Amino acid dipepetide frequency for Halomonas axialensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.909AlaAla: 11.909 ± 0.136
1.275AlaCys: 1.275 ± 0.038
5.407AlaAsp: 5.407 ± 0.076
6.697AlaGlu: 6.697 ± 0.098
3.888AlaPhe: 3.888 ± 0.064
8.162AlaGly: 8.162 ± 0.092
2.4AlaHis: 2.4 ± 0.052
5.361AlaIle: 5.361 ± 0.088
3.589AlaLys: 3.589 ± 0.076
13.687AlaLeu: 13.687 ± 0.134
3.437AlaMet: 3.437 ± 0.059
3.205AlaAsn: 3.205 ± 0.053
4.736AlaPro: 4.736 ± 0.083
4.698AlaGln: 4.698 ± 0.084
6.682AlaArg: 6.682 ± 0.085
6.379AlaSer: 6.379 ± 0.084
5.665AlaThr: 5.665 ± 0.074
7.191AlaVal: 7.191 ± 0.091
1.803AlaTrp: 1.803 ± 0.043
2.489AlaTyr: 2.489 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
1.111CysAla: 1.111 ± 0.038
0.283CysCys: 0.283 ± 0.019
0.559CysAsp: 0.559 ± 0.025
0.48CysGlu: 0.48 ± 0.022
0.381CysPhe: 0.381 ± 0.019
0.988CysGly: 0.988 ± 0.031
0.399CysHis: 0.399 ± 0.02
0.412CysIle: 0.412 ± 0.02
0.234CysLys: 0.234 ± 0.013
1.121CysLeu: 1.121 ± 0.036
0.378CysMet: 0.378 ± 0.021
0.234CysAsn: 0.234 ± 0.016
0.64CysPro: 0.64 ± 0.027
0.48CysGln: 0.48 ± 0.023
0.87CysArg: 0.87 ± 0.033
0.686CysSer: 0.686 ± 0.025
0.481CysThr: 0.481 ± 0.023
0.743CysVal: 0.743 ± 0.029
0.274CysTrp: 0.274 ± 0.017
0.287CysTyr: 0.287 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
6.082AspAla: 6.082 ± 0.078
0.443AspCys: 0.443 ± 0.022
3.241AspAsp: 3.241 ± 0.069
3.766AspGlu: 3.766 ± 0.07
1.867AspPhe: 1.867 ± 0.046
3.939AspGly: 3.939 ± 0.072
1.293AspHis: 1.293 ± 0.046
3.017AspIle: 3.017 ± 0.052
1.627AspLys: 1.627 ± 0.042
4.764AspLeu: 4.764 ± 0.074
1.264AspMet: 1.264 ± 0.033
1.688AspAsn: 1.688 ± 0.042
2.59AspPro: 2.59 ± 0.061
2.057AspGln: 2.057 ± 0.05
2.948AspArg: 2.948 ± 0.057
2.753AspSer: 2.753 ± 0.059
2.856AspThr: 2.856 ± 0.048
3.992AspVal: 3.992 ± 0.063
0.808AspTrp: 0.808 ± 0.028
1.573AspTyr: 1.573 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
7.245GluAla: 7.245 ± 0.106
0.432GluCys: 0.432 ± 0.024
2.671GluAsp: 2.671 ± 0.056
3.973GluGlu: 3.973 ± 0.073
1.609GluPhe: 1.609 ± 0.044
4.479GluGly: 4.479 ± 0.076
1.774GluHis: 1.774 ± 0.048
2.798GluIle: 2.798 ± 0.051
2.098GluLys: 2.098 ± 0.046
6.568GluLeu: 6.568 ± 0.111
1.553GluMet: 1.553 ± 0.04
1.677GluAsn: 1.677 ± 0.039
2.517GluPro: 2.517 ± 0.052
3.809GluGln: 3.809 ± 0.066
5.3GluArg: 5.3 ± 0.076
3.243GluSer: 3.243 ± 0.053
2.955GluThr: 2.955 ± 0.06
4.168GluVal: 4.168 ± 0.078
0.868GluTrp: 0.868 ± 0.028
1.235GluTyr: 1.235 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
3.483PheAla: 3.483 ± 0.059
0.441PheCys: 0.441 ± 0.022
2.341PheAsp: 2.341 ± 0.046
2.127PheGlu: 2.127 ± 0.047
1.174PhePhe: 1.174 ± 0.038
3.064PheGly: 3.064 ± 0.063
0.804PheHis: 0.804 ± 0.027
1.969PheIle: 1.969 ± 0.046
1.103PheLys: 1.103 ± 0.036
2.824PheLeu: 2.824 ± 0.054
1.044PheMet: 1.044 ± 0.03
1.164PheAsn: 1.164 ± 0.035
1.468PhePro: 1.468 ± 0.037
1.216PheGln: 1.216 ± 0.031
1.831PheArg: 1.831 ± 0.046
2.4PheSer: 2.4 ± 0.05
2.099PheThr: 2.099 ± 0.052
2.347PheVal: 2.347 ± 0.052
0.526PheTrp: 0.526 ± 0.024
0.951PheTyr: 0.951 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
6.891GlyAla: 6.891 ± 0.091
0.989GlyCys: 0.989 ± 0.034
4.083GlyAsp: 4.083 ± 0.074
4.861GlyGlu: 4.861 ± 0.074
3.028GlyPhe: 3.028 ± 0.054
6.056GlyGly: 6.056 ± 0.099
1.993GlyHis: 1.993 ± 0.048
4.433GlyIle: 4.433 ± 0.078
2.996GlyLys: 2.996 ± 0.06
8.273GlyLeu: 8.273 ± 0.103
2.63GlyMet: 2.63 ± 0.051
2.141GlyAsn: 2.141 ± 0.052
2.486GlyPro: 2.486 ± 0.052
3.22GlyGln: 3.22 ± 0.065
4.922GlyArg: 4.922 ± 0.072
4.366GlySer: 4.366 ± 0.073
3.68GlyThr: 3.68 ± 0.06
6.07GlyVal: 6.07 ± 0.093
1.407GlyTrp: 1.407 ± 0.036
2.438GlyTyr: 2.438 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
2.49HisAla: 2.49 ± 0.052
0.349HisCys: 0.349 ± 0.018
1.349HisAsp: 1.349 ± 0.039
1.25HisGlu: 1.25 ± 0.031
0.992HisPhe: 0.992 ± 0.033
2.093HisGly: 2.093 ± 0.049
0.846HisHis: 0.846 ± 0.034
1.106HisIle: 1.106 ± 0.036
0.632HisLys: 0.632 ± 0.028
2.56HisLeu: 2.56 ± 0.054
0.616HisMet: 0.616 ± 0.027
0.611HisAsn: 0.611 ± 0.026
1.505HisPro: 1.505 ± 0.046
1.25HisGln: 1.25 ± 0.04
1.797HisArg: 1.797 ± 0.042
1.309HisSer: 1.309 ± 0.042
1.187HisThr: 1.187 ± 0.033
1.476HisVal: 1.476 ± 0.039
0.437HisTrp: 0.437 ± 0.02
0.83HisTyr: 0.83 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
5.903IleAla: 5.903 ± 0.088
0.475IleCys: 0.475 ± 0.022
3.298IleAsp: 3.298 ± 0.053
3.642IleGlu: 3.642 ± 0.065
1.497IlePhe: 1.497 ± 0.044
4.19IleGly: 4.19 ± 0.084
1.081IleHis: 1.081 ± 0.03
2.249IleIle: 2.249 ± 0.055
1.622IleLys: 1.622 ± 0.042
3.799IleLeu: 3.799 ± 0.069
1.12IleMet: 1.12 ± 0.035
1.792IleAsn: 1.792 ± 0.044
2.228IlePro: 2.228 ± 0.052
1.611IleGln: 1.611 ± 0.041
2.898IleArg: 2.898 ± 0.06
3.067IleSer: 3.067 ± 0.051
3.027IleThr: 3.027 ± 0.058
3.33IleVal: 3.33 ± 0.062
0.5IleTrp: 0.5 ± 0.022
1.138IleTyr: 1.138 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
3.811LysAla: 3.811 ± 0.064
0.256LysCys: 0.256 ± 0.016
1.342LysAsp: 1.342 ± 0.035
1.847LysGlu: 1.847 ± 0.036
0.709LysPhe: 0.709 ± 0.025
2.367LysGly: 2.367 ± 0.05
0.808LysHis: 0.808 ± 0.032
1.299LysIle: 1.299 ± 0.037
1.15LysLys: 1.15 ± 0.038
3.295LysLeu: 3.295 ± 0.055
0.811LysMet: 0.811 ± 0.027
0.761LysAsn: 0.761 ± 0.032
1.932LysPro: 1.932 ± 0.045
1.572LysGln: 1.572 ± 0.038
3.128LysArg: 3.128 ± 0.061
1.763LysSer: 1.763 ± 0.043
1.797LysThr: 1.797 ± 0.044
2.363LysVal: 2.363 ± 0.057
0.381LysTrp: 0.381 ± 0.02
0.592LysTyr: 0.592 ± 0.026
0.0LysXaa: 0.0 ± 0.0
Leu
13.308LeuAla: 13.308 ± 0.146
1.141LeuCys: 1.141 ± 0.031
6.053LeuAsp: 6.053 ± 0.091
6.641LeuGlu: 6.641 ± 0.097
3.809LeuPhe: 3.809 ± 0.059
8.263LeuGly: 8.263 ± 0.116
2.336LeuHis: 2.336 ± 0.053
5.283LeuIle: 5.283 ± 0.069
3.869LeuLys: 3.869 ± 0.069
11.818LeuLeu: 11.818 ± 0.15
2.976LeuMet: 2.976 ± 0.06
3.442LeuAsn: 3.442 ± 0.057
6.4LeuPro: 6.4 ± 0.081
3.57LeuGln: 3.57 ± 0.057
6.526LeuArg: 6.526 ± 0.079
7.081LeuSer: 7.081 ± 0.089
6.273LeuThr: 6.273 ± 0.064
7.494LeuVal: 7.494 ± 0.096
1.442LeuTrp: 1.442 ± 0.041
2.412LeuTyr: 2.412 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
3.455MetAla: 3.455 ± 0.058
0.223MetCys: 0.223 ± 0.015
1.26MetAsp: 1.26 ± 0.039
1.414MetGlu: 1.414 ± 0.038
0.777MetPhe: 0.777 ± 0.032
2.184MetGly: 2.184 ± 0.049
0.583MetHis: 0.583 ± 0.022
1.396MetIle: 1.396 ± 0.036
1.01MetLys: 1.01 ± 0.028
3.156MetLeu: 3.156 ± 0.055
0.801MetMet: 0.801 ± 0.031
0.862MetAsn: 0.862 ± 0.027
1.589MetPro: 1.589 ± 0.038
1.179MetGln: 1.179 ± 0.036
1.773MetArg: 1.773 ± 0.037
1.88MetSer: 1.88 ± 0.043
1.784MetThr: 1.784 ± 0.039
2.086MetVal: 2.086 ± 0.046
0.259MetTrp: 0.259 ± 0.014
0.435MetTyr: 0.435 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.388AsnAla: 3.388 ± 0.056
0.303AsnCys: 0.303 ± 0.016
1.641AsnAsp: 1.641 ± 0.045
1.644AsnGlu: 1.644 ± 0.039
0.945AsnPhe: 0.945 ± 0.035
2.407AsnGly: 2.407 ± 0.049
0.647AsnHis: 0.647 ± 0.027
1.452AsnIle: 1.452 ± 0.037
0.799AsnLys: 0.799 ± 0.026
2.751AsnLeu: 2.751 ± 0.053
0.66AsnMet: 0.66 ± 0.026
0.893AsnAsn: 0.893 ± 0.029
1.842AsnPro: 1.842 ± 0.038
1.286AsnGln: 1.286 ± 0.036
1.9AsnArg: 1.9 ± 0.046
1.484AsnSer: 1.484 ± 0.042
1.507AsnThr: 1.507 ± 0.037
2.155AsnVal: 2.155 ± 0.044
0.414AsnTrp: 0.414 ± 0.021
0.747AsnTyr: 0.747 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
4.942ProAla: 4.942 ± 0.076
0.493ProCys: 0.493 ± 0.02
2.773ProAsp: 2.773 ± 0.052
3.727ProGlu: 3.727 ± 0.071
1.751ProPhe: 1.751 ± 0.041
3.808ProGly: 3.808 ± 0.073
1.096ProHis: 1.096 ± 0.032
2.295ProIle: 2.295 ± 0.048
1.613ProLys: 1.613 ± 0.041
5.63ProLeu: 5.63 ± 0.074
1.462ProMet: 1.462 ± 0.034
1.51ProAsn: 1.51 ± 0.041
2.311ProPro: 2.311 ± 0.051
1.812ProGln: 1.812 ± 0.048
2.927ProArg: 2.927 ± 0.06
3.163ProSer: 3.163 ± 0.062
2.717ProThr: 2.717 ± 0.047
3.635ProVal: 3.635 ± 0.065
0.916ProTrp: 0.916 ± 0.03
1.113ProTyr: 1.113 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
5.681GlnAla: 5.681 ± 0.078
0.404GlnCys: 0.404 ± 0.021
1.672GlnAsp: 1.672 ± 0.041
2.461GlnGlu: 2.461 ± 0.051
1.234GlnPhe: 1.234 ± 0.036
3.295GlnGly: 3.295 ± 0.061
1.251GlnHis: 1.251 ± 0.034
1.656GlnIle: 1.656 ± 0.037
1.151GlnLys: 1.151 ± 0.032
5.073GlnLeu: 5.073 ± 0.076
0.974GlnMet: 0.974 ± 0.027
0.946GlnAsn: 0.946 ± 0.033
2.245GlnPro: 2.245 ± 0.051
2.94GlnGln: 2.94 ± 0.068
3.999GlnArg: 3.999 ± 0.072
2.183GlnSer: 2.183 ± 0.046
1.962GlnThr: 1.962 ± 0.045
3.103GlnVal: 3.103 ± 0.055
0.771GlnTrp: 0.771 ± 0.03
0.833GlnTyr: 0.833 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
5.86ArgAla: 5.86 ± 0.081
0.999ArgCys: 0.999 ± 0.033
3.621ArgAsp: 3.621 ± 0.06
4.348ArgGlu: 4.348 ± 0.063
2.802ArgPhe: 2.802 ± 0.049
4.113ArgGly: 4.113 ± 0.065
2.203ArgHis: 2.203 ± 0.051
3.187ArgIle: 3.187 ± 0.064
2.065ArgLys: 2.065 ± 0.045
8.306ArgLeu: 8.306 ± 0.1
2.101ArgMet: 2.101 ± 0.049
1.701ArgAsn: 1.701 ± 0.049
2.899ArgPro: 2.899 ± 0.055
3.533ArgGln: 3.533 ± 0.056
5.031ArgArg: 5.031 ± 0.081
3.524ArgSer: 3.524 ± 0.055
2.867ArgThr: 2.867 ± 0.049
4.376ArgVal: 4.376 ± 0.073
1.369ArgTrp: 1.369 ± 0.039
2.342ArgTyr: 2.342 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
6.228SerAla: 6.228 ± 0.08
0.625SerCys: 0.625 ± 0.027
3.107SerAsp: 3.107 ± 0.06
3.241SerGlu: 3.241 ± 0.065
1.992SerPhe: 1.992 ± 0.045
5.133SerGly: 5.133 ± 0.072
1.433SerHis: 1.433 ± 0.04
2.629SerIle: 2.629 ± 0.05
1.612SerLys: 1.612 ± 0.042
6.619SerLeu: 6.619 ± 0.079
1.662SerMet: 1.662 ± 0.042
1.595SerAsn: 1.595 ± 0.043
3.028SerPro: 3.028 ± 0.055
2.666SerGln: 2.666 ± 0.057
3.999SerArg: 3.999 ± 0.065
3.55SerSer: 3.55 ± 0.064
3.077SerThr: 3.077 ± 0.057
4.154SerVal: 4.154 ± 0.071
0.875SerTrp: 0.875 ± 0.035
1.338SerTyr: 1.338 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
5.397ThrAla: 5.397 ± 0.07
0.594ThrCys: 0.594 ± 0.026
2.446ThrAsp: 2.446 ± 0.049
2.45ThrGlu: 2.45 ± 0.043
1.942ThrPhe: 1.942 ± 0.04
4.217ThrGly: 4.217 ± 0.068
1.274ThrHis: 1.274 ± 0.033
2.332ThrIle: 2.332 ± 0.051
1.313ThrLys: 1.313 ± 0.035
7.49ThrLeu: 7.49 ± 0.089
1.213ThrMet: 1.213 ± 0.033
1.37ThrAsn: 1.37 ± 0.041
3.743ThrPro: 3.743 ± 0.06
2.262ThrGln: 2.262 ± 0.047
3.319ThrArg: 3.319 ± 0.054
2.992ThrSer: 2.992 ± 0.051
2.971ThrThr: 2.971 ± 0.06
3.578ThrVal: 3.578 ± 0.066
0.759ThrTrp: 0.759 ± 0.031
1.196ThrTyr: 1.196 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
7.744ValAla: 7.744 ± 0.097
0.691ValCys: 0.691 ± 0.028
3.925ValAsp: 3.925 ± 0.075
4.555ValGlu: 4.555 ± 0.074
2.476ValPhe: 2.476 ± 0.053
5.292ValGly: 5.292 ± 0.073
1.369ValHis: 1.369 ± 0.035
3.958ValIle: 3.958 ± 0.073
2.386ValLys: 2.386 ± 0.059
7.254ValLeu: 7.254 ± 0.092
2.306ValMet: 2.306 ± 0.049
2.267ValAsn: 2.267 ± 0.046
3.26ValPro: 3.26 ± 0.051
2.245ValGln: 2.245 ± 0.044
4.093ValArg: 4.093 ± 0.063
4.492ValSer: 4.492 ± 0.069
4.125ValThr: 4.125 ± 0.066
5.863ValVal: 5.863 ± 0.085
0.936ValTrp: 0.936 ± 0.032
1.578ValTyr: 1.578 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
1.278TrpAla: 1.278 ± 0.036
0.313TrpCys: 0.313 ± 0.017
0.524TrpAsp: 0.524 ± 0.025
0.701TrpGlu: 0.701 ± 0.028
0.536TrpPhe: 0.536 ± 0.024
0.886TrpGly: 0.886 ± 0.03
0.407TrpHis: 0.407 ± 0.022
0.659TrpIle: 0.659 ± 0.024
0.497TrpLys: 0.497 ± 0.023
2.358TrpLeu: 2.358 ± 0.054
0.534TrpMet: 0.534 ± 0.023
0.374TrpAsn: 0.374 ± 0.017
0.889TrpPro: 0.889 ± 0.03
1.118TrpGln: 1.118 ± 0.033
1.275TrpArg: 1.275 ± 0.037
0.833TrpSer: 0.833 ± 0.025
0.608TrpThr: 0.608 ± 0.025
1.031TrpVal: 1.031 ± 0.026
0.377TrpTrp: 0.377 ± 0.021
0.35TrpTyr: 0.35 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.454TyrAla: 2.454 ± 0.05
0.313TyrCys: 0.313 ± 0.018
1.257TyrAsp: 1.257 ± 0.038
1.146TyrGlu: 1.146 ± 0.036
0.966TyrPhe: 0.966 ± 0.032
2.025TyrGly: 2.025 ± 0.038
0.685TyrHis: 0.685 ± 0.026
0.98TyrIle: 0.98 ± 0.031
0.616TyrLys: 0.616 ± 0.026
2.791TyrLeu: 2.791 ± 0.049
0.563TyrMet: 0.563 ± 0.021
0.633TyrAsn: 0.633 ± 0.026
1.386TyrPro: 1.386 ± 0.038
1.311TyrGln: 1.311 ± 0.039
2.029TyrArg: 2.029 ± 0.041
1.417TyrSer: 1.417 ± 0.035
1.219TyrThr: 1.219 ± 0.033
1.663TyrVal: 1.663 ± 0.039
0.426TyrTrp: 0.426 ± 0.021
0.734TyrTyr: 0.734 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5488 proteins (1002324 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski