Amino acid dipepetide frequency for Salinibacterium sp. dk2585

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.564AlaAla: 18.564 ± 0.22
0.625AlaCys: 0.625 ± 0.027
7.085AlaAsp: 7.085 ± 0.11
8.393AlaGlu: 8.393 ± 0.129
3.763AlaPhe: 3.763 ± 0.076
11.321AlaGly: 11.321 ± 0.137
2.276AlaHis: 2.276 ± 0.058
6.409AlaIle: 6.409 ± 0.092
2.97AlaLys: 2.97 ± 0.074
13.461AlaLeu: 13.461 ± 0.165
2.79AlaMet: 2.79 ± 0.053
2.582AlaAsn: 2.582 ± 0.052
6.065AlaPro: 6.065 ± 0.101
3.611AlaGln: 3.611 ± 0.084
8.721AlaArg: 8.721 ± 0.113
8.106AlaSer: 8.106 ± 0.105
7.349AlaThr: 7.349 ± 0.108
11.031AlaVal: 11.031 ± 0.14
1.696AlaTrp: 1.696 ± 0.05
2.21AlaTyr: 2.21 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.584CysAla: 0.584 ± 0.029
0.045CysCys: 0.045 ± 0.007
0.316CysAsp: 0.316 ± 0.022
0.288CysGlu: 0.288 ± 0.017
0.196CysPhe: 0.196 ± 0.016
0.578CysGly: 0.578 ± 0.026
0.11CysHis: 0.11 ± 0.012
0.213CysIle: 0.213 ± 0.016
0.056CysLys: 0.056 ± 0.008
0.502CysLeu: 0.502 ± 0.024
0.096CysMet: 0.096 ± 0.012
0.108CysAsn: 0.108 ± 0.013
0.235CysPro: 0.235 ± 0.017
0.115CysGln: 0.115 ± 0.013
0.331CysArg: 0.331 ± 0.021
0.359CysSer: 0.359 ± 0.019
0.306CysThr: 0.306 ± 0.02
0.415CysVal: 0.415 ± 0.019
0.071CysTrp: 0.071 ± 0.013
0.102CysTyr: 0.102 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
8.295AspAla: 8.295 ± 0.119
0.26AspCys: 0.26 ± 0.016
3.896AspAsp: 3.896 ± 0.095
4.345AspGlu: 4.345 ± 0.078
1.879AspPhe: 1.879 ± 0.048
5.317AspGly: 5.317 ± 0.103
1.116AspHis: 1.116 ± 0.035
2.529AspIle: 2.529 ± 0.06
1.042AspLys: 1.042 ± 0.042
5.533AspLeu: 5.533 ± 0.083
0.9AspMet: 0.9 ± 0.033
1.082AspAsn: 1.082 ± 0.035
3.602AspPro: 3.602 ± 0.062
1.179AspGln: 1.179 ± 0.035
3.984AspArg: 3.984 ± 0.083
2.979AspSer: 2.979 ± 0.062
2.877AspThr: 2.877 ± 0.062
5.072AspVal: 5.072 ± 0.079
0.834AspTrp: 0.834 ± 0.03
1.368AspTyr: 1.368 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
7.446GluAla: 7.446 ± 0.119
0.271GluCys: 0.271 ± 0.018
2.56GluAsp: 2.56 ± 0.059
3.801GluGlu: 3.801 ± 0.073
2.031GluPhe: 2.031 ± 0.048
4.712GluGly: 4.712 ± 0.092
1.681GluHis: 1.681 ± 0.049
2.948GluIle: 2.948 ± 0.062
1.623GluLys: 1.623 ± 0.053
7.179GluLeu: 7.179 ± 0.107
1.053GluMet: 1.053 ± 0.035
1.343GluAsn: 1.343 ± 0.044
3.11GluPro: 3.11 ± 0.064
2.608GluGln: 2.608 ± 0.064
5.633GluArg: 5.633 ± 0.096
3.397GluSer: 3.397 ± 0.076
3.223GluThr: 3.223 ± 0.068
5.215GluVal: 5.215 ± 0.096
0.981GluTrp: 0.981 ± 0.032
1.25GluTyr: 1.25 ± 0.037
0.0GluXaa: 0.0 ± 0.0
Phe
4.142PheAla: 4.142 ± 0.066
0.198PheCys: 0.198 ± 0.016
2.325PheAsp: 2.325 ± 0.053
2.001PheGlu: 2.001 ± 0.051
1.065PhePhe: 1.065 ± 0.039
3.539PheGly: 3.539 ± 0.077
0.515PheHis: 0.515 ± 0.025
1.367PheIle: 1.367 ± 0.038
0.57PheLys: 0.57 ± 0.027
2.704PheLeu: 2.704 ± 0.062
0.557PheMet: 0.557 ± 0.029
0.713PheAsn: 0.713 ± 0.031
1.347PhePro: 1.347 ± 0.039
0.671PheGln: 0.671 ± 0.029
1.685PheArg: 1.685 ± 0.043
2.016PheSer: 2.016 ± 0.044
2.217PheThr: 2.217 ± 0.052
2.902PheVal: 2.902 ± 0.069
0.481PheTrp: 0.481 ± 0.027
0.673PheTyr: 0.673 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
10.301GlyAla: 10.301 ± 0.131
0.581GlyCys: 0.581 ± 0.026
4.935GlyAsp: 4.935 ± 0.072
5.508GlyGlu: 5.508 ± 0.095
3.143GlyPhe: 3.143 ± 0.061
7.663GlyGly: 7.663 ± 0.112
1.912GlyHis: 1.912 ± 0.054
4.86GlyIle: 4.86 ± 0.091
2.248GlyLys: 2.248 ± 0.055
8.828GlyLeu: 8.828 ± 0.111
1.978GlyMet: 1.978 ± 0.053
1.89GlyAsn: 1.89 ± 0.055
3.575GlyPro: 3.575 ± 0.062
2.481GlyGln: 2.481 ± 0.052
5.923GlyArg: 5.923 ± 0.086
5.324GlySer: 5.324 ± 0.076
5.535GlyThr: 5.535 ± 0.1
7.891GlyVal: 7.891 ± 0.116
1.472GlyTrp: 1.472 ± 0.045
2.172GlyTyr: 2.172 ± 0.052
0.0GlyXaa: 0.0 ± 0.0
His
2.142HisAla: 2.142 ± 0.051
0.136HisCys: 0.136 ± 0.012
1.38HisAsp: 1.38 ± 0.043
1.294HisGlu: 1.294 ± 0.039
0.606HisPhe: 0.606 ± 0.027
1.943HisGly: 1.943 ± 0.049
0.542HisHis: 0.542 ± 0.026
0.795HisIle: 0.795 ± 0.031
0.328HisLys: 0.328 ± 0.02
1.982HisLeu: 1.982 ± 0.049
0.359HisMet: 0.359 ± 0.019
0.406HisAsn: 0.406 ± 0.021
1.574HisPro: 1.574 ± 0.045
0.506HisGln: 0.506 ± 0.027
1.517HisArg: 1.517 ± 0.042
1.197HisSer: 1.197 ± 0.031
0.963HisThr: 0.963 ± 0.036
1.587HisVal: 1.587 ± 0.045
0.295HisTrp: 0.295 ± 0.015
0.5HisTyr: 0.5 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
7.066IleAla: 7.066 ± 0.1
0.25IleCys: 0.25 ± 0.018
3.478IleAsp: 3.478 ± 0.061
3.256IleGlu: 3.256 ± 0.057
1.28IlePhe: 1.28 ± 0.038
4.554IleGly: 4.554 ± 0.082
0.748IleHis: 0.748 ± 0.031
2.155IleIle: 2.155 ± 0.059
0.96IleLys: 0.96 ± 0.041
3.745IleLeu: 3.745 ± 0.077
0.798IleMet: 0.798 ± 0.029
1.127IleAsn: 1.127 ± 0.038
2.459IlePro: 2.459 ± 0.056
1.044IleGln: 1.044 ± 0.033
2.94IleArg: 2.94 ± 0.05
2.571IleSer: 2.571 ± 0.057
2.924IleThr: 2.924 ± 0.069
4.986IleVal: 4.986 ± 0.076
0.452IleTrp: 0.452 ± 0.025
0.786IleTyr: 0.786 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
2.739LysAla: 2.739 ± 0.065
0.074LysCys: 0.074 ± 0.009
1.18LysAsp: 1.18 ± 0.038
1.131LysGlu: 1.131 ± 0.036
0.591LysPhe: 0.591 ± 0.028
1.851LysGly: 1.851 ± 0.058
0.502LysHis: 0.502 ± 0.022
0.899LysIle: 0.899 ± 0.036
0.849LysLys: 0.849 ± 0.039
2.132LysLeu: 2.132 ± 0.056
0.415LysMet: 0.415 ± 0.021
0.574LysAsn: 0.574 ± 0.029
1.302LysPro: 1.302 ± 0.053
0.771LysGln: 0.771 ± 0.033
1.81LysArg: 1.81 ± 0.051
1.306LysSer: 1.306 ± 0.046
1.336LysThr: 1.336 ± 0.044
1.866LysVal: 1.866 ± 0.055
0.279LysTrp: 0.279 ± 0.018
0.489LysTyr: 0.489 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
14.609LeuAla: 14.609 ± 0.156
0.528LeuCys: 0.528 ± 0.023
6.458LeuAsp: 6.458 ± 0.087
5.965LeuGlu: 5.965 ± 0.102
2.881LeuPhe: 2.881 ± 0.066
9.497LeuGly: 9.497 ± 0.118
1.871LeuHis: 1.871 ± 0.047
4.449LeuIle: 4.449 ± 0.087
2.06LeuLys: 2.06 ± 0.051
10.203LeuLeu: 10.203 ± 0.163
1.846LeuMet: 1.846 ± 0.045
1.894LeuAsn: 1.894 ± 0.045
5.265LeuPro: 5.265 ± 0.082
2.577LeuGln: 2.577 ± 0.059
7.086LeuArg: 7.086 ± 0.104
6.171LeuSer: 6.171 ± 0.092
5.893LeuThr: 5.893 ± 0.088
9.269LeuVal: 9.269 ± 0.141
1.253LeuTrp: 1.253 ± 0.036
1.692LeuTyr: 1.692 ± 0.048
0.0LeuXaa: 0.0 ± 0.0
Met
2.332MetAla: 2.332 ± 0.052
0.105MetCys: 0.105 ± 0.01
0.836MetAsp: 0.836 ± 0.029
0.814MetGlu: 0.814 ± 0.033
0.541MetPhe: 0.541 ± 0.026
1.481MetGly: 1.481 ± 0.046
0.384MetHis: 0.384 ± 0.023
0.855MetIle: 0.855 ± 0.035
0.471MetLys: 0.471 ± 0.025
2.344MetLeu: 2.344 ± 0.055
0.324MetMet: 0.324 ± 0.02
0.521MetAsn: 0.521 ± 0.024
1.228MetPro: 1.228 ± 0.032
0.594MetGln: 0.594 ± 0.025
1.504MetArg: 1.504 ± 0.044
1.53MetSer: 1.53 ± 0.037
1.723MetThr: 1.723 ± 0.049
1.495MetVal: 1.495 ± 0.044
0.191MetTrp: 0.191 ± 0.014
0.267MetTyr: 0.267 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
2.497AsnAla: 2.497 ± 0.053
0.153AsnCys: 0.153 ± 0.014
1.256AsnAsp: 1.256 ± 0.037
1.234AsnGlu: 1.234 ± 0.036
0.709AsnPhe: 0.709 ± 0.032
2.032AsnGly: 2.032 ± 0.057
0.385AsnHis: 0.385 ± 0.02
0.939AsnIle: 0.939 ± 0.034
0.491AsnLys: 0.491 ± 0.023
2.089AsnLeu: 2.089 ± 0.053
0.419AsnMet: 0.419 ± 0.024
0.558AsnAsn: 0.558 ± 0.028
1.593AsnPro: 1.593 ± 0.047
0.615AsnGln: 0.615 ± 0.03
1.379AsnArg: 1.379 ± 0.038
1.188AsnSer: 1.188 ± 0.04
1.22AsnThr: 1.22 ± 0.042
1.821AsnVal: 1.821 ± 0.049
0.317AsnTrp: 0.317 ± 0.021
0.552AsnTyr: 0.552 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
6.619ProAla: 6.619 ± 0.111
0.164ProCys: 0.164 ± 0.013
3.269ProAsp: 3.269 ± 0.068
4.147ProGlu: 4.147 ± 0.071
1.65ProPhe: 1.65 ± 0.047
4.855ProGly: 4.855 ± 0.082
1.037ProHis: 1.037 ± 0.036
2.087ProIle: 2.087 ± 0.047
1.238ProLys: 1.238 ± 0.039
4.876ProLeu: 4.876 ± 0.087
0.924ProMet: 0.924 ± 0.039
1.084ProAsn: 1.084 ± 0.036
2.203ProPro: 2.203 ± 0.064
1.567ProGln: 1.567 ± 0.044
3.238ProArg: 3.238 ± 0.073
3.545ProSer: 3.545 ± 0.079
2.975ProThr: 2.975 ± 0.059
4.757ProVal: 4.757 ± 0.079
0.798ProTrp: 0.798 ± 0.028
1.004ProTyr: 1.004 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
3.401GlnAla: 3.401 ± 0.072
0.128GlnCys: 0.128 ± 0.012
1.237GlnAsp: 1.237 ± 0.039
1.526GlnGlu: 1.526 ± 0.053
0.879GlnPhe: 0.879 ± 0.033
2.138GlnGly: 2.138 ± 0.053
0.765GlnHis: 0.765 ± 0.03
1.311GlnIle: 1.311 ± 0.041
0.73GlnLys: 0.73 ± 0.029
3.356GlnLeu: 3.356 ± 0.08
0.594GlnMet: 0.594 ± 0.026
0.643GlnAsn: 0.643 ± 0.032
1.425GlnPro: 1.425 ± 0.042
1.306GlnGln: 1.306 ± 0.05
2.474GlnArg: 2.474 ± 0.061
1.463GlnSer: 1.463 ± 0.047
1.314GlnThr: 1.314 ± 0.041
2.526GlnVal: 2.526 ± 0.056
0.457GlnTrp: 0.457 ± 0.023
0.588GlnTyr: 0.588 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
8.277ArgAla: 8.277 ± 0.106
0.343ArgCys: 0.343 ± 0.02
4.141ArgAsp: 4.141 ± 0.076
4.612ArgGlu: 4.612 ± 0.085
2.381ArgPhe: 2.381 ± 0.057
5.3ArgGly: 5.3 ± 0.078
1.549ArgHis: 1.549 ± 0.046
3.547ArgIle: 3.547 ± 0.065
1.5ArgLys: 1.5 ± 0.044
7.288ArgLeu: 7.288 ± 0.106
1.9ArgMet: 1.9 ± 0.045
1.539ArgAsn: 1.539 ± 0.046
3.36ArgPro: 3.36 ± 0.061
2.15ArgGln: 2.15 ± 0.058
6.34ArgArg: 6.34 ± 0.11
4.225ArgSer: 4.225 ± 0.075
3.727ArgThr: 3.727 ± 0.065
5.885ArgVal: 5.885 ± 0.085
1.073ArgTrp: 1.073 ± 0.033
1.575ArgTyr: 1.575 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
7.426SerAla: 7.426 ± 0.095
0.281SerCys: 0.281 ± 0.018
3.326SerAsp: 3.326 ± 0.065
3.296SerGlu: 3.296 ± 0.066
2.028SerPhe: 2.028 ± 0.052
5.889SerGly: 5.889 ± 0.083
1.153SerHis: 1.153 ± 0.039
2.972SerIle: 2.972 ± 0.055
1.32SerLys: 1.32 ± 0.041
5.869SerLeu: 5.869 ± 0.094
1.253SerMet: 1.253 ± 0.041
1.327SerAsn: 1.327 ± 0.042
3.342SerPro: 3.342 ± 0.076
1.642SerGln: 1.642 ± 0.044
4.092SerArg: 4.092 ± 0.068
3.791SerSer: 3.791 ± 0.072
3.758SerThr: 3.758 ± 0.07
5.314SerVal: 5.314 ± 0.086
0.894SerTrp: 0.894 ± 0.032
1.286SerTyr: 1.286 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
7.295ThrAla: 7.295 ± 0.109
0.222ThrCys: 0.222 ± 0.017
3.068ThrAsp: 3.068 ± 0.066
3.233ThrGlu: 3.233 ± 0.061
1.875ThrPhe: 1.875 ± 0.052
5.463ThrGly: 5.463 ± 0.091
1.142ThrHis: 1.142 ± 0.034
3.133ThrIle: 3.133 ± 0.066
1.221ThrLys: 1.221 ± 0.039
6.078ThrLeu: 6.078 ± 0.095
1.037ThrMet: 1.037 ± 0.034
1.188ThrAsn: 1.188 ± 0.038
3.945ThrPro: 3.945 ± 0.076
1.478ThrGln: 1.478 ± 0.044
3.671ThrArg: 3.671 ± 0.066
3.556ThrSer: 3.556 ± 0.069
3.644ThrThr: 3.644 ± 0.07
5.977ThrVal: 5.977 ± 0.092
0.817ThrTrp: 0.817 ± 0.032
1.114ThrTyr: 1.114 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
11.506ValAla: 11.506 ± 0.135
0.458ValCys: 0.458 ± 0.025
5.391ValAsp: 5.391 ± 0.087
5.332ValGlu: 5.332 ± 0.084
2.904ValPhe: 2.904 ± 0.061
7.21ValGly: 7.21 ± 0.112
1.676ValHis: 1.676 ± 0.04
4.704ValIle: 4.704 ± 0.07
1.689ValLys: 1.689 ± 0.051
9.408ValLeu: 9.408 ± 0.134
1.629ValMet: 1.629 ± 0.04
1.937ValAsn: 1.937 ± 0.052
4.71ValPro: 4.71 ± 0.086
2.225ValGln: 2.225 ± 0.054
5.663ValArg: 5.663 ± 0.084
5.455ValSer: 5.455 ± 0.093
6.209ValThr: 6.209 ± 0.107
8.558ValVal: 8.558 ± 0.12
1.059ValTrp: 1.059 ± 0.039
1.566ValTyr: 1.566 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
1.547TrpAla: 1.547 ± 0.045
0.073TrpCys: 0.073 ± 0.01
0.677TrpAsp: 0.677 ± 0.028
0.63TrpGlu: 0.63 ± 0.024
0.541TrpPhe: 0.541 ± 0.028
1.007TrpGly: 1.007 ± 0.046
0.35TrpHis: 0.35 ± 0.02
0.642TrpIle: 0.642 ± 0.027
0.319TrpLys: 0.319 ± 0.02
1.721TrpLeu: 1.721 ± 0.042
0.351TrpMet: 0.351 ± 0.021
0.43TrpAsn: 0.43 ± 0.023
0.682TrpPro: 0.682 ± 0.024
0.535TrpGln: 0.535 ± 0.022
1.124TrpArg: 1.124 ± 0.039
0.844TrpSer: 0.844 ± 0.031
0.818TrpThr: 0.818 ± 0.035
1.144TrpVal: 1.144 ± 0.038
0.337TrpTrp: 0.337 ± 0.02
0.284TrpTyr: 0.284 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.241TyrAla: 2.241 ± 0.046
0.131TyrCys: 0.131 ± 0.014
1.273TyrAsp: 1.273 ± 0.034
1.259TyrGlu: 1.259 ± 0.042
0.746TyrPhe: 0.746 ± 0.03
1.869TyrGly: 1.869 ± 0.05
0.338TyrHis: 0.338 ± 0.019
0.765TyrIle: 0.765 ± 0.027
0.413TyrLys: 0.413 ± 0.02
2.172TyrLeu: 2.172 ± 0.048
0.314TyrMet: 0.314 ± 0.017
0.501TyrAsn: 0.501 ± 0.026
1.014TyrPro: 1.014 ± 0.031
0.588TyrGln: 0.588 ± 0.027
1.595TyrArg: 1.595 ± 0.047
1.236TyrSer: 1.236 ± 0.037
1.147TyrThr: 1.147 ± 0.037
1.578TyrVal: 1.578 ± 0.042
0.298TyrTrp: 0.298 ± 0.019
0.449TyrTyr: 0.449 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2617 proteins (860142 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski