Amino acid dipepetide frequency for Edaphobacter sp. 12200R-103

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.769AlaAla: 12.769 ± 0.132
0.921AlaCys: 0.921 ± 0.027
4.922AlaAsp: 4.922 ± 0.059
6.106AlaGlu: 6.106 ± 0.09
3.64AlaPhe: 3.64 ± 0.049
8.767AlaGly: 8.767 ± 0.102
2.088AlaHis: 2.088 ± 0.047
5.728AlaIle: 5.728 ± 0.08
4.049AlaLys: 4.049 ± 0.068
10.363AlaLeu: 10.363 ± 0.097
2.774AlaMet: 2.774 ± 0.051
3.421AlaAsn: 3.421 ± 0.068
5.095AlaPro: 5.095 ± 0.083
4.166AlaGln: 4.166 ± 0.066
5.974AlaArg: 5.974 ± 0.067
6.762AlaSer: 6.762 ± 0.08
6.039AlaThr: 6.039 ± 0.074
7.537AlaVal: 7.537 ± 0.081
1.339AlaTrp: 1.339 ± 0.037
2.492AlaTyr: 2.492 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.826CysAla: 0.826 ± 0.026
0.154CysCys: 0.154 ± 0.012
0.465CysAsp: 0.465 ± 0.02
0.387CysGlu: 0.387 ± 0.016
0.378CysPhe: 0.378 ± 0.018
0.913CysGly: 0.913 ± 0.029
0.266CysHis: 0.266 ± 0.018
0.438CysIle: 0.438 ± 0.021
0.221CysLys: 0.221 ± 0.012
0.756CysLeu: 0.756 ± 0.024
0.197CysMet: 0.197 ± 0.011
0.27CysAsn: 0.27 ± 0.015
0.432CysPro: 0.432 ± 0.021
0.223CysGln: 0.223 ± 0.013
0.526CysArg: 0.526 ± 0.02
0.588CysSer: 0.588 ± 0.023
0.5CysThr: 0.5 ± 0.022
0.613CysVal: 0.613 ± 0.023
0.125CysTrp: 0.125 ± 0.01
0.23CysTyr: 0.23 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
5.43AspAla: 5.43 ± 0.067
0.395AspCys: 0.395 ± 0.019
2.415AspAsp: 2.415 ± 0.048
2.916AspGlu: 2.916 ± 0.053
2.166AspPhe: 2.166 ± 0.045
4.329AspGly: 4.329 ± 0.07
1.244AspHis: 1.244 ± 0.032
2.587AspIle: 2.587 ± 0.055
1.738AspLys: 1.738 ± 0.043
5.198AspLeu: 5.198 ± 0.076
0.931AspMet: 0.931 ± 0.028
1.429AspAsn: 1.429 ± 0.034
3.372AspPro: 3.372 ± 0.056
1.808AspGln: 1.808 ± 0.042
3.354AspArg: 3.354 ± 0.063
2.826AspSer: 2.826 ± 0.046
2.548AspThr: 2.548 ± 0.049
3.575AspVal: 3.575 ± 0.062
0.824AspTrp: 0.824 ± 0.026
1.612AspTyr: 1.612 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
5.786GluAla: 5.786 ± 0.081
0.362GluCys: 0.362 ± 0.018
2.695GluAsp: 2.695 ± 0.051
3.434GluGlu: 3.434 ± 0.064
1.926GluPhe: 1.926 ± 0.039
3.759GluGly: 3.759 ± 0.056
1.422GluHis: 1.422 ± 0.031
3.494GluIle: 3.494 ± 0.056
2.55GluLys: 2.55 ± 0.052
5.304GluLeu: 5.304 ± 0.079
1.554GluMet: 1.554 ± 0.038
1.788GluAsn: 1.788 ± 0.041
2.316GluPro: 2.316 ± 0.046
2.558GluGln: 2.558 ± 0.046
4.052GluArg: 4.052 ± 0.066
3.076GluSer: 3.076 ± 0.051
3.101GluThr: 3.101 ± 0.053
3.704GluVal: 3.704 ± 0.064
0.757GluTrp: 0.757 ± 0.026
1.399GluTyr: 1.399 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
4.103PheAla: 4.103 ± 0.053
0.416PheCys: 0.416 ± 0.018
2.383PheAsp: 2.383 ± 0.037
1.945PheGlu: 1.945 ± 0.039
1.809PhePhe: 1.809 ± 0.049
3.496PheGly: 3.496 ± 0.06
1.053PheHis: 1.053 ± 0.027
1.626PheIle: 1.626 ± 0.042
1.045PheLys: 1.045 ± 0.031
3.803PheLeu: 3.803 ± 0.059
0.719PheMet: 0.719 ± 0.023
1.495PheAsn: 1.495 ± 0.041
1.874PhePro: 1.874 ± 0.044
1.268PheGln: 1.268 ± 0.034
2.413PheArg: 2.413 ± 0.042
2.803PheSer: 2.803 ± 0.052
2.439PheThr: 2.439 ± 0.047
2.625PheVal: 2.625 ± 0.048
0.56PheTrp: 0.56 ± 0.024
1.251PheTyr: 1.251 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
7.514GlyAla: 7.514 ± 0.083
0.832GlyCys: 0.832 ± 0.031
3.947GlyAsp: 3.947 ± 0.059
3.99GlyGlu: 3.99 ± 0.059
3.421GlyPhe: 3.421 ± 0.052
6.547GlyGly: 6.547 ± 0.093
1.866GlyHis: 1.866 ± 0.043
4.77GlyIle: 4.77 ± 0.06
3.692GlyLys: 3.692 ± 0.058
7.394GlyLeu: 7.394 ± 0.089
2.066GlyMet: 2.066 ± 0.041
2.861GlyAsn: 2.861 ± 0.058
3.282GlyPro: 3.282 ± 0.072
2.905GlyGln: 2.905 ± 0.049
4.832GlyArg: 4.832 ± 0.066
5.366GlySer: 5.366 ± 0.071
5.188GlyThr: 5.188 ± 0.089
5.947GlyVal: 5.947 ± 0.071
1.285GlyTrp: 1.285 ± 0.033
2.604GlyTyr: 2.604 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
2.176HisAla: 2.176 ± 0.048
0.232HisCys: 0.232 ± 0.014
1.22HisAsp: 1.22 ± 0.032
1.2HisGlu: 1.2 ± 0.03
1.019HisPhe: 1.019 ± 0.03
2.021HisGly: 2.021 ± 0.043
0.673HisHis: 0.673 ± 0.024
1.161HisIle: 1.161 ± 0.03
0.656HisLys: 0.656 ± 0.023
2.428HisLeu: 2.428 ± 0.043
0.507HisMet: 0.507 ± 0.022
0.763HisAsn: 0.763 ± 0.023
1.542HisPro: 1.542 ± 0.03
0.81HisGln: 0.81 ± 0.025
1.55HisArg: 1.55 ± 0.036
1.326HisSer: 1.326 ± 0.033
1.215HisThr: 1.215 ± 0.031
1.575HisVal: 1.575 ± 0.035
0.4HisTrp: 0.4 ± 0.016
0.7HisTyr: 0.7 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
6.392IleAla: 6.392 ± 0.078
0.484IleCys: 0.484 ± 0.02
3.079IleAsp: 3.079 ± 0.057
3.206IleGlu: 3.206 ± 0.054
2.109IlePhe: 2.109 ± 0.042
4.394IleGly: 4.394 ± 0.069
1.217IleHis: 1.217 ± 0.033
2.002IleIle: 2.002 ± 0.044
1.502IleLys: 1.502 ± 0.039
4.782IleLeu: 4.782 ± 0.082
0.743IleMet: 0.743 ± 0.027
1.708IleAsn: 1.708 ± 0.044
2.997IlePro: 2.997 ± 0.047
1.717IleGln: 1.717 ± 0.043
3.342IleArg: 3.342 ± 0.06
3.517IleSer: 3.517 ± 0.056
3.227IleThr: 3.227 ± 0.053
4.059IleVal: 4.059 ± 0.057
0.588IleTrp: 0.588 ± 0.023
1.495IleTyr: 1.495 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
3.852LysAla: 3.852 ± 0.067
0.179LysCys: 0.179 ± 0.013
1.99LysAsp: 1.99 ± 0.046
2.071LysGlu: 2.071 ± 0.049
1.177LysPhe: 1.177 ± 0.031
2.612LysGly: 2.612 ± 0.053
0.803LysHis: 0.803 ± 0.026
2.056LysIle: 2.056 ± 0.045
1.89LysLys: 1.89 ± 0.058
3.63LysLeu: 3.63 ± 0.06
1.038LysMet: 1.038 ± 0.029
1.398LysAsn: 1.398 ± 0.036
2.166LysPro: 2.166 ± 0.045
1.572LysGln: 1.572 ± 0.034
2.301LysArg: 2.301 ± 0.041
2.14LysSer: 2.14 ± 0.044
2.407LysThr: 2.407 ± 0.048
2.694LysVal: 2.694 ± 0.048
0.428LysTrp: 0.428 ± 0.019
1.026LysTyr: 1.026 ± 0.029
0.0LysXaa: 0.0 ± 0.0
Leu
10.827LeuAla: 10.827 ± 0.111
0.916LeuCys: 0.916 ± 0.026
4.942LeuAsp: 4.942 ± 0.063
5.364LeuGlu: 5.364 ± 0.074
3.629LeuPhe: 3.629 ± 0.057
7.316LeuGly: 7.316 ± 0.07
2.372LeuHis: 2.372 ± 0.054
4.681LeuIle: 4.681 ± 0.079
3.878LeuLys: 3.878 ± 0.062
10.069LeuLeu: 10.069 ± 0.133
2.029LeuMet: 2.029 ± 0.043
3.315LeuAsn: 3.315 ± 0.054
5.514LeuPro: 5.514 ± 0.064
3.499LeuGln: 3.499 ± 0.059
6.83LeuArg: 6.83 ± 0.089
6.568LeuSer: 6.568 ± 0.084
6.011LeuThr: 6.011 ± 0.078
6.49LeuVal: 6.49 ± 0.074
1.275LeuTrp: 1.275 ± 0.033
2.496LeuTyr: 2.496 ± 0.053
0.0LeuXaa: 0.0 ± 0.0
Met
2.484MetAla: 2.484 ± 0.049
0.155MetCys: 0.155 ± 0.01
1.087MetAsp: 1.087 ± 0.029
1.205MetGlu: 1.205 ± 0.033
0.68MetPhe: 0.68 ± 0.024
1.7MetGly: 1.7 ± 0.038
0.561MetHis: 0.561 ± 0.021
1.149MetIle: 1.149 ± 0.035
1.098MetLys: 1.098 ± 0.03
2.357MetLeu: 2.357 ± 0.044
0.624MetMet: 0.624 ± 0.023
0.848MetAsn: 0.848 ± 0.026
1.37MetPro: 1.37 ± 0.033
1.024MetGln: 1.024 ± 0.033
1.712MetArg: 1.712 ± 0.034
1.451MetSer: 1.451 ± 0.028
1.43MetThr: 1.43 ± 0.03
1.563MetVal: 1.563 ± 0.036
0.235MetTrp: 0.235 ± 0.013
0.456MetTyr: 0.456 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.395AsnAla: 3.395 ± 0.064
0.302AsnCys: 0.302 ± 0.015
1.64AsnAsp: 1.64 ± 0.039
1.578AsnGlu: 1.578 ± 0.036
1.494AsnPhe: 1.494 ± 0.045
3.113AsnGly: 3.113 ± 0.069
0.787AsnHis: 0.787 ± 0.025
1.807AsnIle: 1.807 ± 0.041
1.005AsnLys: 1.005 ± 0.027
3.473AsnLeu: 3.473 ± 0.059
0.643AsnMet: 0.643 ± 0.023
1.239AsnAsn: 1.239 ± 0.048
2.462AsnPro: 2.462 ± 0.058
1.376AsnGln: 1.376 ± 0.041
2.057AsnArg: 2.057 ± 0.041
2.07AsnSer: 2.07 ± 0.056
1.986AsnThr: 1.986 ± 0.046
2.4AsnVal: 2.4 ± 0.048
0.504AsnTrp: 0.504 ± 0.02
1.243AsnTyr: 1.243 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
6.055ProAla: 6.055 ± 0.077
0.345ProCys: 0.345 ± 0.016
3.254ProAsp: 3.254 ± 0.049
3.667ProGlu: 3.667 ± 0.057
1.96ProPhe: 1.96 ± 0.042
4.707ProGly: 4.707 ± 0.073
1.18ProHis: 1.18 ± 0.028
2.449ProIle: 2.449 ± 0.043
1.884ProLys: 1.884 ± 0.041
4.612ProLeu: 4.612 ± 0.065
1.145ProMet: 1.145 ± 0.03
1.94ProAsn: 1.94 ± 0.049
2.556ProPro: 2.556 ± 0.066
2.16ProGln: 2.16 ± 0.049
2.658ProArg: 2.658 ± 0.047
3.557ProSer: 3.557 ± 0.056
2.88ProThr: 2.88 ± 0.049
4.169ProVal: 4.169 ± 0.056
0.691ProTrp: 0.691 ± 0.028
1.452ProTyr: 1.452 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
3.872GlnAla: 3.872 ± 0.052
0.228GlnCys: 0.228 ± 0.015
1.607GlnAsp: 1.607 ± 0.032
1.863GlnGlu: 1.863 ± 0.038
1.414GlnPhe: 1.414 ± 0.037
2.609GlnGly: 2.609 ± 0.05
0.899GlnHis: 0.899 ± 0.027
2.231GlnIle: 2.231 ± 0.042
1.645GlnLys: 1.645 ± 0.041
3.59GlnLeu: 3.59 ± 0.057
1.095GlnMet: 1.095 ± 0.031
1.428GlnAsn: 1.428 ± 0.04
2.066GlnPro: 2.066 ± 0.047
2.14GlnGln: 2.14 ± 0.044
2.58GlnArg: 2.58 ± 0.051
2.361GlnSer: 2.361 ± 0.05
2.314GlnThr: 2.314 ± 0.044
2.704GlnVal: 2.704 ± 0.045
0.539GlnTrp: 0.539 ± 0.019
1.087GlnTyr: 1.087 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
5.551ArgAla: 5.551 ± 0.063
0.46ArgCys: 0.46 ± 0.02
3.126ArgAsp: 3.126 ± 0.051
3.989ArgGlu: 3.989 ± 0.068
2.686ArgPhe: 2.686 ± 0.046
4.139ArgGly: 4.139 ± 0.059
1.465ArgHis: 1.465 ± 0.031
3.765ArgIle: 3.765 ± 0.058
2.505ArgLys: 2.505 ± 0.048
6.258ArgLeu: 6.258 ± 0.078
1.859ArgMet: 1.859 ± 0.039
2.274ArgAsn: 2.274 ± 0.043
2.989ArgPro: 2.989 ± 0.051
2.631ArgGln: 2.631 ± 0.052
4.629ArgArg: 4.629 ± 0.079
4.118ArgSer: 4.118 ± 0.051
3.545ArgThr: 3.545 ± 0.047
4.336ArgVal: 4.336 ± 0.055
1.104ArgTrp: 1.104 ± 0.032
1.961ArgTyr: 1.961 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
6.583SerAla: 6.583 ± 0.081
0.553SerCys: 0.553 ± 0.022
2.98SerAsp: 2.98 ± 0.05
3.132SerGlu: 3.132 ± 0.054
2.757SerPhe: 2.757 ± 0.048
5.967SerGly: 5.967 ± 0.089
1.446SerHis: 1.446 ± 0.035
3.522SerIle: 3.522 ± 0.057
2.112SerLys: 2.112 ± 0.039
6.294SerLeu: 6.294 ± 0.066
1.433SerMet: 1.433 ± 0.034
2.199SerAsn: 2.199 ± 0.054
3.506SerPro: 3.506 ± 0.052
2.278SerGln: 2.278 ± 0.047
3.94SerArg: 3.94 ± 0.053
4.882SerSer: 4.882 ± 0.087
3.971SerThr: 3.971 ± 0.063
4.478SerVal: 4.478 ± 0.06
0.876SerTrp: 0.876 ± 0.027
1.805SerTyr: 1.805 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
6.223ThrAla: 6.223 ± 0.073
0.501ThrCys: 0.501 ± 0.023
2.829ThrAsp: 2.829 ± 0.049
2.91ThrGlu: 2.91 ± 0.055
2.416ThrPhe: 2.416 ± 0.048
5.563ThrGly: 5.563 ± 0.081
1.297ThrHis: 1.297 ± 0.032
3.369ThrIle: 3.369 ± 0.05
1.835ThrLys: 1.835 ± 0.037
6.075ThrLeu: 6.075 ± 0.071
1.236ThrMet: 1.236 ± 0.032
1.973ThrAsn: 1.973 ± 0.054
3.928ThrPro: 3.928 ± 0.059
1.908ThrGln: 1.908 ± 0.038
3.119ThrArg: 3.119 ± 0.05
3.785ThrSer: 3.785 ± 0.061
3.634ThrThr: 3.634 ± 0.068
4.674ThrVal: 4.674 ± 0.081
0.766ThrTrp: 0.766 ± 0.029
1.58ThrTyr: 1.58 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
7.398ValAla: 7.398 ± 0.105
0.671ValCys: 0.671 ± 0.022
3.892ValAsp: 3.892 ± 0.049
4.065ValGlu: 4.065 ± 0.063
2.628ValPhe: 2.628 ± 0.044
4.988ValGly: 4.988 ± 0.064
1.557ValHis: 1.557 ± 0.032
3.725ValIle: 3.725 ± 0.058
2.522ValLys: 2.522 ± 0.051
7.412ValLeu: 7.412 ± 0.084
1.626ValMet: 1.626 ± 0.033
2.517ValAsn: 2.517 ± 0.044
3.805ValPro: 3.805 ± 0.054
2.545ValGln: 2.545 ± 0.042
4.565ValArg: 4.565 ± 0.058
4.739ValSer: 4.739 ± 0.059
4.583ValThr: 4.583 ± 0.068
5.474ValVal: 5.474 ± 0.072
0.86ValTrp: 0.86 ± 0.024
1.765ValTyr: 1.765 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.051TrpAla: 1.051 ± 0.036
0.139TrpCys: 0.139 ± 0.01
0.623TrpAsp: 0.623 ± 0.022
0.592TrpGlu: 0.592 ± 0.021
0.564TrpPhe: 0.564 ± 0.02
0.921TrpGly: 0.921 ± 0.029
0.36TrpHis: 0.36 ± 0.017
0.801TrpIle: 0.801 ± 0.028
0.717TrpLys: 0.717 ± 0.026
1.496TrpLeu: 1.496 ± 0.035
0.445TrpMet: 0.445 ± 0.017
0.656TrpAsn: 0.656 ± 0.022
0.589TrpPro: 0.589 ± 0.02
0.657TrpGln: 0.657 ± 0.023
0.927TrpArg: 0.927 ± 0.03
0.925TrpSer: 0.925 ± 0.026
0.855TrpThr: 0.855 ± 0.027
0.868TrpVal: 0.868 ± 0.029
0.239TrpTrp: 0.239 ± 0.014
0.409TrpTyr: 0.409 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.665TyrAla: 2.665 ± 0.047
0.261TyrCys: 0.261 ± 0.014
1.602TyrAsp: 1.602 ± 0.038
1.419TyrGlu: 1.419 ± 0.042
1.253TyrPhe: 1.253 ± 0.033
2.447TyrGly: 2.447 ± 0.046
0.618TyrHis: 0.618 ± 0.021
1.199TyrIle: 1.199 ± 0.032
0.888TyrLys: 0.888 ± 0.032
2.725TyrLeu: 2.725 ± 0.049
0.523TyrMet: 0.523 ± 0.02
1.052TyrAsn: 1.052 ± 0.039
1.459TyrPro: 1.459 ± 0.036
1.028TyrGln: 1.028 ± 0.027
2.027TyrArg: 2.027 ± 0.041
1.853TyrSer: 1.853 ± 0.038
1.75TyrThr: 1.75 ± 0.039
1.85TyrVal: 1.85 ± 0.038
0.438TyrTrp: 0.438 ± 0.019
0.878TyrTyr: 0.878 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3688 proteins (1316478 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski