Amino acid dipepetide frequency for Clostridium niameyense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.416AlaAla: 3.416 ± 0.102
0.681AlaCys: 0.681 ± 0.033
2.269AlaAsp: 2.269 ± 0.063
2.961AlaGlu: 2.961 ± 0.077
2.288AlaPhe: 2.288 ± 0.063
3.324AlaGly: 3.324 ± 0.092
0.765AlaHis: 0.765 ± 0.036
5.626AlaIle: 5.626 ± 0.087
4.713AlaLys: 4.713 ± 0.095
5.422AlaLeu: 5.422 ± 0.101
1.459AlaMet: 1.459 ± 0.052
2.563AlaAsn: 2.563 ± 0.063
1.361AlaPro: 1.361 ± 0.045
1.261AlaGln: 1.261 ± 0.046
1.673AlaArg: 1.673 ± 0.054
3.068AlaSer: 3.068 ± 0.068
2.6AlaThr: 2.6 ± 0.07
3.524AlaVal: 3.524 ± 0.083
0.293AlaTrp: 0.293 ± 0.019
1.923AlaTyr: 1.923 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
0.638CysAla: 0.638 ± 0.033
0.265CysCys: 0.265 ± 0.029
0.768CysAsp: 0.768 ± 0.029
0.783CysGlu: 0.783 ± 0.035
0.493CysPhe: 0.493 ± 0.026
1.084CysGly: 1.084 ± 0.042
0.233CysHis: 0.233 ± 0.02
1.326CysIle: 1.326 ± 0.049
1.107CysLys: 1.107 ± 0.043
0.884CysLeu: 0.884 ± 0.03
0.316CysMet: 0.316 ± 0.02
0.89CysAsn: 0.89 ± 0.037
0.515CysPro: 0.515 ± 0.03
0.221CysGln: 0.221 ± 0.017
0.458CysArg: 0.458 ± 0.026
0.874CysSer: 0.874 ± 0.035
0.623CysThr: 0.623 ± 0.029
0.703CysVal: 0.703 ± 0.032
0.058CysTrp: 0.058 ± 0.009
0.526CysTyr: 0.526 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
2.304AspAla: 2.304 ± 0.073
0.635AspCys: 0.635 ± 0.033
2.324AspAsp: 2.324 ± 0.066
4.037AspGlu: 4.037 ± 0.094
2.711AspPhe: 2.711 ± 0.067
2.973AspGly: 2.973 ± 0.073
0.554AspHis: 0.554 ± 0.031
6.646AspIle: 6.646 ± 0.099
6.272AspLys: 6.272 ± 0.107
4.899AspLeu: 4.899 ± 0.091
1.583AspMet: 1.583 ± 0.047
3.412AspAsn: 3.412 ± 0.069
1.166AspPro: 1.166 ± 0.036
0.763AspGln: 0.763 ± 0.033
1.721AspArg: 1.721 ± 0.051
3.008AspSer: 3.008 ± 0.068
2.48AspThr: 2.48 ± 0.055
3.293AspVal: 3.293 ± 0.078
0.298AspTrp: 0.298 ± 0.022
2.447AspTyr: 2.447 ± 0.066
0.0AspXaa: 0.0 ± 0.0
Glu
3.63GluAla: 3.63 ± 0.089
0.818GluCys: 0.818 ± 0.041
4.526GluAsp: 4.526 ± 0.09
6.891GluGlu: 6.891 ± 0.123
2.897GluPhe: 2.897 ± 0.078
4.066GluGly: 4.066 ± 0.081
0.859GluHis: 0.859 ± 0.035
6.963GluIle: 6.963 ± 0.111
8.466GluLys: 8.466 ± 0.139
6.228GluLeu: 6.228 ± 0.109
1.709GluMet: 1.709 ± 0.053
5.748GluAsn: 5.748 ± 0.106
1.407GluPro: 1.407 ± 0.049
1.727GluGln: 1.727 ± 0.053
2.434GluArg: 2.434 ± 0.062
3.168GluSer: 3.168 ± 0.07
2.679GluThr: 2.679 ± 0.068
4.654GluVal: 4.654 ± 0.092
0.355GluTrp: 0.355 ± 0.021
2.806GluTyr: 2.806 ± 0.069
0.0GluXaa: 0.0 ± 0.0
Phe
1.956PheAla: 1.956 ± 0.059
0.597PheCys: 0.597 ± 0.029
2.147PheAsp: 2.147 ± 0.06
2.355PheGlu: 2.355 ± 0.059
1.847PhePhe: 1.847 ± 0.055
2.55PheGly: 2.55 ± 0.063
0.528PheHis: 0.528 ± 0.03
5.065PheIle: 5.065 ± 0.114
4.39PheLys: 4.39 ± 0.083
3.975PheLeu: 3.975 ± 0.099
1.196PheMet: 1.196 ± 0.044
3.195PheAsn: 3.195 ± 0.062
1.199PhePro: 1.199 ± 0.042
1.005PheGln: 1.005 ± 0.035
1.154PheArg: 1.154 ± 0.047
3.084PheSer: 3.084 ± 0.077
2.204PheThr: 2.204 ± 0.055
2.308PheVal: 2.308 ± 0.059
0.288PheTrp: 0.288 ± 0.022
1.853PheTyr: 1.853 ± 0.058
0.0PheXaa: 0.0 ± 0.0
Gly
3.807GlyAla: 3.807 ± 0.089
0.88GlyCys: 0.88 ± 0.039
2.98GlyAsp: 2.98 ± 0.062
4.155GlyGlu: 4.155 ± 0.087
2.912GlyPhe: 2.912 ± 0.069
3.932GlyGly: 3.932 ± 0.093
0.943GlyHis: 0.943 ± 0.037
6.884GlyIle: 6.884 ± 0.113
6.022GlyLys: 6.022 ± 0.097
4.987GlyLeu: 4.987 ± 0.097
1.61GlyMet: 1.61 ± 0.052
3.374GlyAsn: 3.374 ± 0.072
1.249GlyPro: 1.249 ± 0.045
1.373GlyGln: 1.373 ± 0.04
2.191GlyArg: 2.191 ± 0.054
3.479GlySer: 3.479 ± 0.068
3.297GlyThr: 3.297 ± 0.07
4.253GlyVal: 4.253 ± 0.07
0.394GlyTrp: 0.394 ± 0.022
2.766GlyTyr: 2.766 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
0.609HisAla: 0.609 ± 0.031
0.237HisCys: 0.237 ± 0.02
0.586HisAsp: 0.586 ± 0.027
0.733HisGlu: 0.733 ± 0.036
0.547HisPhe: 0.547 ± 0.029
0.913HisGly: 0.913 ± 0.044
0.257HisHis: 0.257 ± 0.018
1.386HisIle: 1.386 ± 0.051
1.274HisLys: 1.274 ± 0.045
0.99HisLeu: 0.99 ± 0.039
0.33HisMet: 0.33 ± 0.021
0.93HisAsn: 0.93 ± 0.035
0.536HisPro: 0.536 ± 0.025
0.29HisGln: 0.29 ± 0.02
0.467HisArg: 0.467 ± 0.023
0.795HisSer: 0.795 ± 0.032
0.635HisThr: 0.635 ± 0.032
0.733HisVal: 0.733 ± 0.031
0.093HisTrp: 0.093 ± 0.01
0.531HisTyr: 0.531 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
5.545IleAla: 5.545 ± 0.095
1.364IleCys: 1.364 ± 0.054
6.069IleAsp: 6.069 ± 0.11
7.182IleGlu: 7.182 ± 0.126
4.413IlePhe: 4.413 ± 0.101
6.375IleGly: 6.375 ± 0.109
1.293IleHis: 1.293 ± 0.04
10.599IleIle: 10.599 ± 0.176
10.778IleLys: 10.778 ± 0.143
10.039IleLeu: 10.039 ± 0.157
2.5IleMet: 2.5 ± 0.061
7.182IleAsn: 7.182 ± 0.131
3.546IlePro: 3.546 ± 0.067
2.246IleGln: 2.246 ± 0.055
3.085IleArg: 3.085 ± 0.072
7.117IleSer: 7.117 ± 0.112
5.243IleThr: 5.243 ± 0.078
6.402IleVal: 6.402 ± 0.099
0.562IleTrp: 0.562 ± 0.029
3.998IleTyr: 3.998 ± 0.094
0.0IleXaa: 0.0 ± 0.0
Lys
4.931LysAla: 4.931 ± 0.11
1.012LysCys: 1.012 ± 0.044
7.062LysAsp: 7.062 ± 0.129
9.951LysGlu: 9.951 ± 0.15
3.81LysPhe: 3.81 ± 0.079
5.703LysGly: 5.703 ± 0.094
1.197LysHis: 1.197 ± 0.037
9.704LysIle: 9.704 ± 0.118
9.768LysLys: 9.768 ± 0.16
8.363LysLeu: 8.363 ± 0.106
2.431LysMet: 2.431 ± 0.053
8.078LysAsn: 8.078 ± 0.138
2.275LysPro: 2.275 ± 0.058
2.56LysGln: 2.56 ± 0.066
3.265LysArg: 3.265 ± 0.065
5.916LysSer: 5.916 ± 0.102
4.293LysThr: 4.293 ± 0.074
6.581LysVal: 6.581 ± 0.113
0.616LysTrp: 0.616 ± 0.031
4.547LysTyr: 4.547 ± 0.08
0.0LysXaa: 0.0 ± 0.0
Leu
4.558LeuAla: 4.558 ± 0.087
1.186LeuCys: 1.186 ± 0.04
5.166LeuAsp: 5.166 ± 0.085
6.087LeuGlu: 6.087 ± 0.102
3.551LeuPhe: 3.551 ± 0.079
5.947LeuGly: 5.947 ± 0.098
0.986LeuHis: 0.986 ± 0.033
8.427LeuIle: 8.427 ± 0.129
9.758LeuLys: 9.758 ± 0.133
7.418LeuLeu: 7.418 ± 0.123
2.294LeuMet: 2.294 ± 0.058
6.696LeuAsn: 6.696 ± 0.109
2.667LeuPro: 2.667 ± 0.07
2.189LeuGln: 2.189 ± 0.052
2.955LeuArg: 2.955 ± 0.057
6.462LeuSer: 6.462 ± 0.095
4.265LeuThr: 4.265 ± 0.089
5.103LeuVal: 5.103 ± 0.095
0.52LeuTrp: 0.52 ± 0.031
3.413LeuTyr: 3.413 ± 0.079
0.0LeuXaa: 0.0 ± 0.0
Met
1.597MetAla: 1.597 ± 0.055
0.336MetCys: 0.336 ± 0.019
1.552MetAsp: 1.552 ± 0.045
2.025MetGlu: 2.025 ± 0.055
1.107MetPhe: 1.107 ± 0.041
1.738MetGly: 1.738 ± 0.049
0.344MetHis: 0.344 ± 0.02
2.198MetIle: 2.198 ± 0.062
2.594MetLys: 2.594 ± 0.061
2.296MetLeu: 2.296 ± 0.059
0.604MetMet: 0.604 ± 0.029
1.701MetAsn: 1.701 ± 0.04
0.853MetPro: 0.853 ± 0.032
0.642MetGln: 0.642 ± 0.028
0.764MetArg: 0.764 ± 0.034
1.629MetSer: 1.629 ± 0.049
1.058MetThr: 1.058 ± 0.043
1.463MetVal: 1.463 ± 0.053
0.165MetTrp: 0.165 ± 0.014
0.899MetTyr: 0.899 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
2.671AsnAla: 2.671 ± 0.066
0.883AsnCys: 0.883 ± 0.038
2.721AsnAsp: 2.721 ± 0.066
4.273AsnGlu: 4.273 ± 0.08
2.965AsnPhe: 2.965 ± 0.066
3.406AsnGly: 3.406 ± 0.088
0.826AsnHis: 0.826 ± 0.027
8.744AsnIle: 8.744 ± 0.144
8.03AsnLys: 8.03 ± 0.13
6.544AsnLeu: 6.544 ± 0.124
1.831AsnMet: 1.831 ± 0.043
5.507AsnAsn: 5.507 ± 0.13
2.274AsnPro: 2.274 ± 0.053
1.218AsnGln: 1.218 ± 0.045
2.037AsnArg: 2.037 ± 0.055
4.19AsnSer: 4.19 ± 0.099
3.137AsnThr: 3.137 ± 0.07
3.867AsnVal: 3.867 ± 0.084
0.463AsnTrp: 0.463 ± 0.021
3.035AsnTyr: 3.035 ± 0.061
0.0AsnXaa: 0.0 ± 0.0
Pro
1.262ProAla: 1.262 ± 0.049
0.359ProCys: 0.359 ± 0.024
1.3ProAsp: 1.3 ± 0.04
1.987ProGlu: 1.987 ± 0.06
1.35ProPhe: 1.35 ± 0.045
1.715ProGly: 1.715 ± 0.056
0.442ProHis: 0.442 ± 0.021
2.886ProIle: 2.886 ± 0.067
2.617ProLys: 2.617 ± 0.072
2.461ProLeu: 2.461 ± 0.059
0.674ProMet: 0.674 ± 0.037
1.765ProAsn: 1.765 ± 0.055
0.604ProPro: 0.604 ± 0.039
0.753ProGln: 0.753 ± 0.034
0.739ProArg: 0.739 ± 0.03
1.765ProSer: 1.765 ± 0.056
1.494ProThr: 1.494 ± 0.049
1.976ProVal: 1.976 ± 0.053
0.209ProTrp: 0.209 ± 0.017
1.367ProTyr: 1.367 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
1.23GlnAla: 1.23 ± 0.046
0.295GlnCys: 0.295 ± 0.018
1.222GlnAsp: 1.222 ± 0.041
1.765GlnGlu: 1.765 ± 0.059
0.856GlnPhe: 0.856 ± 0.037
1.571GlnGly: 1.571 ± 0.051
0.314GlnHis: 0.314 ± 0.02
2.029GlnIle: 2.029 ± 0.054
2.097GlnLys: 2.097 ± 0.058
2.03GlnLeu: 2.03 ± 0.062
0.637GlnMet: 0.637 ± 0.027
1.497GlnAsn: 1.497 ± 0.046
0.542GlnPro: 0.542 ± 0.03
0.781GlnGln: 0.781 ± 0.037
0.89GlnArg: 0.89 ± 0.033
1.212GlnSer: 1.212 ± 0.04
0.97GlnThr: 0.97 ± 0.038
1.388GlnVal: 1.388 ± 0.048
0.194GlnTrp: 0.194 ± 0.016
1.051GlnTyr: 1.051 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
1.757ArgAla: 1.757 ± 0.06
0.4ArgCys: 0.4 ± 0.023
1.728ArgAsp: 1.728 ± 0.048
2.871ArgGlu: 2.871 ± 0.062
1.372ArgPhe: 1.372 ± 0.043
1.979ArgGly: 1.979 ± 0.054
0.443ArgHis: 0.443 ± 0.028
3.134ArgIle: 3.134 ± 0.072
3.115ArgLys: 3.115 ± 0.069
2.767ArgLeu: 2.767 ± 0.062
0.859ArgMet: 0.859 ± 0.037
1.999ArgAsn: 1.999 ± 0.054
0.836ArgPro: 0.836 ± 0.033
0.888ArgGln: 0.888 ± 0.032
1.373ArgArg: 1.373 ± 0.046
1.467ArgSer: 1.467 ± 0.041
1.423ArgThr: 1.423 ± 0.044
2.093ArgVal: 2.093 ± 0.052
0.244ArgTrp: 0.244 ± 0.02
1.358ArgTyr: 1.358 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
2.778SerAla: 2.778 ± 0.071
0.753SerCys: 0.753 ± 0.032
2.702SerAsp: 2.702 ± 0.059
3.654SerGlu: 3.654 ± 0.068
2.889SerPhe: 2.889 ± 0.067
3.857SerGly: 3.857 ± 0.089
0.834SerHis: 0.834 ± 0.03
7.279SerIle: 7.279 ± 0.107
6.416SerLys: 6.416 ± 0.105
5.831SerLeu: 5.831 ± 0.107
1.696SerMet: 1.696 ± 0.044
4.083SerAsn: 4.083 ± 0.095
1.625SerPro: 1.625 ± 0.044
1.507SerGln: 1.507 ± 0.052
1.995SerArg: 1.995 ± 0.06
4.321SerSer: 4.321 ± 0.098
3.16SerThr: 3.16 ± 0.065
3.661SerVal: 3.661 ± 0.072
0.368SerTrp: 0.368 ± 0.023
2.584SerTyr: 2.584 ± 0.059
0.0SerXaa: 0.0 ± 0.0
Thr
2.688ThrAla: 2.688 ± 0.079
0.513ThrCys: 0.513 ± 0.025
2.193ThrAsp: 2.193 ± 0.055
2.852ThrGlu: 2.852 ± 0.068
2.075ThrPhe: 2.075 ± 0.056
3.455ThrGly: 3.455 ± 0.073
0.699ThrHis: 0.699 ± 0.034
5.105ThrIle: 5.105 ± 0.089
3.953ThrLys: 3.953 ± 0.077
4.804ThrLeu: 4.804 ± 0.073
1.081ThrMet: 1.081 ± 0.038
2.836ThrAsn: 2.836 ± 0.078
1.773ThrPro: 1.773 ± 0.059
0.987ThrGln: 0.987 ± 0.033
1.468ThrArg: 1.468 ± 0.043
3.123ThrSer: 3.123 ± 0.073
2.499ThrThr: 2.499 ± 0.067
3.29ThrVal: 3.29 ± 0.074
0.284ThrTrp: 0.284 ± 0.017
1.85ThrTyr: 1.85 ± 0.056
0.0ThrXaa: 0.0 ± 0.0
Val
3.704ValAla: 3.704 ± 0.091
0.844ValCys: 0.844 ± 0.037
3.615ValAsp: 3.615 ± 0.082
4.19ValGlu: 4.19 ± 0.078
2.604ValPhe: 2.604 ± 0.066
4.032ValGly: 4.032 ± 0.08
0.784ValHis: 0.784 ± 0.032
6.237ValIle: 6.237 ± 0.092
5.728ValLys: 5.728 ± 0.102
5.824ValLeu: 5.824 ± 0.1
1.503ValMet: 1.503 ± 0.049
3.596ValAsn: 3.596 ± 0.071
1.961ValPro: 1.961 ± 0.06
1.396ValGln: 1.396 ± 0.04
1.842ValArg: 1.842 ± 0.056
4.216ValSer: 4.216 ± 0.076
3.194ValThr: 3.194 ± 0.068
4.386ValVal: 4.386 ± 0.094
0.312ValTrp: 0.312 ± 0.025
2.346ValTyr: 2.346 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
0.301TrpAla: 0.301 ± 0.024
0.096TrpCys: 0.096 ± 0.013
0.322TrpAsp: 0.322 ± 0.023
0.409TrpGlu: 0.409 ± 0.024
0.267TrpPhe: 0.267 ± 0.02
0.435TrpGly: 0.435 ± 0.03
0.115TrpHis: 0.115 ± 0.013
0.702TrpIle: 0.702 ± 0.03
0.481TrpLys: 0.481 ± 0.025
0.437TrpLeu: 0.437 ± 0.025
0.177TrpMet: 0.177 ± 0.015
0.46TrpAsn: 0.46 ± 0.03
0.138TrpPro: 0.138 ± 0.015
0.181TrpGln: 0.181 ± 0.015
0.219TrpArg: 0.219 ± 0.017
0.349TrpSer: 0.349 ± 0.02
0.257TrpThr: 0.257 ± 0.017
0.356TrpVal: 0.356 ± 0.025
0.065TrpTrp: 0.065 ± 0.009
0.27TrpTyr: 0.27 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.807TyrAla: 1.807 ± 0.047
0.607TyrCys: 0.607 ± 0.032
2.275TyrAsp: 2.275 ± 0.054
2.869TyrGlu: 2.869 ± 0.066
1.942TyrPhe: 1.942 ± 0.05
2.434TyrGly: 2.434 ± 0.067
0.458TyrHis: 0.458 ± 0.026
4.601TyrIle: 4.601 ± 0.095
4.486TyrLys: 4.486 ± 0.087
3.45TyrLeu: 3.45 ± 0.081
1.071TyrMet: 1.071 ± 0.034
3.111TyrAsn: 3.111 ± 0.075
1.197TyrPro: 1.197 ± 0.042
0.581TyrGln: 0.581 ± 0.028
1.373TyrArg: 1.373 ± 0.041
2.749TyrSer: 2.749 ± 0.059
2.019TyrThr: 2.019 ± 0.061
2.282TyrVal: 2.282 ± 0.057
0.257TyrTrp: 0.257 ± 0.017
1.946TyrTyr: 1.946 ± 0.067
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2446 proteins (738339 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski