Amino acid dipepetide frequency for Rhizobium phage vB_RleS_L338C

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.238AlaAla: 11.238 ± 1.015
0.788AlaCys: 0.788 ± 0.153
4.877AlaAsp: 4.877 ± 0.432
7.058AlaGlu: 7.058 ± 0.693
2.999AlaPhe: 2.999 ± 0.279
6.119AlaGly: 6.119 ± 0.445
1.424AlaHis: 1.424 ± 0.239
5.18AlaIle: 5.18 ± 0.556
6.755AlaLys: 6.755 ± 0.621
7.573AlaLeu: 7.573 ± 0.458
3.12AlaMet: 3.12 ± 0.282
3.514AlaAsn: 3.514 ± 0.437
4.513AlaPro: 4.513 ± 0.4
3.514AlaGln: 3.514 ± 0.362
5.816AlaArg: 5.816 ± 0.532
5.543AlaSer: 5.543 ± 0.518
6.422AlaThr: 6.422 ± 0.563
5.695AlaVal: 5.695 ± 0.455
1.272AlaTrp: 1.272 ± 0.191
3.12AlaTyr: 3.12 ± 0.267
0.0AlaXaa: 0.0 ± 0.0
Cys
0.939CysAla: 0.939 ± 0.184
0.273CysCys: 0.273 ± 0.093
0.666CysAsp: 0.666 ± 0.134
0.818CysGlu: 0.818 ± 0.164
0.515CysPhe: 0.515 ± 0.109
0.666CysGly: 0.666 ± 0.126
0.303CysHis: 0.303 ± 0.111
0.394CysIle: 0.394 ± 0.098
0.576CysLys: 0.576 ± 0.12
0.697CysLeu: 0.697 ± 0.166
0.212CysMet: 0.212 ± 0.085
0.515CysAsn: 0.515 ± 0.125
0.727CysPro: 0.727 ± 0.175
0.424CysGln: 0.424 ± 0.12
0.697CysArg: 0.697 ± 0.144
0.636CysSer: 0.636 ± 0.15
0.697CysThr: 0.697 ± 0.127
0.666CysVal: 0.666 ± 0.169
0.182CysTrp: 0.182 ± 0.079
0.485CysTyr: 0.485 ± 0.116
0.0CysXaa: 0.0 ± 0.0
Asp
6.028AspAla: 6.028 ± 0.519
0.788AspCys: 0.788 ± 0.145
3.786AspAsp: 3.786 ± 0.386
3.938AspGlu: 3.938 ± 0.384
2.302AspPhe: 2.302 ± 0.253
5.028AspGly: 5.028 ± 0.436
1.272AspHis: 1.272 ± 0.209
3.908AspIle: 3.908 ± 0.335
3.181AspLys: 3.181 ± 0.416
4.574AspLeu: 4.574 ± 0.373
2.09AspMet: 2.09 ± 0.238
2.423AspAsn: 2.423 ± 0.331
3.241AspPro: 3.241 ± 0.329
1.999AspGln: 1.999 ± 0.223
2.878AspArg: 2.878 ± 0.331
1.757AspSer: 1.757 ± 0.227
3.574AspThr: 3.574 ± 0.277
3.393AspVal: 3.393 ± 0.263
0.909AspTrp: 0.909 ± 0.153
2.393AspTyr: 2.393 ± 0.268
0.0AspXaa: 0.0 ± 0.0
Glu
6.634GluAla: 6.634 ± 0.588
0.545GluCys: 0.545 ± 0.114
3.847GluAsp: 3.847 ± 0.385
5.543GluGlu: 5.543 ± 0.619
2.272GluPhe: 2.272 ± 0.232
4.968GluGly: 4.968 ± 0.401
1.636GluHis: 1.636 ± 0.253
2.878GluIle: 2.878 ± 0.279
4.059GluLys: 4.059 ± 0.508
4.574GluLeu: 4.574 ± 0.364
1.817GluMet: 1.817 ± 0.197
2.575GluAsn: 2.575 ± 0.286
2.151GluPro: 2.151 ± 0.282
3.059GluGln: 3.059 ± 0.239
5.18GluArg: 5.18 ± 0.469
2.09GluSer: 2.09 ± 0.228
3.544GluThr: 3.544 ± 0.294
5.089GluVal: 5.089 ± 0.557
1.363GluTrp: 1.363 ± 0.222
1.969GluTyr: 1.969 ± 0.256
0.0GluXaa: 0.0 ± 0.0
Phe
2.696PheAla: 2.696 ± 0.313
0.333PheCys: 0.333 ± 0.11
2.423PheAsp: 2.423 ± 0.257
2.242PheGlu: 2.242 ± 0.254
1.242PhePhe: 1.242 ± 0.188
2.938PheGly: 2.938 ± 0.272
1.09PheHis: 1.09 ± 0.197
1.636PheIle: 1.636 ± 0.259
1.848PheLys: 1.848 ± 0.231
2.726PheLeu: 2.726 ± 0.298
0.969PheMet: 0.969 ± 0.192
1.484PheAsn: 1.484 ± 0.214
1.787PhePro: 1.787 ± 0.229
1.0PheGln: 1.0 ± 0.169
2.575PheArg: 2.575 ± 0.269
2.211PheSer: 2.211 ± 0.238
2.06PheThr: 2.06 ± 0.276
2.878PheVal: 2.878 ± 0.293
0.545PheTrp: 0.545 ± 0.099
1.121PheTyr: 1.121 ± 0.173
0.0PheXaa: 0.0 ± 0.0
Gly
5.695GlyAla: 5.695 ± 0.425
0.878GlyCys: 0.878 ± 0.182
4.301GlyAsp: 4.301 ± 0.361
4.332GlyGlu: 4.332 ± 0.354
3.332GlyPhe: 3.332 ± 0.344
5.301GlyGly: 5.301 ± 0.501
1.545GlyHis: 1.545 ± 0.259
4.544GlyIle: 4.544 ± 0.364
4.301GlyLys: 4.301 ± 0.423
4.968GlyLeu: 4.968 ± 0.416
2.454GlyMet: 2.454 ± 0.259
3.211GlyAsn: 3.211 ± 0.357
1.878GlyPro: 1.878 ± 0.301
3.332GlyGln: 3.332 ± 0.315
3.877GlyArg: 3.877 ± 0.411
5.18GlySer: 5.18 ± 0.529
4.847GlyThr: 4.847 ± 0.489
5.271GlyVal: 5.271 ± 0.367
1.545GlyTrp: 1.545 ± 0.207
2.847GlyTyr: 2.847 ± 0.305
0.0GlyXaa: 0.0 ± 0.0
His
1.545HisAla: 1.545 ± 0.228
0.242HisCys: 0.242 ± 0.097
1.454HisAsp: 1.454 ± 0.175
1.484HisGlu: 1.484 ± 0.193
0.878HisPhe: 0.878 ± 0.17
1.908HisGly: 1.908 ± 0.265
0.606HisHis: 0.606 ± 0.15
1.424HisIle: 1.424 ± 0.188
0.818HisLys: 0.818 ± 0.154
1.908HisLeu: 1.908 ± 0.27
0.636HisMet: 0.636 ± 0.14
0.727HisAsn: 0.727 ± 0.14
1.454HisPro: 1.454 ± 0.254
0.697HisGln: 0.697 ± 0.163
1.393HisArg: 1.393 ± 0.213
0.909HisSer: 0.909 ± 0.203
1.09HisThr: 1.09 ± 0.19
2.12HisVal: 2.12 ± 0.289
0.242HisTrp: 0.242 ± 0.089
0.666HisTyr: 0.666 ± 0.165
0.0HisXaa: 0.0 ± 0.0
Ile
5.846IleAla: 5.846 ± 0.383
0.727IleCys: 0.727 ± 0.137
3.786IleAsp: 3.786 ± 0.336
3.605IleGlu: 3.605 ± 0.338
1.393IlePhe: 1.393 ± 0.213
4.968IleGly: 4.968 ± 0.445
1.212IleHis: 1.212 ± 0.223
2.423IleIle: 2.423 ± 0.255
2.787IleLys: 2.787 ± 0.335
3.817IleLeu: 3.817 ± 0.361
1.242IleMet: 1.242 ± 0.169
1.817IleAsn: 1.817 ± 0.227
2.575IlePro: 2.575 ± 0.263
1.666IleGln: 1.666 ± 0.174
3.029IleArg: 3.029 ± 0.279
2.514IleSer: 2.514 ± 0.261
3.877IleThr: 3.877 ± 0.469
3.665IleVal: 3.665 ± 0.345
0.545IleTrp: 0.545 ± 0.132
1.454IleTyr: 1.454 ± 0.228
0.0IleXaa: 0.0 ± 0.0
Lys
6.21LysAla: 6.21 ± 0.743
0.333LysCys: 0.333 ± 0.08
3.12LysAsp: 3.12 ± 0.383
3.877LysGlu: 3.877 ± 0.437
2.09LysPhe: 2.09 ± 0.215
4.21LysGly: 4.21 ± 0.406
1.696LysHis: 1.696 ± 0.256
2.393LysIle: 2.393 ± 0.233
3.332LysLys: 3.332 ± 0.377
4.21LysLeu: 4.21 ± 0.454
1.696LysMet: 1.696 ± 0.223
1.636LysAsn: 1.636 ± 0.198
2.696LysPro: 2.696 ± 0.296
1.969LysGln: 1.969 ± 0.28
3.211LysArg: 3.211 ± 0.368
3.12LysSer: 3.12 ± 0.323
3.181LysThr: 3.181 ± 0.35
3.332LysVal: 3.332 ± 0.296
0.757LysTrp: 0.757 ± 0.188
1.303LysTyr: 1.303 ± 0.218
0.0LysXaa: 0.0 ± 0.0
Leu
6.513LeuAla: 6.513 ± 0.487
0.939LeuCys: 0.939 ± 0.169
5.392LeuAsp: 5.392 ± 0.472
4.998LeuGlu: 4.998 ± 0.435
2.272LeuPhe: 2.272 ± 0.277
4.998LeuGly: 4.998 ± 0.454
1.303LeuHis: 1.303 ± 0.222
4.029LeuIle: 4.029 ± 0.387
4.483LeuLys: 4.483 ± 0.364
5.149LeuLeu: 5.149 ± 0.428
1.817LeuMet: 1.817 ± 0.268
2.575LeuAsn: 2.575 ± 0.287
3.908LeuPro: 3.908 ± 0.35
2.09LeuGln: 2.09 ± 0.298
5.028LeuArg: 5.028 ± 0.391
4.695LeuSer: 4.695 ± 0.341
4.544LeuThr: 4.544 ± 0.439
4.483LeuVal: 4.483 ± 0.351
1.242LeuTrp: 1.242 ± 0.183
2.605LeuTyr: 2.605 ± 0.27
0.0LeuXaa: 0.0 ± 0.0
Met
3.029MetAla: 3.029 ± 0.268
0.333MetCys: 0.333 ± 0.105
1.575MetAsp: 1.575 ± 0.263
1.696MetGlu: 1.696 ± 0.234
0.909MetPhe: 0.909 ± 0.156
1.969MetGly: 1.969 ± 0.229
0.697MetHis: 0.697 ± 0.147
1.787MetIle: 1.787 ± 0.228
1.151MetLys: 1.151 ± 0.229
1.757MetLeu: 1.757 ± 0.243
0.848MetMet: 0.848 ± 0.165
0.969MetAsn: 0.969 ± 0.179
1.454MetPro: 1.454 ± 0.222
1.333MetGln: 1.333 ± 0.207
1.939MetArg: 1.939 ± 0.25
2.635MetSer: 2.635 ± 0.273
2.03MetThr: 2.03 ± 0.238
1.545MetVal: 1.545 ± 0.257
0.273MetTrp: 0.273 ± 0.099
0.757MetTyr: 0.757 ± 0.146
0.0MetXaa: 0.0 ± 0.0
Asn
3.332AsnAla: 3.332 ± 0.303
0.485AsnCys: 0.485 ± 0.14
2.06AsnAsp: 2.06 ± 0.236
2.242AsnGlu: 2.242 ± 0.292
1.181AsnPhe: 1.181 ± 0.183
3.483AsnGly: 3.483 ± 0.37
1.09AsnHis: 1.09 ± 0.187
1.939AsnIle: 1.939 ± 0.253
1.696AsnLys: 1.696 ± 0.274
3.12AsnLeu: 3.12 ± 0.34
0.727AsnMet: 0.727 ± 0.163
1.424AsnAsn: 1.424 ± 0.234
2.06AsnPro: 2.06 ± 0.294
0.848AsnGln: 0.848 ± 0.147
2.332AsnArg: 2.332 ± 0.238
2.12AsnSer: 2.12 ± 0.318
2.151AsnThr: 2.151 ± 0.243
2.847AsnVal: 2.847 ± 0.297
0.333AsnTrp: 0.333 ± 0.112
1.272AsnTyr: 1.272 ± 0.209
0.0AsnXaa: 0.0 ± 0.0
Pro
5.18ProAla: 5.18 ± 0.413
