Amino acid dipepetide frequency for Lodeiro virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.901AlaAla: 1.901 ± 0.843
0.0AlaCys: 0.0 ± 0.0
1.901AlaAsp: 1.901 ± 0.702
2.852AlaGlu: 2.852 ± 1.285
1.584AlaPhe: 1.584 ± 0.826
2.535AlaGly: 2.535 ± 1.424
0.951AlaHis: 0.951 ± 0.534
4.436AlaIle: 4.436 ± 4.159
2.218AlaLys: 2.218 ± 1.578
5.703AlaLeu: 5.703 ± 2.193
0.951AlaMet: 0.951 ± 0.918
2.218AlaAsn: 2.218 ± 0.852
2.218AlaPro: 2.218 ± 0.701
2.218AlaGln: 2.218 ± 1.81
2.852AlaArg: 2.852 ± 1.013
3.485AlaSer: 3.485 ± 0.443
0.634AlaThr: 0.634 ± 0.369
2.218AlaVal: 2.218 ± 0.701
0.634AlaTrp: 0.634 ± 0.356
3.802AlaTyr: 3.802 ± 0.825
0.0AlaXaa: 0.0 ± 0.0
Cys
0.634CysAla: 0.634 ± 0.619
0.634CysCys: 0.634 ± 0.356
0.951CysAsp: 0.951 ± 0.865
0.951CysGlu: 0.951 ± 0.813
0.634CysPhe: 0.634 ± 0.918
0.951CysGly: 0.951 ± 0.353
0.317CysHis: 0.317 ± 0.459
0.951CysIle: 0.951 ± 0.813
1.267CysLys: 1.267 ± 0.701
0.951CysLeu: 0.951 ± 0.353
1.267CysMet: 1.267 ± 0.421
0.0CysAsn: 0.0 ± 0.0
0.951CysPro: 0.951 ± 0.534
1.584CysGln: 1.584 ± 0.541
1.267CysArg: 1.267 ± 0.712
1.584CysSer: 1.584 ± 0.541
0.317CysThr: 0.317 ± 0.459
1.267CysVal: 1.267 ± 0.594
0.0CysTrp: 0.0 ± 0.0
0.951CysTyr: 0.951 ± 0.353
0.0CysXaa: 0.0 ± 0.0
Asp
2.535AspAla: 2.535 ± 1.01
1.267AspCys: 1.267 ± 0.738
3.169AspAsp: 3.169 ± 1.103
4.753AspGlu: 4.753 ± 1.853
3.485AspPhe: 3.485 ± 0.895
2.852AspGly: 2.852 ± 0.742
2.218AspHis: 2.218 ± 0.98
3.485AspIle: 3.485 ± 1.223
2.535AspLys: 2.535 ± 1.01
6.337AspLeu: 6.337 ± 1.429
1.584AspMet: 1.584 ± 1.195
0.951AspAsn: 0.951 ± 0.938
2.535AspPro: 2.535 ± 1.424
4.119AspGln: 4.119 ± 0.399
2.535AspArg: 2.535 ± 0.841
3.802AspSer: 3.802 ± 1.262
2.218AspThr: 2.218 ± 1.272
3.802AspVal: 3.802 ± 1.76
1.901AspTrp: 1.901 ± 0.707
2.535AspTyr: 2.535 ± 0.825
0.0AspXaa: 0.0 ± 0.0
Glu
3.485GluAla: 3.485 ± 1.527
1.584GluCys: 1.584 ± 0.7
3.802GluAsp: 3.802 ± 0.801
5.387GluGlu: 5.387 ± 1.203
3.485GluPhe: 3.485 ± 1.527
5.07GluGly: 5.07 ± 1.25
3.169GluHis: 3.169 ± 0.908
4.119GluIle: 4.119 ± 1.529
7.288GluLys: 7.288 ± 3.018
4.436GluLeu: 4.436 ± 1.542
2.852GluMet: 2.852 ± 0.93
4.119GluAsn: 4.119 ± 0.619
1.267GluPro: 1.267 ± 0.955
0.634GluGln: 0.634 ± 0.619
2.852GluArg: 2.852 ± 0.766
5.703GluSer: 5.703 ± 1.408
4.753GluThr: 4.753 ± 0.99
5.703GluVal: 5.703 ± 2.414
0.634GluTrp: 0.634 ± 0.369
4.753GluTyr: 4.753 ± 1.338
0.0GluXaa: 0.0 ± 0.0
Phe
0.951PheAla: 0.951 ± 1.168
1.584PheCys: 1.584 ± 0.765
4.119PheAsp: 4.119 ± 1.207
3.802PheGlu: 3.802 ± 2.355
1.584PhePhe: 1.584 ± 0.87
1.584PheGly: 1.584 ± 0.972
1.267PheHis: 1.267 ± 0.421
2.535PheIle: 2.535 ± 0.642
2.535PheLys: 2.535 ± 0.853
3.169PheLeu: 3.169 ± 0.695
1.584PheMet: 1.584 ± 0.541
2.218PheAsn: 2.218 ± 0.756
1.584PhePro: 1.584 ± 0.541
0.951PheGln: 0.951 ± 0.704
1.584PheArg: 1.584 ± 0.89
4.436PheSer: 4.436 ± 2.409
2.535PheThr: 2.535 ± 0.786
2.535PheVal: 2.535 ± 0.755
1.584PheTrp: 1.584 ± 0.866
2.218PheTyr: 2.218 ± 1.125
0.0PheXaa: 0.0 ± 0.0
Gly
2.535GlyAla: 2.535 ± 1.519
0.951GlyCys: 0.951 ± 0.353
3.169GlyAsp: 3.169 ± 1.082
5.703GlyGlu: 5.703 ± 2.078
2.535GlyPhe: 2.535 ± 1.757
1.267GlyGly: 1.267 ± 0.611
0.634GlyHis: 0.634 ± 0.619
4.119GlyIle: 4.119 ± 0.619
3.802GlyLys: 3.802 ± 1.205
3.802GlyLeu: 3.802 ± 2.487
1.267GlyMet: 1.267 ± 0.611
2.218GlyAsn: 2.218 ± 0.932
1.584GlyPro: 1.584 ± 0.522
1.267GlyGln: 1.267 ± 0.611
1.901GlyArg: 1.901 ± 0.687
2.852GlySer: 2.852 ± 0.698
1.901GlyThr: 1.901 ± 0.887
2.852GlyVal: 2.852 ± 1.216
0.317GlyTrp: 0.317 ± 0.178
0.634GlyTyr: 0.634 ± 0.619
0.0GlyXaa: 0.0 ± 0.0
His
0.951HisAla: 0.951 ± 0.353
0.634HisCys: 0.634 ± 0.838
1.901HisAsp: 1.901 ± 0.707
2.535HisGlu: 2.535 ± 0.642
1.584HisPhe: 1.584 ± 0.522
0.951HisGly: 0.951 ± 0.353
0.317HisHis: 0.317 ± 0.178
1.267HisIle: 1.267 ± 0.712
1.901HisLys: 1.901 ± 0.861
2.218HisLeu: 2.218 ± 1.09
0.634HisMet: 0.634 ± 0.369
0.317HisAsn: 0.317 ± 0.178
2.535HisPro: 2.535 ± 0.841
0.951HisGln: 0.951 ± 0.534
0.951HisArg: 0.951 ± 0.704
4.436HisSer: 4.436 ± 0.881
1.267HisThr: 1.267 ± 0.611
0.951HisVal: 0.951 ± 0.589
0.0HisTrp: 0.0 ± 0.0
1.584HisTyr: 1.584 ± 0.68
0.0HisXaa: 0.0 ± 0.0
Ile
4.753IleAla: 4.753 ± 1.227
1.901IleCys: 1.901 ± 0.687
3.169IleAsp: 3.169 ± 1.082
4.119IleGlu: 4.119 ± 1.37
2.535IlePhe: 2.535 ± 0.825
3.169IleGly: 3.169 ± 4.328
2.535IleHis: 2.535 ± 1.188
2.535IleIle: 2.535 ± 1.046
3.485IleLys: 3.485 ± 1.794
6.337IleLeu: 6.337 ± 2.735
1.901IleMet: 1.901 ± 0.702
1.584IleAsn: 1.584 ± 0.68
2.852IlePro: 2.852 ± 1.894
2.852IleGln: 2.852 ± 0.742
6.971IleArg: 6.971 ± 2.909
4.753IleSer: 4.753 ± 1.51
2.218IleThr: 2.218 ± 1.465
5.703IleVal: 5.703 ± 0.998
0.634IleTrp: 0.634 ± 0.866
1.267IleTyr: 1.267 ± 0.712
0.0IleXaa: 0.0 ± 0.0
Lys
5.07LysAla: 5.07 ± 2.149
1.584LysCys: 1.584 ± 0.883
5.387LysAsp: 5.387 ± 1.069
6.654LysGlu: 6.654 ± 2.295
4.119LysPhe: 4.119 ± 2.24
2.218LysGly: 2.218 ± 1.246
1.267LysHis: 1.267 ± 0.712
5.07LysIle: 5.07 ± 1.523
8.238LysLys: 8.238 ± 3.089
7.288LysLeu: 7.288 ± 2.279
3.802LysMet: 3.802 ± 2.136
2.852LysAsn: 2.852 ± 1.355
1.901LysPro: 1.901 ± 0.687
1.901LysGln: 1.901 ± 0.707
5.07LysArg: 5.07 ± 1.128
6.654LysSer: 6.654 ± 1.78
5.387LysThr: 5.387 ± 3.054
6.654LysVal: 6.654 ± 1.76
0.317LysTrp: 0.317 ± 0.459
5.387LysTyr: 5.387 ± 1.514
0.0LysXaa: 0.0 ± 0.0
Leu
4.119LeuAla: 4.119 ± 5.249
0.0LeuCys: 0.0 ± 0.0
5.703LeuAsp: 5.703 ± 1.817
8.555LeuGlu: 8.555 ± 1.682
3.485LeuPhe: 3.485 ± 1.108
4.436LeuGly: 4.436 ± 1.62
1.584LeuHis: 1.584 ± 1.244
5.703LeuIle: 5.703 ± 3.854
9.506LeuLys: 9.506 ± 2.2
8.555LeuLeu: 8.555 ± 2.177
2.535LeuMet: 2.535 ± 1.424
3.485LeuAsn: 3.485 ± 1.43
3.485LeuPro: 3.485 ± 1.172
2.218LeuGln: 2.218 ± 0.756
4.436LeuArg: 4.436 ± 1.177
2.852LeuSer: 2.852 ± 0.698
5.387LeuThr: 5.387 ± 1.518
9.506LeuVal: 9.506 ± 3.522
1.267LeuTrp: 1.267 ± 0.829
2.535LeuTyr: 2.535 ± 0.755
0.0LeuXaa: 0.0 ± 0.0
Met
2.218MetAla: 2.218 ± 1.633
0.634MetCys: 0.634 ± 0.369
1.267MetAsp: 1.267 ± 0.594
2.218MetGlu: 2.218 ± 1.186
0.951MetPhe: 0.951 ± 0.534
1.267MetGly: 1.267 ± 0.712
0.317MetHis: 0.317 ± 0.178
0.951MetIle: 0.951 ± 0.534
2.218MetLys: 2.218 ± 0.977
0.951MetLeu: 0.951 ± 0.353
0.317MetMet: 0.317 ± 0.459
0.634MetAsn: 0.634 ± 0.356
0.317MetPro: 0.317 ± 0.178
2.218MetGln: 2.218 ± 0.687
2.218MetArg: 2.218 ± 0.98
1.267MetSer: 1.267 ± 0.611
1.584MetThr: 1.584 ± 0.89
2.852MetVal: 2.852 ± 0.953
0.0MetTrp: 0.0 ± 0.0
1.584MetTyr: 1.584 ± 0.972
0.0MetXaa: 0.0 ± 0.0
Asn
1.901AsnAla: 1.901 ± 0.687
0.951AsnCys: 0.951 ± 0.813
0.951AsnAsp: 0.951 ± 0.353
2.218AsnGlu: 2.218 ± 1.66
1.901AsnPhe: 1.901 ± 0.771
1.901AsnGly: 1.901 ± 0.887
0.951AsnHis: 0.951 ± 0.353
5.07AsnIle: 5.07 ± 0.572
2.852AsnLys: 2.852 ± 0.877
4.119AsnLeu: 4.119 ± 1.9
1.267AsnMet: 1.267 ± 0.592
1.267AsnAsn: 1.267 ± 0.78
1.267AsnPro: 1.267 ± 0.923
1.901AsnGln: 1.901 ± 0.887
2.218AsnArg: 2.218 ± 0.551
3.802AsnSer: 3.802 ± 1.923
0.951AsnThr: 0.951 ± 1.009
2.852AsnVal: 2.852 ± 1.483
0.634AsnTrp: 0.634 ± 0.356
1.267AsnTyr: 1.267 ± 1.731
0.0AsnXaa: 0.0 ± 0.0
Pro
1.901ProAla: 1.901 ± 0.861
0.634ProCys: 0.634 ± 0.369
3.485ProAsp: 3.485 ± 1.223
3.169ProGlu: 3.169 ± 1.364
1.584ProPhe: 1.584 ± 0.883
2.535ProGly: 2.535 ± 1.01
0.951ProHis: 0.951 ± 0.704
2.218ProIle: 2.218 ± 1.246
5.703ProLys: 5.703 ± 1.759
1.901ProLeu: 1.901 ± 0.816
0.634ProMet: 0.634 ± 0.619
0.951ProAsn: 0.951 ± 0.353
0.634ProPro: 0.634 ± 0.356
0.951ProGln: 0.951 ± 0.353
0.951ProArg: 0.951 ± 0.68
0.634ProSer: 0.634 ± 0.866
0.634ProThr: 0.634 ± 0.369
2.535ProVal: 2.535 ± 1.284
0.317ProTrp: 0.317 ± 0.459
1.584ProTyr: 1.584 ± 1.846
0.0ProXaa: 0.0 ± 0.0
Gln
0.951GlnAla: 0.951 ± 0.534
0.634GlnCys: 0.634 ± 0.369
1.584GlnAsp: 1.584 ± 0.7
4.436GlnGlu: 4.436 ± 2.03
0.634GlnPhe: 0.634 ± 0.356
2.535GlnGly: 2.535 ± 1.188
0.634GlnHis: 0.634 ± 0.356
2.535GlnIle: 2.535 ± 1.188
2.852GlnLys: 2.852 ± 1.206
3.802GlnLeu: 3.802 ± 0.908
0.0GlnMet: 0.0 ± 0.0
3.169GlnAsn: 3.169 ± 2.264
0.317GlnPro: 0.317 ± 0.178
2.218GlnGln: 2.218 ± 0.756
1.584GlnArg: 1.584 ± 0.541
3.802GlnSer: 3.802 ± 2.024
2.218GlnThr: 2.218 ± 1.578
1.901GlnVal: 1.901 ± 0.702
0.951GlnTrp: 0.951 ± 0.534
1.584GlnTyr: 1.584 ± 0.765
0.0GlnXaa: 0.0 ± 0.0
Arg
4.119ArgAla: 4.119 ± 1.87
0.0ArgCys: 0.0 ± 0.0
4.119ArgAsp: 4.119 ± 1.032
3.802ArgGlu: 3.802 ± 0.956
2.218ArgPhe: 2.218 ± 1.246
2.852ArgGly: 2.852 ± 3.157
1.901ArgHis: 1.901 ± 1.068
4.119ArgIle: 4.119 ± 2.314
5.387ArgLys: 5.387 ± 3.147
4.119ArgLeu: 4.119 ± 1.347
1.267ArgMet: 1.267 ± 0.421
4.436ArgAsn: 4.436 ± 1.101
1.901ArgPro: 1.901 ± 0.861
1.901ArgGln: 1.901 ± 0.785
1.584ArgArg: 1.584 ± 1.149
3.485ArgSer: 3.485 ± 2.444
1.901ArgThr: 1.901 ± 1.357
3.169ArgVal: 3.169 ± 1.567
0.317ArgTrp: 0.317 ± 0.459
2.535ArgTyr: 2.535 ± 1.284
0.0ArgXaa: 0.0 ± 0.0
Ser
2.218SerAla: 2.218 ± 0.845
1.267SerCys: 1.267 ± 0.78
4.436SerAsp: 4.436 ± 1.551
1.901SerGlu: 1.901 ± 1.068
0.634SerPhe: 0.634 ± 0.369
3.802SerGly: 3.802 ± 1.344
2.535SerHis: 2.535 ± 0.643
5.387SerIle: 5.387 ± 2.552
6.337SerLys: 6.337 ± 1.745
8.872SerLeu: 8.872 ± 3.789
1.584SerMet: 1.584 ± 0.743
1.901SerAsn: 1.901 ± 2.077
2.852SerPro: 2.852 ± 2.058
2.535SerGln: 2.535 ± 1.05
3.169SerArg: 3.169 ± 2.45
4.119SerSer: 4.119 ± 1.219
2.535SerThr: 2.535 ± 1.05
7.605SerVal: 7.605 ± 1.858
0.951SerTrp: 0.951 ± 0.534
4.753SerTyr: 4.753 ± 1.317
0.0SerXaa: 0.0 ± 0.0
Thr
2.218ThrAla: 2.218 ± 2.1
0.317ThrCys: 0.317 ± 0.178
3.169ThrAsp: 3.169 ± 0.524
2.218ThrGlu: 2.218 ± 0.845
3.802ThrPhe: 3.802 ± 1.896
1.267ThrGly: 1.267 ± 0.421
1.584ThrHis: 1.584 ± 0.883
1.901ThrIle: 1.901 ± 0.827
3.169ThrLys: 3.169 ± 2.68
3.802ThrLeu: 3.802 ± 2.326
0.317ThrMet: 0.317 ± 0.178
0.951ThrAsn: 0.951 ± 0.534
0.951ThrPro: 0.951 ± 0.353
2.218ThrGln: 2.218 ± 0.701
5.07ThrArg: 5.07 ± 1.923
3.802ThrSer: 3.802 ± 1.438
2.218ThrThr: 2.218 ± 1.605
3.802ThrVal: 3.802 ± 1.612
0.634ThrTrp: 0.634 ± 0.369
1.584ThrTyr: 1.584 ± 0.68
0.0ThrXaa: 0.0 ± 0.0
Val
1.267ValAla: 1.267 ± 1.072
2.535ValCys: 2.535 ± 1.424
2.535ValAsp: 2.535 ± 0.841
5.387ValGlu: 5.387 ± 0.701
4.753ValPhe: 4.753 ± 2.99
2.852ValGly: 2.852 ± 1.871
1.584ValHis: 1.584 ± 0.765
5.703ValIle: 5.703 ± 1.613
11.407ValLys: 11.407 ± 2.156
8.238ValLeu: 8.238 ± 1.536
0.951ValMet: 0.951 ± 0.813
2.852ValAsn: 2.852 ± 1.216
3.169ValPro: 3.169 ± 0.524
2.535ValGln: 2.535 ± 1.01
5.387ValArg: 5.387 ± 1.451
4.753ValSer: 4.753 ± 1.201
2.218ValThr: 2.218 ± 1.287
5.07ValVal: 5.07 ± 2.621
0.634ValTrp: 0.634 ± 0.619
3.169ValTyr: 3.169 ± 0.931
0.0ValXaa: 0.0 ± 0.0
Trp
0.317TrpAla: 0.317 ± 0.178
0.0TrpCys: 0.0 ± 0.0
0.634TrpAsp: 0.634 ± 0.356
0.951TrpGlu: 0.951 ± 0.68
0.634TrpPhe: 0.634 ± 0.356
0.317TrpGly: 0.317 ± 0.696
0.317TrpHis: 0.317 ± 0.459
0.634TrpIle: 0.634 ± 0.356
0.634TrpLys: 0.634 ± 0.369
0.951TrpLeu: 0.951 ± 0.534
0.317TrpMet: 0.317 ± 0.948
1.901TrpAsn: 1.901 ± 1.414
0.0TrpPro: 0.0 ± 0.0
0.317TrpGln: 0.317 ± 0.178
0.634TrpArg: 0.634 ± 0.619
0.634TrpSer: 0.634 ± 0.356
0.634TrpThr: 0.634 ± 0.369
1.267TrpVal: 1.267 ± 0.421
0.634TrpTrp: 0.634 ± 0.369
0.634TrpTyr: 0.634 ± 0.369
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.584TyrAla: 1.584 ± 0.89
0.317TyrCys: 0.317 ± 0.459
3.169TyrAsp: 3.169 ± 1.349
3.485TyrGlu: 3.485 ± 1.108
2.218TyrPhe: 2.218 ± 1.245
0.951TyrGly: 0.951 ± 0.353
2.852TyrHis: 2.852 ± 1.08
2.535TyrIle: 2.535 ± 1.685
3.485TyrLys: 3.485 ± 1.458
3.802TyrLeu: 3.802 ± 1.74
0.634TyrMet: 0.634 ± 0.356
2.218TyrAsn: 2.218 ± 1.39
1.584TyrPro: 1.584 ± 0.68
2.852TyrGln: 2.852 ± 1.852
1.901TyrArg: 1.901 ± 1.36
2.535TyrSer: 2.535 ± 0.643
3.485TyrThr: 3.485 ± 1.626
4.753TyrVal: 4.753 ± 1.726
0.0TyrTrp: 0.0 ± 0.0
2.852TyrTyr: 2.852 ± 0.531
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (3157 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski