Amino acid dipepetide frequency for Rothia mucilaginosa (strain DY-18) (Stomatococcus mucilaginosus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.994AlaAla: 14.994 ± 0.228	1.205AlaCys: 1.205 ± 0.047	5.76AlaAsp: 5.76 ± 0.099	8.304AlaGlu: 8.304 ± 0.174	3.194AlaPhe: 3.194 ± 0.067	10.11AlaGly: 10.11 ± 0.16	2.991AlaHis: 2.991 ± 0.071	4.305AlaIle: 4.305 ± 0.101	3.635AlaLys: 3.635 ± 0.093	11.728AlaLeu: 11.728 ± 0.155	2.18AlaMet: 2.18 ± 0.057	3.135AlaAsn: 3.135 ± 0.063	5.793AlaPro: 5.793 ± 0.167	5.426AlaGln: 5.426 ± 0.122	7.091AlaArg: 7.091 ± 0.12	7.467AlaSer: 7.467 ± 0.173	6.091AlaThr: 6.091 ± 0.109	9.182AlaVal: 9.182 ± 0.127	1.029AlaTrp: 1.029 ± 0.044	2.307AlaTyr: 2.307 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	1.172CysAla: 1.172 ± 0.049	0.286CysCys: 0.286 ± 0.025	0.454CysAsp: 0.454 ± 0.024	0.545CysGlu: 0.545 ± 0.029	0.371CysPhe: 0.371 ± 0.025	1.403CysGly: 1.403 ± 0.061	0.359CysHis: 0.359 ± 0.026	0.352CysIle: 0.352 ± 0.025	0.131CysLys: 0.131 ± 0.012	1.061CysLeu: 1.061 ± 0.047	0.133CysMet: 0.133 ± 0.016	0.255CysAsn: 0.255 ± 0.018	0.374CysPro: 0.374 ± 0.022	0.38CysGln: 0.38 ± 0.023	0.787CysArg: 0.787 ± 0.042	0.619CysSer: 0.619 ± 0.033	0.673CysThr: 0.673 ± 0.035	0.915CysVal: 0.915 ± 0.045	0.071CysTrp: 0.071 ± 0.009	0.201CysTyr: 0.201 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.211AspAla: 6.211 ± 0.113	0.467AspCys: 0.467 ± 0.032	2.534AspAsp: 2.534 ± 0.077	3.987AspGlu: 3.987 ± 0.083	1.743AspPhe: 1.743 ± 0.051	4.914AspGly: 4.914 ± 0.098	1.131AspHis: 1.131 ± 0.04	2.327AspIle: 2.327 ± 0.061	1.326AspLys: 1.326 ± 0.052	4.671AspLeu: 4.671 ± 0.084	0.95AspMet: 0.95 ± 0.039	1.357AspAsn: 1.357 ± 0.051	2.663AspPro: 2.663 ± 0.064	1.476AspGln: 1.476 ± 0.042	2.908AspArg: 2.908 ± 0.065	3.135AspSer: 3.135 ± 0.078	2.618AspThr: 2.618 ± 0.063	3.834AspVal: 3.834 ± 0.077	0.507AspTrp: 0.507 ± 0.03	1.362AspTyr: 1.362 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	7.593GluAla: 7.593 ± 0.124	0.538GluCys: 0.538 ± 0.03	3.55GluAsp: 3.55 ± 0.077	4.651GluGlu: 4.651 ± 0.107	1.853GluPhe: 1.853 ± 0.05	5.134GluGly: 5.134 ± 0.088	2.048GluHis: 2.048 ± 0.058	2.587GluIle: 2.587 ± 0.072	2.45GluLys: 2.45 ± 0.085	6.317GluLeu: 6.317 ± 0.1	1.025GluMet: 1.025 ± 0.036	2.349GluAsn: 2.349 ± 0.054	2.761GluPro: 2.761 ± 0.095	3.226GluGln: 3.226 ± 0.074	4.854GluArg: 4.854 ± 0.094	3.413GluSer: 3.413 ± 0.068	2.839GluThr: 2.839 ± 0.061	4.603GluVal: 4.603 ± 0.085	0.564GluTrp: 0.564 ± 0.033	1.679GluTyr: 1.679 ± 0.067	0.0GluXaa: 0.0 ± 0.0
Phe	3.302PheAla: 3.302 ± 0.074	0.396PheCys: 0.396 ± 0.025	1.784PheAsp: 1.784 ± 0.054	1.873PheGlu: 1.873 ± 0.051	1.303PhePhe: 1.303 ± 0.052	3.113PheGly: 3.113 ± 0.073	0.582PheHis: 0.582 ± 0.029	1.411PheIle: 1.411 ± 0.059	0.938PheLys: 0.938 ± 0.042	2.82PheLeu: 2.82 ± 0.072	0.645PheMet: 0.645 ± 0.033	1.02PheAsn: 1.02 ± 0.034	1.175PhePro: 1.175 ± 0.046	0.759PheGln: 0.759 ± 0.034	1.468PheArg: 1.468 ± 0.045	2.224PheSer: 2.224 ± 0.061	2.129PheThr: 2.129 ± 0.056	2.401PheVal: 2.401 ± 0.062	0.362PheTrp: 0.362 ± 0.021	0.85PheTyr: 0.85 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	9.966GlyAla: 9.966 ± 0.152	1.454GlyCys: 1.454 ± 0.076	4.376GlyAsp: 4.376 ± 0.092	5.539GlyGlu: 5.539 ± 0.097	3.026GlyPhe: 3.026 ± 0.07	8.142GlyGly: 8.142 ± 0.21	2.176GlyHis: 2.176 ± 0.079	3.887GlyIle: 3.887 ± 0.085	2.956GlyLys: 2.956 ± 0.072	7.304GlyLeu: 7.304 ± 0.154	1.774GlyMet: 1.774 ± 0.045	2.665GlyAsn: 2.665 ± 0.076	2.31GlyPro: 2.31 ± 0.062	3.161GlyGln: 3.161 ± 0.08	4.66GlyArg: 4.66 ± 0.1	5.498GlySer: 5.498 ± 0.117	5.651GlyThr: 5.651 ± 0.098	7.943GlyVal: 7.943 ± 0.146	1.018GlyTrp: 1.018 ± 0.037	2.393GlyTyr: 2.393 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	2.977HisAla: 2.977 ± 0.075	0.352HisCys: 0.352 ± 0.022	1.285HisAsp: 1.285 ± 0.043	1.565HisGlu: 1.565 ± 0.055	0.652HisPhe: 0.652 ± 0.034	2.506HisGly: 2.506 ± 0.066	0.986HisHis: 0.986 ± 0.046	1.069HisIle: 1.069 ± 0.045	0.577HisLys: 0.577 ± 0.033	2.546HisLeu: 2.546 ± 0.069	0.491HisMet: 0.491 ± 0.029	0.787HisAsn: 0.787 ± 0.036	1.454HisPro: 1.454 ± 0.044	1.024HisGln: 1.024 ± 0.051	2.256HisArg: 2.256 ± 0.072	1.456HisSer: 1.456 ± 0.039	1.688HisThr: 1.688 ± 0.056	2.077HisVal: 2.077 ± 0.055	0.212HisTrp: 0.212 ± 0.017	0.505HisTyr: 0.505 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.3IleAla: 5.3 ± 0.094	0.374IleCys: 0.374 ± 0.022	2.443IleAsp: 2.443 ± 0.058	2.893IleGlu: 2.893 ± 0.075	1.572IlePhe: 1.572 ± 0.06	3.467IleGly: 3.467 ± 0.093	1.065IleHis: 1.065 ± 0.043	2.229IleIle: 2.229 ± 0.073	1.303IleLys: 1.303 ± 0.046	4.209IleLeu: 4.209 ± 0.09	0.917IleMet: 0.917 ± 0.045	1.388IleAsn: 1.388 ± 0.047	2.374IlePro: 2.374 ± 0.063	1.348IleGln: 1.348 ± 0.044	2.856IleArg: 2.856 ± 0.065	2.882IleSer: 2.882 ± 0.073	2.603IleThr: 2.603 ± 0.058	3.405IleVal: 3.405 ± 0.08	0.441IleTrp: 0.441 ± 0.027	1.012IleTyr: 1.012 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	3.437LysAla: 3.437 ± 0.096	0.144LysCys: 0.144 ± 0.014	1.879LysAsp: 1.879 ± 0.062	1.846LysGlu: 1.846 ± 0.06	0.851LysPhe: 0.851 ± 0.038	2.124LysGly: 2.124 ± 0.075	0.74LysHis: 0.74 ± 0.03	1.683LysIle: 1.683 ± 0.054	1.693LysLys: 1.693 ± 0.064	2.756LysLeu: 2.756 ± 0.069	0.701LysMet: 0.701 ± 0.03	1.41LysAsn: 1.41 ± 0.052	1.708LysPro: 1.708 ± 0.06	1.024LysGln: 1.024 ± 0.036	1.811LysArg: 1.811 ± 0.059	1.857LysSer: 1.857 ± 0.063	1.988LysThr: 1.988 ± 0.057	2.596LysVal: 2.596 ± 0.066	0.284LysTrp: 0.284 ± 0.019	0.882LysTyr: 0.882 ± 0.042	0.0LysXaa: 0.0 ± 0.0
Leu	10.719LeuAla: 10.719 ± 0.142	1.101LeuCys: 1.101 ± 0.046	5.055LeuAsp: 5.055 ± 0.089	5.207LeuGlu: 5.207 ± 0.096	2.857LeuPhe: 2.857 ± 0.072	8.368LeuGly: 8.368 ± 0.146	2.488LeuHis: 2.488 ± 0.072	4.453LeuIle: 4.453 ± 0.087	3.111LeuLys: 3.111 ± 0.07	10.066LeuLeu: 10.066 ± 0.183	1.941LeuMet: 1.941 ± 0.058	3.87LeuAsn: 3.87 ± 0.076	4.609LeuPro: 4.609 ± 0.08	3.338LeuGln: 3.338 ± 0.084	6.887LeuArg: 6.887 ± 0.127	6.792LeuSer: 6.792 ± 0.113	6.35LeuThr: 6.35 ± 0.102	7.752LeuVal: 7.752 ± 0.146	0.956LeuTrp: 0.956 ± 0.038	2.093LeuTyr: 2.093 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	1.902MetAla: 1.902 ± 0.059	0.173MetCys: 0.173 ± 0.014	0.859MetAsp: 0.859 ± 0.036	0.952MetGlu: 0.952 ± 0.041	0.55MetPhe: 0.55 ± 0.028	1.458MetGly: 1.458 ± 0.054	0.474MetHis: 0.474 ± 0.026	0.933MetIle: 0.933 ± 0.036	0.618MetLys: 0.618 ± 0.031	1.944MetLeu: 1.944 ± 0.053	0.471MetMet: 0.471 ± 0.027	0.714MetAsn: 0.714 ± 0.031	1.085MetPro: 1.085 ± 0.043	0.601MetGln: 0.601 ± 0.029	1.507MetArg: 1.507 ± 0.044	1.608MetSer: 1.608 ± 0.044	1.407MetThr: 1.407 ± 0.049	1.545MetVal: 1.545 ± 0.049	0.201MetTrp: 0.201 ± 0.015	0.428MetTyr: 0.428 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.604AsnAla: 3.604 ± 0.072	0.227AsnCys: 0.227 ± 0.017	1.608AsnAsp: 1.608 ± 0.051	1.641AsnGlu: 1.641 ± 0.044	0.926AsnPhe: 0.926 ± 0.04	2.878AsnGly: 2.878 ± 0.084	1.037AsnHis: 1.037 ± 0.049	1.582AsnIle: 1.582 ± 0.056	0.747AsnLys: 0.747 ± 0.037	3.553AsnLeu: 3.553 ± 0.088	0.61AsnMet: 0.61 ± 0.029	1.258AsnAsn: 1.258 ± 0.046	2.191AsnPro: 2.191 ± 0.061	1.348AsnGln: 1.348 ± 0.051	2.306AsnArg: 2.306 ± 0.062	1.956AsnSer: 1.956 ± 0.062	2.273AsnThr: 2.273 ± 0.064	2.459AsnVal: 2.459 ± 0.061	0.333AsnTrp: 0.333 ± 0.024	0.839AsnTyr: 0.839 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	6.373ProAla: 6.373 ± 0.163	0.304ProCys: 0.304 ± 0.019	2.341ProAsp: 2.341 ± 0.06	3.892ProGlu: 3.892 ± 0.091	1.369ProPhe: 1.369 ± 0.044	3.789ProGly: 3.789 ± 0.07	1.057ProHis: 1.057 ± 0.041	1.772ProIle: 1.772 ± 0.055	1.646ProLys: 1.646 ± 0.066	4.082ProLeu: 4.082 ± 0.081	0.864ProMet: 0.864 ± 0.037	1.499ProAsn: 1.499 ± 0.053	1.408ProPro: 1.408 ± 0.05	1.858ProGln: 1.858 ± 0.06	2.498ProArg: 2.498 ± 0.068	3.058ProSer: 3.058 ± 0.083	2.835ProThr: 2.835 ± 0.09	4.283ProVal: 4.283 ± 0.092	0.491ProTrp: 0.491 ± 0.028	1.113ProTyr: 1.113 ± 0.049	0.0ProXaa: 0.0 ± 0.0
Gln	4.251GlnAla: 4.251 ± 0.098	0.383GlnCys: 0.383 ± 0.025	1.54GlnAsp: 1.54 ± 0.047	1.887GlnGlu: 1.887 ± 0.058	0.903GlnPhe: 0.903 ± 0.035	3.076GlnGly: 3.076 ± 0.084	1.103GlnHis: 1.103 ± 0.047	1.654GlnIle: 1.654 ± 0.047	1.435GlnLys: 1.435 ± 0.052	4.12GlnLeu: 4.12 ± 0.097	0.771GlnMet: 0.771 ± 0.042	1.635GlnAsn: 1.635 ± 0.061	1.716GlnPro: 1.716 ± 0.067	2.143GlnGln: 2.143 ± 0.067	2.935GlnArg: 2.935 ± 0.088	1.922GlnSer: 1.922 ± 0.06	2.083GlnThr: 2.083 ± 0.058	3.73GlnVal: 3.73 ± 0.091	0.335GlnTrp: 0.335 ± 0.02	0.791GlnTyr: 0.791 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	6.998ArgAla: 6.998 ± 0.127	0.715ArgCys: 0.715 ± 0.037	2.671ArgAsp: 2.671 ± 0.065	4.412ArgGlu: 4.412 ± 0.089	1.973ArgPhe: 1.973 ± 0.056	4.976ArgGly: 4.976 ± 0.096	1.766ArgHis: 1.766 ± 0.064	3.338ArgIle: 3.338 ± 0.079	1.908ArgLys: 1.908 ± 0.055	6.392ArgLeu: 6.392 ± 0.121	1.412ArgMet: 1.412 ± 0.043	2.369ArgAsn: 2.369 ± 0.073	2.584ArgPro: 2.584 ± 0.075	2.625ArgGln: 2.625 ± 0.08	5.55ArgArg: 5.55 ± 0.135	3.944ArgSer: 3.944 ± 0.093	4.402ArgThr: 4.402 ± 0.105	5.383ArgVal: 5.383 ± 0.092	0.805ArgTrp: 0.805 ± 0.033	1.758ArgTyr: 1.758 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	7.937SerAla: 7.937 ± 0.18	0.607SerCys: 0.607 ± 0.031	2.72SerAsp: 2.72 ± 0.068	3.707SerGlu: 3.707 ± 0.084	2.079SerPhe: 2.079 ± 0.064	5.593SerGly: 5.593 ± 0.101	1.553SerHis: 1.553 ± 0.056	2.638SerIle: 2.638 ± 0.063	1.901SerLys: 1.901 ± 0.057	6.154SerLeu: 6.154 ± 0.111	1.399SerMet: 1.399 ± 0.044	1.999SerAsn: 1.999 ± 0.067	3.092SerPro: 3.092 ± 0.071	2.098SerGln: 2.098 ± 0.061	3.912SerArg: 3.912 ± 0.078	5.055SerSer: 5.055 ± 0.144	3.849SerThr: 3.849 ± 0.072	4.879SerVal: 4.879 ± 0.092	0.698SerTrp: 0.698 ± 0.033	1.605SerTyr: 1.605 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	6.575ThrAla: 6.575 ± 0.117	0.537ThrCys: 0.537 ± 0.032	2.91ThrAsp: 2.91 ± 0.068	3.685ThrGlu: 3.685 ± 0.077	1.712ThrPhe: 1.712 ± 0.048	5.667ThrGly: 5.667 ± 0.1	1.775ThrHis: 1.775 ± 0.06	2.604ThrIle: 2.604 ± 0.063	1.666ThrLys: 1.666 ± 0.053	6.146ThrLeu: 6.146 ± 0.106	1.028ThrMet: 1.028 ± 0.039	1.824ThrAsn: 1.824 ± 0.051	3.549ThrPro: 3.549 ± 0.078	2.179ThrGln: 2.179 ± 0.071	3.693ThrArg: 3.693 ± 0.091	3.541ThrSer: 3.541 ± 0.075	3.244ThrThr: 3.244 ± 0.084	5.539ThrVal: 5.539 ± 0.097	0.59ThrTrp: 0.59 ± 0.032	1.358ThrTyr: 1.358 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	8.952ValAla: 8.952 ± 0.138	0.962ValCys: 0.962 ± 0.039	4.501ValAsp: 4.501 ± 0.082	5.35ValGlu: 5.35 ± 0.105	2.386ValPhe: 2.386 ± 0.062	6.293ValGly: 6.293 ± 0.137	2.549ValHis: 2.549 ± 0.076	3.706ValIle: 3.706 ± 0.081	2.345ValLys: 2.345 ± 0.064	8.807ValLeu: 8.807 ± 0.13	1.384ValMet: 1.384 ± 0.046	2.774ValAsn: 2.774 ± 0.069	4.043ValPro: 4.043 ± 0.083	3.323ValGln: 3.323 ± 0.072	5.498ValArg: 5.498 ± 0.086	4.842ValSer: 4.842 ± 0.083	4.981ValThr: 4.981 ± 0.092	6.988ValVal: 6.988 ± 0.128	0.669ValTrp: 0.669 ± 0.03	1.714ValTyr: 1.714 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	1.068TrpAla: 1.068 ± 0.042	0.131TrpCys: 0.131 ± 0.013	0.569TrpAsp: 0.569 ± 0.034	0.577TrpGlu: 0.577 ± 0.03	0.387TrpPhe: 0.387 ± 0.022	0.73TrpGly: 0.73 ± 0.035	0.216TrpHis: 0.216 ± 0.015	0.533TrpIle: 0.533 ± 0.027	0.321TrpLys: 0.321 ± 0.023	1.061TrpLeu: 1.061 ± 0.046	0.26TrpMet: 0.26 ± 0.019	0.338TrpAsn: 0.338 ± 0.024	0.341TrpPro: 0.341 ± 0.02	0.356TrpGln: 0.356 ± 0.023	0.68TrpArg: 0.68 ± 0.032	0.597TrpSer: 0.597 ± 0.029	0.55TrpThr: 0.55 ± 0.03	0.875TrpVal: 0.875 ± 0.037	0.211TrpTrp: 0.211 ± 0.016	0.26TrpTyr: 0.26 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.593TyrAla: 2.593 ± 0.058	0.185TyrCys: 0.185 ± 0.016	1.28TyrAsp: 1.28 ± 0.054	1.52TyrGlu: 1.52 ± 0.051	0.847TyrPhe: 0.847 ± 0.036	2.158TyrGly: 2.158 ± 0.057	0.37TyrHis: 0.37 ± 0.02	1.018TyrIle: 1.018 ± 0.041	0.709TyrLys: 0.709 ± 0.03	2.274TyrLeu: 2.274 ± 0.058	0.469TyrMet: 0.469 ± 0.023	0.73TyrAsn: 0.73 ± 0.033	1.305TyrPro: 1.305 ± 0.044	0.721TyrGln: 0.721 ± 0.034	1.825TyrArg: 1.825 ± 0.053	1.613TyrSer: 1.613 ± 0.052	1.571TyrThr: 1.571 ± 0.052	1.679TyrVal: 1.679 ± 0.046	0.284TyrTrp: 0.284 ± 0.019	0.645TyrTyr: 0.645 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1991 proteins (757693 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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