0.485ProCys: 0.485 ± 0.114
3.211ProAsp: 3.211 ± 0.4
3.544ProGlu: 3.544 ± 0.333
1.575ProPhe: 1.575 ± 0.209
3.726ProGly: 3.726 ± 0.401
0.727ProHis: 0.727 ± 0.184
2.12ProIle: 2.12 ± 0.263
1.878ProLys: 1.878 ± 0.26
2.817ProLeu: 2.817 ± 0.307
1.212ProMet: 1.212 ± 0.222
1.575ProAsn: 1.575 ± 0.21
3.029ProPro: 3.029 ± 0.407
1.393ProGln: 1.393 ± 0.235
2.635ProArg: 2.635 ± 0.325
3.241ProSer: 3.241 ± 0.329
3.332ProThr: 3.332 ± 0.288
4.089ProVal: 4.089 ± 0.364
0.636ProTrp: 0.636 ± 0.13
1.333ProTyr: 1.333 ± 0.174
0.0ProXaa: 0.0 ± 0.0
Gln
3.786GlnAla: 3.786 ± 0.451
0.485GlnCys: 0.485 ± 0.131
1.303GlnAsp: 1.303 ± 0.183
2.575GlnGlu: 2.575 ± 0.313
1.636GlnPhe: 1.636 ± 0.224
1.969GlnGly: 1.969 ± 0.259
1.03GlnHis: 1.03 ± 0.206
2.544GlnIle: 2.544 ± 0.253
1.605GlnLys: 1.605 ± 0.239
2.756GlnLeu: 2.756 ± 0.31
1.06GlnMet: 1.06 ± 0.173
1.06GlnAsn: 1.06 ± 0.204
1.303GlnPro: 1.303 ± 0.19
2.03GlnGln: 2.03 ± 0.325
2.847GlnArg: 2.847 ± 0.306
1.969GlnSer: 1.969 ± 0.238
2.332GlnThr: 2.332 ± 0.358
2.938GlnVal: 2.938 ± 0.301
0.788GlnTrp: 0.788 ± 0.139
1.333GlnTyr: 1.333 ± 0.229
0.0GlnXaa: 0.0 ± 0.0
Arg
6.179ArgAla: 6.179 ± 0.471
0.818ArgCys: 0.818 ± 0.155
3.12ArgAsp: 3.12 ± 0.316
3.605ArgGlu: 3.605 ± 0.383
2.454ArgPhe: 2.454 ± 0.255
4.089ArgGly: 4.089 ± 0.349
1.727ArgHis: 1.727 ± 0.261
3.302ArgIle: 3.302 ± 0.288
3.635ArgLys: 3.635 ± 0.351
4.968ArgLeu: 4.968 ± 0.332
2.151ArgMet: 2.151 ± 0.227
2.393ArgAsn: 2.393 ± 0.277
2.878ArgPro: 2.878 ± 0.361
2.908ArgGln: 2.908 ± 0.4
5.149ArgArg: 5.149 ± 0.575
4.12ArgSer: 4.12 ± 0.35
3.514ArgThr: 3.514 ± 0.355
4.604ArgVal: 4.604 ± 0.355
1.363ArgTrp: 1.363 ± 0.193
2.151ArgTyr: 2.151 ± 0.261
0.0ArgXaa: 0.0 ± 0.0
Ser
5.24SerAla: 5.24 ± 0.442
0.576SerCys: 0.576 ± 0.11
3.059SerAsp: 3.059 ± 0.347
3.241SerGlu: 3.241 ± 0.336
2.484SerPhe: 2.484 ± 0.305
5.18SerGly: 5.18 ± 0.455
1.06SerHis: 1.06 ± 0.198
3.029SerIle: 3.029 ± 0.31
2.938SerLys: 2.938 ± 0.34
4.15SerLeu: 4.15 ± 0.355
1.908SerMet: 1.908 ± 0.209
1.787SerAsn: 1.787 ± 0.259
2.847SerPro: 2.847 ± 0.425
2.03SerGln: 2.03 ± 0.322
3.908SerArg: 3.908 ± 0.343
3.393SerSer: 3.393 ± 0.47
4.12SerThr: 4.12 ± 0.467
3.938SerVal: 3.938 ± 0.468
1.06SerTrp: 1.06 ± 0.213
2.06SerTyr: 2.06 ± 0.274
0.0SerXaa: 0.0 ± 0.0
Thr
6.119ThrAla: 6.119 ± 0.583
0.454ThrCys: 0.454 ± 0.127
3.271ThrAsp: 3.271 ± 0.299
3.574ThrGlu: 3.574 ± 0.361
2.181ThrPhe: 2.181 ± 0.226
5.059ThrGly: 5.059 ± 0.386
1.06ThrHis: 1.06 ± 0.168
4.059ThrIle: 4.059 ± 0.325
3.12ThrLys: 3.12 ± 0.281
5.119ThrLeu: 5.119 ± 0.484
1.636ThrMet: 1.636 ± 0.225
2.363ThrAsn: 2.363 ± 0.273
3.635ThrPro: 3.635 ± 0.342
2.393ThrGln: 2.393 ± 0.243
3.968ThrArg: 3.968 ± 0.36
3.847ThrSer: 3.847 ± 0.418
3.938ThrThr: 3.938 ± 0.475
4.968ThrVal: 4.968 ± 0.475
1.0ThrTrp: 1.0 ± 0.18
1.696ThrTyr: 1.696 ± 0.252
0.0ThrXaa: 0.0 ± 0.0
Val
6.301ValAla: 6.301 ± 0.483
0.969ValCys: 0.969 ± 0.167
4.513ValAsp: 4.513 ± 0.353
4.362ValGlu: 4.362 ± 0.398
2.666ValPhe: 2.666 ± 0.287
4.059ValGly: 4.059 ± 0.348
1.484ValHis: 1.484 ± 0.253
3.362ValIle: 3.362 ± 0.331
3.817ValLys: 3.817 ± 0.353
4.756ValLeu: 4.756 ± 0.375
1.757ValMet: 1.757 ± 0.236
2.666ValAsn: 2.666 ± 0.281
3.726ValPro: 3.726 ± 0.357
3.059ValGln: 3.059 ± 0.386
5.422ValArg: 5.422 ± 0.473
4.907ValSer: 4.907 ± 0.491
4.877ValThr: 4.877 ± 0.341
5.028ValVal: 5.028 ± 0.452
0.818ValTrp: 0.818 ± 0.176
1.848ValTyr: 1.848 ± 0.279
0.0ValXaa: 0.0 ± 0.0
Trp
1.303TrpAla: 1.303 ± 0.181
0.151TrpCys: 0.151 ± 0.074
1.06TrpAsp: 1.06 ± 0.182
0.757TrpGlu: 0.757 ± 0.162
0.545TrpPhe: 0.545 ± 0.127
0.788TrpGly: 0.788 ± 0.142
0.545TrpHis: 0.545 ± 0.127
0.666TrpIle: 0.666 ± 0.162
0.878TrpLys: 0.878 ± 0.184
1.212TrpLeu: 1.212 ± 0.186
0.606TrpMet: 0.606 ± 0.143
0.636TrpAsn: 0.636 ± 0.159
0.576TrpPro: 0.576 ± 0.147
0.485TrpGln: 0.485 ± 0.105
1.151TrpArg: 1.151 ± 0.185
1.212TrpSer: 1.212 ± 0.174
1.06TrpThr: 1.06 ± 0.228
1.454TrpVal: 1.454 ± 0.278
0.303TrpTrp: 0.303 ± 0.087
0.424TrpTyr: 0.424 ± 0.105
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.726TyrAla: 2.726 ± 0.3
0.485TyrCys: 0.485 ± 0.138
2.666TyrAsp: 2.666 ± 0.32
2.302TyrGlu: 2.302 ± 0.261
0.878TyrPhe: 0.878 ± 0.18
2.211TyrGly: 2.211 ± 0.239
0.697TyrHis: 0.697 ± 0.155
1.333TyrIle: 1.333 ± 0.219
1.515TyrLys: 1.515 ± 0.21
2.211TyrLeu: 2.211 ± 0.236
0.697TyrMet: 0.697 ± 0.133
1.393TyrAsn: 1.393 ± 0.201
1.303TyrPro: 1.303 ± 0.241
1.121TyrGln: 1.121 ± 0.175
2.09TyrArg: 2.09 ± 0.249
1.908TyrSer: 1.908 ± 0.188
2.272TyrThr: 2.272 ± 0.298
2.393TyrVal: 2.393 ± 0.279
0.636TyrTrp: 0.636 ± 0.122
0.939TyrTyr: 0.939 ± 0.178
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 181 proteins (33014 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski