Amino acid dipepetide frequency for Bovine group B rotavirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.535AlaAla: 5.535 ± 1.501
1.277AlaCys: 1.277 ± 0.284
4.258AlaAsp: 4.258 ± 1.014
3.832AlaGlu: 3.832 ± 0.701
2.981AlaPhe: 2.981 ± 0.547
2.555AlaGly: 2.555 ± 0.97
0.213AlaHis: 0.213 ± 0.178
5.748AlaIle: 5.748 ± 0.971
3.619AlaLys: 3.619 ± 0.989
4.684AlaLeu: 4.684 ± 1.356
1.703AlaMet: 1.703 ± 0.715
2.768AlaAsn: 2.768 ± 0.758
3.619AlaPro: 3.619 ± 0.857
1.916AlaGln: 1.916 ± 0.6
2.342AlaArg: 2.342 ± 0.764
3.619AlaSer: 3.619 ± 0.993
3.832AlaThr: 3.832 ± 0.906
3.832AlaVal: 3.832 ± 0.582
1.065AlaTrp: 1.065 ± 0.307
1.703AlaTyr: 1.703 ± 0.462
0.0AlaXaa: 0.0 ± 0.0
Cys
1.065CysAla: 1.065 ± 0.433
0.639CysCys: 0.639 ± 0.449
0.639CysAsp: 0.639 ± 0.352
0.852CysGlu: 0.852 ± 0.277
0.426CysPhe: 0.426 ± 0.24
2.555CysGly: 2.555 ± 1.508
0.0CysHis: 0.0 ± 0.0
1.065CysIle: 1.065 ± 0.472
0.213CysLys: 0.213 ± 0.217
0.639CysLeu: 0.639 ± 0.33
0.213CysMet: 0.213 ± 0.178
0.852CysAsn: 0.852 ± 0.313
1.065CysPro: 1.065 ± 0.749
1.277CysGln: 1.277 ± 0.462
0.639CysArg: 0.639 ± 0.332
1.49CysSer: 1.49 ± 0.69
0.639CysThr: 0.639 ± 0.452
0.852CysVal: 0.852 ± 0.486
0.0CysTrp: 0.0 ± 0.0
0.852CysTyr: 0.852 ± 0.574
0.0CysXaa: 0.0 ± 0.0
Asp
2.981AspAla: 2.981 ± 0.688
0.639AspCys: 0.639 ± 0.448
3.832AspAsp: 3.832 ± 0.879
2.981AspGlu: 2.981 ± 0.933
3.832AspPhe: 3.832 ± 0.933
1.916AspGly: 1.916 ± 0.812
0.639AspHis: 0.639 ± 0.352
5.748AspIle: 5.748 ± 1.403
3.406AspLys: 3.406 ± 0.619
4.045AspLeu: 4.045 ± 0.64
0.639AspMet: 0.639 ± 0.258
3.406AspAsn: 3.406 ± 0.862
1.277AspPro: 1.277 ± 0.506
1.916AspGln: 1.916 ± 0.599
4.045AspArg: 4.045 ± 1.326
3.619AspSer: 3.619 ± 1.207
3.832AspThr: 3.832 ± 1.012
5.961AspVal: 5.961 ± 1.157
0.852AspTrp: 0.852 ± 0.277
2.555AspTyr: 2.555 ± 0.653
0.0AspXaa: 0.0 ± 0.0
Glu
3.194GluAla: 3.194 ± 0.56
0.639GluCys: 0.639 ± 0.275
3.406GluAsp: 3.406 ± 0.532
2.768GluGlu: 2.768 ± 0.677
3.832GluPhe: 3.832 ± 0.804
1.49GluGly: 1.49 ± 0.309
1.703GluHis: 1.703 ± 0.576
2.981GluIle: 2.981 ± 0.619
2.981GluLys: 2.981 ± 0.47
4.045GluLeu: 4.045 ± 0.95
2.342GluMet: 2.342 ± 0.511
2.981GluAsn: 2.981 ± 0.707
1.49GluPro: 1.49 ± 0.393
3.194GluGln: 3.194 ± 0.769
3.194GluArg: 3.194 ± 0.542
4.471GluSer: 4.471 ± 0.87
3.194GluThr: 3.194 ± 0.676
2.981GluVal: 2.981 ± 0.924
1.703GluTrp: 1.703 ± 0.502
1.916GluTyr: 1.916 ± 0.561
0.0GluXaa: 0.0 ± 0.0
Phe
3.619PheAla: 3.619 ± 0.592
0.639PheCys: 0.639 ± 0.422
2.129PheAsp: 2.129 ± 0.982
4.471PheGlu: 4.471 ± 0.66
1.916PhePhe: 1.916 ± 0.838
1.277PheGly: 1.277 ± 0.417
0.213PheHis: 0.213 ± 0.167
1.703PheIle: 1.703 ± 0.354
2.555PheLys: 2.555 ± 0.706
2.342PheLeu: 2.342 ± 0.689
0.852PheMet: 0.852 ± 0.5
2.555PheAsn: 2.555 ± 0.626
1.916PhePro: 1.916 ± 0.43
2.342PheGln: 2.342 ± 0.455
2.981PheArg: 2.981 ± 0.497
3.619PheSer: 3.619 ± 0.981
2.768PheThr: 2.768 ± 0.697
4.045PheVal: 4.045 ± 1.215
0.426PheTrp: 0.426 ± 0.293
2.342PheTyr: 2.342 ± 1.103
0.0PheXaa: 0.0 ± 0.0
Gly
2.768GlyAla: 2.768 ± 0.393
0.213GlyCys: 0.213 ± 0.178
2.129GlyAsp: 2.129 ± 0.778
2.342GlyGlu: 2.342 ± 1.213
2.129GlyPhe: 2.129 ± 0.633
1.916GlyGly: 1.916 ± 0.639
0.639GlyHis: 0.639 ± 0.457
2.129GlyIle: 2.129 ± 0.498
2.981GlyLys: 2.981 ± 1.259
2.768GlyLeu: 2.768 ± 0.613
0.639GlyMet: 0.639 ± 0.347
2.768GlyAsn: 2.768 ± 0.481
0.852GlyPro: 0.852 ± 0.277
2.129GlyGln: 2.129 ± 0.863
2.342GlyArg: 2.342 ± 0.365
2.129GlySer: 2.129 ± 0.488
2.129GlyThr: 2.129 ± 0.511
3.832GlyVal: 3.832 ± 0.847
0.0GlyTrp: 0.0 ± 0.0
1.703GlyTyr: 1.703 ± 0.648
0.0GlyXaa: 0.0 ± 0.0
His
1.065HisAla: 1.065 ± 0.372
0.213HisCys: 0.213 ± 0.246
0.426HisAsp: 0.426 ± 0.356
0.852HisGlu: 0.852 ± 0.462
0.639HisPhe: 0.639 ± 0.339
0.852HisGly: 0.852 ± 0.47
0.213HisHis: 0.213 ± 0.167
1.277HisIle: 1.277 ± 0.522
0.0HisLys: 0.0 ± 0.0
2.129HisLeu: 2.129 ± 0.533
1.065HisMet: 1.065 ± 0.47
1.703HisAsn: 1.703 ± 0.472
0.426HisPro: 0.426 ± 0.217
0.213HisGln: 0.213 ± 0.203
0.852HisArg: 0.852 ± 0.468
2.129HisSer: 2.129 ± 0.708
1.49HisThr: 1.49 ± 0.7
0.639HisVal: 0.639 ± 0.332
0.0HisTrp: 0.0 ± 0.0
1.065HisTyr: 1.065 ± 0.325
0.0HisXaa: 0.0 ± 0.0
Ile
4.045IleAla: 4.045 ± 0.76
2.129IleCys: 2.129 ± 0.807
4.471IleAsp: 4.471 ± 0.994
4.897IleGlu: 4.897 ± 1.357
2.768IlePhe: 2.768 ± 0.763
1.277IleGly: 1.277 ± 0.302
2.555IleHis: 2.555 ± 0.713
7.452IleIle: 7.452 ± 0.987
4.258IleLys: 4.258 ± 0.79
7.026IleLeu: 7.026 ± 0.817
1.703IleMet: 1.703 ± 0.682
5.11IleAsn: 5.11 ± 0.668
3.832IlePro: 3.832 ± 0.94
3.194IleGln: 3.194 ± 1.057
4.684IleArg: 4.684 ± 1.451
8.09IleSer: 8.09 ± 1.132
3.832IleThr: 3.832 ± 0.972
2.768IleVal: 2.768 ± 0.409
0.0IleTrp: 0.0 ± 0.0
2.342IleTyr: 2.342 ± 0.762
0.0IleXaa: 0.0 ± 0.0
Lys
3.406LysAla: 3.406 ± 0.514
0.639LysCys: 0.639 ± 0.446
3.194LysAsp: 3.194 ± 1.262
3.406LysGlu: 3.406 ± 1.167
1.703LysPhe: 1.703 ± 0.488
2.129LysGly: 2.129 ± 0.585
0.639LysHis: 0.639 ± 0.382
6.174LysIle: 6.174 ± 0.859
4.258LysLys: 4.258 ± 0.987
7.452LysLeu: 7.452 ± 1.24
2.129LysMet: 2.129 ± 0.579
2.555LysAsn: 2.555 ± 0.715
3.619LysPro: 3.619 ± 0.654
2.981LysGln: 2.981 ± 0.781
3.406LysArg: 3.406 ± 0.931
3.406LysSer: 3.406 ± 0.757
5.748LysThr: 5.748 ± 1.61
2.981LysVal: 2.981 ± 0.949
1.065LysTrp: 1.065 ± 0.433
2.129LysTyr: 2.129 ± 0.778
0.0LysXaa: 0.0 ± 0.0
Leu
5.323LeuAla: 5.323 ± 0.748
1.49LeuCys: 1.49 ± 0.504
5.748LeuAsp: 5.748 ± 1.041
3.619LeuGlu: 3.619 ± 1.034
4.045LeuPhe: 4.045 ± 0.497
1.703LeuGly: 1.703 ± 0.772
1.277LeuHis: 1.277 ± 0.451
4.684LeuIle: 4.684 ± 0.645
5.961LeuLys: 5.961 ± 1.404
6.387LeuLeu: 6.387 ± 1.332
1.703LeuMet: 1.703 ± 0.331
7.452LeuAsn: 7.452 ± 1.296
2.342LeuPro: 2.342 ± 0.396
2.768LeuGln: 2.768 ± 0.617
5.323LeuArg: 5.323 ± 0.826
8.09LeuSer: 8.09 ± 1.249
6.6LeuThr: 6.6 ± 1.301
5.11LeuVal: 5.11 ± 1.592
0.639LeuTrp: 0.639 ± 0.203
3.406LeuTyr: 3.406 ± 1.412
0.0LeuXaa: 0.0 ± 0.0
Met
1.49MetAla: 1.49 ± 0.682
0.426MetCys: 0.426 ± 0.254
1.49MetAsp: 1.49 ± 0.44
0.852MetGlu: 0.852 ± 0.419
1.277MetPhe: 1.277 ± 0.649
1.277MetGly: 1.277 ± 0.364
0.0MetHis: 0.0 ± 0.0
1.065MetIle: 1.065 ± 0.425
1.277MetLys: 1.277 ± 0.345
3.832MetLeu: 3.832 ± 0.835
0.426MetMet: 0.426 ± 0.201
1.065MetAsn: 1.065 ± 0.308
1.916MetPro: 1.916 ± 0.5
0.426MetGln: 0.426 ± 0.221
0.639MetArg: 0.639 ± 0.347
2.342MetSer: 2.342 ± 0.48
1.49MetThr: 1.49 ± 0.431
1.277MetVal: 1.277 ± 0.411
0.0MetTrp: 0.0 ± 0.0
0.852MetTyr: 0.852 ± 0.253
0.0MetXaa: 0.0 ± 0.0
Asn
3.832AsnAla: 3.832 ± 1.078
0.852AsnCys: 0.852 ± 0.416
3.619AsnAsp: 3.619 ± 1.103
2.342AsnGlu: 2.342 ± 0.92
1.916AsnPhe: 1.916 ± 0.677
3.832AsnGly: 3.832 ± 1.001
0.852AsnHis: 0.852 ± 0.205
6.174AsnIle: 6.174 ± 0.96
2.555AsnLys: 2.555 ± 0.381
3.832AsnLeu: 3.832 ± 1.062
1.49AsnMet: 1.49 ± 0.508
2.768AsnAsn: 2.768 ± 1.064
2.342AsnPro: 2.342 ± 0.628
1.49AsnGln: 1.49 ± 0.375
3.406AsnArg: 3.406 ± 0.952
5.11AsnSer: 5.11 ± 0.687
5.535AsnThr: 5.535 ± 0.932
5.748AsnVal: 5.748 ± 1.368
0.213AsnTrp: 0.213 ± 0.178
2.129AsnTyr: 2.129 ± 0.649
0.0AsnXaa: 0.0 ± 0.0
Pro
1.703ProAla: 1.703 ± 0.7
0.639ProCys: 0.639 ± 0.382
1.49ProAsp: 1.49 ± 0.259
2.768ProGlu: 2.768 ± 0.706
1.49ProPhe: 1.49 ± 0.739
1.277ProGly: 1.277 ± 0.298
1.277ProHis: 1.277 ± 0.603
3.194ProIle: 3.194 ± 0.633
2.129ProLys: 2.129 ± 0.514
3.619ProLeu: 3.619 ± 0.962
1.49ProMet: 1.49 ± 0.538
2.129ProAsn: 2.129 ± 0.745
1.277ProPro: 1.277 ± 0.492
1.065ProGln: 1.065 ± 0.672
1.065ProArg: 1.065 ± 0.333
4.045ProSer: 4.045 ± 0.938
4.471ProThr: 4.471 ± 1.171
2.555ProVal: 2.555 ± 0.549
0.639ProTrp: 0.639 ± 0.251
3.406ProTyr: 3.406 ± 0.415
0.0ProXaa: 0.0 ± 0.0
Gln
1.703GlnAla: 1.703 ± 0.676
0.0GlnCys: 0.0 ± 0.0
1.277GlnAsp: 1.277 ± 0.351
1.277GlnGlu: 1.277 ± 0.328
2.555GlnPhe: 2.555 ± 0.726
1.277GlnGly: 1.277 ± 0.307
0.852GlnHis: 0.852 ± 0.345
3.194GlnIle: 3.194 ± 0.493
3.832GlnLys: 3.832 ± 0.822
2.981GlnLeu: 2.981 ± 0.61
0.426GlnMet: 0.426 ± 0.376
1.065GlnAsn: 1.065 ± 0.349
1.916GlnPro: 1.916 ± 0.723
2.129GlnGln: 2.129 ± 0.53
2.342GlnArg: 2.342 ± 1.354
5.535GlnSer: 5.535 ± 0.831
2.342GlnThr: 2.342 ± 0.654
2.981GlnVal: 2.981 ± 0.661
0.852GlnTrp: 0.852 ± 0.301
0.639GlnTyr: 0.639 ± 0.255
0.0GlnXaa: 0.0 ± 0.0
Arg
2.129ArgAla: 2.129 ± 0.704
1.065ArgCys: 1.065 ± 0.462
3.832ArgAsp: 3.832 ± 0.648
4.897ArgGlu: 4.897 ± 1.04
1.916ArgPhe: 1.916 ± 0.69
2.342ArgGly: 2.342 ± 0.619
0.213ArgHis: 0.213 ± 0.188
4.258ArgIle: 4.258 ± 1.016
3.406ArgLys: 3.406 ± 0.719
4.897ArgLeu: 4.897 ± 1.144
1.065ArgMet: 1.065 ± 0.336
3.619ArgAsn: 3.619 ± 0.809
1.916ArgPro: 1.916 ± 0.686
1.916ArgGln: 1.916 ± 0.607
1.703ArgArg: 1.703 ± 0.598
2.768ArgSer: 2.768 ± 0.938
3.619ArgThr: 3.619 ± 1.034
2.981ArgVal: 2.981 ± 0.831
1.277ArgTrp: 1.277 ± 0.298
2.129ArgTyr: 2.129 ± 0.628
0.0ArgXaa: 0.0 ± 0.0
Ser
5.11SerAla: 5.11 ± 0.874
2.129SerCys: 2.129 ± 0.825
5.748SerAsp: 5.748 ± 0.983
3.832SerGlu: 3.832 ± 1.44
3.406SerPhe: 3.406 ± 0.927
3.194SerGly: 3.194 ± 0.798
0.852SerHis: 0.852 ± 0.277
7.877SerIle: 7.877 ± 0.91
7.664SerLys: 7.664 ± 1.19
7.026SerLeu: 7.026 ± 1.738
2.342SerMet: 2.342 ± 0.662
4.258SerAsn: 4.258 ± 0.916
4.258SerPro: 4.258 ± 0.703
2.342SerGln: 2.342 ± 0.777
4.471SerArg: 4.471 ± 1.005
7.452SerSer: 7.452 ± 1.292
3.619SerThr: 3.619 ± 0.763
6.174SerVal: 6.174 ± 1.083
0.639SerTrp: 0.639 ± 0.388
2.342SerTyr: 2.342 ± 1.231
0.0SerXaa: 0.0 ± 0.0
Thr
5.535ThrAla: 5.535 ± 1.056
0.852ThrCys: 0.852 ± 0.619
3.194ThrAsp: 3.194 ± 0.844
4.684ThrGlu: 4.684 ± 1.708
3.619ThrPhe: 3.619 ± 0.742
3.832ThrGly: 3.832 ± 1.154
1.49ThrHis: 1.49 ± 0.662
4.258ThrIle: 4.258 ± 0.897
4.258ThrLys: 4.258 ± 1.451
6.174ThrLeu: 6.174 ± 1.047
1.703ThrMet: 1.703 ± 0.382
4.258ThrAsn: 4.258 ± 0.434
2.342ThrPro: 2.342 ± 0.439
3.406ThrGln: 3.406 ± 0.626
2.129ThrArg: 2.129 ± 0.428
6.174ThrSer: 6.174 ± 1.004
3.619ThrThr: 3.619 ± 0.81
4.471ThrVal: 4.471 ± 0.521
0.213ThrTrp: 0.213 ± 0.232
3.619ThrTyr: 3.619 ± 0.902
0.0ThrXaa: 0.0 ± 0.0
Val
4.471ValAla: 4.471 ± 0.728
1.065ValCys: 1.065 ± 0.423
3.194ValAsp: 3.194 ± 1.098
1.703ValGlu: 1.703 ± 1.02
2.768ValPhe: 2.768 ± 0.939
2.342ValGly: 2.342 ± 0.513
1.703ValHis: 1.703 ± 0.612
4.045ValIle: 4.045 ± 1.238
3.619ValLys: 3.619 ± 0.566
5.323ValLeu: 5.323 ± 0.851
0.852ValMet: 0.852 ± 0.382
4.897ValAsn: 4.897 ± 0.959
2.768ValPro: 2.768 ± 0.531
2.129ValGln: 2.129 ± 0.799
4.045ValArg: 4.045 ± 1.09
5.748ValSer: 5.748 ± 1.092
7.452ValThr: 7.452 ± 1.082
4.258ValVal: 4.258 ± 1.554
0.639ValTrp: 0.639 ± 0.313
2.981ValTyr: 2.981 ± 0.672
0.0ValXaa: 0.0 ± 0.0
Trp
0.426TrpAla: 0.426 ± 0.341
0.0TrpCys: 0.0 ± 0.0
0.426TrpAsp: 0.426 ± 0.259
0.213TrpGlu: 0.213 ± 0.167
0.852TrpPhe: 0.852 ± 0.404
0.213TrpGly: 0.213 ± 0.188
0.0TrpHis: 0.0 ± 0.0
0.639TrpIle: 0.639 ± 0.275
1.277TrpLys: 1.277 ± 0.345
0.852TrpLeu: 0.852 ± 0.337
0.426TrpMet: 0.426 ± 0.198
0.426TrpAsn: 0.426 ± 0.256
0.852TrpPro: 0.852 ± 0.708
0.852TrpGln: 0.852 ± 0.441
0.639TrpArg: 0.639 ± 0.382
1.065TrpSer: 1.065 ± 0.48
0.639TrpThr: 0.639 ± 0.339
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.426TrpTyr: 0.426 ± 0.217
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.916TyrAla: 1.916 ± 0.572
0.426TyrCys: 0.426 ± 0.259
3.619TyrAsp: 3.619 ± 0.663
1.916TyrGlu: 1.916 ± 0.741
0.639TyrPhe: 0.639 ± 0.388
1.277TyrGly: 1.277 ± 0.729
1.916TyrHis: 1.916 ± 0.653
2.768TyrIle: 2.768 ± 0.758
2.768TyrLys: 2.768 ± 0.493
3.619TyrLeu: 3.619 ± 0.506
0.0TyrMet: 0.0 ± 0.0
3.406TyrAsn: 3.406 ± 0.647
1.703TyrPro: 1.703 ± 0.626
1.49TyrGln: 1.49 ± 0.611
1.703TyrArg: 1.703 ± 0.497
3.832TyrSer: 3.832 ± 1.026
2.981TyrThr: 2.981 ± 1.364
2.555TyrVal: 2.555 ± 0.651
0.0TyrTrp: 0.0 ± 0.0
1.065TyrTyr: 1.065 ± 0.625
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10 proteins (4698 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski