Amino acid dipepetide frequency for Streptococcus satellite phage Javan298

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.392AlaCys: 0.392 ± 0.386
4.309AlaAsp: 4.309 ± 1.386
6.659AlaGlu: 6.659 ± 2.165
2.742AlaPhe: 2.742 ± 0.81
3.134AlaGly: 3.134 ± 0.8
1.175AlaHis: 1.175 ± 0.814
4.309AlaIle: 4.309 ± 0.839
5.484AlaLys: 5.484 ± 1.444
6.659AlaLeu: 6.659 ± 1.541
3.134AlaMet: 3.134 ± 1.044
5.092AlaAsn: 5.092 ± 1.083
0.392AlaPro: 0.392 ± 0.392
2.742AlaGln: 2.742 ± 0.719
1.958AlaArg: 1.958 ± 0.676
2.742AlaSer: 2.742 ± 0.905
1.958AlaThr: 1.958 ± 1.072
2.35AlaVal: 2.35 ± 0.982
0.392AlaTrp: 0.392 ± 0.348
1.958AlaTyr: 1.958 ± 0.923
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.783CysIle: 0.783 ± 0.695
0.392CysLys: 0.392 ± 0.386
0.392CysLeu: 0.392 ± 0.456
0.0CysMet: 0.0 ± 0.0
0.783CysAsn: 0.783 ± 0.657
0.0CysPro: 0.0 ± 0.0
0.392CysGln: 0.392 ± 0.348
0.392CysArg: 0.392 ± 0.386
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.392CysVal: 0.392 ± 0.348
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.567AspAla: 1.567 ± 0.787
0.0AspCys: 0.0 ± 0.0
5.092AspAsp: 5.092 ± 1.352
7.051AspGlu: 7.051 ± 1.916
5.092AspPhe: 5.092 ± 1.776
2.35AspGly: 2.35 ± 1.126
0.783AspHis: 0.783 ± 0.602
5.875AspIle: 5.875 ± 1.076
5.875AspLys: 5.875 ± 1.466
6.267AspLeu: 6.267 ± 2.523
2.35AspMet: 2.35 ± 1.188
4.309AspAsn: 4.309 ± 1.152
0.783AspPro: 0.783 ± 0.477
1.175AspGln: 1.175 ± 0.78
3.134AspArg: 3.134 ± 0.966
3.134AspSer: 3.134 ± 0.886
3.134AspThr: 3.134 ± 0.974
3.525AspVal: 3.525 ± 1.17
0.392AspTrp: 0.392 ± 0.467
3.525AspTyr: 3.525 ± 1.052
0.0AspXaa: 0.0 ± 0.0
Glu
6.267GluAla: 6.267 ± 1.395
0.0GluCys: 0.0 ± 0.0
3.917GluAsp: 3.917 ± 1.601
8.617GluGlu: 8.617 ± 2.365
4.7GluPhe: 4.7 ± 1.354
2.35GluGly: 2.35 ± 0.845
1.958GluHis: 1.958 ± 1.425
8.617GluIle: 8.617 ± 1.864
10.576GluLys: 10.576 ± 1.986
11.751GluLeu: 11.751 ± 3.055
1.958GluMet: 1.958 ± 0.78
5.484GluAsn: 5.484 ± 2.048
0.783GluPro: 0.783 ± 0.504
4.7GluGln: 4.7 ± 1.457
4.7GluArg: 4.7 ± 1.296
3.134GluSer: 3.134 ± 0.996
4.7GluThr: 4.7 ± 1.092
7.051GluVal: 7.051 ± 2.134
1.175GluTrp: 1.175 ± 0.714
2.742GluTyr: 2.742 ± 0.671
0.0GluXaa: 0.0 ± 0.0
Phe
1.958PheAla: 1.958 ± 0.907
0.0PheCys: 0.0 ± 0.0
3.917PheAsp: 3.917 ± 1.053
4.7PheGlu: 4.7 ± 1.098
0.783PhePhe: 0.783 ± 0.695
1.958PheGly: 1.958 ± 0.717
1.567PheHis: 1.567 ± 0.691
3.134PheIle: 3.134 ± 1.045
4.309PheLys: 4.309 ± 1.373
3.917PheLeu: 3.917 ± 0.975
0.783PheMet: 0.783 ± 0.57
1.567PheAsn: 1.567 ± 1.008
0.783PhePro: 0.783 ± 0.702
3.917PheGln: 3.917 ± 1.12
0.783PheArg: 0.783 ± 0.532
2.742PheSer: 2.742 ± 1.001
1.175PheThr: 1.175 ± 0.486
3.134PheVal: 3.134 ± 1.302
0.392PheTrp: 0.392 ± 0.407
1.567PheTyr: 1.567 ± 0.693
0.0PheXaa: 0.0 ± 0.0
Gly
1.567GlyAla: 1.567 ± 0.741
0.783GlyCys: 0.783 ± 0.425
2.742GlyAsp: 2.742 ± 0.955
4.309GlyGlu: 4.309 ± 1.149
3.917GlyPhe: 3.917 ± 1.317
2.35GlyGly: 2.35 ± 0.962
0.783GlyHis: 0.783 ± 0.532
3.525GlyIle: 3.525 ± 0.87
3.917GlyLys: 3.917 ± 1.085
5.484GlyLeu: 5.484 ± 1.816
0.392GlyMet: 0.392 ± 0.336
2.742GlyAsn: 2.742 ± 0.955
0.0GlyPro: 0.0 ± 0.0
0.392GlyGln: 0.392 ± 0.348
3.134GlyArg: 3.134 ± 1.283
0.783GlySer: 0.783 ± 0.577
1.175GlyThr: 1.175 ± 0.752
3.917GlyVal: 3.917 ± 1.31
0.783GlyTrp: 0.783 ± 0.87
3.134GlyTyr: 3.134 ± 1.217
0.0GlyXaa: 0.0 ± 0.0
His
0.783HisAla: 0.783 ± 0.785
0.0HisCys: 0.0 ± 0.0
1.175HisAsp: 1.175 ± 0.814
0.783HisGlu: 0.783 ± 0.581
1.175HisPhe: 1.175 ± 0.544
0.783HisGly: 0.783 ± 0.59
0.0HisHis: 0.0 ± 0.0
1.567HisIle: 1.567 ± 1.063
0.392HisLys: 0.392 ± 0.392
1.567HisLeu: 1.567 ± 0.639
0.0HisMet: 0.0 ± 0.0
0.783HisAsn: 0.783 ± 0.425
0.392HisPro: 0.392 ± 0.392
0.392HisGln: 0.392 ± 0.392
1.175HisArg: 1.175 ± 0.826
0.783HisSer: 0.783 ± 0.497
1.567HisThr: 1.567 ± 1.092
0.392HisVal: 0.392 ± 0.348
0.0HisTrp: 0.0 ± 0.0
1.567HisTyr: 1.567 ± 0.658
0.0HisXaa: 0.0 ± 0.0
Ile
5.484IleAla: 5.484 ± 1.918
0.392IleCys: 0.392 ± 0.435
6.267IleAsp: 6.267 ± 2.16
7.442IleGlu: 7.442 ± 2.006
1.567IlePhe: 1.567 ± 1.003
3.525IleGly: 3.525 ± 0.854
0.392IleHis: 0.392 ± 0.392
4.309IleIle: 4.309 ± 2.225
6.659IleLys: 6.659 ± 1.421
3.917IleLeu: 3.917 ± 1.42
0.783IleMet: 0.783 ± 0.499
3.525IleAsn: 3.525 ± 1.176
0.392IlePro: 0.392 ± 0.386
2.742IleGln: 2.742 ± 1.041
3.525IleArg: 3.525 ± 1.814
4.7IleSer: 4.7 ± 1.191
1.958IleThr: 1.958 ± 0.871
2.742IleVal: 2.742 ± 0.793
0.783IleTrp: 0.783 ± 0.493
4.7IleTyr: 4.7 ± 1.721
0.0IleXaa: 0.0 ± 0.0
Lys
6.659LysAla: 6.659 ± 1.75
0.0LysCys: 0.0 ± 0.0
6.659LysAsp: 6.659 ± 1.69
9.792LysGlu: 9.792 ± 1.997
2.35LysPhe: 2.35 ± 0.979
4.7LysGly: 4.7 ± 1.099
1.958LysHis: 1.958 ± 1.024
4.7LysIle: 4.7 ± 1.108
9.401LysLys: 9.401 ± 2.001
7.051LysLeu: 7.051 ± 1.809
1.567LysMet: 1.567 ± 0.743
7.442LysAsn: 7.442 ± 1.567
2.35LysPro: 2.35 ± 0.803
5.092LysGln: 5.092 ± 1.589
5.484LysArg: 5.484 ± 1.594
6.267LysSer: 6.267 ± 1.047
6.267LysThr: 6.267 ± 1.622
2.742LysVal: 2.742 ± 0.899
0.392LysTrp: 0.392 ± 0.386
5.092LysTyr: 5.092 ± 1.215
0.0LysXaa: 0.0 ± 0.0
Leu
9.009LeuAla: 9.009 ± 2.067
0.392LeuCys: 0.392 ± 0.348
10.184LeuAsp: 10.184 ± 1.566
12.534LeuGlu: 12.534 ± 3.406
5.875LeuPhe: 5.875 ± 1.942
3.134LeuGly: 3.134 ± 1.462
0.783LeuHis: 0.783 ± 0.425
4.309LeuIle: 4.309 ± 1.66
7.834LeuLys: 7.834 ± 1.922
11.359LeuLeu: 11.359 ± 2.016
3.525LeuMet: 3.525 ± 1.118
5.092LeuAsn: 5.092 ± 1.14
1.958LeuPro: 1.958 ± 0.781
3.525LeuGln: 3.525 ± 0.744
1.958LeuArg: 1.958 ± 0.836
4.309LeuSer: 4.309 ± 1.592
4.309LeuThr: 4.309 ± 1.07
6.267LeuVal: 6.267 ± 1.404
0.0LeuTrp: 0.0 ± 0.0
3.525LeuTyr: 3.525 ± 1.02
0.0LeuXaa: 0.0 ± 0.0
Met
3.134MetAla: 3.134 ± 1.18
0.0MetCys: 0.0 ± 0.0
2.35MetAsp: 2.35 ± 1.266
2.35MetGlu: 2.35 ± 1.126
0.392MetPhe: 0.392 ± 0.348
1.567MetGly: 1.567 ± 0.911
0.0MetHis: 0.0 ± 0.0
1.567MetIle: 1.567 ± 1.193
2.742MetLys: 2.742 ± 1.029
1.175MetLeu: 1.175 ± 0.566
1.175MetMet: 1.175 ± 0.676
1.958MetAsn: 1.958 ± 0.822
1.175MetPro: 1.175 ± 0.834
0.783MetGln: 0.783 ± 0.675
0.392MetArg: 0.392 ± 0.435
0.783MetSer: 0.783 ± 0.59
2.35MetThr: 2.35 ± 1.448
2.35MetVal: 2.35 ± 0.94
0.0MetTrp: 0.0 ± 0.0
1.175MetTyr: 1.175 ± 0.592
0.0MetXaa: 0.0 ± 0.0
Asn
3.917AsnAla: 3.917 ± 0.979
0.392AsnCys: 0.392 ± 0.456
1.958AsnAsp: 1.958 ± 0.626
3.134AsnGlu: 3.134 ± 1.394
1.567AsnPhe: 1.567 ± 0.704
5.092AsnGly: 5.092 ± 1.357
1.175AsnHis: 1.175 ± 0.845
1.958AsnIle: 1.958 ± 0.958
6.659AsnLys: 6.659 ± 2.341
4.309AsnLeu: 4.309 ± 1.077
1.567AsnMet: 1.567 ± 1.036
4.7AsnAsn: 4.7 ± 2.041
1.958AsnPro: 1.958 ± 0.827
3.525AsnGln: 3.525 ± 1.308
2.742AsnArg: 2.742 ± 1.003
1.175AsnSer: 1.175 ± 0.758
4.7AsnThr: 4.7 ± 1.485
2.35AsnVal: 2.35 ± 0.882
1.175AsnTrp: 1.175 ± 0.939
3.917AsnTyr: 3.917 ± 1.372
0.0AsnXaa: 0.0 ± 0.0
Pro
0.783ProAla: 0.783 ± 0.497
0.0ProCys: 0.0 ± 0.0
1.175ProAsp: 1.175 ± 0.749
2.35ProGlu: 2.35 ± 0.967
1.958ProPhe: 1.958 ± 0.845
0.0ProGly: 0.0 ± 0.0
0.0ProHis: 0.0 ± 0.0
1.958ProIle: 1.958 ± 0.672
1.958ProLys: 1.958 ± 0.81
0.783ProLeu: 0.783 ± 0.559
0.392ProMet: 0.392 ± 0.336
0.783ProAsn: 0.783 ± 0.55
0.0ProPro: 0.0 ± 0.0
0.0ProGln: 0.0 ± 0.0
1.567ProArg: 1.567 ± 0.524
1.175ProSer: 1.175 ± 0.606
1.567ProThr: 1.567 ± 0.635
1.175ProVal: 1.175 ± 0.486
0.0ProTrp: 0.0 ± 0.0
0.783ProTyr: 0.783 ± 0.513
0.0ProXaa: 0.0 ± 0.0
Gln
3.917GlnAla: 3.917 ± 1.872
0.0GlnCys: 0.0 ± 0.0
1.175GlnAsp: 1.175 ± 0.839
4.7GlnGlu: 4.7 ± 1.352
1.958GlnPhe: 1.958 ± 1.041
1.567GlnGly: 1.567 ± 0.839
0.392GlnHis: 0.392 ± 0.392
3.134GlnIle: 3.134 ± 0.902
3.525GlnLys: 3.525 ± 0.922
5.092GlnLeu: 5.092 ± 1.408
1.958GlnMet: 1.958 ± 0.924
0.392GlnAsn: 0.392 ± 0.392
0.392GlnPro: 0.392 ± 0.348
1.958GlnGln: 1.958 ± 1.613
2.35GlnArg: 2.35 ± 0.951
3.134GlnSer: 3.134 ± 1.243
2.742GlnThr: 2.742 ± 0.535
3.134GlnVal: 3.134 ± 0.83
0.783GlnTrp: 0.783 ± 0.669
2.35GlnTyr: 2.35 ± 0.976
0.0GlnXaa: 0.0 ± 0.0
Arg
0.783ArgAla: 0.783 ± 0.497
0.392ArgCys: 0.392 ± 0.348
2.35ArgAsp: 2.35 ± 0.739
3.525ArgGlu: 3.525 ± 1.213
1.175ArgPhe: 1.175 ± 0.639
2.35ArgGly: 2.35 ± 0.847
1.567ArgHis: 1.567 ± 0.626
4.7ArgIle: 4.7 ± 1.111
4.7ArgLys: 4.7 ± 1.026
5.484ArgLeu: 5.484 ± 1.329
2.742ArgMet: 2.742 ± 1.09
1.958ArgAsn: 1.958 ± 0.787
0.392ArgPro: 0.392 ± 0.348
3.917ArgGln: 3.917 ± 0.914
2.35ArgArg: 2.35 ± 0.972
1.175ArgSer: 1.175 ± 0.677
3.134ArgThr: 3.134 ± 1.052
2.742ArgVal: 2.742 ± 0.986
0.0ArgTrp: 0.0 ± 0.0
2.35ArgTyr: 2.35 ± 0.639
0.0ArgXaa: 0.0 ± 0.0
Ser
1.567SerAla: 1.567 ± 0.674
0.392SerCys: 0.392 ± 0.348
3.525SerAsp: 3.525 ± 0.836
1.958SerGlu: 1.958 ± 0.855
2.742SerPhe: 2.742 ± 1.193
3.917SerGly: 3.917 ± 1.659
0.0SerHis: 0.0 ± 0.0
3.917SerIle: 3.917 ± 1.323
5.092SerLys: 5.092 ± 1.374
5.092SerLeu: 5.092 ± 1.186
0.783SerMet: 0.783 ± 0.488
3.134SerAsn: 3.134 ± 1.567
2.742SerPro: 2.742 ± 0.633
2.35SerGln: 2.35 ± 0.908
2.35SerArg: 2.35 ± 1.091
3.134SerSer: 3.134 ± 1.051
2.35SerThr: 2.35 ± 1.099
1.958SerVal: 1.958 ± 0.829
0.783SerTrp: 0.783 ± 0.538
1.958SerTyr: 1.958 ± 0.77
0.0SerXaa: 0.0 ± 0.0
Thr
3.917ThrAla: 3.917 ± 1.01
0.0ThrCys: 0.0 ± 0.0
1.958ThrAsp: 1.958 ± 1.269
5.092ThrGlu: 5.092 ± 1.515
0.392ThrPhe: 0.392 ± 0.36
3.525ThrGly: 3.525 ± 0.996
1.175ThrHis: 1.175 ± 0.491
2.742ThrIle: 2.742 ± 0.723
2.742ThrLys: 2.742 ± 0.905
6.267ThrLeu: 6.267 ± 1.338
1.567ThrMet: 1.567 ± 0.896
2.35ThrAsn: 2.35 ± 0.761
1.175ThrPro: 1.175 ± 0.71
3.134ThrGln: 3.134 ± 1.369
2.35ThrArg: 2.35 ± 0.57
2.35ThrSer: 2.35 ± 0.941
3.525ThrThr: 3.525 ± 1.698
4.7ThrVal: 4.7 ± 2.043
0.392ThrTrp: 0.392 ± 0.425
3.134ThrTyr: 3.134 ± 0.809
0.0ThrXaa: 0.0 ± 0.0
Val
3.525ValAla: 3.525 ± 0.79
0.392ValCys: 0.392 ± 0.456
4.309ValAsp: 4.309 ± 1.526
5.484ValGlu: 5.484 ± 1.75
2.35ValPhe: 2.35 ± 1.069
1.958ValGly: 1.958 ± 0.748
0.392ValHis: 0.392 ± 0.386
3.134ValIle: 3.134 ± 1.259
5.092ValLys: 5.092 ± 1.925
6.267ValLeu: 6.267 ± 1.578
0.783ValMet: 0.783 ± 0.547
2.742ValAsn: 2.742 ± 0.875
1.175ValPro: 1.175 ± 0.514
1.175ValGln: 1.175 ± 0.808
3.134ValArg: 3.134 ± 1.108
4.309ValSer: 4.309 ± 1.17
3.134ValThr: 3.134 ± 1.556
2.35ValVal: 2.35 ± 1.107
1.175ValTrp: 1.175 ± 0.635
2.35ValTyr: 2.35 ± 1.135
0.0ValXaa: 0.0 ± 0.0
Trp
1.175TrpAla: 1.175 ± 0.491
0.0TrpCys: 0.0 ± 0.0
1.567TrpAsp: 1.567 ± 0.838
1.175TrpGlu: 1.175 ± 0.511
0.0TrpPhe: 0.0 ± 0.0
0.392TrpGly: 0.392 ± 0.336
0.392TrpHis: 0.392 ± 0.386
0.392TrpIle: 0.392 ± 0.435
1.175TrpLys: 1.175 ± 0.486
1.175TrpLeu: 1.175 ± 0.902
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.392TrpPro: 0.392 ± 0.467
1.175TrpGln: 1.175 ± 0.643
0.0TrpArg: 0.0 ± 0.0
0.392TrpSer: 0.392 ± 0.386
0.783TrpThr: 0.783 ± 0.353
0.0TrpVal: 0.0 ± 0.0
0.392TrpTrp: 0.392 ± 0.386
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.567TyrAla: 1.567 ± 1.092
0.0TyrCys: 0.0 ± 0.0
1.175TyrAsp: 1.175 ± 0.621
3.525TyrGlu: 3.525 ± 1.423
2.35TyrPhe: 2.35 ± 0.968
1.175TyrGly: 1.175 ± 0.674
0.783TyrHis: 0.783 ± 0.487
1.175TyrIle: 1.175 ± 0.77
7.442TyrLys: 7.442 ± 2.107
5.875TyrLeu: 5.875 ± 2.052
1.567TyrMet: 1.567 ± 0.787
3.134TyrAsn: 3.134 ± 0.883
1.175TyrPro: 1.175 ± 0.48
1.567TyrGln: 1.567 ± 0.845
4.309TyrArg: 4.309 ± 1.521
3.525TyrSer: 3.525 ± 1.406
1.958TyrThr: 1.958 ± 0.67
1.958TyrVal: 1.958 ± 0.744
1.567TyrTrp: 1.567 ± 0.613
2.35TyrTyr: 2.35 ± 0.952
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 18 proteins (2554 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski