Amino acid dipepetide frequency for Penicillium digitatum (strain PHI26 / CECT 20796) (Green mold)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.29AlaAla: 8.29 ± 0.071	0.966AlaCys: 0.966 ± 0.016	4.211AlaAsp: 4.211 ± 0.038	5.215AlaGlu: 5.215 ± 0.062	3.03AlaPhe: 3.03 ± 0.03	5.509AlaGly: 5.509 ± 0.044	1.807AlaHis: 1.807 ± 0.022	4.279AlaIle: 4.279 ± 0.032	3.954AlaLys: 3.954 ± 0.037	7.607AlaLeu: 7.607 ± 0.057	1.944AlaMet: 1.944 ± 0.024	2.95AlaAsn: 2.95 ± 0.03	4.776AlaPro: 4.776 ± 0.06	3.394AlaGln: 3.394 ± 0.034	4.845AlaArg: 4.845 ± 0.043	7.162AlaSer: 7.162 ± 0.054	5.207AlaThr: 5.207 ± 0.056	5.209AlaVal: 5.209 ± 0.04	1.093AlaTrp: 1.093 ± 0.018	2.066AlaTyr: 2.066 ± 0.025	0.0AlaXaa: 0.0 ± 0.0
Cys	0.89CysAla: 0.89 ± 0.017	0.2CysCys: 0.2 ± 0.008	0.623CysAsp: 0.623 ± 0.013	0.586CysGlu: 0.586 ± 0.014	0.519CysPhe: 0.519 ± 0.013	0.883CysGly: 0.883 ± 0.015	0.34CysHis: 0.34 ± 0.01	0.665CysIle: 0.665 ± 0.013	0.483CysLys: 0.483 ± 0.011	1.21CysLeu: 1.21 ± 0.018	0.252CysMet: 0.252 ± 0.008	0.411CysAsn: 0.411 ± 0.011	0.618CysPro: 0.618 ± 0.012	0.439CysGln: 0.439 ± 0.01	0.706CysArg: 0.706 ± 0.016	0.864CysSer: 0.864 ± 0.017	0.65CysThr: 0.65 ± 0.014	0.787CysVal: 0.787 ± 0.016	0.185CysTrp: 0.185 ± 0.007	0.32CysTyr: 0.32 ± 0.009	0.001CysXaa: 0.001 ± 0.0
Asp	4.544AspAla: 4.544 ± 0.037	0.589AspCys: 0.589 ± 0.012	4.21AspAsp: 4.21 ± 0.22	4.434AspGlu: 4.434 ± 0.047	2.224AspPhe: 2.224 ± 0.023	3.801AspGly: 3.801 ± 0.039	1.337AspHis: 1.337 ± 0.019	3.048AspIle: 3.048 ± 0.027	2.249AspLys: 2.249 ± 0.026	5.365AspLeu: 5.365 ± 0.034	1.233AspMet: 1.233 ± 0.019	1.891AspAsn: 1.891 ± 0.023	3.418AspPro: 3.418 ± 0.026	2.038AspGln: 2.038 ± 0.027	3.158AspArg: 3.158 ± 0.033	4.314AspSer: 4.314 ± 0.035	2.963AspThr: 2.963 ± 0.028	3.626AspVal: 3.626 ± 0.032	0.856AspTrp: 0.856 ± 0.014	1.556AspTyr: 1.556 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	5.165GluAla: 5.165 ± 0.051	0.608GluCys: 0.608 ± 0.014	4.25GluAsp: 4.25 ± 0.042	5.536GluGlu: 5.536 ± 0.089	2.069GluPhe: 2.069 ± 0.022	3.666GluGly: 3.666 ± 0.035	1.442GluHis: 1.442 ± 0.02	3.409GluIle: 3.409 ± 0.031	3.674GluLys: 3.674 ± 0.041	5.278GluLeu: 5.278 ± 0.051	1.551GluMet: 1.551 ± 0.021	2.481GluAsn: 2.481 ± 0.027	2.916GluPro: 2.916 ± 0.069	2.545GluGln: 2.545 ± 0.028	3.908GluArg: 3.908 ± 0.04	4.512GluSer: 4.512 ± 0.044	3.728GluThr: 3.728 ± 0.033	3.524GluVal: 3.524 ± 0.034	0.881GluTrp: 0.881 ± 0.017	1.695GluTyr: 1.695 ± 0.018	0.001GluXaa: 0.001 ± 0.0
Phe	3.028PheAla: 3.028 ± 0.03	0.552PheCys: 0.552 ± 0.012	2.351PheAsp: 2.351 ± 0.025	2.253PheGlu: 2.253 ± 0.024	1.665PhePhe: 1.665 ± 0.023	2.818PheGly: 2.818 ± 0.032	0.948PheHis: 0.948 ± 0.016	1.832PheIle: 1.832 ± 0.026	1.53PheLys: 1.53 ± 0.02	3.5PheLeu: 3.5 ± 0.036	0.836PheMet: 0.836 ± 0.015	1.505PheAsn: 1.505 ± 0.021	1.974PhePro: 1.974 ± 0.022	1.46PheGln: 1.46 ± 0.019	1.991PheArg: 1.991 ± 0.021	3.072PheSer: 3.072 ± 0.03	2.151PheThr: 2.151 ± 0.023	2.426PheVal: 2.426 ± 0.026	0.622PheTrp: 0.622 ± 0.013	1.115PheTyr: 1.115 ± 0.018	0.001PheXaa: 0.001 ± 0.001
Gly	5.061GlyAla: 5.061 ± 0.049	0.82GlyCys: 0.82 ± 0.017	3.535GlyAsp: 3.535 ± 0.033	3.573GlyGlu: 3.573 ± 0.035	2.807GlyPhe: 2.807 ± 0.032	5.335GlyGly: 5.335 ± 0.06	1.663GlyHis: 1.663 ± 0.021	3.563GlyIle: 3.563 ± 0.032	3.324GlyLys: 3.324 ± 0.035	6.029GlyLeu: 6.029 ± 0.042	1.601GlyMet: 1.601 ± 0.024	2.503GlyAsn: 2.503 ± 0.03	3.278GlyPro: 3.278 ± 0.038	2.563GlyGln: 2.563 ± 0.031	3.924GlyArg: 3.924 ± 0.036	5.674GlySer: 5.674 ± 0.048	3.892GlyThr: 3.892 ± 0.034	4.242GlyVal: 4.242 ± 0.039	1.102GlyTrp: 1.102 ± 0.018	2.049GlyTyr: 2.049 ± 0.024	0.002GlyXaa: 0.002 ± 0.001
His	1.841HisAla: 1.841 ± 0.02	0.317HisCys: 0.317 ± 0.008	1.3HisAsp: 1.3 ± 0.02	1.381HisGlu: 1.381 ± 0.021	0.981HisPhe: 0.981 ± 0.017	1.726HisGly: 1.726 ± 0.022	0.814HisHis: 0.814 ± 0.016	1.245HisIle: 1.245 ± 0.019	0.912HisLys: 0.912 ± 0.016	2.34HisLeu: 2.34 ± 0.023	0.513HisMet: 0.513 ± 0.011	0.896HisAsn: 0.896 ± 0.016	1.706HisPro: 1.706 ± 0.024	1.012HisGln: 1.012 ± 0.016	1.622HisArg: 1.622 ± 0.021	1.931HisSer: 1.931 ± 0.025	1.327HisThr: 1.327 ± 0.019	1.487HisVal: 1.487 ± 0.019	0.341HisTrp: 0.341 ± 0.009	0.707HisTyr: 0.707 ± 0.013	0.001HisXaa: 0.001 ± 0.0
Ile	4.199IleAla: 4.199 ± 0.037	0.753IleCys: 0.753 ± 0.014	2.974IleAsp: 2.974 ± 0.029	3.096IleGlu: 3.096 ± 0.032	2.084IlePhe: 2.084 ± 0.026	3.236IleGly: 3.236 ± 0.032	1.258IleHis: 1.258 ± 0.018	2.555IleIle: 2.555 ± 0.034	2.215IleLys: 2.215 ± 0.027	4.63IleLeu: 4.63 ± 0.039	1.072IleMet: 1.072 ± 0.018	1.873IleAsn: 1.873 ± 0.022	3.292IlePro: 3.292 ± 0.031	2.064IleGln: 2.064 ± 0.023	2.833IleArg: 2.833 ± 0.024	4.143IleSer: 4.143 ± 0.035	2.912IleThr: 2.912 ± 0.027	3.153IleVal: 3.153 ± 0.031	0.726IleTrp: 0.726 ± 0.014	1.434IleTyr: 1.434 ± 0.021	0.001IleXaa: 0.001 ± 0.001
Lys	4.058LysAla: 4.058 ± 0.042	0.489LysCys: 0.489 ± 0.012	2.677LysAsp: 2.677 ± 0.025	3.332LysGlu: 3.332 ± 0.04	1.514LysPhe: 1.514 ± 0.018	2.873LysGly: 2.873 ± 0.028	1.101LysHis: 1.101 ± 0.016	2.454LysIle: 2.454 ± 0.024	3.565LysLys: 3.565 ± 0.111	4.07LysLeu: 4.07 ± 0.034	1.03LysMet: 1.03 ± 0.014	1.847LysAsn: 1.847 ± 0.024	2.703LysPro: 2.703 ± 0.032	1.931LysGln: 1.931 ± 0.024	3.356LysArg: 3.356 ± 0.036	3.623LysSer: 3.623 ± 0.031	2.821LysThr: 2.821 ± 0.029	2.788LysVal: 2.788 ± 0.028	0.636LysTrp: 0.636 ± 0.013	1.293LysTyr: 1.293 ± 0.017	0.001LysXaa: 0.001 ± 0.0
Leu	7.712LeuAla: 7.712 ± 0.05	1.164LeuCys: 1.164 ± 0.019	5.251LeuAsp: 5.251 ± 0.045	5.591LeuGlu: 5.591 ± 0.043	3.364LeuPhe: 3.364 ± 0.033	5.916LeuGly: 5.916 ± 0.043	2.239LeuHis: 2.239 ± 0.025	4.084LeuIle: 4.084 ± 0.04	4.224LeuLys: 4.224 ± 0.039	8.212LeuLeu: 8.212 ± 0.068	1.86LeuMet: 1.86 ± 0.024	3.357LeuAsn: 3.357 ± 0.03	5.502LeuPro: 5.502 ± 0.035	3.881LeuGln: 3.881 ± 0.038	5.813LeuArg: 5.813 ± 0.042	7.583LeuSer: 7.583 ± 0.055	4.903LeuThr: 4.903 ± 0.039	5.442LeuVal: 5.442 ± 0.043	1.141LeuTrp: 1.141 ± 0.019	2.293LeuTyr: 2.293 ± 0.023	0.001LeuXaa: 0.001 ± 0.001
Met	2.154MetAla: 2.154 ± 0.022	0.253MetCys: 0.253 ± 0.008	1.307MetAsp: 1.307 ± 0.018	1.343MetGlu: 1.343 ± 0.021	0.765MetPhe: 0.765 ± 0.014	1.509MetGly: 1.509 ± 0.023	0.5MetHis: 0.5 ± 0.011	1.069MetIle: 1.069 ± 0.016	1.04MetLys: 1.04 ± 0.019	1.865MetLeu: 1.865 ± 0.025	0.58MetMet: 0.58 ± 0.013	0.846MetAsn: 0.846 ± 0.015	1.28MetPro: 1.28 ± 0.018	0.924MetGln: 0.924 ± 0.016	1.268MetArg: 1.268 ± 0.016	1.893MetSer: 1.893 ± 0.021	1.312MetThr: 1.312 ± 0.02	1.367MetVal: 1.367 ± 0.02	0.258MetTrp: 0.258 ± 0.008	0.505MetTyr: 0.505 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.151AsnAla: 3.151 ± 0.028	0.438AsnCys: 0.438 ± 0.013	1.999AsnAsp: 1.999 ± 0.024	2.179AsnGlu: 2.179 ± 0.026	1.473AsnPhe: 1.473 ± 0.02	2.828AsnGly: 2.828 ± 0.03	0.89AsnHis: 0.89 ± 0.017	2.046AsnIle: 2.046 ± 0.025	1.582AsnLys: 1.582 ± 0.023	3.419AsnLeu: 3.419 ± 0.033	0.848AsnMet: 0.848 ± 0.015	1.47AsnAsn: 1.47 ± 0.022	2.701AsnPro: 2.701 ± 0.031	1.461AsnGln: 1.461 ± 0.02	2.045AsnArg: 2.045 ± 0.022	2.907AsnSer: 2.907 ± 0.026	2.195AsnThr: 2.195 ± 0.027	2.353AsnVal: 2.353 ± 0.027	0.574AsnTrp: 0.574 ± 0.013	1.072AsnTyr: 1.072 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.205ProAla: 5.205 ± 0.068	0.51ProCys: 0.51 ± 0.013	3.14ProAsp: 3.14 ± 0.031	3.959ProGlu: 3.959 ± 0.041	2.132ProPhe: 2.132 ± 0.024	3.857ProGly: 3.857 ± 0.042	1.409ProHis: 1.409 ± 0.028	2.717ProIle: 2.717 ± 0.027	2.711ProLys: 2.711 ± 0.036	4.757ProLeu: 4.757 ± 0.04	1.128ProMet: 1.128 ± 0.018	2.284ProAsn: 2.284 ± 0.026	5.05ProPro: 5.05 ± 0.145	2.471ProGln: 2.471 ± 0.038	3.449ProArg: 3.449 ± 0.035	6.132ProSer: 6.132 ± 0.061	4.194ProThr: 4.194 ± 0.045	3.714ProVal: 3.714 ± 0.041	0.719ProTrp: 0.719 ± 0.013	1.46ProTyr: 1.46 ± 0.022	0.003ProXaa: 0.003 ± 0.001
Gln	3.425GlnAla: 3.425 ± 0.032	0.423GlnCys: 0.423 ± 0.012	2.068GlnAsp: 2.068 ± 0.023	2.462GlnGlu: 2.462 ± 0.033	1.397GlnPhe: 1.397 ± 0.022	2.394GlnGly: 2.394 ± 0.026	1.09GlnHis: 1.09 ± 0.019	2.079GlnIle: 2.079 ± 0.024	2.072GlnLys: 2.072 ± 0.027	3.549GlnLeu: 3.549 ± 0.038	0.963GlnMet: 0.963 ± 0.018	1.671GlnAsn: 1.671 ± 0.02	2.61GlnPro: 2.61 ± 0.036	2.224GlnGln: 2.224 ± 0.044	2.647GlnArg: 2.647 ± 0.027	3.378GlnSer: 3.378 ± 0.035	2.432GlnThr: 2.432 ± 0.027	2.278GlnVal: 2.278 ± 0.025	0.567GlnTrp: 0.567 ± 0.013	1.157GlnTyr: 1.157 ± 0.019	0.002GlnXaa: 0.002 ± 0.001
Arg	4.65ArgAla: 4.65 ± 0.041	0.668ArgCys: 0.668 ± 0.014	3.333ArgAsp: 3.333 ± 0.034	3.851ArgGlu: 3.851 ± 0.041	2.207ArgPhe: 2.207 ± 0.022	3.736ArgGly: 3.736 ± 0.037	1.571ArgHis: 1.571 ± 0.022	2.959ArgIle: 2.959 ± 0.032	3.446ArgLys: 3.446 ± 0.031	5.496ArgLeu: 5.496 ± 0.042	1.342ArgMet: 1.342 ± 0.019	2.288ArgAsn: 2.288 ± 0.022	3.436ArgPro: 3.436 ± 0.038	2.625ArgGln: 2.625 ± 0.023	4.942ArgArg: 4.942 ± 0.05	4.881ArgSer: 4.881 ± 0.045	3.293ArgThr: 3.293 ± 0.031	3.455ArgVal: 3.455 ± 0.029	0.933ArgTrp: 0.933 ± 0.014	1.578ArgTyr: 1.578 ± 0.019	0.001ArgXaa: 0.001 ± 0.0
Ser	6.708SerAla: 6.708 ± 0.049	0.854SerCys: 0.854 ± 0.017	4.37SerAsp: 4.37 ± 0.036	4.411SerGlu: 4.411 ± 0.036	3.132SerPhe: 3.132 ± 0.029	5.545SerGly: 5.545 ± 0.049	2.117SerHis: 2.117 ± 0.022	4.15SerIle: 4.15 ± 0.032	3.837SerLys: 3.837 ± 0.034	7.452SerLeu: 7.452 ± 0.058	1.79SerMet: 1.79 ± 0.023	3.197SerAsn: 3.197 ± 0.03	5.629SerPro: 5.629 ± 0.069	3.494SerGln: 3.494 ± 0.036	5.053SerArg: 5.053 ± 0.049	8.723SerSer: 8.723 ± 0.081	5.698SerThr: 5.698 ± 0.05	4.803SerVal: 4.803 ± 0.041	1.103SerTrp: 1.103 ± 0.018	2.051SerTyr: 2.051 ± 0.022	0.002SerXaa: 0.002 ± 0.001
Thr	5.079ThrAla: 5.079 ± 0.04	0.68ThrCys: 0.68 ± 0.013	2.977ThrAsp: 2.977 ± 0.025	3.42ThrGlu: 3.42 ± 0.04	2.175ThrPhe: 2.175 ± 0.025	4.151ThrGly: 4.151 ± 0.036	1.347ThrHis: 1.347 ± 0.02	3.138ThrIle: 3.138 ± 0.03	2.708ThrLys: 2.708 ± 0.03	5.296ThrLeu: 5.296 ± 0.04	1.199ThrMet: 1.199 ± 0.017	2.15ThrAsn: 2.15 ± 0.023	4.416ThrPro: 4.416 ± 0.045	2.228ThrGln: 2.228 ± 0.023	3.195ThrArg: 3.195 ± 0.03	5.342ThrSer: 5.342 ± 0.051	4.207ThrThr: 4.207 ± 0.061	3.802ThrVal: 3.802 ± 0.039	0.816ThrTrp: 0.816 ± 0.015	1.558ThrTyr: 1.558 ± 0.019	0.001ThrXaa: 0.001 ± 0.001
Val	5.165ValAla: 5.165 ± 0.044	0.802ValCys: 0.802 ± 0.016	3.791ValAsp: 3.791 ± 0.031	3.877ValGlu: 3.877 ± 0.043	2.482ValPhe: 2.482 ± 0.028	3.9ValGly: 3.9 ± 0.039	1.433ValHis: 1.433 ± 0.019	3.08ValIle: 3.08 ± 0.032	2.777ValLys: 2.777 ± 0.028	5.525ValLeu: 5.525 ± 0.04	1.324ValMet: 1.324 ± 0.016	2.272ValAsn: 2.272 ± 0.023	3.664ValPro: 3.664 ± 0.035	2.451ValGln: 2.451 ± 0.029	3.415ValArg: 3.415 ± 0.031	4.878ValSer: 4.878 ± 0.039	3.568ValThr: 3.568 ± 0.035	4.288ValVal: 4.288 ± 0.061	0.815ValTrp: 0.815 ± 0.016	1.676ValTyr: 1.676 ± 0.021	0.002ValXaa: 0.002 ± 0.001
Trp	1.089TrpAla: 1.089 ± 0.02	0.186TrpCys: 0.186 ± 0.006	0.881TrpAsp: 0.881 ± 0.017	0.835TrpGlu: 0.835 ± 0.015	0.487TrpPhe: 0.487 ± 0.013	0.885TrpGly: 0.885 ± 0.016	0.349TrpHis: 0.349 ± 0.009	0.74TrpIle: 0.74 ± 0.014	0.79TrpLys: 0.79 ± 0.013	1.306TrpLeu: 1.306 ± 0.019	0.374TrpMet: 0.374 ± 0.009	0.617TrpAsn: 0.617 ± 0.013	0.556TrpPro: 0.556 ± 0.011	0.543TrpGln: 0.543 ± 0.012	0.936TrpArg: 0.936 ± 0.015	1.057TrpSer: 1.057 ± 0.017	0.88TrpThr: 0.88 ± 0.017	0.857TrpVal: 0.857 ± 0.016	0.272TrpTrp: 0.272 ± 0.008	0.412TrpTyr: 0.412 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.098TyrAla: 2.098 ± 0.026	0.361TyrCys: 0.361 ± 0.009	1.603TyrAsp: 1.603 ± 0.02	1.504TyrGlu: 1.504 ± 0.02	1.123TyrPhe: 1.123 ± 0.017	1.967TyrGly: 1.967 ± 0.022	0.745TyrHis: 0.745 ± 0.013	1.391TyrIle: 1.391 ± 0.019	1.069TyrLys: 1.069 ± 0.015	2.627TyrLeu: 2.627 ± 0.028	0.596TyrMet: 0.596 ± 0.013	1.121TyrAsn: 1.121 ± 0.018	1.473TyrPro: 1.473 ± 0.023	1.141TyrGln: 1.141 ± 0.016	1.586TyrArg: 1.586 ± 0.021	2.044TyrSer: 2.044 ± 0.025	1.554TyrThr: 1.554 ± 0.022	1.584TyrVal: 1.584 ± 0.021	0.413TyrTrp: 0.413 ± 0.01	0.882TyrTyr: 0.882 ± 0.016	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.002XaaGly: 0.002 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.001XaaLys: 0.001 ± 0.0	0.002XaaLeu: 0.002 ± 0.001	0.001XaaMet: 0.001 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.004XaaPro: 0.004 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.003XaaSer: 0.003 ± 0.001	0.002XaaThr: 0.002 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.001XaaTrp: 0.001 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9101 proteins (4201956 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---