Amino acid dipepetide frequency for Mycobacterium phage Bipolar

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.15AlaAla: 14.15 ± 1.631
1.06AlaCys: 1.06 ± 0.271
7.579AlaAsp: 7.579 ± 0.576
7.208AlaGlu: 7.208 ± 0.848
2.915AlaPhe: 2.915 ± 0.378
9.645AlaGly: 9.645 ± 1.203
2.226AlaHis: 2.226 ± 0.339
4.452AlaIle: 4.452 ± 0.71
4.081AlaLys: 4.081 ± 0.451
7.95AlaLeu: 7.95 ± 0.761
2.544AlaMet: 2.544 ± 0.437
3.074AlaAsn: 3.074 ± 0.349
5.406AlaPro: 5.406 ± 0.575
3.71AlaGln: 3.71 ± 0.459
8.003AlaArg: 8.003 ± 0.787
5.141AlaSer: 5.141 ± 0.487
5.512AlaThr: 5.512 ± 0.616
7.102AlaVal: 7.102 ± 0.644
2.544AlaTrp: 2.544 ± 0.35
2.438AlaTyr: 2.438 ± 0.422
0.0AlaXaa: 0.0 ± 0.0
Cys
0.901CysAla: 0.901 ± 0.288
0.212CysCys: 0.212 ± 0.116
1.643CysAsp: 1.643 ± 0.332
0.53CysGlu: 0.53 ± 0.147
0.318CysPhe: 0.318 ± 0.121
1.484CysGly: 1.484 ± 0.307
0.159CysHis: 0.159 ± 0.091
0.212CysIle: 0.212 ± 0.137
0.477CysLys: 0.477 ± 0.151
0.848CysLeu: 0.848 ± 0.254
0.212CysMet: 0.212 ± 0.112
0.371CysAsn: 0.371 ± 0.144
1.007CysPro: 1.007 ± 0.274
0.371CysGln: 0.371 ± 0.142
0.742CysArg: 0.742 ± 0.205
0.583CysSer: 0.583 ± 0.159
0.636CysThr: 0.636 ± 0.167
0.477CysVal: 0.477 ± 0.155
0.371CysTrp: 0.371 ± 0.15
0.265CysTyr: 0.265 ± 0.12
0.0CysXaa: 0.0 ± 0.0
Asp
7.367AspAla: 7.367 ± 0.699
0.848AspCys: 0.848 ± 0.21
4.611AspAsp: 4.611 ± 0.484
3.551AspGlu: 3.551 ± 0.488
2.12AspPhe: 2.12 ± 0.285
7.155AspGly: 7.155 ± 0.554
1.484AspHis: 1.484 ± 0.297
2.597AspIle: 2.597 ± 0.317
2.014AspLys: 2.014 ± 0.306
5.724AspLeu: 5.724 ± 0.611
1.325AspMet: 1.325 ± 0.286
1.166AspAsn: 1.166 ± 0.255
4.134AspPro: 4.134 ± 0.509
2.438AspGln: 2.438 ± 0.283
5.035AspArg: 5.035 ± 0.569
3.869AspSer: 3.869 ± 0.506
4.134AspThr: 4.134 ± 0.496
4.929AspVal: 4.929 ± 0.558
1.219AspTrp: 1.219 ± 0.255
1.908AspTyr: 1.908 ± 0.303
0.0AspXaa: 0.0 ± 0.0
Glu
6.413GluAla: 6.413 ± 0.741
0.901GluCys: 0.901 ± 0.23
3.286GluAsp: 3.286 ± 0.408
3.021GluGlu: 3.021 ± 0.549
2.279GluPhe: 2.279 ± 0.344
3.18GluGly: 3.18 ± 0.434
1.431GluHis: 1.431 ± 0.363
2.279GluIle: 2.279 ± 0.387
2.173GluLys: 2.173 ± 0.358
4.77GluLeu: 4.77 ± 0.555
2.014GluMet: 2.014 ± 0.302
1.431GluAsn: 1.431 ± 0.256
2.915GluPro: 2.915 ± 0.47
3.18GluGln: 3.18 ± 0.452
4.929GluArg: 4.929 ± 0.569
2.756GluSer: 2.756 ± 0.438
4.77GluThr: 4.77 ± 0.645
4.293GluVal: 4.293 ± 0.415
1.696GluTrp: 1.696 ± 0.25
1.749GluTyr: 1.749 ± 0.281
0.0GluXaa: 0.0 ± 0.0
Phe
2.703PheAla: 2.703 ± 0.362
0.477PheCys: 0.477 ± 0.148
2.703PheAsp: 2.703 ± 0.413
1.855PheGlu: 1.855 ± 0.345
0.53PhePhe: 0.53 ± 0.169
2.544PheGly: 2.544 ± 0.506
0.583PheHis: 0.583 ± 0.164
1.378PheIle: 1.378 ± 0.302
0.901PheLys: 0.901 ± 0.208
1.961PheLeu: 1.961 ± 0.285
0.848PheMet: 0.848 ± 0.271
1.007PheAsn: 1.007 ± 0.32
1.378PhePro: 1.378 ± 0.319
0.901PheGln: 0.901 ± 0.282
1.431PheArg: 1.431 ± 0.277
1.113PheSer: 1.113 ± 0.28
2.332PheThr: 2.332 ± 0.359
2.173PheVal: 2.173 ± 0.282
0.583PheTrp: 0.583 ± 0.179
0.795PheTyr: 0.795 ± 0.238
0.0PheXaa: 0.0 ± 0.0
Gly
9.115GlyAla: 9.115 ± 1.114
1.007GlyCys: 1.007 ± 0.222
5.777GlyAsp: 5.777 ± 0.523
4.134GlyGlu: 4.134 ± 0.556
2.438GlyPhe: 2.438 ± 0.375
11.235GlyGly: 11.235 ± 1.896
1.696GlyHis: 1.696 ± 0.325
3.763GlyIle: 3.763 ± 0.514
2.809GlyLys: 2.809 ± 0.376
6.095GlyLeu: 6.095 ± 0.588
1.908GlyMet: 1.908 ± 0.364
2.65GlyAsn: 2.65 ± 0.421
3.657GlyPro: 3.657 ± 0.494
3.021GlyGln: 3.021 ± 0.549
5.777GlyArg: 5.777 ± 0.542
6.042GlySer: 6.042 ± 0.984
5.989GlyThr: 5.989 ± 0.71
5.83GlyVal: 5.83 ± 0.535
2.014GlyTrp: 2.014 ± 0.327
2.332GlyTyr: 2.332 ± 0.424
0.0GlyXaa: 0.0 ± 0.0
His
1.643HisAla: 1.643 ± 0.331
0.265HisCys: 0.265 ± 0.141
1.007HisAsp: 1.007 ± 0.204
1.219HisGlu: 1.219 ± 0.267
0.424HisPhe: 0.424 ± 0.149
2.067HisGly: 2.067 ± 0.391
0.954HisHis: 0.954 ± 0.252
1.484HisIle: 1.484 ± 0.236
0.795HisLys: 0.795 ± 0.208
1.378HisLeu: 1.378 ± 0.261
0.477HisMet: 0.477 ± 0.175
1.007HisAsn: 1.007 ± 0.19
1.696HisPro: 1.696 ± 0.302
0.742HisGln: 0.742 ± 0.213
2.173HisArg: 2.173 ± 0.369
0.795HisSer: 0.795 ± 0.186
1.166HisThr: 1.166 ± 0.235
1.537HisVal: 1.537 ± 0.274
0.53HisTrp: 0.53 ± 0.163
0.795HisTyr: 0.795 ± 0.215
0.0HisXaa: 0.0 ± 0.0
Ile
5.035IleAla: 5.035 ± 0.528
0.583IleCys: 0.583 ± 0.188
4.346IleAsp: 4.346 ± 0.439
3.816IleGlu: 3.816 ± 0.423
0.848IlePhe: 0.848 ± 0.178
3.657IleGly: 3.657 ± 0.427
1.113IleHis: 1.113 ± 0.243
1.272IleIle: 1.272 ± 0.3
0.901IleLys: 0.901 ± 0.203
2.332IleLeu: 2.332 ± 0.364
0.424IleMet: 0.424 ± 0.139
1.59IleAsn: 1.59 ± 0.282
3.18IlePro: 3.18 ± 0.466
1.325IleGln: 1.325 ± 0.293
2.862IleArg: 2.862 ± 0.496
1.643IleSer: 1.643 ± 0.455
4.293IleThr: 4.293 ± 0.571
2.968IleVal: 2.968 ± 0.261
0.636IleTrp: 0.636 ± 0.219
1.06IleTyr: 1.06 ± 0.199
0.0IleXaa: 0.0 ± 0.0
Lys
4.346LysAla: 4.346 ± 0.587
0.53LysCys: 0.53 ± 0.174
1.643LysAsp: 1.643 ± 0.286
1.431LysGlu: 1.431 ± 0.317
1.113LysPhe: 1.113 ± 0.248
2.597LysGly: 2.597 ± 0.441
1.06LysHis: 1.06 ± 0.286
1.113LysIle: 1.113 ± 0.24
1.802LysLys: 1.802 ± 0.464
2.756LysLeu: 2.756 ± 0.471
0.795LysMet: 0.795 ± 0.214
0.742LysAsn: 0.742 ± 0.183
2.597LysPro: 2.597 ± 0.481
1.325LysGln: 1.325 ± 0.303
2.491LysArg: 2.491 ± 0.354
2.438LysSer: 2.438 ± 0.309
2.438LysThr: 2.438 ± 0.313
2.968LysVal: 2.968 ± 0.438
0.848LysTrp: 0.848 ± 0.192
1.007LysTyr: 1.007 ± 0.253
0.0LysXaa: 0.0 ± 0.0
Leu
7.897LeuAla: 7.897 ± 0.782
0.689LeuCys: 0.689 ± 0.193
4.77LeuAsp: 4.77 ± 0.643
4.505LeuGlu: 4.505 ± 0.62
2.067LeuPhe: 2.067 ± 0.283
5.088LeuGly: 5.088 ± 0.615
1.219LeuHis: 1.219 ± 0.238
3.392LeuIle: 3.392 ± 0.524
2.226LeuLys: 2.226 ± 0.327
5.088LeuLeu: 5.088 ± 0.501
1.961LeuMet: 1.961 ± 0.314
2.65LeuAsn: 2.65 ± 0.338
5.035LeuPro: 5.035 ± 0.701
2.597LeuGln: 2.597 ± 0.451
5.088LeuArg: 5.088 ± 0.695
5.035LeuSer: 5.035 ± 0.548
5.618LeuThr: 5.618 ± 0.592
4.664LeuVal: 4.664 ± 0.464
1.643LeuTrp: 1.643 ± 0.314
2.014LeuTyr: 2.014 ± 0.373
0.0LeuXaa: 0.0 ± 0.0
Met
2.597MetAla: 2.597 ± 0.47
0.106MetCys: 0.106 ± 0.087
1.219MetAsp: 1.219 ± 0.275
1.06MetGlu: 1.06 ± 0.234
0.636MetPhe: 0.636 ± 0.206
1.484MetGly: 1.484 ± 0.269
0.159MetHis: 0.159 ± 0.109
1.007MetIle: 1.007 ± 0.25
0.689MetLys: 0.689 ± 0.255
1.696MetLeu: 1.696 ± 0.27
0.636MetMet: 0.636 ± 0.229
0.848MetAsn: 0.848 ± 0.202
1.431MetPro: 1.431 ± 0.265
0.53MetGln: 0.53 ± 0.139
1.855MetArg: 1.855 ± 0.311
2.703MetSer: 2.703 ± 0.377
2.12MetThr: 2.12 ± 0.298
1.272MetVal: 1.272 ± 0.318
0.265MetTrp: 0.265 ± 0.112
0.583MetTyr: 0.583 ± 0.22
0.0MetXaa: 0.0 ± 0.0
Asn
3.127AsnAla: 3.127 ± 0.401
0.159AsnCys: 0.159 ± 0.093
1.643AsnAsp: 1.643 ± 0.224
1.802AsnGlu: 1.802 ± 0.334
0.583AsnPhe: 0.583 ± 0.187
4.399AsnGly: 4.399 ± 0.61
0.954AsnHis: 0.954 ± 0.187
1.59AsnIle: 1.59 ± 0.363
1.007AsnLys: 1.007 ± 0.201
2.544AsnLeu: 2.544 ± 0.364
0.318AsnMet: 0.318 ± 0.105
1.484AsnAsn: 1.484 ± 0.33
2.332AsnPro: 2.332 ± 0.377
1.166AsnGln: 1.166 ± 0.334
1.908AsnArg: 1.908 ± 0.287
1.219AsnSer: 1.219 ± 0.281
2.385AsnThr: 2.385 ± 0.318
1.961AsnVal: 1.961 ± 0.327
0.742AsnTrp: 0.742 ± 0.157
0.583AsnTyr: 0.583 ± 0.123
0.0AsnXaa: 0.0 ± 0.0
Pro
5.247ProAla: 5.247 ± 0.576
0.689ProCys: 0.689 ± 0.187
4.134ProAsp: 4.134 ± 0.43
4.134ProGlu: 4.134 ± 0.44
1.855ProPhe: 1.855 ± 0.303
6.148ProGly: 6.148 ± 0.642
1.696ProHis: 1.696 ± 0.303
2.279ProIle: 2.279 ± 0.335
2.226ProLys: 2.226 ± 0.416
4.399ProLeu: 4.399 ± 0.453
1.431ProMet: 1.431 ± 0.337
1.696ProAsn: 1.696 ± 0.231
3.127ProPro: 3.127 ± 0.407
1.961ProGln: 1.961 ± 0.307
3.763ProArg: 3.763 ± 0.574
2.809ProSer: 2.809 ± 0.294
3.445ProThr: 3.445 ± 0.471
4.399ProVal: 4.399 ± 0.478
0.954ProTrp: 0.954 ± 0.222
1.431ProTyr: 1.431 ± 0.282
0.0ProXaa: 0.0 ± 0.0
Gln
4.611GlnAla: 4.611 ± 0.558
0.424GlnCys: 0.424 ± 0.165
1.537GlnAsp: 1.537 ± 0.27
1.749GlnGlu: 1.749 ± 0.339
1.219GlnPhe: 1.219 ± 0.263
2.014GlnGly: 2.014 ± 0.401
0.583GlnHis: 0.583 ± 0.175
1.855GlnIle: 1.855 ± 0.314
1.59GlnLys: 1.59 ± 0.3
3.498GlnLeu: 3.498 ± 0.483
0.689GlnMet: 0.689 ± 0.22
0.901GlnAsn: 0.901 ± 0.329
2.65GlnPro: 2.65 ± 0.387
1.272GlnGln: 1.272 ± 0.264
2.226GlnArg: 2.226 ± 0.32
2.014GlnSer: 2.014 ± 0.324
1.643GlnThr: 1.643 ± 0.28
3.074GlnVal: 3.074 ± 0.358
0.742GlnTrp: 0.742 ± 0.176
0.636GlnTyr: 0.636 ± 0.237
0.0GlnXaa: 0.0 ± 0.0
Arg
6.307ArgAla: 6.307 ± 0.69
1.166ArgCys: 1.166 ± 0.327
4.77ArgAsp: 4.77 ± 0.552
4.558ArgGlu: 4.558 ± 0.561
2.067ArgPhe: 2.067 ± 0.339
4.24ArgGly: 4.24 ± 0.445
1.484ArgHis: 1.484 ± 0.341
3.71ArgIle: 3.71 ± 0.498
3.233ArgLys: 3.233 ± 0.5
5.088ArgLeu: 5.088 ± 0.531
2.226ArgMet: 2.226 ± 0.349
2.65ArgAsn: 2.65 ± 0.359
3.498ArgPro: 3.498 ± 0.441
2.226ArgGln: 2.226 ± 0.447
6.042ArgArg: 6.042 ± 0.869
3.975ArgSer: 3.975 ± 0.368
3.498ArgThr: 3.498 ± 0.468
5.671ArgVal: 5.671 ± 0.697
1.855ArgTrp: 1.855 ± 0.304
1.855ArgTyr: 1.855 ± 0.336
0.0ArgXaa: 0.0 ± 0.0
Ser
5.83SerAla: 5.83 ± 0.865
0.318SerCys: 0.318 ± 0.123
3.922SerAsp: 3.922 ± 0.518
3.074SerGlu: 3.074 ± 0.464
1.696SerPhe: 1.696 ± 0.288
6.148SerGly: 6.148 ± 0.824
1.166SerHis: 1.166 ± 0.25
2.65SerIle: 2.65 ± 0.329
2.703SerLys: 2.703 ± 0.414
4.028SerLeu: 4.028 ± 0.421
1.484SerMet: 1.484 ± 0.286
2.014SerAsn: 2.014 ± 0.36
3.127SerPro: 3.127 ± 0.34
1.696SerGln: 1.696 ± 0.294
3.657SerArg: 3.657 ± 0.41
3.816SerSer: 3.816 ± 0.516
3.127SerThr: 3.127 ± 0.444
4.452SerVal: 4.452 ± 0.476
1.431SerTrp: 1.431 ± 0.216
1.007SerTyr: 1.007 ± 0.169
0.0SerXaa: 0.0 ± 0.0
Thr
6.572ThrAla: 6.572 ± 0.613
0.795ThrCys: 0.795 ± 0.231
4.452ThrAsp: 4.452 ± 0.581
3.71ThrGlu: 3.71 ± 0.454
1.537ThrPhe: 1.537 ± 0.231
6.095ThrGly: 6.095 ± 0.702
1.643ThrHis: 1.643 ± 0.293
3.763ThrIle: 3.763 ± 0.572
2.014ThrLys: 2.014 ± 0.28
3.975ThrLeu: 3.975 ± 0.458
1.166ThrMet: 1.166 ± 0.257
2.438ThrAsn: 2.438 ± 0.36
4.505ThrPro: 4.505 ± 0.515
2.12ThrGln: 2.12 ± 0.293
3.392ThrArg: 3.392 ± 0.387
4.558ThrSer: 4.558 ± 0.583
5.035ThrThr: 5.035 ± 0.581
5.883ThrVal: 5.883 ± 0.613
1.219ThrTrp: 1.219 ± 0.306
1.961ThrTyr: 1.961 ± 0.369
0.0ThrXaa: 0.0 ± 0.0
Val
8.268ValAla: 8.268 ± 0.547
1.113ValCys: 1.113 ± 0.259
5.141ValAsp: 5.141 ± 0.545
4.982ValGlu: 4.982 ± 0.588
2.014ValPhe: 2.014 ± 0.327
5.406ValGly: 5.406 ± 0.617
1.219ValHis: 1.219 ± 0.271
3.127ValIle: 3.127 ± 0.441
2.756ValLys: 2.756 ± 0.351
4.982ValLeu: 4.982 ± 0.623
1.325ValMet: 1.325 ± 0.267
2.65ValAsn: 2.65 ± 0.424
3.869ValPro: 3.869 ± 0.417
2.544ValGln: 2.544 ± 0.394
4.611ValArg: 4.611 ± 0.583
4.823ValSer: 4.823 ± 0.591
5.406ValThr: 5.406 ± 0.628
6.519ValVal: 6.519 ± 0.599
1.908ValTrp: 1.908 ± 0.28
1.537ValTyr: 1.537 ± 0.296
0.0ValXaa: 0.0 ± 0.0
Trp
1.961TrpAla: 1.961 ± 0.335
0.212TrpCys: 0.212 ± 0.1
1.855TrpAsp: 1.855 ± 0.287
0.954TrpGlu: 0.954 ± 0.282
0.795TrpPhe: 0.795 ± 0.203
0.901TrpGly: 0.901 ± 0.197
0.583TrpHis: 0.583 ± 0.172
0.954TrpIle: 0.954 ± 0.213
0.795TrpLys: 0.795 ± 0.195
2.279TrpLeu: 2.279 ± 0.387
0.848TrpMet: 0.848 ± 0.2
0.53TrpAsn: 0.53 ± 0.152
0.954TrpPro: 0.954 ± 0.238
1.007TrpGln: 1.007 ± 0.255
2.014TrpArg: 2.014 ± 0.367
1.219TrpSer: 1.219 ± 0.234
1.431TrpThr: 1.431 ± 0.274
1.908TrpVal: 1.908 ± 0.366
0.901TrpTrp: 0.901 ± 0.209
0.424TrpTyr: 0.424 ± 0.146
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.65TyrAla: 2.65 ± 0.343
0.265TyrCys: 0.265 ± 0.117
1.59TyrAsp: 1.59 ± 0.349
2.173TyrGlu: 2.173 ± 0.309
0.742TyrPhe: 0.742 ± 0.208
1.802TyrGly: 1.802 ± 0.445
0.742TyrHis: 0.742 ± 0.204
1.007TyrIle: 1.007 ± 0.224
0.848TyrLys: 0.848 ± 0.228
1.855TyrLeu: 1.855 ± 0.316
0.212TyrMet: 0.212 ± 0.102
1.007TyrAsn: 1.007 ± 0.25
1.325TyrPro: 1.325 ± 0.227
0.848TyrGln: 0.848 ± 0.24
2.12TyrArg: 2.12 ± 0.353
0.795TyrSer: 0.795 ± 0.198
1.855TyrThr: 1.855 ± 0.354
2.12TyrVal: 2.12 ± 0.295
0.424TyrTrp: 0.424 ± 0.154
0.636TyrTyr: 0.636 ± 0.115
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 106 proteins (18870 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski