Amino acid dipepetide frequency for Eikenella longinqua

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.474AlaAla: 18.474 ± 0.346
1.32AlaCys: 1.32 ± 0.049
6.765AlaAsp: 6.765 ± 0.128
8.706AlaGlu: 8.706 ± 0.154
3.887AlaPhe: 3.887 ± 0.09
8.965AlaGly: 8.965 ± 0.146
2.423AlaHis: 2.423 ± 0.073
4.523AlaIle: 4.523 ± 0.105
4.614AlaLys: 4.614 ± 0.098
12.141AlaLeu: 12.141 ± 0.167
2.6AlaMet: 2.6 ± 0.07
3.436AlaAsn: 3.436 ± 0.086
4.68AlaPro: 4.68 ± 0.114
5.771AlaGln: 5.771 ± 0.112
6.395AlaArg: 6.395 ± 0.113
4.735AlaSer: 4.735 ± 0.104
4.031AlaThr: 4.031 ± 0.082
8.581AlaVal: 8.581 ± 0.14
1.521AlaTrp: 1.521 ± 0.058
2.967AlaTyr: 2.967 ± 0.073
0.0AlaXaa: 0.0 ± 0.0
Cys
1.134CysAla: 1.134 ± 0.045
0.174CysCys: 0.174 ± 0.016
0.469CysAsp: 0.469 ± 0.028
0.534CysGlu: 0.534 ± 0.034
0.373CysPhe: 0.373 ± 0.024
1.154CysGly: 1.154 ± 0.042
0.341CysHis: 0.341 ± 0.021
0.483CysIle: 0.483 ± 0.033
0.283CysLys: 0.283 ± 0.023
1.05CysLeu: 1.05 ± 0.047
0.201CysMet: 0.201 ± 0.017
0.348CysAsn: 0.348 ± 0.025
0.575CysPro: 0.575 ± 0.034
0.375CysGln: 0.375 ± 0.025
0.851CysArg: 0.851 ± 0.036
0.523CysSer: 0.523 ± 0.028
0.52CysThr: 0.52 ± 0.028
0.626CysVal: 0.626 ± 0.031
0.124CysTrp: 0.124 ± 0.013
0.343CysTyr: 0.343 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
4.793AspAla: 4.793 ± 0.085
0.512AspCys: 0.512 ± 0.034
2.276AspAsp: 2.276 ± 0.08
3.105AspGlu: 3.105 ± 0.079
2.397AspPhe: 2.397 ± 0.063
3.649AspGly: 3.649 ± 0.087
0.89AspHis: 0.89 ± 0.037
3.161AspIle: 3.161 ± 0.077
2.162AspLys: 2.162 ± 0.068
4.779AspLeu: 4.779 ± 0.105
1.286AspMet: 1.286 ± 0.041
1.869AspAsn: 1.869 ± 0.061
1.978AspPro: 1.978 ± 0.062
1.384AspGln: 1.384 ± 0.052
2.249AspArg: 2.249 ± 0.065
2.737AspSer: 2.737 ± 0.065
2.689AspThr: 2.689 ± 0.077
3.118AspVal: 3.118 ± 0.082
0.95AspTrp: 0.95 ± 0.044
1.937AspTyr: 1.937 ± 0.062
0.0AspXaa: 0.0 ± 0.0
Glu
6.985GluAla: 6.985 ± 0.126
0.525GluCys: 0.525 ± 0.028
2.332GluAsp: 2.332 ± 0.063
3.492GluGlu: 3.492 ± 0.093
2.027GluPhe: 2.027 ± 0.068
3.555GluGly: 3.555 ± 0.081
1.751GluHis: 1.751 ± 0.056
3.591GluIle: 3.591 ± 0.098
2.737GluLys: 2.737 ± 0.075
5.961GluLeu: 5.961 ± 0.116
1.627GluMet: 1.627 ± 0.051
2.443GluAsn: 2.443 ± 0.075
2.409GluPro: 2.409 ± 0.072
3.787GluGln: 3.787 ± 0.089
4.114GluArg: 4.114 ± 0.083
2.559GluSer: 2.559 ± 0.066
2.943GluThr: 2.943 ± 0.073
3.49GluVal: 3.49 ± 0.091
0.844GluTrp: 0.844 ± 0.04
1.548GluTyr: 1.548 ± 0.051
0.0GluXaa: 0.0 ± 0.0
Phe
4.914PheAla: 4.914 ± 0.102
0.489PheCys: 0.489 ± 0.031
2.448PheAsp: 2.448 ± 0.058
1.968PheGlu: 1.968 ± 0.056
1.524PhePhe: 1.524 ± 0.059
3.598PheGly: 3.598 ± 0.08
0.849PheHis: 0.849 ± 0.044
1.949PheIle: 1.949 ± 0.061
1.349PheLys: 1.349 ± 0.046
3.393PheLeu: 3.393 ± 0.084
0.849PheMet: 0.849 ± 0.037
1.471PheAsn: 1.471 ± 0.06
1.592PhePro: 1.592 ± 0.048
1.413PheGln: 1.413 ± 0.049
1.94PheArg: 1.94 ± 0.06
2.474PheSer: 2.474 ± 0.069
1.983PheThr: 1.983 ± 0.066
2.612PheVal: 2.612 ± 0.068
0.598PheTrp: 0.598 ± 0.038
1.214PheTyr: 1.214 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
6.585GlyAla: 6.585 ± 0.13
0.929GlyCys: 0.929 ± 0.038
3.182GlyAsp: 3.182 ± 0.079
4.563GlyGlu: 4.563 ± 0.089
3.379GlyPhe: 3.379 ± 0.09
6.303GlyGly: 6.303 ± 0.124
1.782GlyHis: 1.782 ± 0.059
4.815GlyIle: 4.815 ± 0.091
4.261GlyLys: 4.261 ± 0.09
7.817GlyLeu: 7.817 ± 0.132
2.259GlyMet: 2.259 ± 0.068
2.781GlyAsn: 2.781 ± 0.081
1.347GlyPro: 1.347 ± 0.043
3.565GlyGln: 3.565 ± 0.084
5.05GlyArg: 5.05 ± 0.106
5.361GlySer: 5.361 ± 0.106
3.332GlyThr: 3.332 ± 0.084
5.008GlyVal: 5.008 ± 0.113
1.367GlyTrp: 1.367 ± 0.053
2.58GlyTyr: 2.58 ± 0.072
0.0GlyXaa: 0.0 ± 0.0
His
2.399HisAla: 2.399 ± 0.064
0.293HisCys: 0.293 ± 0.021
1.13HisAsp: 1.13 ± 0.044
1.228HisGlu: 1.228 ± 0.046
0.991HisPhe: 0.991 ± 0.041
2.193HisGly: 2.193 ± 0.057
0.772HisHis: 0.772 ± 0.039
1.676HisIle: 1.676 ± 0.051
0.883HisLys: 0.883 ± 0.036
2.436HisLeu: 2.436 ± 0.08
0.496HisMet: 0.496 ± 0.028
0.859HisAsn: 0.859 ± 0.041
1.545HisPro: 1.545 ± 0.06
0.996HisGln: 0.996 ± 0.039
1.451HisArg: 1.451 ± 0.054
1.431HisSer: 1.431 ± 0.051
1.592HisThr: 1.592 ± 0.059
1.081HisVal: 1.081 ± 0.048
0.36HisTrp: 0.36 ± 0.024
0.846HisTyr: 0.846 ± 0.043
0.0HisXaa: 0.0 ± 0.0
Ile
6.041IleAla: 6.041 ± 0.121
0.559IleCys: 0.559 ± 0.031
3.118IleAsp: 3.118 ± 0.088
3.313IleGlu: 3.313 ± 0.091
1.63IlePhe: 1.63 ± 0.055
4.73IleGly: 4.73 ± 0.105
1.17IleHis: 1.17 ± 0.043
2.769IleIle: 2.769 ± 0.068
2.032IleLys: 2.032 ± 0.07
4.941IleLeu: 4.941 ± 0.107
1.142IleMet: 1.142 ± 0.047
2.107IleAsn: 2.107 ± 0.053
2.46IlePro: 2.46 ± 0.058
1.976IleGln: 1.976 ± 0.062
3.448IleArg: 3.448 ± 0.083
2.837IleSer: 2.837 ± 0.078
2.878IleThr: 2.878 ± 0.069
3.42IleVal: 3.42 ± 0.091
0.544IleTrp: 0.544 ± 0.032
1.25IleTyr: 1.25 ± 0.051
0.0IleXaa: 0.0 ± 0.0
Lys
3.995LysAla: 3.995 ± 0.093
0.208LysCys: 0.208 ± 0.021
1.758LysAsp: 1.758 ± 0.053
2.205LysGlu: 2.205 ± 0.078
1.118LysPhe: 1.118 ± 0.045
2.554LysGly: 2.554 ± 0.069
1.038LysHis: 1.038 ± 0.047
2.482LysIle: 2.482 ± 0.071
1.84LysLys: 1.84 ± 0.068
4.581LysLeu: 4.581 ± 0.087
1.173LysMet: 1.173 ± 0.05
1.616LysAsn: 1.616 ± 0.055
2.399LysPro: 2.399 ± 0.082
2.389LysGln: 2.389 ± 0.063
2.467LysArg: 2.467 ± 0.072
1.906LysSer: 1.906 ± 0.063
2.389LysThr: 2.389 ± 0.066
2.479LysVal: 2.479 ± 0.067
0.423LysTrp: 0.423 ± 0.025
1.079LysTyr: 1.079 ± 0.051
0.0LysXaa: 0.0 ± 0.0
Leu
13.613LeuAla: 13.613 ± 0.187
1.192LeuCys: 1.192 ± 0.042
5.127LeuAsp: 5.127 ± 0.098
5.149LeuGlu: 5.149 ± 0.105
4.167LeuPhe: 4.167 ± 0.096
7.62LeuGly: 7.62 ± 0.135
2.682LeuHis: 2.682 ± 0.083
4.999LeuIle: 4.999 ± 0.097
4.3LeuLys: 4.3 ± 0.092
12.327LeuLeu: 12.327 ± 0.247
2.498LeuMet: 2.498 ± 0.072
3.864LeuAsn: 3.864 ± 0.086
7.39LeuPro: 7.39 ± 0.125
4.827LeuGln: 4.827 ± 0.109
6.262LeuArg: 6.262 ± 0.11
6.484LeuSer: 6.484 ± 0.105
4.852LeuThr: 4.852 ± 0.098
6.206LeuVal: 6.206 ± 0.125
1.446LeuTrp: 1.446 ± 0.068
2.648LeuTyr: 2.648 ± 0.066
0.002LeuXaa: 0.002 ± 0.002
Met
2.559MetAla: 2.559 ± 0.068
0.198MetCys: 0.198 ± 0.017
0.953MetAsp: 0.953 ± 0.043
1.074MetGlu: 1.074 ± 0.048
0.841MetPhe: 0.841 ± 0.037
1.661MetGly: 1.661 ± 0.061
0.501MetHis: 0.501 ± 0.03
1.047MetIle: 1.047 ± 0.043
1.255MetLys: 1.255 ± 0.047
2.723MetLeu: 2.723 ± 0.083
0.718MetMet: 0.718 ± 0.037
0.989MetAsn: 0.989 ± 0.042
1.436MetPro: 1.436 ± 0.049
1.395MetGln: 1.395 ± 0.049
1.492MetArg: 1.492 ± 0.052
1.517MetSer: 1.517 ± 0.053
1.178MetThr: 1.178 ± 0.048
1.637MetVal: 1.637 ± 0.062
0.268MetTrp: 0.268 ± 0.022
0.512MetTyr: 0.512 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
3.419AsnAla: 3.419 ± 0.089
0.358AsnCys: 0.358 ± 0.026
1.478AsnAsp: 1.478 ± 0.055
1.939AsnGlu: 1.939 ± 0.068
1.17AsnPhe: 1.17 ± 0.043
3.2AsnGly: 3.2 ± 0.095
0.856AsnHis: 0.856 ± 0.037
2.293AsnIle: 2.293 ± 0.063
1.318AsnLys: 1.318 ± 0.05
3.456AsnLeu: 3.456 ± 0.083
0.847AsnMet: 0.847 ± 0.034
1.251AsnAsn: 1.251 ± 0.059
2.428AsnPro: 2.428 ± 0.067
1.555AsnGln: 1.555 ± 0.057
2.322AsnArg: 2.322 ± 0.068
1.683AsnSer: 1.683 ± 0.053
1.806AsnThr: 1.806 ± 0.068
2.257AsnVal: 2.257 ± 0.07
0.471AsnTrp: 0.471 ± 0.029
0.943AsnTyr: 0.943 ± 0.044
0.0AsnXaa: 0.0 ± 0.0
Pro
6.598ProAla: 6.598 ± 0.139
0.38ProCys: 0.38 ± 0.026
2.818ProAsp: 2.818 ± 0.069
4.414ProGlu: 4.414 ± 0.107
1.981ProPhe: 1.981 ± 0.058
2.905ProGly: 2.905 ± 0.074
1.299ProHis: 1.299 ± 0.054
2.06ProIle: 2.06 ± 0.061
1.84ProLys: 1.84 ± 0.064
4.927ProLeu: 4.927 ± 0.094
0.974ProMet: 0.974 ± 0.041
1.751ProAsn: 1.751 ± 0.057
2.454ProPro: 2.454 ± 0.088
2.829ProGln: 2.829 ± 0.073
2.131ProArg: 2.131 ± 0.06
2.124ProSer: 2.124 ± 0.06
2.032ProThr: 2.032 ± 0.061
3.567ProVal: 3.567 ± 0.082
0.5ProTrp: 0.5 ± 0.032
1.321ProTyr: 1.321 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
6.52GlnAla: 6.52 ± 0.131
0.353GlnCys: 0.353 ± 0.027
1.973GlnAsp: 1.973 ± 0.063
2.462GlnGlu: 2.462 ± 0.073
1.62GlnPhe: 1.62 ± 0.052
3.362GlnGly: 3.362 ± 0.078
1.517GlnHis: 1.517 ± 0.057
2.691GlnIle: 2.691 ± 0.06
1.783GlnLys: 1.783 ± 0.044
4.394GlnLeu: 4.394 ± 0.09
1.19GlnMet: 1.19 ± 0.046
1.797GlnAsn: 1.797 ± 0.059
2.74GlnPro: 2.74 ± 0.087
3.269GlnGln: 3.269 ± 0.116
3.11GlnArg: 3.11 ± 0.076
2.673GlnSer: 2.673 ± 0.065
2.82GlnThr: 2.82 ± 0.063
3.032GlnVal: 3.032 ± 0.075
0.754GlnTrp: 0.754 ± 0.04
1.407GlnTyr: 1.407 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
5.85ArgAla: 5.85 ± 0.121
0.537ArgCys: 0.537 ± 0.029
2.682ArgAsp: 2.682 ± 0.079
3.816ArgGlu: 3.816 ± 0.085
2.905ArgPhe: 2.905 ± 0.081
3.683ArgGly: 3.683 ± 0.085
2.007ArgHis: 2.007 ± 0.057
3.448ArgIle: 3.448 ± 0.083
2.286ArgLys: 2.286 ± 0.075
7.574ArgLeu: 7.574 ± 0.127
1.557ArgMet: 1.557 ± 0.05
2.065ArgAsn: 2.065 ± 0.067
2.721ArgPro: 2.721 ± 0.069
4.07ArgGln: 4.07 ± 0.104
4.82ArgArg: 4.82 ± 0.104
3.183ArgSer: 3.183 ± 0.082
2.459ArgThr: 2.459 ± 0.072
3.553ArgVal: 3.553 ± 0.074
0.81ArgTrp: 0.81 ± 0.045
2.066ArgTyr: 2.066 ± 0.063
0.0ArgXaa: 0.0 ± 0.0
Ser
5.526SerAla: 5.526 ± 0.114
0.523SerCys: 0.523 ± 0.032
2.24SerAsp: 2.24 ± 0.063
2.766SerGlu: 2.766 ± 0.079
2.085SerPhe: 2.085 ± 0.064
5.618SerGly: 5.618 ± 0.098
1.286SerHis: 1.286 ± 0.044
2.721SerIle: 2.721 ± 0.061
1.911SerLys: 1.911 ± 0.059
5.915SerLeu: 5.915 ± 0.109
1.125SerMet: 1.125 ± 0.043
1.671SerAsn: 1.671 ± 0.06
2.825SerPro: 2.825 ± 0.08
2.382SerGln: 2.382 ± 0.067
3.645SerArg: 3.645 ± 0.078
2.887SerSer: 2.887 ± 0.083
2.336SerThr: 2.336 ± 0.069
3.63SerVal: 3.63 ± 0.086
0.675SerTrp: 0.675 ± 0.03
1.506SerTyr: 1.506 ± 0.055
0.0SerXaa: 0.0 ± 0.0
Thr
5.826ThrAla: 5.826 ± 0.118
0.435ThrCys: 0.435 ± 0.032
2.402ThrAsp: 2.402 ± 0.068
2.607ThrGlu: 2.607 ± 0.064
1.637ThrPhe: 1.637 ± 0.055
3.761ThrGly: 3.761 ± 0.084
1.061ThrHis: 1.061 ± 0.045
2.399ThrIle: 2.399 ± 0.068
1.323ThrLys: 1.323 ± 0.053
5.777ThrLeu: 5.777 ± 0.09
0.919ThrMet: 0.919 ± 0.039
1.357ThrAsn: 1.357 ± 0.062
3.049ThrPro: 3.049 ± 0.068
1.903ThrGln: 1.903 ± 0.066
2.648ThrArg: 2.648 ± 0.071
1.894ThrSer: 1.894 ± 0.059
2.063ThrThr: 2.063 ± 0.063
3.727ThrVal: 3.727 ± 0.087
0.464ThrTrp: 0.464 ± 0.028
1.115ThrTyr: 1.115 ± 0.046
0.0ThrXaa: 0.0 ± 0.0
Val
7.18ValAla: 7.18 ± 0.121
0.929ValCys: 0.929 ± 0.04
2.868ValAsp: 2.868 ± 0.076
3.466ValGlu: 3.466 ± 0.083
2.904ValPhe: 2.904 ± 0.084
4.615ValGly: 4.615 ± 0.097
1.354ValHis: 1.354 ± 0.045
3.34ValIle: 3.34 ± 0.071
2.648ValLys: 2.648 ± 0.069
7.691ValLeu: 7.691 ± 0.131
1.695ValMet: 1.695 ± 0.058
2.138ValAsn: 2.138 ± 0.074
2.979ValPro: 2.979 ± 0.073
2.644ValGln: 2.644 ± 0.08
4.237ValArg: 4.237 ± 0.092
4.216ValSer: 4.216 ± 0.086
2.506ValThr: 2.506 ± 0.077
4.745ValVal: 4.745 ± 0.104
1.054ValTrp: 1.054 ± 0.041
1.951ValTyr: 1.951 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
1.183TrpAla: 1.183 ± 0.047
0.172TrpCys: 0.172 ± 0.018
0.471TrpAsp: 0.471 ± 0.025
0.554TrpGlu: 0.554 ± 0.034
0.65TrpPhe: 0.65 ± 0.038
0.847TrpGly: 0.847 ± 0.04
0.416TrpHis: 0.416 ± 0.029
0.588TrpIle: 0.588 ± 0.033
0.448TrpLys: 0.448 ± 0.031
2.39TrpLeu: 2.39 ± 0.093
0.307TrpMet: 0.307 ± 0.024
0.344TrpAsn: 0.344 ± 0.027
0.523TrpPro: 0.523 ± 0.031
1.437TrpGln: 1.437 ± 0.057
1.113TrpArg: 1.113 ± 0.054
0.558TrpSer: 0.558 ± 0.035
0.44TrpThr: 0.44 ± 0.027
0.82TrpVal: 0.82 ± 0.04
0.24TrpTrp: 0.24 ± 0.021
0.38TrpTyr: 0.38 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.943TyrAla: 2.943 ± 0.075
0.394TyrCys: 0.394 ± 0.027
1.427TyrAsp: 1.427 ± 0.053
1.362TyrGlu: 1.362 ± 0.049
1.342TyrPhe: 1.342 ± 0.045
2.292TyrGly: 2.292 ± 0.064
0.663TyrHis: 0.663 ± 0.034
1.333TyrIle: 1.333 ± 0.044
0.825TyrLys: 0.825 ± 0.046
3.379TyrLeu: 3.379 ± 0.085
0.488TyrMet: 0.488 ± 0.028
0.892TyrAsn: 0.892 ± 0.04
1.378TyrPro: 1.378 ± 0.043
1.499TyrGln: 1.499 ± 0.052
2.344TyrArg: 2.344 ± 0.075
1.49TyrSer: 1.49 ± 0.053
1.517TyrThr: 1.517 ± 0.046
1.57TyrVal: 1.57 ± 0.058
0.472TyrTrp: 0.472 ± 0.034
0.91TyrTyr: 0.91 ± 0.045
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.002XaaLys: 0.002 ± 0.002
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2055 proteins (586508 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski