Amino acid dipepetide frequency for Cohaesibacter celericrescens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.257AlaAla: 11.257 ± 0.116	1.017AlaCys: 1.017 ± 0.03	5.825AlaAsp: 5.825 ± 0.075	5.886AlaGlu: 5.886 ± 0.081	4.297AlaPhe: 4.297 ± 0.056	7.923AlaGly: 7.923 ± 0.083	2.067AlaHis: 2.067 ± 0.04	6.741AlaIle: 6.741 ± 0.076	4.785AlaLys: 4.785 ± 0.056	11.503AlaLeu: 11.503 ± 0.094	3.351AlaMet: 3.351 ± 0.048	3.395AlaAsn: 3.395 ± 0.055	3.993AlaPro: 3.993 ± 0.069	3.941AlaGln: 3.941 ± 0.069	5.558AlaArg: 5.558 ± 0.071	6.522AlaSer: 6.522 ± 0.073	5.241AlaThr: 5.241 ± 0.063	7.256AlaVal: 7.256 ± 0.089	1.097AlaTrp: 1.097 ± 0.029	2.545AlaTyr: 2.545 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.934CysAla: 0.934 ± 0.024	0.133CysCys: 0.133 ± 0.01	0.616CysAsp: 0.616 ± 0.022	0.515CysGlu: 0.515 ± 0.02	0.417CysPhe: 0.417 ± 0.018	0.915CysGly: 0.915 ± 0.027	0.279CysHis: 0.279 ± 0.015	0.506CysIle: 0.506 ± 0.019	0.334CysLys: 0.334 ± 0.017	1.042CysLeu: 1.042 ± 0.028	0.214CysMet: 0.214 ± 0.013	0.299CysAsn: 0.299 ± 0.016	0.458CysPro: 0.458 ± 0.019	0.318CysGln: 0.318 ± 0.016	0.527CysArg: 0.527 ± 0.021	0.629CysSer: 0.629 ± 0.021	0.419CysThr: 0.419 ± 0.016	0.635CysVal: 0.635 ± 0.024	0.135CysTrp: 0.135 ± 0.01	0.234CysTyr: 0.234 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	5.93AspAla: 5.93 ± 0.077	0.582AspCys: 0.582 ± 0.019	3.319AspAsp: 3.319 ± 0.053	3.578AspGlu: 3.578 ± 0.056	2.435AspPhe: 2.435 ± 0.043	4.921AspGly: 4.921 ± 0.075	1.412AspHis: 1.412 ± 0.036	3.83AspIle: 3.83 ± 0.056	2.618AspLys: 2.618 ± 0.042	6.274AspLeu: 6.274 ± 0.074	1.653AspMet: 1.653 ± 0.039	1.805AspAsn: 1.805 ± 0.041	2.896AspPro: 2.896 ± 0.04	2.227AspGln: 2.227 ± 0.041	3.434AspArg: 3.434 ± 0.05	2.686AspSer: 2.686 ± 0.046	2.716AspThr: 2.716 ± 0.052	4.172AspVal: 4.172 ± 0.059	0.978AspTrp: 0.978 ± 0.028	1.727AspTyr: 1.727 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	6.559GluAla: 6.559 ± 0.074	0.434GluCys: 0.434 ± 0.02	3.059GluAsp: 3.059 ± 0.052	3.511GluGlu: 3.511 ± 0.063	1.837GluPhe: 1.837 ± 0.037	4.019GluGly: 4.019 ± 0.057	1.178GluHis: 1.178 ± 0.029	3.842GluIle: 3.842 ± 0.058	3.15GluLys: 3.15 ± 0.046	5.453GluLeu: 5.453 ± 0.072	1.721GluMet: 1.721 ± 0.036	2.1GluAsn: 2.1 ± 0.034	2.288GluPro: 2.288 ± 0.042	2.615GluGln: 2.615 ± 0.049	3.694GluArg: 3.694 ± 0.054	2.603GluSer: 2.603 ± 0.04	3.562GluThr: 3.562 ± 0.056	3.667GluVal: 3.667 ± 0.053	0.634GluTrp: 0.634 ± 0.021	1.033GluTyr: 1.033 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.175PheAla: 4.175 ± 0.063	0.501PheCys: 0.501 ± 0.019	2.852PheAsp: 2.852 ± 0.048	2.381PheGlu: 2.381 ± 0.038	1.738PhePhe: 1.738 ± 0.045	3.677PheGly: 3.677 ± 0.061	0.782PheHis: 0.782 ± 0.021	2.236PheIle: 2.236 ± 0.051	1.514PheLys: 1.514 ± 0.035	3.898PheLeu: 3.898 ± 0.06	1.03PheMet: 1.03 ± 0.028	1.329PheAsn: 1.329 ± 0.031	1.553PhePro: 1.553 ± 0.033	1.157PheGln: 1.157 ± 0.031	1.835PheArg: 1.835 ± 0.039	2.942PheSer: 2.942 ± 0.049	2.049PheThr: 2.049 ± 0.043	3.021PheVal: 3.021 ± 0.049	0.558PheTrp: 0.558 ± 0.02	1.013PheTyr: 1.013 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	7.555GlyAla: 7.555 ± 0.075	0.809GlyCys: 0.809 ± 0.023	4.263GlyAsp: 4.263 ± 0.061	4.214GlyGlu: 4.214 ± 0.062	3.679GlyPhe: 3.679 ± 0.06	6.15GlyGly: 6.15 ± 0.089	1.865GlyHis: 1.865 ± 0.044	4.95GlyIle: 4.95 ± 0.07	3.841GlyLys: 3.841 ± 0.062	8.657GlyLeu: 8.657 ± 0.103	2.362GlyMet: 2.362 ± 0.041	2.417GlyAsn: 2.417 ± 0.039	2.803GlyPro: 2.803 ± 0.049	2.872GlyGln: 2.872 ± 0.053	4.335GlyArg: 4.335 ± 0.055	4.745GlySer: 4.745 ± 0.064	4.126GlyThr: 4.126 ± 0.062	5.694GlyVal: 5.694 ± 0.067	1.196GlyTrp: 1.196 ± 0.033	2.31GlyTyr: 2.31 ± 0.044	0.001GlyXaa: 0.001 ± 0.001
His	1.945HisAla: 1.945 ± 0.038	0.273HisCys: 0.273 ± 0.012	1.168HisAsp: 1.168 ± 0.031	1.069HisGlu: 1.069 ± 0.028	0.974HisPhe: 0.974 ± 0.03	1.771HisGly: 1.771 ± 0.035	0.579HisHis: 0.579 ± 0.025	1.28HisIle: 1.28 ± 0.031	0.817HisLys: 0.817 ± 0.025	2.176HisLeu: 2.176 ± 0.042	0.628HisMet: 0.628 ± 0.02	0.654HisAsn: 0.654 ± 0.023	1.212HisPro: 1.212 ± 0.034	0.771HisGln: 0.771 ± 0.025	1.144HisArg: 1.144 ± 0.029	1.251HisSer: 1.251 ± 0.029	0.917HisThr: 0.917 ± 0.027	1.469HisVal: 1.469 ± 0.039	0.34HisTrp: 0.34 ± 0.017	0.647HisTyr: 0.647 ± 0.022	0.001HisXaa: 0.001 ± 0.001
Ile	7.247IleAla: 7.247 ± 0.085	0.709IleCys: 0.709 ± 0.022	4.091IleAsp: 4.091 ± 0.054	4.057IleGlu: 4.057 ± 0.057	2.35IlePhe: 2.35 ± 0.049	5.315IleGly: 5.315 ± 0.074	1.065IleHis: 1.065 ± 0.028	3.314IleIle: 3.314 ± 0.069	2.559IleLys: 2.559 ± 0.041	6.028IleLeu: 6.028 ± 0.072	1.442IleMet: 1.442 ± 0.036	2.031IleAsn: 2.031 ± 0.042	2.609IlePro: 2.609 ± 0.052	1.735IleGln: 1.735 ± 0.037	3.099IleArg: 3.099 ± 0.042	4.141IleSer: 4.141 ± 0.066	3.254IleThr: 3.254 ± 0.05	4.44IleVal: 4.44 ± 0.072	0.74IleTrp: 0.74 ± 0.022	1.394IleTyr: 1.394 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	5.14LysAla: 5.14 ± 0.081	0.276LysCys: 0.276 ± 0.014	2.71LysAsp: 2.71 ± 0.047	2.532LysGlu: 2.532 ± 0.05	1.232LysPhe: 1.232 ± 0.035	3.453LysGly: 3.453 ± 0.059	0.907LysHis: 0.907 ± 0.024	2.713LysIle: 2.713 ± 0.045	2.281LysLys: 2.281 ± 0.049	4.165LysLeu: 4.165 ± 0.059	1.266LysMet: 1.266 ± 0.033	1.524LysAsn: 1.524 ± 0.034	2.329LysPro: 2.329 ± 0.044	1.798LysGln: 1.798 ± 0.034	2.766LysArg: 2.766 ± 0.049	2.953LysSer: 2.953 ± 0.05	2.646LysThr: 2.646 ± 0.039	2.899LysVal: 2.899 ± 0.047	0.482LysTrp: 0.482 ± 0.017	0.849LysTyr: 0.849 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	11.255LeuAla: 11.255 ± 0.11	1.012LeuCys: 1.012 ± 0.029	6.116LeuAsp: 6.116 ± 0.079	5.554LeuGlu: 5.554 ± 0.063	4.149LeuPhe: 4.149 ± 0.063	7.839LeuGly: 7.839 ± 0.077	1.886LeuHis: 1.886 ± 0.037	6.117LeuIle: 6.117 ± 0.068	4.628LeuLys: 4.628 ± 0.063	9.69LeuLeu: 9.69 ± 0.123	2.682LeuMet: 2.682 ± 0.042	3.291LeuAsn: 3.291 ± 0.047	5.011LeuPro: 5.011 ± 0.061	3.153LeuGln: 3.153 ± 0.047	5.263LeuArg: 5.263 ± 0.061	7.806LeuSer: 7.806 ± 0.081	5.746LeuThr: 5.746 ± 0.069	7.118LeuVal: 7.118 ± 0.089	1.099LeuTrp: 1.099 ± 0.025	2.304LeuTyr: 2.304 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	3.189MetAla: 3.189 ± 0.051	0.199MetCys: 0.199 ± 0.012	1.442MetAsp: 1.442 ± 0.037	1.331MetGlu: 1.331 ± 0.028	0.851MetPhe: 0.851 ± 0.027	2.177MetGly: 2.177 ± 0.04	0.521MetHis: 0.521 ± 0.021	1.821MetIle: 1.821 ± 0.038	1.304MetLys: 1.304 ± 0.033	2.832MetLeu: 2.832 ± 0.043	0.873MetMet: 0.873 ± 0.028	0.932MetAsn: 0.932 ± 0.025	1.515MetPro: 1.515 ± 0.035	1.069MetGln: 1.069 ± 0.024	1.747MetArg: 1.747 ± 0.038	1.976MetSer: 1.976 ± 0.04	1.943MetThr: 1.943 ± 0.035	2.05MetVal: 2.05 ± 0.036	0.2MetTrp: 0.2 ± 0.012	0.363MetTyr: 0.363 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.405AsnAla: 3.405 ± 0.052	0.33AsnCys: 0.33 ± 0.014	1.852AsnAsp: 1.852 ± 0.04	1.809AsnGlu: 1.809 ± 0.038	1.231AsnPhe: 1.231 ± 0.035	2.865AsnGly: 2.865 ± 0.048	0.717AsnHis: 0.717 ± 0.024	1.933AsnIle: 1.933 ± 0.04	1.469AsnLys: 1.469 ± 0.034	3.252AsnLeu: 3.252 ± 0.045	0.909AsnMet: 0.909 ± 0.024	1.185AsnAsn: 1.185 ± 0.031	1.94AsnPro: 1.94 ± 0.043	1.288AsnGln: 1.288 ± 0.033	1.948AsnArg: 1.948 ± 0.038	1.896AsnSer: 1.896 ± 0.04	1.544AsnThr: 1.544 ± 0.036	2.217AsnVal: 2.217 ± 0.04	0.574AsnTrp: 0.574 ± 0.02	0.826AsnTyr: 0.826 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	4.157ProAla: 4.157 ± 0.066	0.355ProCys: 0.355 ± 0.017	3.395ProAsp: 3.395 ± 0.051	3.087ProGlu: 3.087 ± 0.047	1.995ProPhe: 1.995 ± 0.036	2.927ProGly: 2.927 ± 0.043	1.045ProHis: 1.045 ± 0.029	2.704ProIle: 2.704 ± 0.048	2.035ProLys: 2.035 ± 0.042	4.278ProLeu: 4.278 ± 0.053	1.204ProMet: 1.204 ± 0.031	1.61ProAsn: 1.61 ± 0.033	1.625ProPro: 1.625 ± 0.038	1.733ProGln: 1.733 ± 0.036	1.927ProArg: 1.927 ± 0.035	2.879ProSer: 2.879 ± 0.049	2.386ProThr: 2.386 ± 0.047	3.568ProVal: 3.568 ± 0.044	0.543ProTrp: 0.543 ± 0.019	1.177ProTyr: 1.177 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.97GlnAla: 3.97 ± 0.06	0.24GlnCys: 0.24 ± 0.012	2.066GlnAsp: 2.066 ± 0.041	1.873GlnGlu: 1.873 ± 0.037	1.282GlnPhe: 1.282 ± 0.029	2.542GlnGly: 2.542 ± 0.041	0.709GlnHis: 0.709 ± 0.024	2.393GlnIle: 2.393 ± 0.044	1.73GlnLys: 1.73 ± 0.039	3.457GlnLeu: 3.457 ± 0.056	1.176GlnMet: 1.176 ± 0.028	1.259GlnAsn: 1.259 ± 0.032	1.619GlnPro: 1.619 ± 0.039	1.564GlnGln: 1.564 ± 0.036	2.098GlnArg: 2.098 ± 0.042	2.603GlnSer: 2.603 ± 0.045	2.264GlnThr: 2.264 ± 0.044	2.329GlnVal: 2.329 ± 0.045	0.432GlnTrp: 0.432 ± 0.018	0.722GlnTyr: 0.722 ± 0.021	0.001GlnXaa: 0.001 ± 0.001
Arg	5.126ArgAla: 5.126 ± 0.069	0.445ArgCys: 0.445 ± 0.017	3.288ArgAsp: 3.288 ± 0.05	3.05ArgGlu: 3.05 ± 0.054	2.435ArgPhe: 2.435 ± 0.04	3.506ArgGly: 3.506 ± 0.05	1.319ArgHis: 1.319 ± 0.031	3.438ArgIle: 3.438 ± 0.054	2.524ArgLys: 2.524 ± 0.044	6.046ArgLeu: 6.046 ± 0.064	1.636ArgMet: 1.636 ± 0.032	1.859ArgAsn: 1.859 ± 0.042	2.431ArgPro: 2.431 ± 0.049	2.295ArgGln: 2.295 ± 0.044	3.371ArgArg: 3.371 ± 0.054	3.501ArgSer: 3.501 ± 0.049	2.687ArgThr: 2.687 ± 0.044	3.613ArgVal: 3.613 ± 0.051	0.7ArgTrp: 0.7 ± 0.022	1.484ArgTyr: 1.484 ± 0.032	0.001ArgXaa: 0.001 ± 0.001
Ser	6.038SerAla: 6.038 ± 0.076	0.613SerCys: 0.613 ± 0.024	3.889SerAsp: 3.889 ± 0.057	3.639SerGlu: 3.639 ± 0.054	2.77SerPhe: 2.77 ± 0.047	5.749SerGly: 5.749 ± 0.066	1.443SerHis: 1.443 ± 0.031	4.017SerIle: 4.017 ± 0.056	2.788SerLys: 2.788 ± 0.045	6.588SerLeu: 6.588 ± 0.078	1.798SerMet: 1.798 ± 0.036	2.306SerAsn: 2.306 ± 0.042	2.617SerPro: 2.617 ± 0.041	2.326SerGln: 2.326 ± 0.047	3.21SerArg: 3.21 ± 0.055	4.188SerSer: 4.188 ± 0.075	3.094SerThr: 3.094 ± 0.059	4.514SerVal: 4.514 ± 0.069	0.798SerTrp: 0.798 ± 0.022	1.683SerTyr: 1.683 ± 0.038	0.001SerXaa: 0.001 ± 0.001
Thr	5.323ThrAla: 5.323 ± 0.063	0.478ThrCys: 0.478 ± 0.021	2.999ThrAsp: 2.999 ± 0.046	2.796ThrGlu: 2.796 ± 0.044	2.021ThrPhe: 2.021 ± 0.044	4.792ThrGly: 4.792 ± 0.065	1.11ThrHis: 1.11 ± 0.03	3.522ThrIle: 3.522 ± 0.057	2.199ThrLys: 2.199 ± 0.042	5.678ThrLeu: 5.678 ± 0.073	1.362ThrMet: 1.362 ± 0.033	1.773ThrAsn: 1.773 ± 0.037	2.863ThrPro: 2.863 ± 0.048	1.831ThrGln: 1.831 ± 0.039	2.732ThrArg: 2.732 ± 0.043	3.35ThrSer: 3.35 ± 0.056	2.832ThrThr: 2.832 ± 0.054	3.916ThrVal: 3.916 ± 0.058	0.543ThrTrp: 0.543 ± 0.021	1.248ThrTyr: 1.248 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	7.656ValAla: 7.656 ± 0.077	0.714ValCys: 0.714 ± 0.022	4.045ValAsp: 4.045 ± 0.061	4.208ValGlu: 4.208 ± 0.053	2.86ValPhe: 2.86 ± 0.054	5.353ValGly: 5.353 ± 0.066	1.308ValHis: 1.308 ± 0.034	4.317ValIle: 4.317 ± 0.061	2.891ValLys: 2.891 ± 0.048	6.804ValLeu: 6.804 ± 0.084	2.062ValMet: 2.062 ± 0.036	2.187ValAsn: 2.187 ± 0.043	3.188ValPro: 3.188 ± 0.059	2.117ValGln: 2.117 ± 0.045	3.752ValArg: 3.752 ± 0.047	5.041ValSer: 5.041 ± 0.064	4.188ValThr: 4.188 ± 0.062	5.439ValVal: 5.439 ± 0.071	0.824ValTrp: 0.824 ± 0.028	1.551ValTyr: 1.551 ± 0.038	0.001ValXaa: 0.001 ± 0.001
Trp	1.047TrpAla: 1.047 ± 0.028	0.128TrpCys: 0.128 ± 0.011	0.668TrpAsp: 0.668 ± 0.025	0.542TrpGlu: 0.542 ± 0.018	0.571TrpPhe: 0.571 ± 0.022	0.867TrpGly: 0.867 ± 0.026	0.315TrpHis: 0.315 ± 0.016	0.748TrpIle: 0.748 ± 0.026	0.504TrpLys: 0.504 ± 0.02	1.453TrpLeu: 1.453 ± 0.036	0.395TrpMet: 0.395 ± 0.017	0.45TrpAsn: 0.45 ± 0.02	0.599TrpPro: 0.599 ± 0.021	0.59TrpGln: 0.59 ± 0.021	0.807TrpArg: 0.807 ± 0.025	0.836TrpSer: 0.836 ± 0.023	0.637TrpThr: 0.637 ± 0.023	0.827TrpVal: 0.827 ± 0.025	0.185TrpTrp: 0.185 ± 0.014	0.268TrpTyr: 0.268 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.292TyrAla: 2.292 ± 0.041	0.31TyrCys: 0.31 ± 0.015	1.531TyrAsp: 1.531 ± 0.036	1.326TyrGlu: 1.326 ± 0.031	1.118TyrPhe: 1.118 ± 0.029	2.085TyrGly: 2.085 ± 0.036	0.581TyrHis: 0.581 ± 0.023	1.196TyrIle: 1.196 ± 0.028	0.947TyrLys: 0.947 ± 0.027	2.443TyrLeu: 2.443 ± 0.041	0.571TyrMet: 0.571 ± 0.02	0.784TyrAsn: 0.784 ± 0.022	1.079TyrPro: 1.079 ± 0.028	0.927TyrGln: 0.927 ± 0.024	1.509TyrArg: 1.509 ± 0.032	1.523TyrSer: 1.523 ± 0.034	1.118TyrThr: 1.118 ± 0.032	1.659TyrVal: 1.659 ± 0.04	0.38TyrTrp: 0.38 ± 0.016	0.656TyrTyr: 0.656 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.001XaaTrp: 0.001 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 4355 proteins (1385776 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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