Amino acid dipepetide frequency for Clostridium isatidis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.274AlaAla: 4.274 ± 0.099	0.62AlaCys: 0.62 ± 0.025	2.687AlaAsp: 2.687 ± 0.06	3.912AlaGlu: 3.912 ± 0.078	2.579AlaPhe: 2.579 ± 0.066	3.801AlaGly: 3.801 ± 0.084	0.797AlaHis: 0.797 ± 0.036	6.125AlaIle: 6.125 ± 0.084	4.952AlaLys: 4.952 ± 0.082	6.25AlaLeu: 6.25 ± 0.094	1.453AlaMet: 1.453 ± 0.047	2.743AlaAsn: 2.743 ± 0.06	1.316AlaPro: 1.316 ± 0.05	1.396AlaGln: 1.396 ± 0.043	2.016AlaArg: 2.016 ± 0.05	3.481AlaSer: 3.481 ± 0.079	2.526AlaThr: 2.526 ± 0.062	3.962AlaVal: 3.962 ± 0.084	0.351AlaTrp: 0.351 ± 0.022	2.156AlaTyr: 2.156 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.455CysAla: 0.455 ± 0.025	0.153CysCys: 0.153 ± 0.015	0.572CysAsp: 0.572 ± 0.028	0.672CysGlu: 0.672 ± 0.029	0.365CysPhe: 0.365 ± 0.019	0.926CysGly: 0.926 ± 0.034	0.186CysHis: 0.186 ± 0.013	0.953CysIle: 0.953 ± 0.033	0.914CysLys: 0.914 ± 0.033	0.839CysLeu: 0.839 ± 0.031	0.206CysMet: 0.206 ± 0.016	0.658CysAsn: 0.658 ± 0.031	0.411CysPro: 0.411 ± 0.022	0.198CysGln: 0.198 ± 0.015	0.328CysArg: 0.328 ± 0.021	0.623CysSer: 0.623 ± 0.03	0.499CysThr: 0.499 ± 0.026	0.472CysVal: 0.472 ± 0.024	0.053CysTrp: 0.053 ± 0.009	0.428CysTyr: 0.428 ± 0.027	0.0CysXaa: 0.0 ± 0.0
Asp	2.705AspAla: 2.705 ± 0.061	0.499AspCys: 0.499 ± 0.026	2.528AspAsp: 2.528 ± 0.054	4.618AspGlu: 4.618 ± 0.074	2.834AspPhe: 2.834 ± 0.061	3.111AspGly: 3.111 ± 0.074	0.523AspHis: 0.523 ± 0.029	6.237AspIle: 6.237 ± 0.103	5.572AspLys: 5.572 ± 0.095	5.347AspLeu: 5.347 ± 0.097	1.391AspMet: 1.391 ± 0.042	3.42AspAsn: 3.42 ± 0.072	1.343AspPro: 1.343 ± 0.047	0.75AspGln: 0.75 ± 0.03	1.781AspArg: 1.781 ± 0.048	2.695AspSer: 2.695 ± 0.063	2.333AspThr: 2.333 ± 0.057	3.177AspVal: 3.177 ± 0.07	0.351AspTrp: 0.351 ± 0.023	2.832AspTyr: 2.832 ± 0.072	0.0AspXaa: 0.0 ± 0.0
Glu	5.153GluAla: 5.153 ± 0.103	0.585GluCys: 0.585 ± 0.03	4.739GluAsp: 4.739 ± 0.079	9.069GluGlu: 9.069 ± 0.131	3.133GluPhe: 3.133 ± 0.061	4.775GluGly: 4.775 ± 0.074	0.846GluHis: 0.846 ± 0.034	8.668GluIle: 8.668 ± 0.121	8.357GluLys: 8.357 ± 0.115	7.502GluLeu: 7.502 ± 0.096	2.037GluMet: 2.037 ± 0.048	5.76GluAsn: 5.76 ± 0.094	1.382GluPro: 1.382 ± 0.043	1.528GluGln: 1.528 ± 0.045	2.947GluArg: 2.947 ± 0.063	3.129GluSer: 3.129 ± 0.063	2.992GluThr: 2.992 ± 0.071	5.246GluVal: 5.246 ± 0.089	0.429GluTrp: 0.429 ± 0.022	3.359GluTyr: 3.359 ± 0.075	0.0GluXaa: 0.0 ± 0.0
Phe	2.238PheAla: 2.238 ± 0.056	0.425PheCys: 0.425 ± 0.025	2.545PheAsp: 2.545 ± 0.052	2.924PheGlu: 2.924 ± 0.064	1.925PhePhe: 1.925 ± 0.059	2.672PheGly: 2.672 ± 0.069	0.465PheHis: 0.465 ± 0.026	5.042PheIle: 5.042 ± 0.109	3.859PheLys: 3.859 ± 0.083	4.141PheLeu: 4.141 ± 0.09	1.062PheMet: 1.062 ± 0.042	3.151PheAsn: 3.151 ± 0.069	1.178PhePro: 1.178 ± 0.043	0.853PheGln: 0.853 ± 0.033	1.282PheArg: 1.282 ± 0.041	3.099PheSer: 3.099 ± 0.075	2.226PheThr: 2.226 ± 0.062	2.538PheVal: 2.538 ± 0.056	0.265PheTrp: 0.265 ± 0.018	1.819PheTyr: 1.819 ± 0.057	0.0PheXaa: 0.0 ± 0.0
Gly	3.851GlyAla: 3.851 ± 0.084	0.803GlyCys: 0.803 ± 0.032	3.168GlyAsp: 3.168 ± 0.06	4.508GlyGlu: 4.508 ± 0.08	2.82GlyPhe: 2.82 ± 0.062	4.025GlyGly: 4.025 ± 0.106	0.907GlyHis: 0.907 ± 0.036	6.8GlyIle: 6.8 ± 0.099	5.515GlyLys: 5.515 ± 0.092	5.53GlyLeu: 5.53 ± 0.109	1.56GlyMet: 1.56 ± 0.047	3.038GlyAsn: 3.038 ± 0.077	1.312GlyPro: 1.312 ± 0.053	1.311GlyGln: 1.311 ± 0.041	2.326GlyArg: 2.326 ± 0.057	3.523GlySer: 3.523 ± 0.067	3.337GlyThr: 3.337 ± 0.06	4.468GlyVal: 4.468 ± 0.081	0.43GlyTrp: 0.43 ± 0.031	2.996GlyTyr: 2.996 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	0.613HisAla: 0.613 ± 0.028	0.194HisCys: 0.194 ± 0.016	0.618HisAsp: 0.618 ± 0.031	0.74HisGlu: 0.74 ± 0.026	0.57HisPhe: 0.57 ± 0.028	0.944HisGly: 0.944 ± 0.036	0.241HisHis: 0.241 ± 0.019	1.211HisIle: 1.211 ± 0.04	0.971HisLys: 0.971 ± 0.035	1.132HisLeu: 1.132 ± 0.033	0.289HisMet: 0.289 ± 0.017	0.77HisAsn: 0.77 ± 0.034	0.59HisPro: 0.59 ± 0.029	0.296HisGln: 0.296 ± 0.02	0.483HisArg: 0.483 ± 0.027	0.764HisSer: 0.764 ± 0.03	0.553HisThr: 0.553 ± 0.029	0.614HisVal: 0.614 ± 0.028	0.09HisTrp: 0.09 ± 0.011	0.523HisTyr: 0.523 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.065IleAla: 6.065 ± 0.105	1.062IleCys: 1.062 ± 0.042	6.177IleAsp: 6.177 ± 0.088	8.161IleGlu: 8.161 ± 0.111	4.68IlePhe: 4.68 ± 0.106	6.047IleGly: 6.047 ± 0.098	1.192IleHis: 1.192 ± 0.044	11.045IleIle: 11.045 ± 0.162	9.858IleLys: 9.858 ± 0.122	9.763IleLeu: 9.763 ± 0.148	2.28IleMet: 2.28 ± 0.054	7.266IleAsn: 7.266 ± 0.124	3.259IlePro: 3.259 ± 0.065	2.042IleGln: 2.042 ± 0.055	3.42IleArg: 3.42 ± 0.058	7.356IleSer: 7.356 ± 0.119	4.999IleThr: 4.999 ± 0.081	6.07IleVal: 6.07 ± 0.096	0.478IleTrp: 0.478 ± 0.025	3.974IleTyr: 3.974 ± 0.073	0.0IleXaa: 0.0 ± 0.0
Lys	5.221LysAla: 5.221 ± 0.087	0.708LysCys: 0.708 ± 0.029	5.967LysAsp: 5.967 ± 0.09	10.601LysGlu: 10.601 ± 0.149	3.363LysPhe: 3.363 ± 0.07	5.294LysGly: 5.294 ± 0.077	0.973LysHis: 0.973 ± 0.033	9.235LysIle: 9.235 ± 0.12	8.284LysLys: 8.284 ± 0.129	8.216LysLeu: 8.216 ± 0.11	2.231LysMet: 2.231 ± 0.048	6.623LysAsn: 6.623 ± 0.101	1.885LysPro: 1.885 ± 0.057	1.706LysGln: 1.706 ± 0.053	3.299LysArg: 3.299 ± 0.053	4.868LysSer: 4.868 ± 0.084	3.8LysThr: 3.8 ± 0.068	6.059LysVal: 6.059 ± 0.093	0.545LysTrp: 0.545 ± 0.027	4.299LysTyr: 4.299 ± 0.088	0.0LysXaa: 0.0 ± 0.0
Leu	5.648LeuAla: 5.648 ± 0.096	0.938LeuCys: 0.938 ± 0.032	5.347LeuAsp: 5.347 ± 0.089	7.474LeuGlu: 7.474 ± 0.095	3.9LeuPhe: 3.9 ± 0.082	6.075LeuGly: 6.075 ± 0.105	1.052LeuHis: 1.052 ± 0.04	9.265LeuIle: 9.265 ± 0.164	9.009LeuLys: 9.009 ± 0.12	8.78LeuLeu: 8.78 ± 0.141	2.243LeuMet: 2.243 ± 0.061	6.289LeuAsn: 6.289 ± 0.094	2.693LeuPro: 2.693 ± 0.06	1.976LeuGln: 1.976 ± 0.058	3.364LeuArg: 3.364 ± 0.061	6.714LeuSer: 6.714 ± 0.11	4.489LeuThr: 4.489 ± 0.083	5.434LeuVal: 5.434 ± 0.089	0.575LeuTrp: 0.575 ± 0.03	3.401LeuTyr: 3.401 ± 0.077	0.0LeuXaa: 0.0 ± 0.0
Met	1.741MetAla: 1.741 ± 0.052	0.174MetCys: 0.174 ± 0.014	1.295MetAsp: 1.295 ± 0.042	1.884MetGlu: 1.884 ± 0.054	0.871MetPhe: 0.871 ± 0.034	1.595MetGly: 1.595 ± 0.053	0.311MetHis: 0.311 ± 0.019	2.144MetIle: 2.144 ± 0.054	2.421MetLys: 2.421 ± 0.054	2.179MetLeu: 2.179 ± 0.051	0.584MetMet: 0.584 ± 0.027	1.576MetAsn: 1.576 ± 0.043	0.878MetPro: 0.878 ± 0.033	0.597MetGln: 0.597 ± 0.03	0.83MetArg: 0.83 ± 0.031	1.382MetSer: 1.382 ± 0.041	1.064MetThr: 1.064 ± 0.035	1.387MetVal: 1.387 ± 0.042	0.136MetTrp: 0.136 ± 0.012	0.767MetTyr: 0.767 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	2.709AsnAla: 2.709 ± 0.053	0.655AsnCys: 0.655 ± 0.031	2.865AsnAsp: 2.865 ± 0.063	4.639AsnGlu: 4.639 ± 0.075	2.852AsnPhe: 2.852 ± 0.062	3.617AsnGly: 3.617 ± 0.076	0.762AsnHis: 0.762 ± 0.028	7.803AsnIle: 7.803 ± 0.117	7.014AsnLys: 7.014 ± 0.111	6.338AsnLeu: 6.338 ± 0.091	1.566AsnMet: 1.566 ± 0.048	5.214AsnAsn: 5.214 ± 0.098	2.11AsnPro: 2.11 ± 0.056	1.281AsnGln: 1.281 ± 0.039	2.025AsnArg: 2.025 ± 0.058	4.061AsnSer: 4.061 ± 0.088	2.699AsnThr: 2.699 ± 0.062	3.166AsnVal: 3.166 ± 0.063	0.415AsnTrp: 0.415 ± 0.029	3.116AsnTyr: 3.116 ± 0.067	0.0AsnXaa: 0.0 ± 0.0
Pro	1.48ProAla: 1.48 ± 0.046	0.265ProCys: 0.265 ± 0.018	1.271ProAsp: 1.271 ± 0.043	2.24ProGlu: 2.24 ± 0.053	1.346ProPhe: 1.346 ± 0.047	1.661ProGly: 1.661 ± 0.048	0.405ProHis: 0.405 ± 0.025	2.718ProIle: 2.718 ± 0.057	2.165ProLys: 2.165 ± 0.061	2.533ProLeu: 2.533 ± 0.061	0.612ProMet: 0.612 ± 0.026	1.532ProAsn: 1.532 ± 0.042	0.519ProPro: 0.519 ± 0.023	0.729ProGln: 0.729 ± 0.032	0.807ProArg: 0.807 ± 0.032	1.637ProSer: 1.637 ± 0.047	1.34ProThr: 1.34 ± 0.039	1.87ProVal: 1.87 ± 0.048	0.23ProTrp: 0.23 ± 0.018	1.268ProTyr: 1.268 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	1.313GlnAla: 1.313 ± 0.04	0.179GlnCys: 0.179 ± 0.019	1.072GlnAsp: 1.072 ± 0.036	1.731GlnGlu: 1.731 ± 0.048	0.829GlnPhe: 0.829 ± 0.031	1.431GlnGly: 1.431 ± 0.051	0.269GlnHis: 0.269 ± 0.018	1.945GlnIle: 1.945 ± 0.052	1.842GlnLys: 1.842 ± 0.054	1.961GlnLeu: 1.961 ± 0.048	0.532GlnMet: 0.532 ± 0.03	1.281GlnAsn: 1.281 ± 0.043	0.459GlnPro: 0.459 ± 0.022	0.512GlnGln: 0.512 ± 0.027	0.846GlnArg: 0.846 ± 0.036	1.041GlnSer: 1.041 ± 0.031	0.884GlnThr: 0.884 ± 0.036	1.297GlnVal: 1.297 ± 0.049	0.151GlnTrp: 0.151 ± 0.014	0.893GlnTyr: 0.893 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.057ArgAla: 2.057 ± 0.055	0.338ArgCys: 0.338 ± 0.022	1.944ArgAsp: 1.944 ± 0.054	3.281ArgGlu: 3.281 ± 0.075	1.446ArgPhe: 1.446 ± 0.043	2.059ArgGly: 2.059 ± 0.059	0.38ArgHis: 0.38 ± 0.02	3.431ArgIle: 3.431 ± 0.067	3.346ArgLys: 3.346 ± 0.072	3.006ArgLeu: 3.006 ± 0.058	0.849ArgMet: 0.849 ± 0.033	2.233ArgAsn: 2.233 ± 0.06	0.829ArgPro: 0.829 ± 0.033	0.759ArgGln: 0.759 ± 0.034	1.568ArgArg: 1.568 ± 0.052	1.656ArgSer: 1.656 ± 0.047	1.481ArgThr: 1.481 ± 0.047	2.278ArgVal: 2.278 ± 0.053	0.213ArgTrp: 0.213 ± 0.018	1.536ArgTyr: 1.536 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	2.989SerAla: 2.989 ± 0.065	0.603SerCys: 0.603 ± 0.029	2.753SerAsp: 2.753 ± 0.062	4.134SerGlu: 4.134 ± 0.083	3.122SerPhe: 3.122 ± 0.075	3.829SerGly: 3.829 ± 0.072	0.819SerHis: 0.819 ± 0.036	6.549SerIle: 6.549 ± 0.122	5.668SerLys: 5.668 ± 0.089	6.197SerLeu: 6.197 ± 0.098	1.447SerMet: 1.447 ± 0.045	3.707SerAsn: 3.707 ± 0.068	1.598SerPro: 1.598 ± 0.045	1.371SerGln: 1.371 ± 0.043	2.072SerArg: 2.072 ± 0.052	4.071SerSer: 4.071 ± 0.089	2.854SerThr: 2.854 ± 0.054	3.291SerVal: 3.291 ± 0.063	0.393SerTrp: 0.393 ± 0.025	2.67SerTyr: 2.67 ± 0.061	0.0SerXaa: 0.0 ± 0.0
Thr	2.913ThrAla: 2.913 ± 0.061	0.418ThrCys: 0.418 ± 0.022	2.218ThrAsp: 2.218 ± 0.047	3.047ThrGlu: 3.047 ± 0.067	2.074ThrPhe: 2.074 ± 0.056	3.426ThrGly: 3.426 ± 0.07	0.624ThrHis: 0.624 ± 0.027	4.914ThrIle: 4.914 ± 0.071	3.502ThrLys: 3.502 ± 0.066	4.538ThrLeu: 4.538 ± 0.087	1.054ThrMet: 1.054 ± 0.039	2.6ThrAsn: 2.6 ± 0.062	1.567ThrPro: 1.567 ± 0.048	0.939ThrGln: 0.939 ± 0.037	1.535ThrArg: 1.535 ± 0.047	2.903ThrSer: 2.903 ± 0.059	2.328ThrThr: 2.328 ± 0.057	3.099ThrVal: 3.099 ± 0.073	0.266ThrTrp: 0.266 ± 0.021	1.716ThrTyr: 1.716 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	3.666ValAla: 3.666 ± 0.081	0.724ValCys: 0.724 ± 0.03	3.49ValAsp: 3.49 ± 0.062	4.466ValGlu: 4.466 ± 0.082	2.615ValPhe: 2.615 ± 0.061	4.001ValGly: 4.001 ± 0.089	0.797ValHis: 0.797 ± 0.031	6.246ValIle: 6.246 ± 0.103	5.271ValLys: 5.271 ± 0.08	5.768ValLeu: 5.768 ± 0.098	1.385ValMet: 1.385 ± 0.044	3.628ValAsn: 3.628 ± 0.065	1.871ValPro: 1.871 ± 0.055	1.211ValGln: 1.211 ± 0.037	2.014ValArg: 2.014 ± 0.052	3.971ValSer: 3.971 ± 0.074	3.069ValThr: 3.069 ± 0.067	4.066ValVal: 4.066 ± 0.086	0.363ValTrp: 0.363 ± 0.023	2.326ValTyr: 2.326 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.335TrpAla: 0.335 ± 0.024	0.084TrpCys: 0.084 ± 0.012	0.345TrpAsp: 0.345 ± 0.022	0.383TrpGlu: 0.383 ± 0.02	0.27TrpPhe: 0.27 ± 0.02	0.442TrpGly: 0.442 ± 0.025	0.13TrpHis: 0.13 ± 0.011	0.584TrpIle: 0.584 ± 0.033	0.445TrpLys: 0.445 ± 0.025	0.6TrpLeu: 0.6 ± 0.029	0.161TrpMet: 0.161 ± 0.015	0.408TrpAsn: 0.408 ± 0.025	0.159TrpPro: 0.159 ± 0.016	0.174TrpGln: 0.174 ± 0.015	0.238TrpArg: 0.238 ± 0.019	0.368TrpSer: 0.368 ± 0.02	0.309TrpThr: 0.309 ± 0.019	0.33TrpVal: 0.33 ± 0.021	0.064TrpTrp: 0.064 ± 0.009	0.288TrpTyr: 0.288 ± 0.028	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.971TyrAla: 1.971 ± 0.044	0.483TyrCys: 0.483 ± 0.026	2.448TyrAsp: 2.448 ± 0.062	3.153TyrGlu: 3.153 ± 0.073	2.114TyrPhe: 2.114 ± 0.06	2.498TyrGly: 2.498 ± 0.052	0.528TyrHis: 0.528 ± 0.023	4.279TyrIle: 4.279 ± 0.087	4.214TyrLys: 4.214 ± 0.085	4.047TyrLeu: 4.047 ± 0.088	0.872TyrMet: 0.872 ± 0.034	3.012TyrAsn: 3.012 ± 0.068	1.266TyrPro: 1.266 ± 0.039	0.838TyrGln: 0.838 ± 0.036	1.507TyrArg: 1.507 ± 0.044	2.795TyrSer: 2.795 ± 0.055	1.899TyrThr: 1.899 ± 0.052	2.126TyrVal: 2.126 ± 0.057	0.316TyrTrp: 0.316 ± 0.022	2.072TyrTyr: 2.072 ± 0.072	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2554 proteins (799527 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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