ± 0.058
4.458ThrGly: 4.458 ± 0.081
0.775ThrHis: 0.775 ± 0.033
3.738ThrIle: 3.738 ± 0.078
2.304ThrLys: 2.304 ± 0.051
5.046ThrLeu: 5.046 ± 0.087
1.257ThrMet: 1.257 ± 0.038
1.591ThrAsn: 1.591 ± 0.047
2.117ThrPro: 2.117 ± 0.057
0.92ThrGln: 0.92 ± 0.037
2.21ThrArg: 2.21 ± 0.054
3.271ThrSer: 3.271 ± 0.068
2.403ThrThr: 2.403 ± 0.061
4.354ThrVal: 4.354 ± 0.079
0.513ThrTrp: 0.513 ± 0.025
1.652ThrTyr: 1.652 ± 0.051
0.0ThrXaa: 0.0 ± 0.0
Val
5.149ValAla: 5.149 ± 0.088
0.58ValCys: 0.58 ± 0.028
4.335ValAsp: 4.335 ± 0.085
5.545ValGlu: 5.545 ± 0.08
4.261ValPhe: 4.261 ± 0.075
5.197ValGly: 5.197 ± 0.082
1.086ValHis: 1.086 ± 0.034
5.721ValIle: 5.721 ± 0.093
4.257ValLys: 4.257 ± 0.083
7.323ValLeu: 7.323 ± 0.099
1.873ValMet: 1.873 ± 0.054
2.663ValAsn: 2.663 ± 0.057
2.817ValPro: 2.817 ± 0.069
1.777ValGln: 1.777 ± 0.045
3.68ValArg: 3.68 ± 0.067
6.088ValSer: 6.088 ± 0.091
3.691ValThr: 3.691 ± 0.071
6.071ValVal: 6.071 ± 0.081
0.678ValTrp: 0.678 ± 0.034
2.369ValTyr: 2.369 ± 0.055
0.0ValXaa: 0.0 ± 0.0
Trp
0.578TrpAla: 0.578 ± 0.025
0.075TrpCys: 0.075 ± 0.01
0.527TrpAsp: 0.527 ± 0.028
0.711TrpGlu: 0.711 ± 0.03
0.503TrpPhe: 0.503 ± 0.027
0.729TrpGly: 0.729 ± 0.033
0.168TrpHis: 0.168 ± 0.015
0.864TrpIle: 0.864 ± 0.038
0.795TrpLys: 0.795 ± 0.03
1.052TrpLeu: 1.052 ± 0.044
0.298TrpMet: 0.298 ± 0.02
0.54TrpAsn: 0.54 ± 0.029
0.36TrpPro: 0.36 ± 0.022
0.349TrpGln: 0.349 ± 0.022
0.503TrpArg: 0.503 ± 0.027
0.732TrpSer: 0.732 ± 0.035
0.542TrpThr: 0.542 ± 0.026
0.639TrpVal: 0.639 ± 0.026
0.19TrpTrp: 0.19 ± 0.021
0.356TrpTyr: 0.356 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.05TyrAla: 2.05 ± 0.052
0.376TyrCys: 0.376 ± 0.024
1.953TyrAsp: 1.953 ± 0.047
2.431TyrGlu: 2.431 ± 0.057
1.93TyrPhe: 1.93 ± 0.047
2.719TyrGly: 2.719 ± 0.068
0.61TyrHis: 0.61 ± 0.028
2.101TyrIle: 2.101 ± 0.049
1.413TyrLys: 1.413 ± 0.045
3.712TyrLeu: 3.712 ± 0.076
0.757TyrMet: 0.757 ± 0.027
1.2TyrAsn: 1.2 ± 0.042
1.342TyrPro: 1.342 ± 0.039
0.737TyrGln: 0.737 ± 0.029
2.075TyrArg: 2.075 ± 0.045
2.891TyrSer: 2.891 ± 0.067
1.585TyrThr: 1.585 ± 0.043
2.372TyrVal: 2.372 ± 0.058
0.426TyrTrp: 0.426 ± 0.021
1.445TyrTyr: 1.445 ± 0.045
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2499 proteins (811598 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski