Amino acid dipepetide frequency for Streptomyces spinoverrucosus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.517AlaAla: 20.517 ± 0.142	1.069AlaCys: 1.069 ± 0.024	8.109AlaAsp: 8.109 ± 0.061	8.708AlaGlu: 8.708 ± 0.078	3.407AlaPhe: 3.407 ± 0.04	12.237AlaGly: 12.237 ± 0.076	2.878AlaHis: 2.878 ± 0.04	3.59AlaIle: 3.59 ± 0.044	2.845AlaLys: 2.845 ± 0.044	14.251AlaLeu: 14.251 ± 0.086	2.522AlaMet: 2.522 ± 0.033	2.019AlaAsn: 2.019 ± 0.031	6.818AlaPro: 6.818 ± 0.077	3.981AlaGln: 3.981 ± 0.045	10.122AlaArg: 10.122 ± 0.082	5.826AlaSer: 5.826 ± 0.059	7.115AlaThr: 7.115 ± 0.059	12.114AlaVal: 12.114 ± 0.084	1.86AlaTrp: 1.86 ± 0.025	2.831AlaTyr: 2.831 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	1.082CysAla: 1.082 ± 0.021	0.11CysCys: 0.11 ± 0.008	0.474CysAsp: 0.474 ± 0.014	0.421CysGlu: 0.421 ± 0.013	0.229CysPhe: 0.229 ± 0.009	0.978CysGly: 0.978 ± 0.019	0.197CysHis: 0.197 ± 0.008	0.177CysIle: 0.177 ± 0.008	0.112CysLys: 0.112 ± 0.007	0.784CysLeu: 0.784 ± 0.021	0.132CysMet: 0.132 ± 0.008	0.142CysAsn: 0.142 ± 0.006	0.503CysPro: 0.503 ± 0.014	0.169CysGln: 0.169 ± 0.008	0.621CysArg: 0.621 ± 0.016	0.446CysSer: 0.446 ± 0.013	0.532CysThr: 0.532 ± 0.014	0.673CysVal: 0.673 ± 0.019	0.136CysTrp: 0.136 ± 0.008	0.149CysTyr: 0.149 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	7.563AspAla: 7.563 ± 0.068	0.449AspCys: 0.449 ± 0.012	3.67AspAsp: 3.67 ± 0.039	3.892AspGlu: 3.892 ± 0.048	1.717AspPhe: 1.717 ± 0.025	6.383AspGly: 6.383 ± 0.056	1.411AspHis: 1.411 ± 0.021	1.981AspIle: 1.981 ± 0.028	1.257AspLys: 1.257 ± 0.027	6.121AspLeu: 6.121 ± 0.055	0.84AspMet: 0.84 ± 0.016	1.031AspAsn: 1.031 ± 0.021	4.399AspPro: 4.399 ± 0.045	1.629AspGln: 1.629 ± 0.024	4.82AspArg: 4.82 ± 0.043	2.552AspSer: 2.552 ± 0.031	3.298AspThr: 3.298 ± 0.037	4.831AspVal: 4.831 ± 0.044	1.074AspTrp: 1.074 ± 0.023	1.157AspTyr: 1.157 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	7.352GluAla: 7.352 ± 0.08	0.375GluCys: 0.375 ± 0.015	2.817GluAsp: 2.817 ± 0.037	3.609GluGlu: 3.609 ± 0.056	1.499GluPhe: 1.499 ± 0.023	4.437GluGly: 4.437 ± 0.038	1.531GluHis: 1.531 ± 0.028	2.269GluIle: 2.269 ± 0.028	1.475GluLys: 1.475 ± 0.03	6.819GluLeu: 6.819 ± 0.063	0.897GluMet: 0.897 ± 0.021	1.059GluAsn: 1.059 ± 0.018	3.48GluPro: 3.48 ± 0.044	2.398GluGln: 2.398 ± 0.033	5.466GluArg: 5.466 ± 0.053	2.537GluSer: 2.537 ± 0.033	2.948GluThr: 2.948 ± 0.035	4.509GluVal: 4.509 ± 0.044	0.833GluTrp: 0.833 ± 0.018	1.164GluTyr: 1.164 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.558PheAla: 3.558 ± 0.041	0.27PheCys: 0.27 ± 0.011	1.906PheAsp: 1.906 ± 0.027	1.434PheGlu: 1.434 ± 0.023	0.867PhePhe: 0.867 ± 0.02	2.985PheGly: 2.985 ± 0.039	0.596PheHis: 0.596 ± 0.014	0.711PheIle: 0.711 ± 0.019	0.529PheLys: 0.529 ± 0.015	2.573PheLeu: 2.573 ± 0.037	0.41PheMet: 0.41 ± 0.014	0.617PheAsn: 0.617 ± 0.016	1.388PhePro: 1.388 ± 0.022	0.737PheGln: 0.737 ± 0.016	1.814PheArg: 1.814 ± 0.033	1.406PheSer: 1.406 ± 0.027	2.058PheThr: 2.058 ± 0.031	2.236PheVal: 2.236 ± 0.031	0.448PheTrp: 0.448 ± 0.013	0.584PheTyr: 0.584 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	10.623GlyAla: 10.623 ± 0.076	0.861GlyCys: 0.861 ± 0.019	5.156GlyAsp: 5.156 ± 0.042	5.23GlyGlu: 5.23 ± 0.049	2.783GlyPhe: 2.783 ± 0.036	8.551GlyGly: 8.551 ± 0.074	2.301GlyHis: 2.301 ± 0.032	3.492GlyIle: 3.492 ± 0.038	2.414GlyLys: 2.414 ± 0.035	9.319GlyLeu: 9.319 ± 0.062	1.992GlyMet: 1.992 ± 0.027	1.832GlyAsn: 1.832 ± 0.034	4.943GlyPro: 4.943 ± 0.05	2.724GlyGln: 2.724 ± 0.035	7.657GlyArg: 7.657 ± 0.056	5.236GlySer: 5.236 ± 0.049	6.399GlyThr: 6.399 ± 0.068	7.515GlyVal: 7.515 ± 0.062	1.775GlyTrp: 1.775 ± 0.031	2.299GlyTyr: 2.299 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.689HisAla: 2.689 ± 0.038	0.224HisCys: 0.224 ± 0.009	1.388HisAsp: 1.388 ± 0.024	1.249HisGlu: 1.249 ± 0.02	0.667HisPhe: 0.667 ± 0.016	2.397HisGly: 2.397 ± 0.034	0.703HisHis: 0.703 ± 0.019	0.756HisIle: 0.756 ± 0.018	0.395HisLys: 0.395 ± 0.013	2.382HisLeu: 2.382 ± 0.033	0.352HisMet: 0.352 ± 0.011	0.411HisAsn: 0.411 ± 0.012	1.833HisPro: 1.833 ± 0.027	0.679HisGln: 0.679 ± 0.017	2.109HisArg: 2.109 ± 0.033	1.012HisSer: 1.012 ± 0.021	1.359HisThr: 1.359 ± 0.023	1.695HisVal: 1.695 ± 0.027	0.372HisTrp: 0.372 ± 0.013	0.499HisTyr: 0.499 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.861IleAla: 4.861 ± 0.052	0.3IleCys: 0.3 ± 0.01	2.306IleAsp: 2.306 ± 0.03	2.044IleGlu: 2.044 ± 0.029	0.722IlePhe: 0.722 ± 0.017	3.594IleGly: 3.594 ± 0.041	0.648IleHis: 0.648 ± 0.015	0.898IleIle: 0.898 ± 0.022	0.769IleLys: 0.769 ± 0.018	2.479IleLeu: 2.479 ± 0.035	0.461IleMet: 0.461 ± 0.015	0.747IleAsn: 0.747 ± 0.017	1.896IlePro: 1.896 ± 0.029	0.771IleGln: 0.771 ± 0.018	2.376IleArg: 2.376 ± 0.032	1.683IleSer: 1.683 ± 0.028	2.338IleThr: 2.338 ± 0.03	2.801IleVal: 2.801 ± 0.035	0.388IleTrp: 0.388 ± 0.013	0.568IleTyr: 0.568 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	3.005LysAla: 3.005 ± 0.04	0.134LysCys: 0.134 ± 0.008	1.381LysAsp: 1.381 ± 0.03	1.275LysGlu: 1.275 ± 0.029	0.463LysPhe: 0.463 ± 0.013	1.89LysGly: 1.89 ± 0.033	0.431LysHis: 0.431 ± 0.014	0.864LysIle: 0.864 ± 0.019	0.85LysLys: 0.85 ± 0.026	2.06LysLeu: 2.06 ± 0.033	0.382LysMet: 0.382 ± 0.013	0.563LysAsn: 0.563 ± 0.019	1.405LysPro: 1.405 ± 0.03	0.751LysGln: 0.751 ± 0.019	1.516LysArg: 1.516 ± 0.024	1.17LysSer: 1.17 ± 0.024	1.275LysThr: 1.275 ± 0.026	1.991LysVal: 1.991 ± 0.031	0.277LysTrp: 0.277 ± 0.011	0.491LysTyr: 0.491 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	14.786LeuAla: 14.786 ± 0.087	0.854LeuCys: 0.854 ± 0.017	6.699LeuAsp: 6.699 ± 0.062	4.501LeuGlu: 4.501 ± 0.049	2.572LeuPhe: 2.572 ± 0.037	9.021LeuGly: 9.021 ± 0.061	2.328LeuHis: 2.328 ± 0.035	3.425LeuIle: 3.425 ± 0.042	2.151LeuLys: 2.151 ± 0.031	11.266LeuLeu: 11.266 ± 0.1	1.655LeuMet: 1.655 ± 0.027	1.763LeuAsn: 1.763 ± 0.029	6.492LeuPro: 6.492 ± 0.057	2.313LeuGln: 2.313 ± 0.033	8.546LeuArg: 8.546 ± 0.085	5.228LeuSer: 5.228 ± 0.05	7.038LeuThr: 7.038 ± 0.049	8.637LeuVal: 8.637 ± 0.074	1.311LeuTrp: 1.311 ± 0.025	1.949LeuTyr: 1.949 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.287MetAla: 2.287 ± 0.03	0.132MetCys: 0.132 ± 0.007	0.867MetAsp: 0.867 ± 0.019	0.765MetGlu: 0.765 ± 0.02	0.442MetPhe: 0.442 ± 0.014	1.32MetGly: 1.32 ± 0.022	0.385MetHis: 0.385 ± 0.011	0.666MetIle: 0.666 ± 0.018	0.436MetLys: 0.436 ± 0.013	1.673MetLeu: 1.673 ± 0.022	0.294MetMet: 0.294 ± 0.012	0.438MetAsn: 0.438 ± 0.012	1.12MetPro: 1.12 ± 0.023	0.48MetGln: 0.48 ± 0.013	1.442MetArg: 1.442 ± 0.026	1.297MetSer: 1.297 ± 0.024	1.606MetThr: 1.606 ± 0.025	1.279MetVal: 1.279 ± 0.024	0.215MetTrp: 0.215 ± 0.008	0.334MetTyr: 0.334 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.322AsnAla: 2.322 ± 0.03	0.176AsnCys: 0.176 ± 0.007	1.028AsnAsp: 1.028 ± 0.022	0.847AsnGlu: 0.847 ± 0.019	0.492AsnPhe: 0.492 ± 0.015	1.985AsnGly: 1.985 ± 0.033	0.399AsnHis: 0.399 ± 0.014	0.676AsnIle: 0.676 ± 0.017	0.446AsnLys: 0.446 ± 0.014	1.692AsnLeu: 1.692 ± 0.024	0.308AsnMet: 0.308 ± 0.012	0.483AsnAsn: 0.483 ± 0.015	1.461AsnPro: 1.461 ± 0.026	0.574AsnGln: 0.574 ± 0.015	1.325AsnArg: 1.325 ± 0.023	1.021AsnSer: 1.021 ± 0.022	1.169AsnThr: 1.169 ± 0.028	1.42AsnVal: 1.42 ± 0.024	0.317AsnTrp: 0.317 ± 0.012	0.445AsnTyr: 0.445 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.018ProAla: 8.018 ± 0.076	0.353ProCys: 0.353 ± 0.011	4.523ProAsp: 4.523 ± 0.051	4.445ProGlu: 4.445 ± 0.049	1.555ProPhe: 1.555 ± 0.025	6.428ProGly: 6.428 ± 0.058	1.486ProHis: 1.486 ± 0.025	1.374ProIle: 1.374 ± 0.025	1.276ProLys: 1.276 ± 0.026	5.266ProLeu: 5.266 ± 0.052	1.01ProMet: 1.01 ± 0.017	0.997ProAsn: 0.997 ± 0.023	3.597ProPro: 3.597 ± 0.06	1.876ProGln: 1.876 ± 0.034	3.915ProArg: 3.915 ± 0.042	3.25ProSer: 3.25 ± 0.043	3.509ProThr: 3.509 ± 0.043	5.418ProVal: 5.418 ± 0.052	0.926ProTrp: 0.926 ± 0.019	1.494ProTyr: 1.494 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.883GlnAla: 3.883 ± 0.047	0.187GlnCys: 0.187 ± 0.009	1.504GlnAsp: 1.504 ± 0.028	1.547GlnGlu: 1.547 ± 0.029	0.695GlnPhe: 0.695 ± 0.014	2.442GlnGly: 2.442 ± 0.032	0.695GlnHis: 0.695 ± 0.015	1.111GlnIle: 1.111 ± 0.022	0.639GlnLys: 0.639 ± 0.018	3.211GlnLeu: 3.211 ± 0.033	0.512GlnMet: 0.512 ± 0.013	0.537GlnAsn: 0.537 ± 0.016	1.815GlnPro: 1.815 ± 0.043	1.347GlnGln: 1.347 ± 0.031	2.526GlnArg: 2.526 ± 0.033	1.321GlnSer: 1.321 ± 0.022	1.417GlnThr: 1.417 ± 0.026	2.438GlnVal: 2.438 ± 0.031	0.495GlnTrp: 0.495 ± 0.014	0.672GlnTyr: 0.672 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	9.702ArgAla: 9.702 ± 0.079	0.619ArgCys: 0.619 ± 0.015	4.262ArgAsp: 4.262 ± 0.039	4.824ArgGlu: 4.824 ± 0.048	2.287ArgPhe: 2.287 ± 0.028	5.768ArgGly: 5.768 ± 0.048	2.149ArgHis: 2.149 ± 0.032	3.347ArgIle: 3.347 ± 0.036	1.706ArgLys: 1.706 ± 0.031	8.774ArgLeu: 8.774 ± 0.074	1.73ArgMet: 1.73 ± 0.03	1.354ArgAsn: 1.354 ± 0.022	4.948ArgPro: 4.948 ± 0.053	2.386ArgGln: 2.386 ± 0.03	7.74ArgArg: 7.74 ± 0.073	3.91ArgSer: 3.91 ± 0.041	5.476ArgThr: 5.476 ± 0.048	5.869ArgVal: 5.869 ± 0.047	1.388ArgTrp: 1.388 ± 0.024	1.823ArgTyr: 1.823 ± 0.024	0.0ArgXaa: 0.0 ± 0.0
Ser	6.606SerAla: 6.606 ± 0.064	0.412SerCys: 0.412 ± 0.013	2.728SerAsp: 2.728 ± 0.034	2.454SerGlu: 2.454 ± 0.033	1.488SerPhe: 1.488 ± 0.025	5.84SerGly: 5.84 ± 0.054	1.021SerHis: 1.021 ± 0.019	1.444SerIle: 1.444 ± 0.025	1.05SerLys: 1.05 ± 0.022	4.69SerLeu: 4.69 ± 0.04	1.061SerMet: 1.061 ± 0.019	0.901SerAsn: 0.901 ± 0.02	3.181SerPro: 3.181 ± 0.038	1.261SerGln: 1.261 ± 0.026	3.625SerArg: 3.625 ± 0.039	2.846SerSer: 2.846 ± 0.039	3.192SerThr: 3.192 ± 0.039	4.182SerVal: 4.182 ± 0.038	0.919SerTrp: 0.919 ± 0.02	1.305SerTyr: 1.305 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	8.927ThrAla: 8.927 ± 0.07	0.46ThrCys: 0.46 ± 0.014	3.816ThrAsp: 3.816 ± 0.043	3.379ThrGlu: 3.379 ± 0.035	1.673ThrPhe: 1.673 ± 0.027	6.726ThrGly: 6.726 ± 0.059	1.266ThrHis: 1.266 ± 0.021	1.819ThrIle: 1.819 ± 0.028	1.245ThrLys: 1.245 ± 0.023	5.837ThrLeu: 5.837 ± 0.055	0.946ThrMet: 0.946 ± 0.019	1.128ThrAsn: 1.128 ± 0.021	4.341ThrPro: 4.341 ± 0.054	1.46ThrGln: 1.46 ± 0.025	3.994ThrArg: 3.994 ± 0.048	3.232ThrSer: 3.232 ± 0.039	4.124ThrThr: 4.124 ± 0.046	6.139ThrVal: 6.139 ± 0.058	0.973ThrTrp: 0.973 ± 0.022	1.482ThrTyr: 1.482 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	10.496ValAla: 10.496 ± 0.076	0.751ValCys: 0.751 ± 0.016	4.9ValAsp: 4.9 ± 0.044	4.729ValGlu: 4.729 ± 0.046	2.392ValPhe: 2.392 ± 0.038	6.612ValGly: 6.612 ± 0.06	1.955ValHis: 1.955 ± 0.027	2.944ValIle: 2.944 ± 0.035	1.801ValLys: 1.801 ± 0.031	9.393ValLeu: 9.393 ± 0.078	1.402ValMet: 1.402 ± 0.024	1.689ValAsn: 1.689 ± 0.026	5.208ValPro: 5.208 ± 0.047	2.163ValGln: 2.163 ± 0.029	7.232ValArg: 7.232 ± 0.056	4.298ValSer: 4.298 ± 0.032	5.777ValThr: 5.777 ± 0.057	7.928ValVal: 7.928 ± 0.079	1.18ValTrp: 1.18 ± 0.022	1.602ValTyr: 1.602 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.677TrpAla: 1.677 ± 0.024	0.154TrpCys: 0.154 ± 0.007	0.877TrpAsp: 0.877 ± 0.019	0.744TrpGlu: 0.744 ± 0.018	0.505TrpPhe: 0.505 ± 0.013	1.116TrpGly: 1.116 ± 0.022	0.401TrpHis: 0.401 ± 0.013	0.579TrpIle: 0.579 ± 0.015	0.37TrpLys: 0.37 ± 0.012	1.812TrpLeu: 1.812 ± 0.03	0.295TrpMet: 0.295 ± 0.01	0.439TrpAsn: 0.439 ± 0.013	0.794TrpPro: 0.794 ± 0.017	0.662TrpGln: 0.662 ± 0.019	1.376TrpArg: 1.376 ± 0.024	0.964TrpSer: 0.964 ± 0.017	1.082TrpThr: 1.082 ± 0.025	1.024TrpVal: 1.024 ± 0.023	0.351TrpTrp: 0.351 ± 0.012	0.391TrpTyr: 0.391 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.866TyrAla: 2.866 ± 0.034	0.179TyrCys: 0.179 ± 0.009	1.664TyrAsp: 1.664 ± 0.029	1.375TyrGlu: 1.375 ± 0.023	0.671TyrPhe: 0.671 ± 0.016	2.394TyrGly: 2.394 ± 0.03	0.39TyrHis: 0.39 ± 0.012	0.527TyrIle: 0.527 ± 0.016	0.406TyrLys: 0.406 ± 0.013	2.133TyrLeu: 2.133 ± 0.035	0.278TyrMet: 0.278 ± 0.011	0.436TyrAsn: 0.436 ± 0.011	1.092TyrPro: 1.092 ± 0.02	0.633TyrGln: 0.633 ± 0.015	1.841TyrArg: 1.841 ± 0.028	0.97TyrSer: 0.97 ± 0.022	1.255TyrThr: 1.255 ± 0.027	1.755TyrVal: 1.755 ± 0.026	0.375TyrTrp: 0.375 ± 0.013	0.493TyrTyr: 0.493 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8452 proteins (2674752 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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