Amino acid dipepetide frequency for Apple rubbery wood virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.882AlaAla: 1.882 ± 2.479
0.269AlaCys: 0.269 ± 0.152
1.344AlaAsp: 1.344 ± 0.803
2.689AlaGlu: 2.689 ± 0.201
4.033AlaPhe: 4.033 ± 2.279
0.538AlaGly: 0.538 ± 0.384
1.076AlaHis: 1.076 ± 0.393
3.227AlaIle: 3.227 ± 0.694
3.764AlaLys: 3.764 ± 0.493
4.571AlaLeu: 4.571 ± 1.018
0.538AlaMet: 0.538 ± 0.304
1.882AlaAsn: 1.882 ± 1.315
0.269AlaPro: 0.269 ± 0.468
0.807AlaGln: 0.807 ± 0.457
1.613AlaArg: 1.613 ± 0.541
3.496AlaSer: 3.496 ± 1.947
2.151AlaThr: 2.151 ± 0.716
1.076AlaVal: 1.076 ± 0.983
0.538AlaTrp: 0.538 ± 0.712
2.689AlaTyr: 2.689 ± 1.145
0.0AlaXaa: 0.0 ± 0.0
Cys
0.538CysAla: 0.538 ± 0.304
0.269CysCys: 0.269 ± 0.152
1.076CysAsp: 1.076 ± 0.551
0.807CysGlu: 0.807 ± 0.915
1.344CysPhe: 1.344 ± 0.761
0.269CysGly: 0.269 ± 0.468
1.344CysHis: 1.344 ± 0.522
0.807CysIle: 0.807 ± 0.412
1.613CysLys: 1.613 ± 0.485
2.689CysLeu: 2.689 ± 0.446
0.269CysMet: 0.269 ± 0.152
0.807CysAsn: 0.807 ± 0.575
0.269CysPro: 0.269 ± 0.152
0.538CysGln: 0.538 ± 0.304
0.269CysArg: 0.269 ± 0.152
1.076CysSer: 1.076 ± 0.474
1.344CysThr: 1.344 ± 0.539
1.613CysVal: 1.613 ± 0.645
0.0CysTrp: 0.0 ± 0.0
0.269CysTyr: 0.269 ± 0.152
0.0CysXaa: 0.0 ± 0.0
Asp
2.151AspAla: 2.151 ± 0.674
0.807AspCys: 0.807 ± 0.457
4.033AspAsp: 4.033 ± 1.29
5.378AspGlu: 5.378 ± 2.463
4.571AspPhe: 4.571 ± 0.986
1.882AspGly: 1.882 ± 1.155
1.344AspHis: 1.344 ± 0.406
4.571AspIle: 4.571 ± 0.646
4.302AspLys: 4.302 ± 1.268
7.26AspLeu: 7.26 ± 1.218
1.882AspMet: 1.882 ± 0.429
2.958AspAsn: 2.958 ± 0.915
1.613AspPro: 1.613 ± 1.017
1.613AspGln: 1.613 ± 0.68
1.076AspArg: 1.076 ± 0.38
6.453AspSer: 6.453 ± 0.605
1.344AspThr: 1.344 ± 0.761
3.764AspVal: 3.764 ± 0.89
0.538AspTrp: 0.538 ± 0.304
2.958AspTyr: 2.958 ± 0.134
0.0AspXaa: 0.0 ± 0.0
Glu
1.613GluAla: 1.613 ± 1.151
1.076GluCys: 1.076 ± 0.38
4.84GluAsp: 4.84 ± 1.031
8.067GluGlu: 8.067 ± 0.366
3.227GluPhe: 3.227 ± 0.619
3.764GluGly: 3.764 ± 0.62
1.076GluHis: 1.076 ± 0.609
5.378GluIle: 5.378 ± 1.379
6.722GluLys: 6.722 ± 1.536
9.411GluLeu: 9.411 ± 2.002
1.076GluMet: 1.076 ± 0.376
6.453GluAsn: 6.453 ± 1.815
0.538GluPro: 0.538 ± 0.304
3.227GluGln: 3.227 ± 1.196
3.764GluArg: 3.764 ± 2.969
5.109GluSer: 5.109 ± 0.98
4.033GluThr: 4.033 ± 1.086
3.496GluVal: 3.496 ± 0.834
0.538GluTrp: 0.538 ± 0.304
2.151GluTyr: 2.151 ± 0.513
0.0GluXaa: 0.0 ± 0.0
Phe
3.227PheAla: 3.227 ± 1.54
1.076PheCys: 1.076 ± 0.609
5.378PheAsp: 5.378 ± 2.197
2.151PheGlu: 2.151 ± 0.833
2.42PhePhe: 2.42 ± 0.973
2.42PheGly: 2.42 ± 1.107
2.151PheHis: 2.151 ± 0.513
3.764PheIle: 3.764 ± 0.885
5.378PheLys: 5.378 ± 1.215
5.378PheLeu: 5.378 ± 1.702
1.882PheMet: 1.882 ± 0.71
3.227PheAsn: 3.227 ± 1.16
2.42PhePro: 2.42 ± 0.33
2.689PheGln: 2.689 ± 0.899
1.613PheArg: 1.613 ± 0.389
2.42PheSer: 2.42 ± 0.668
1.882PheThr: 1.882 ± 1.604
2.42PheVal: 2.42 ± 0.668
0.0PheTrp: 0.0 ± 0.0
1.882PheTyr: 1.882 ± 0.698
0.0PheXaa: 0.0 ± 0.0
Gly
0.538GlyAla: 0.538 ± 0.304
0.807GlyCys: 0.807 ± 0.457
1.882GlyAsp: 1.882 ± 0.415
2.42GlyGlu: 2.42 ± 0.737
4.571GlyPhe: 4.571 ± 2.57
1.076GlyGly: 1.076 ± 0.474
0.0GlyHis: 0.0 ± 0.0
4.033GlyIle: 4.033 ± 0.75
5.647GlyLys: 5.647 ± 1.169
3.227GlyLeu: 3.227 ± 1.847
0.269GlyMet: 0.269 ± 0.152
3.496GlyAsn: 3.496 ± 1.63
0.269GlyPro: 0.269 ± 0.152
1.076GlyGln: 1.076 ± 0.609
1.613GlyArg: 1.613 ± 0.826
3.764GlySer: 3.764 ± 1.167
2.42GlyThr: 2.42 ± 2.272
1.076GlyVal: 1.076 ± 0.474
0.538GlyTrp: 0.538 ± 0.304
1.613GlyTyr: 1.613 ± 0.913
0.0GlyXaa: 0.0 ± 0.0
His
0.807HisAla: 0.807 ± 0.457
0.269HisCys: 0.269 ± 0.152
1.344HisAsp: 1.344 ± 0.842
1.344HisGlu: 1.344 ± 0.849
1.076HisPhe: 1.076 ± 0.609
1.613HisGly: 1.613 ± 0.483
0.269HisHis: 0.269 ± 0.152
1.076HisIle: 1.076 ± 0.46
1.344HisLys: 1.344 ± 0.761
3.496HisLeu: 3.496 ± 0.629
0.0HisMet: 0.0 ± 0.0
1.882HisAsn: 1.882 ± 0.429
1.076HisPro: 1.076 ± 0.474
0.269HisGln: 0.269 ± 0.152
0.0HisArg: 0.0 ± 0.0
1.613HisSer: 1.613 ± 0.535
1.344HisThr: 1.344 ± 0.761
1.076HisVal: 1.076 ± 0.499
0.0HisTrp: 0.0 ± 0.0
1.076HisTyr: 1.076 ± 0.728
0.0HisXaa: 0.0 ± 0.0
Ile
2.42IleAla: 2.42 ± 1.101
0.807IleCys: 0.807 ± 0.457
5.378IleAsp: 5.378 ± 0.942
5.109IleGlu: 5.109 ± 0.332
2.689IlePhe: 2.689 ± 0.548
1.613IleGly: 1.613 ± 0.419
1.344IleHis: 1.344 ± 0.539
3.764IleIle: 3.764 ± 1.745
7.26IleLys: 7.26 ± 1.775
6.453IleLeu: 6.453 ± 1.32
2.151IleMet: 2.151 ± 0.869
3.496IleAsn: 3.496 ± 0.497
2.958IlePro: 2.958 ± 0.52
3.496IleGln: 3.496 ± 0.912
2.689IleArg: 2.689 ± 1.062
6.722IleSer: 6.722 ± 1.083
4.571IleThr: 4.571 ± 0.476
5.378IleVal: 5.378 ± 1.335
0.807IleTrp: 0.807 ± 0.575
1.344IleTyr: 1.344 ± 0.485
0.0IleXaa: 0.0 ± 0.0
Lys
4.302LysAla: 4.302 ± 2.142
0.807LysCys: 0.807 ± 0.457
7.26LysAsp: 7.26 ± 0.404
8.067LysGlu: 8.067 ± 2.199
4.571LysPhe: 4.571 ± 0.918
3.496LysGly: 3.496 ± 2.034
1.882LysHis: 1.882 ± 1.072
8.336LysIle: 8.336 ± 0.829
8.604LysLys: 8.604 ± 1.655
8.336LysLeu: 8.336 ± 1.231
2.689LysMet: 2.689 ± 1.236
4.571LysAsn: 4.571 ± 0.801
2.958LysPro: 2.958 ± 0.828
3.496LysGln: 3.496 ± 0.804
4.571LysArg: 4.571 ± 0.585
4.571LysSer: 4.571 ± 1.449
6.453LysThr: 6.453 ± 1.419
3.764LysVal: 3.764 ± 0.645
1.344LysTrp: 1.344 ± 0.564
4.302LysTyr: 4.302 ± 1.083
0.0LysXaa: 0.0 ± 0.0
Leu
1.613LeuAla: 1.613 ± 0.535
1.344LeuCys: 1.344 ± 0.522
5.378LeuAsp: 5.378 ± 1.228
8.604LeuGlu: 8.604 ± 2.331
4.571LeuPhe: 4.571 ± 1.401
4.84LeuGly: 4.84 ± 0.597
1.344LeuHis: 1.344 ± 0.695
4.571LeuIle: 4.571 ± 0.741
11.562LeuLys: 11.562 ± 3.228
7.798LeuLeu: 7.798 ± 2.188
4.033LeuMet: 4.033 ± 1.031
5.916LeuAsn: 5.916 ± 1.777
3.764LeuPro: 3.764 ± 1.025
2.689LeuGln: 2.689 ± 0.201
4.571LeuArg: 4.571 ± 0.258
9.949LeuSer: 9.949 ± 1.62
10.487LeuThr: 10.487 ± 2.873
5.378LeuVal: 5.378 ± 0.691
0.269LeuTrp: 0.269 ± 0.152
2.689LeuTyr: 2.689 ± 0.712
0.0LeuXaa: 0.0 ± 0.0
Met
2.42MetAla: 2.42 ± 0.813
0.0MetCys: 0.0 ± 0.0
0.269MetAsp: 0.269 ± 0.152
1.882MetGlu: 1.882 ± 0.687
1.344MetPhe: 1.344 ± 0.761
1.076MetGly: 1.076 ± 0.38
0.269MetHis: 0.269 ± 0.152
2.958MetIle: 2.958 ± 0.647
3.227MetLys: 3.227 ± 0.553
1.344MetLeu: 1.344 ± 0.761
1.076MetMet: 1.076 ± 1.181
1.613MetAsn: 1.613 ± 0.572
1.613MetPro: 1.613 ± 0.783
0.807MetGln: 0.807 ± 0.457
1.076MetArg: 1.076 ± 0.474
2.151MetSer: 2.151 ± 0.349
1.882MetThr: 1.882 ± 0.698
0.807MetVal: 0.807 ± 0.575
0.0MetTrp: 0.0 ± 0.0
0.538MetTyr: 0.538 ± 0.695
0.0MetXaa: 0.0 ± 0.0
Asn
2.958AsnAla: 2.958 ± 2.12
2.958AsnCys: 2.958 ± 0.52
4.302AsnAsp: 4.302 ± 0.281
4.302AsnGlu: 4.302 ± 0.655
4.571AsnPhe: 4.571 ± 0.527
2.689AsnGly: 2.689 ± 1.175
2.151AsnHis: 2.151 ± 0.674
4.571AsnIle: 4.571 ± 1.706
5.109AsnLys: 5.109 ± 1.218
6.184AsnLeu: 6.184 ± 1.1
1.882AsnMet: 1.882 ± 0.757
4.84AsnAsn: 4.84 ± 2.17
1.613AsnPro: 1.613 ± 0.485
1.344AsnGln: 1.344 ± 0.539
0.538AsnArg: 0.538 ± 0.304
4.033AsnSer: 4.033 ± 0.552
2.958AsnThr: 2.958 ± 0.597
5.109AsnVal: 5.109 ± 0.984
0.807AsnTrp: 0.807 ± 0.575
3.764AsnTyr: 3.764 ± 0.493
0.0AsnXaa: 0.0 ± 0.0
Pro
0.807ProAla: 0.807 ± 1.083
0.807ProCys: 0.807 ± 0.575
1.076ProAsp: 1.076 ± 0.609
1.882ProGlu: 1.882 ± 0.429
1.344ProPhe: 1.344 ± 0.468
0.538ProGly: 0.538 ± 0.406
0.269ProHis: 0.269 ± 0.152
1.344ProIle: 1.344 ± 0.406
3.496ProLys: 3.496 ± 1.557
1.076ProLeu: 1.076 ± 0.474
1.344ProMet: 1.344 ± 0.761
2.42ProAsn: 2.42 ± 0.644
0.538ProPro: 0.538 ± 0.304
0.807ProGln: 0.807 ± 0.457
1.076ProArg: 1.076 ± 0.947
2.689ProSer: 2.689 ± 0.603
1.613ProThr: 1.613 ± 0.645
0.807ProVal: 0.807 ± 1.102
0.0ProTrp: 0.0 ± 0.0
1.344ProTyr: 1.344 ± 0.522
0.0ProXaa: 0.0 ± 0.0
Gln
1.613GlnAla: 1.613 ± 0.572
0.538GlnCys: 0.538 ± 0.712
1.344GlnAsp: 1.344 ± 0.636
2.689GlnGlu: 2.689 ± 0.749
0.807GlnPhe: 0.807 ± 0.457
1.344GlnGly: 1.344 ± 0.761
0.538GlnHis: 0.538 ± 0.304
2.42GlnIle: 2.42 ± 0.831
2.958GlnLys: 2.958 ± 0.774
4.571GlnLeu: 4.571 ± 1.491
1.076GlnMet: 1.076 ± 0.609
1.882GlnAsn: 1.882 ± 0.473
0.538GlnPro: 0.538 ± 0.304
0.538GlnGln: 0.538 ± 0.304
0.807GlnArg: 0.807 ± 0.457
3.496GlnSer: 3.496 ± 1.663
0.538GlnThr: 0.538 ± 0.304
3.227GlnVal: 3.227 ± 0.619
0.269GlnTrp: 0.269 ± 0.152
1.344GlnTyr: 1.344 ± 0.522
0.0GlnXaa: 0.0 ± 0.0
Arg
1.076ArgAla: 1.076 ± 0.474
0.538ArgCys: 0.538 ± 0.695
1.613ArgAsp: 1.613 ± 0.389
3.496ArgGlu: 3.496 ± 0.629
1.613ArgPhe: 1.613 ± 1.151
2.689ArgGly: 2.689 ± 1.958
0.538ArgHis: 0.538 ± 0.304
2.42ArgIle: 2.42 ± 0.478
3.496ArgLys: 3.496 ± 2.157
2.689ArgLeu: 2.689 ± 0.749
0.538ArgMet: 0.538 ± 0.304
2.151ArgAsn: 2.151 ± 0.513
0.807ArgPro: 0.807 ± 0.575
1.613ArgGln: 1.613 ± 0.572
2.42ArgArg: 2.42 ± 1.068
2.689ArgSer: 2.689 ± 0.746
2.689ArgThr: 2.689 ± 1.236
1.613ArgVal: 1.613 ± 0.389
0.0ArgTrp: 0.0 ± 0.0
0.807ArgTyr: 0.807 ± 0.412
0.0ArgXaa: 0.0 ± 0.0
Ser
3.496SerAla: 3.496 ± 1.294
2.151SerCys: 2.151 ± 0.473
4.302SerAsp: 4.302 ± 1.175
4.84SerGlu: 4.84 ± 0.998
4.302SerPhe: 4.302 ± 1.139
3.496SerGly: 3.496 ± 1.269
1.344SerHis: 1.344 ± 0.92
5.916SerIle: 5.916 ± 2.219
6.184SerLys: 6.184 ± 0.838
10.218SerLeu: 10.218 ± 0.917
1.344SerMet: 1.344 ± 0.842
6.184SerAsn: 6.184 ± 1.325
1.076SerPro: 1.076 ± 0.609
4.033SerGln: 4.033 ± 0.472
3.496SerArg: 3.496 ± 0.935
5.916SerSer: 5.916 ± 1.766
5.109SerThr: 5.109 ± 0.783
3.227SerVal: 3.227 ± 1.823
0.269SerTrp: 0.269 ± 0.152
4.033SerTyr: 4.033 ± 1.454
0.0SerXaa: 0.0 ± 0.0
Thr
2.689ThrAla: 2.689 ± 1.44
0.807ThrCys: 0.807 ± 0.457
3.227ThrAsp: 3.227 ± 0.416
3.764ThrGlu: 3.764 ± 1.021
3.496ThrPhe: 3.496 ± 0.321
1.882ThrGly: 1.882 ± 1.305
1.076ThrHis: 1.076 ± 0.609
5.378ThrIle: 5.378 ± 0.834
3.496ThrLys: 3.496 ± 0.335
6.722ThrLeu: 6.722 ± 1.023
0.807ThrMet: 0.807 ± 0.842
4.84ThrAsn: 4.84 ± 1.139
1.613ThrPro: 1.613 ± 0.572
1.613ThrGln: 1.613 ± 0.913
1.613ThrArg: 1.613 ± 1.237
5.109ThrSer: 5.109 ± 1.199
2.958ThrThr: 2.958 ± 1.026
3.496ThrVal: 3.496 ± 1.05
0.807ThrTrp: 0.807 ± 0.618
2.151ThrTyr: 2.151 ± 0.666
0.0ThrXaa: 0.0 ± 0.0
Val
2.958ValAla: 2.958 ± 1.416
0.807ValCys: 0.807 ± 0.457
2.689ValAsp: 2.689 ± 0.98
3.764ValGlu: 3.764 ± 1.396
1.344ValPhe: 1.344 ± 0.522
2.42ValGly: 2.42 ± 1.143
1.613ValHis: 1.613 ± 0.389
2.958ValIle: 2.958 ± 0.506
5.378ValLys: 5.378 ± 1.107
5.647ValLeu: 5.647 ± 1.461
1.076ValMet: 1.076 ± 0.418
4.571ValAsn: 4.571 ± 1.694
0.807ValPro: 0.807 ± 0.457
1.344ValGln: 1.344 ± 0.539
1.344ValArg: 1.344 ± 0.406
4.84ValSer: 4.84 ± 1.086
1.882ValThr: 1.882 ± 1.065
3.496ValVal: 3.496 ± 1.185
0.807ValTrp: 0.807 ± 0.457
3.764ValTyr: 3.764 ± 0.981
0.0ValXaa: 0.0 ± 0.0
Trp
0.269TrpAla: 0.269 ± 0.437
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.538TrpGlu: 0.538 ± 0.304
0.538TrpPhe: 0.538 ± 0.304
0.807TrpGly: 0.807 ± 0.457
0.0TrpHis: 0.0 ± 0.0
0.269TrpIle: 0.269 ± 0.152
0.807TrpLys: 0.807 ± 0.457
1.076TrpLeu: 1.076 ± 0.609
0.538TrpMet: 0.538 ± 0.347
0.538TrpAsn: 0.538 ± 0.712
0.269TrpPro: 0.269 ± 0.152
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.269TrpSer: 0.269 ± 0.152
0.807TrpThr: 0.807 ± 0.351
0.538TrpVal: 0.538 ± 0.695
0.0TrpTrp: 0.0 ± 0.0
0.807TrpTyr: 0.807 ± 0.618
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.076TyrAla: 1.076 ± 0.609
1.076TyrCys: 1.076 ± 0.551
3.764TyrAsp: 3.764 ± 1.394
3.764TyrGlu: 3.764 ± 1.008
1.344TyrPhe: 1.344 ± 0.522
1.882TyrGly: 1.882 ± 0.589
1.344TyrHis: 1.344 ± 0.406
2.689TyrIle: 2.689 ± 1.522
4.033TyrLys: 4.033 ± 0.825
3.496TyrLeu: 3.496 ± 1.283
1.613TyrMet: 1.613 ± 0.911
2.958TyrAsn: 2.958 ± 1.046
0.269TyrPro: 0.269 ± 0.152
0.538TyrGln: 0.538 ± 0.304
1.344TyrArg: 1.344 ± 0.92
4.571TyrSer: 4.571 ± 2.013
1.076TyrThr: 1.076 ± 0.947
2.151TyrVal: 2.151 ± 0.674
0.538TyrTrp: 0.538 ± 0.304
1.076TyrTyr: 1.076 ± 0.609
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (3720 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski