Amino acid dipepetide frequency for Desulfovibrio ferrophilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.702AlaAla: 9.702 ± 0.126	1.309AlaCys: 1.309 ± 0.035	5.04AlaAsp: 5.04 ± 0.071	6.43AlaGlu: 6.43 ± 0.091	3.513AlaPhe: 3.513 ± 0.056	8.004AlaGly: 8.004 ± 0.101	1.877AlaHis: 1.877 ± 0.046	4.72AlaIle: 4.72 ± 0.076	4.413AlaLys: 4.413 ± 0.079	10.982AlaLeu: 10.982 ± 0.108	3.207AlaMet: 3.207 ± 0.056	2.535AlaAsn: 2.535 ± 0.05	3.95AlaPro: 3.95 ± 0.066	3.601AlaGln: 3.601 ± 0.06	5.615AlaArg: 5.615 ± 0.072	5.277AlaSer: 5.277 ± 0.069	4.579AlaThr: 4.579 ± 0.069	7.161AlaVal: 7.161 ± 0.101	1.207AlaTrp: 1.207 ± 0.033	2.375AlaTyr: 2.375 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	1.134CysAla: 1.134 ± 0.029	0.233CysCys: 0.233 ± 0.017	0.62CysAsp: 0.62 ± 0.024	0.639CysGlu: 0.639 ± 0.026	0.475CysPhe: 0.475 ± 0.02	1.339CysGly: 1.339 ± 0.043	0.534CysHis: 0.534 ± 0.039	0.709CysIle: 0.709 ± 0.031	0.519CysLys: 0.519 ± 0.022	1.266CysLeu: 1.266 ± 0.032	0.335CysMet: 0.335 ± 0.019	0.389CysAsn: 0.389 ± 0.02	0.852CysPro: 0.852 ± 0.025	0.357CysGln: 0.357 ± 0.018	0.742CysArg: 0.742 ± 0.026	0.8CysSer: 0.8 ± 0.03	0.642CysThr: 0.642 ± 0.027	0.869CysVal: 0.869 ± 0.03	0.158CysTrp: 0.158 ± 0.014	0.291CysTyr: 0.291 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.019AspAla: 5.019 ± 0.079	0.741AspCys: 0.741 ± 0.028	3.325AspAsp: 3.325 ± 0.094	4.035AspGlu: 4.035 ± 0.068	2.569AspPhe: 2.569 ± 0.054	4.494AspGly: 4.494 ± 0.079	1.199AspHis: 1.199 ± 0.032	3.629AspIle: 3.629 ± 0.059	2.715AspLys: 2.715 ± 0.055	5.95AspLeu: 5.95 ± 0.089	1.738AspMet: 1.738 ± 0.039	1.786AspAsn: 1.786 ± 0.044	2.705AspPro: 2.705 ± 0.054	1.818AspGln: 1.818 ± 0.044	3.106AspArg: 3.106 ± 0.056	3.136AspSer: 3.136 ± 0.064	2.722AspThr: 2.722 ± 0.074	4.13AspVal: 4.13 ± 0.071	0.804AspTrp: 0.804 ± 0.027	1.773AspTyr: 1.773 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	6.696GluAla: 6.696 ± 0.079	0.616GluCys: 0.616 ± 0.026	3.571GluAsp: 3.571 ± 0.066	4.261GluGlu: 4.261 ± 0.079	2.435GluPhe: 2.435 ± 0.049	4.477GluGly: 4.477 ± 0.063	1.479GluHis: 1.479 ± 0.034	3.883GluIle: 3.883 ± 0.058	3.066GluLys: 3.066 ± 0.061	7.052GluLeu: 7.052 ± 0.091	2.112GluMet: 2.112 ± 0.042	2.176GluAsn: 2.176 ± 0.046	2.43GluPro: 2.43 ± 0.053	2.981GluGln: 2.981 ± 0.056	4.332GluArg: 4.332 ± 0.081	3.336GluSer: 3.336 ± 0.05	3.49GluThr: 3.49 ± 0.059	4.614GluVal: 4.614 ± 0.069	0.606GluTrp: 0.606 ± 0.023	1.622GluTyr: 1.622 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.468PheAla: 3.468 ± 0.058	0.575PheCys: 0.575 ± 0.024	2.391PheAsp: 2.391 ± 0.049	2.473PheGlu: 2.473 ± 0.054	1.767PhePhe: 1.767 ± 0.048	3.247PheGly: 3.247 ± 0.068	0.794PheHis: 0.794 ± 0.027	2.124PheIle: 2.124 ± 0.042	1.788PheLys: 1.788 ± 0.044	3.937PheLeu: 3.937 ± 0.056	1.227PheMet: 1.227 ± 0.037	1.339PheAsn: 1.339 ± 0.036	1.737PhePro: 1.737 ± 0.042	1.105PheGln: 1.105 ± 0.03	2.003PheArg: 2.003 ± 0.039	2.702PheSer: 2.702 ± 0.053	2.263PheThr: 2.263 ± 0.045	2.732PheVal: 2.732 ± 0.058	0.602PheTrp: 0.602 ± 0.023	1.105PheTyr: 1.105 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	6.902GlyAla: 6.902 ± 0.104	1.325GlyCys: 1.325 ± 0.037	4.338GlyAsp: 4.338 ± 0.119	4.904GlyGlu: 4.904 ± 0.078	3.399GlyPhe: 3.399 ± 0.053	6.631GlyGly: 6.631 ± 0.148	1.85GlyHis: 1.85 ± 0.047	4.656GlyIle: 4.656 ± 0.071	4.206GlyLys: 4.206 ± 0.072	9.011GlyLeu: 9.011 ± 0.108	2.7GlyMet: 2.7 ± 0.053	2.531GlyAsn: 2.531 ± 0.074	2.88GlyPro: 2.88 ± 0.056	3.038GlyGln: 3.038 ± 0.058	4.806GlyArg: 4.806 ± 0.076	4.298GlySer: 4.298 ± 0.072	4.418GlyThr: 4.418 ± 0.073	6.066GlyVal: 6.066 ± 0.079	1.06GlyTrp: 1.06 ± 0.034	2.441GlyTyr: 2.441 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.791HisAla: 1.791 ± 0.043	0.384HisCys: 0.384 ± 0.018	1.235HisAsp: 1.235 ± 0.035	1.356HisGlu: 1.356 ± 0.035	0.99HisPhe: 0.99 ± 0.029	1.782HisGly: 1.782 ± 0.038	0.537HisHis: 0.537 ± 0.022	1.117HisIle: 1.117 ± 0.034	0.888HisLys: 0.888 ± 0.031	2.171HisLeu: 2.171 ± 0.052	0.526HisMet: 0.526 ± 0.022	0.655HisAsn: 0.655 ± 0.025	1.295HisPro: 1.295 ± 0.037	0.678HisGln: 0.678 ± 0.024	1.212HisArg: 1.212 ± 0.038	1.179HisSer: 1.179 ± 0.036	1.005HisThr: 1.005 ± 0.034	1.423HisVal: 1.423 ± 0.034	0.288HisTrp: 0.288 ± 0.017	0.614HisTyr: 0.614 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.09IleAla: 5.09 ± 0.06	0.762IleCys: 0.762 ± 0.028	2.878IleAsp: 2.878 ± 0.058	3.415IleGlu: 3.415 ± 0.062	2.148IlePhe: 2.148 ± 0.048	4.151IleGly: 4.151 ± 0.066	1.138IleHis: 1.138 ± 0.032	3.188IleIle: 3.188 ± 0.06	2.562IleLys: 2.562 ± 0.055	5.684IleLeu: 5.684 ± 0.07	1.556IleMet: 1.556 ± 0.044	1.906IleAsn: 1.906 ± 0.041	2.91IlePro: 2.91 ± 0.057	1.7IleGln: 1.7 ± 0.042	3.222IleArg: 3.222 ± 0.062	3.45IleSer: 3.45 ± 0.057	3.022IleThr: 3.022 ± 0.054	3.952IleVal: 3.952 ± 0.063	0.534IleTrp: 0.534 ± 0.023	1.347IleTyr: 1.347 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.937LysAla: 4.937 ± 0.071	0.415LysCys: 0.415 ± 0.021	2.877LysAsp: 2.877 ± 0.064	2.86LysGlu: 2.86 ± 0.065	1.4LysPhe: 1.4 ± 0.041	3.645LysGly: 3.645 ± 0.064	0.951LysHis: 0.951 ± 0.035	2.596LysIle: 2.596 ± 0.056	2.748LysLys: 2.748 ± 0.076	4.353LysLeu: 4.353 ± 0.065	1.241LysMet: 1.241 ± 0.036	1.623LysAsn: 1.623 ± 0.044	2.128LysPro: 2.128 ± 0.045	1.656LysGln: 1.656 ± 0.045	2.852LysArg: 2.852 ± 0.051	2.44LysSer: 2.44 ± 0.047	2.663LysThr: 2.663 ± 0.05	3.194LysVal: 3.194 ± 0.058	0.452LysTrp: 0.452 ± 0.022	1.157LysTyr: 1.157 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	11.171LeuAla: 11.171 ± 0.124	1.318LeuCys: 1.318 ± 0.036	6.389LeuAsp: 6.389 ± 0.086	6.924LeuGlu: 6.924 ± 0.09	4.141LeuPhe: 4.141 ± 0.083	8.769LeuGly: 8.769 ± 0.102	2.062LeuHis: 2.062 ± 0.047	5.141LeuIle: 5.141 ± 0.072	4.901LeuLys: 4.901 ± 0.068	10.218LeuLeu: 10.218 ± 0.12	2.786LeuMet: 2.786 ± 0.048	3.312LeuAsn: 3.312 ± 0.062	5.273LeuPro: 5.273 ± 0.076	2.98LeuGln: 2.98 ± 0.05	6.01LeuArg: 6.01 ± 0.081	6.849LeuSer: 6.849 ± 0.086	6.118LeuThr: 6.118 ± 0.075	7.257LeuVal: 7.257 ± 0.083	1.134LeuTrp: 1.134 ± 0.034	2.449LeuTyr: 2.449 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	3.196MetAla: 3.196 ± 0.056	0.285MetCys: 0.285 ± 0.015	2.01MetAsp: 2.01 ± 0.045	1.876MetGlu: 1.876 ± 0.042	0.947MetPhe: 0.947 ± 0.031	2.557MetGly: 2.557 ± 0.054	0.593MetHis: 0.593 ± 0.02	1.513MetIle: 1.513 ± 0.043	1.372MetLys: 1.372 ± 0.038	2.853MetLeu: 2.853 ± 0.054	0.738MetMet: 0.738 ± 0.028	1.104MetAsn: 1.104 ± 0.034	1.47MetPro: 1.47 ± 0.041	0.996MetGln: 0.996 ± 0.03	1.745MetArg: 1.745 ± 0.045	1.974MetSer: 1.974 ± 0.043	1.792MetThr: 1.792 ± 0.042	1.99MetVal: 1.99 ± 0.048	0.219MetTrp: 0.219 ± 0.014	0.556MetTyr: 0.556 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.802AsnAla: 2.802 ± 0.054	0.433AsnCys: 0.433 ± 0.02	1.764AsnAsp: 1.764 ± 0.063	1.802AsnGlu: 1.802 ± 0.043	1.2AsnPhe: 1.2 ± 0.034	2.313AsnGly: 2.313 ± 0.051	0.66AsnHis: 0.66 ± 0.024	2.049AsnIle: 2.049 ± 0.05	1.397AsnLys: 1.397 ± 0.037	3.429AsnLeu: 3.429 ± 0.059	0.984AsnMet: 0.984 ± 0.029	0.996AsnAsn: 0.996 ± 0.039	1.941AsnPro: 1.941 ± 0.037	0.966AsnGln: 0.966 ± 0.033	1.776AsnArg: 1.776 ± 0.038	1.641AsnSer: 1.641 ± 0.044	1.632AsnThr: 1.632 ± 0.046	2.242AsnVal: 2.242 ± 0.047	0.418AsnTrp: 0.418 ± 0.019	0.86AsnTyr: 0.86 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	4.236ProAla: 4.236 ± 0.062	0.581ProCys: 0.581 ± 0.026	3.121ProAsp: 3.121 ± 0.055	4.313ProGlu: 4.313 ± 0.069	1.8ProPhe: 1.8 ± 0.04	4.216ProGly: 4.216 ± 0.064	0.969ProHis: 0.969 ± 0.032	1.997ProIle: 1.997 ± 0.041	2.136ProLys: 2.136 ± 0.046	4.543ProLeu: 4.543 ± 0.076	1.225ProMet: 1.225 ± 0.036	1.191ProAsn: 1.191 ± 0.034	1.97ProPro: 1.97 ± 0.046	1.63ProGln: 1.63 ± 0.041	2.255ProArg: 2.255 ± 0.047	2.487ProSer: 2.487 ± 0.05	2.055ProThr: 2.055 ± 0.053	3.702ProVal: 3.702 ± 0.068	0.667ProTrp: 0.667 ± 0.025	1.178ProTyr: 1.178 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.141GlnAla: 4.141 ± 0.073	0.403GlnCys: 0.403 ± 0.019	2.06GlnAsp: 2.06 ± 0.044	2.19GlnGlu: 2.19 ± 0.044	1.182GlnPhe: 1.182 ± 0.031	3.019GlnGly: 3.019 ± 0.051	0.65GlnHis: 0.65 ± 0.026	1.746GlnIle: 1.746 ± 0.043	1.403GlnLys: 1.403 ± 0.037	3.123GlnLeu: 3.123 ± 0.056	1.009GlnMet: 1.009 ± 0.034	1.098GlnAsn: 1.098 ± 0.032	1.318GlnPro: 1.318 ± 0.04	1.385GlnGln: 1.385 ± 0.036	2.156GlnArg: 2.156 ± 0.044	1.947GlnSer: 1.947 ± 0.044	1.823GlnThr: 1.823 ± 0.047	2.336GlnVal: 2.336 ± 0.046	0.413GlnTrp: 0.413 ± 0.022	0.838GlnTyr: 0.838 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	4.923ArgAla: 4.923 ± 0.08	0.661ArgCys: 0.661 ± 0.021	3.198ArgAsp: 3.198 ± 0.054	4.346ArgGlu: 4.346 ± 0.074	2.548ArgPhe: 2.548 ± 0.048	3.806ArgGly: 3.806 ± 0.062	1.341ArgHis: 1.341 ± 0.038	3.749ArgIle: 3.749 ± 0.058	3.026ArgLys: 3.026 ± 0.06	6.485ArgLeu: 6.485 ± 0.078	1.858ArgMet: 1.858 ± 0.042	1.839ArgAsn: 1.839 ± 0.044	2.494ArgPro: 2.494 ± 0.049	2.209ArgGln: 2.209 ± 0.049	3.845ArgArg: 3.845 ± 0.079	3.185ArgSer: 3.185 ± 0.062	2.9ArgThr: 2.9 ± 0.054	4.004ArgVal: 4.004 ± 0.066	0.699ArgTrp: 0.699 ± 0.025	1.658ArgTyr: 1.658 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	4.918SerAla: 4.918 ± 0.08	0.777SerCys: 0.777 ± 0.03	3.141SerAsp: 3.141 ± 0.056	3.494SerGlu: 3.494 ± 0.063	2.346SerPhe: 2.346 ± 0.05	5.603SerGly: 5.603 ± 0.096	1.164SerHis: 1.164 ± 0.033	3.232SerIle: 3.232 ± 0.057	2.482SerLys: 2.482 ± 0.049	6.178SerLeu: 6.178 ± 0.083	1.93SerMet: 1.93 ± 0.036	1.576SerAsn: 1.576 ± 0.042	2.76SerPro: 2.76 ± 0.053	1.879SerGln: 1.879 ± 0.046	3.427SerArg: 3.427 ± 0.055	3.36SerSer: 3.36 ± 0.059	2.934SerThr: 2.934 ± 0.062	4.071SerVal: 4.071 ± 0.069	0.753SerTrp: 0.753 ± 0.029	1.482SerTyr: 1.482 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.059ThrAla: 5.059 ± 0.076	0.626ThrCys: 0.626 ± 0.022	2.763ThrAsp: 2.763 ± 0.051	3.079ThrGlu: 3.079 ± 0.057	1.954ThrPhe: 1.954 ± 0.048	5.0ThrGly: 5.0 ± 0.071	1.059ThrHis: 1.059 ± 0.032	2.91ThrIle: 2.91 ± 0.055	2.058ThrLys: 2.058 ± 0.045	5.905ThrLeu: 5.905 ± 0.087	1.574ThrMet: 1.574 ± 0.043	1.543ThrAsn: 1.543 ± 0.039	3.065ThrPro: 3.065 ± 0.054	1.59ThrGln: 1.59 ± 0.037	2.913ThrArg: 2.913 ± 0.055	2.904ThrSer: 2.904 ± 0.058	2.926ThrThr: 2.926 ± 0.065	4.134ThrVal: 4.134 ± 0.064	0.609ThrTrp: 0.609 ± 0.025	1.344ThrTyr: 1.344 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	6.967ValAla: 6.967 ± 0.096	0.936ValCys: 0.936 ± 0.031	4.42ValAsp: 4.42 ± 0.07	4.579ValGlu: 4.579 ± 0.059	2.921ValPhe: 2.921 ± 0.06	5.216ValGly: 5.216 ± 0.072	1.503ValHis: 1.503 ± 0.036	3.89ValIle: 3.89 ± 0.058	2.804ValLys: 2.804 ± 0.055	7.828ValLeu: 7.828 ± 0.086	2.086ValMet: 2.086 ± 0.048	2.417ValAsn: 2.417 ± 0.044	3.235ValPro: 3.235 ± 0.063	2.398ValGln: 2.398 ± 0.054	4.474ValArg: 4.474 ± 0.061	4.312ValSer: 4.312 ± 0.065	4.02ValThr: 4.02 ± 0.061	5.789ValVal: 5.789 ± 0.097	0.739ValTrp: 0.739 ± 0.029	1.7ValTyr: 1.7 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.03TrpAla: 1.03 ± 0.03	0.138TrpCys: 0.138 ± 0.012	0.702TrpAsp: 0.702 ± 0.027	0.728TrpGlu: 0.728 ± 0.024	0.48TrpPhe: 0.48 ± 0.023	0.924TrpGly: 0.924 ± 0.029	0.235TrpHis: 0.235 ± 0.016	0.613TrpIle: 0.613 ± 0.026	0.633TrpLys: 0.633 ± 0.023	1.42TrpLeu: 1.42 ± 0.042	0.34TrpMet: 0.34 ± 0.017	0.446TrpAsn: 0.446 ± 0.021	0.568TrpPro: 0.568 ± 0.025	0.447TrpGln: 0.447 ± 0.019	0.715TrpArg: 0.715 ± 0.028	0.641TrpSer: 0.641 ± 0.026	0.648TrpThr: 0.648 ± 0.024	0.755TrpVal: 0.755 ± 0.029	0.2TrpTrp: 0.2 ± 0.014	0.283TrpTyr: 0.283 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.316TyrAla: 2.316 ± 0.049	0.386TyrCys: 0.386 ± 0.019	1.552TyrAsp: 1.552 ± 0.037	1.532TyrGlu: 1.532 ± 0.035	1.164TyrPhe: 1.164 ± 0.035	2.263TyrGly: 2.263 ± 0.052	0.531TyrHis: 0.531 ± 0.021	1.154TyrIle: 1.154 ± 0.032	1.072TyrLys: 1.072 ± 0.036	2.814TyrLeu: 2.814 ± 0.056	0.611TyrMet: 0.611 ± 0.023	0.844TyrAsn: 0.844 ± 0.029	1.289TyrPro: 1.289 ± 0.034	0.828TyrGln: 0.828 ± 0.032	1.569TyrArg: 1.569 ± 0.036	1.589TyrSer: 1.589 ± 0.036	1.363TyrThr: 1.363 ± 0.035	1.812TyrVal: 1.812 ± 0.035	0.382TyrTrp: 0.382 ± 0.02	0.842TyrTyr: 0.842 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3428 proteins (1088601 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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