Amino acid dipepetide frequency for Protaetiibacter intestinalis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.606AlaAla: 21.606 ± 0.21	0.573AlaCys: 0.573 ± 0.028	8.284AlaAsp: 8.284 ± 0.113	9.196AlaGlu: 9.196 ± 0.132	4.117AlaPhe: 4.117 ± 0.086	12.95AlaGly: 12.95 ± 0.184	2.465AlaHis: 2.465 ± 0.059	6.277AlaIle: 6.277 ± 0.088	2.528AlaLys: 2.528 ± 0.069	14.955AlaLeu: 14.955 ± 0.159	2.306AlaMet: 2.306 ± 0.06	2.21AlaAsn: 2.21 ± 0.06	6.835AlaPro: 6.835 ± 0.13	3.66AlaGln: 3.66 ± 0.074	10.03AlaArg: 10.03 ± 0.13	7.806AlaSer: 7.806 ± 0.132	7.577AlaThr: 7.577 ± 0.2	12.344AlaVal: 12.344 ± 0.139	2.035AlaTrp: 2.035 ± 0.049	2.513AlaTyr: 2.513 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	0.583CysAla: 0.583 ± 0.03	0.05CysCys: 0.05 ± 0.008	0.274CysAsp: 0.274 ± 0.019	0.198CysGlu: 0.198 ± 0.014	0.143CysPhe: 0.143 ± 0.012	0.478CysGly: 0.478 ± 0.025	0.082CysHis: 0.082 ± 0.01	0.163CysIle: 0.163 ± 0.014	0.049CysLys: 0.049 ± 0.007	0.413CysLeu: 0.413 ± 0.02	0.066CysMet: 0.066 ± 0.008	0.103CysAsn: 0.103 ± 0.012	0.242CysPro: 0.242 ± 0.017	0.093CysGln: 0.093 ± 0.009	0.276CysArg: 0.276 ± 0.019	0.291CysSer: 0.291 ± 0.021	0.351CysThr: 0.351 ± 0.021	0.4CysVal: 0.4 ± 0.019	0.066CysTrp: 0.066 ± 0.007	0.108CysTyr: 0.108 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	9.822AspAla: 9.822 ± 0.126	0.253AspCys: 0.253 ± 0.018	4.107AspAsp: 4.107 ± 0.083	4.36AspGlu: 4.36 ± 0.075	1.779AspPhe: 1.779 ± 0.049	6.105AspGly: 6.105 ± 0.117	1.111AspHis: 1.111 ± 0.04	2.26AspIle: 2.26 ± 0.048	0.844AspLys: 0.844 ± 0.038	5.14AspLeu: 5.14 ± 0.07	0.659AspMet: 0.659 ± 0.028	0.851AspAsn: 0.851 ± 0.032	4.377AspPro: 4.377 ± 0.072	1.328AspGln: 1.328 ± 0.04	4.344AspArg: 4.344 ± 0.083	2.374AspSer: 2.374 ± 0.061	2.924AspThr: 2.924 ± 0.076	4.891AspVal: 4.891 ± 0.079	0.956AspTrp: 0.956 ± 0.034	1.348AspTyr: 1.348 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	7.513GluAla: 7.513 ± 0.113	0.204GluCys: 0.204 ± 0.015	2.434GluAsp: 2.434 ± 0.062	3.163GluGlu: 3.163 ± 0.081	1.845GluPhe: 1.845 ± 0.05	4.248GluGly: 4.248 ± 0.08	1.518GluHis: 1.518 ± 0.045	2.402GluIle: 2.402 ± 0.056	1.286GluLys: 1.286 ± 0.052	8.741GluLeu: 8.741 ± 0.139	0.72GluMet: 0.72 ± 0.034	1.15GluAsn: 1.15 ± 0.036	3.249GluPro: 3.249 ± 0.058	2.202GluGln: 2.202 ± 0.054	5.499GluArg: 5.499 ± 0.091	2.524GluSer: 2.524 ± 0.053	3.047GluThr: 3.047 ± 0.066	5.175GluVal: 5.175 ± 0.088	0.799GluTrp: 0.799 ± 0.032	1.158GluTyr: 1.158 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.474PheAla: 4.474 ± 0.08	0.148PheCys: 0.148 ± 0.013	2.27PheAsp: 2.27 ± 0.054	1.724PheGlu: 1.724 ± 0.044	1.017PhePhe: 1.017 ± 0.042	3.468PheGly: 3.468 ± 0.074	0.506PheHis: 0.506 ± 0.023	1.068PheIle: 1.068 ± 0.04	0.39PheLys: 0.39 ± 0.021	2.98PheLeu: 2.98 ± 0.071	0.427PheMet: 0.427 ± 0.021	0.566PheAsn: 0.566 ± 0.028	1.465PhePro: 1.465 ± 0.046	0.811PheGln: 0.811 ± 0.028	1.996PheArg: 1.996 ± 0.049	1.744PheSer: 1.744 ± 0.045	2.062PheThr: 2.062 ± 0.047	2.859PheVal: 2.859 ± 0.063	0.498PheTrp: 0.498 ± 0.026	0.623PheTyr: 0.623 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	11.422GlyAla: 11.422 ± 0.172	0.56GlyCys: 0.56 ± 0.027	5.186GlyAsp: 5.186 ± 0.105	5.302GlyGlu: 5.302 ± 0.074	3.28GlyPhe: 3.28 ± 0.062	8.214GlyGly: 8.214 ± 0.162	1.782GlyHis: 1.782 ± 0.042	4.992GlyIle: 4.992 ± 0.078	1.981GlyLys: 1.981 ± 0.052	9.208GlyLeu: 9.208 ± 0.122	1.914GlyMet: 1.914 ± 0.052	1.604GlyAsn: 1.604 ± 0.052	3.822GlyPro: 3.822 ± 0.066	2.247GlyGln: 2.247 ± 0.053	6.534GlyArg: 6.534 ± 0.087	5.352GlySer: 5.352 ± 0.166	5.711GlyThr: 5.711 ± 0.11	8.578GlyVal: 8.578 ± 0.105	1.72GlyTrp: 1.72 ± 0.054	2.434GlyTyr: 2.434 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	2.37HisAla: 2.37 ± 0.058	0.086HisCys: 0.086 ± 0.009	1.257HisAsp: 1.257 ± 0.038	1.18HisGlu: 1.18 ± 0.035	0.481HisPhe: 0.481 ± 0.025	1.929HisGly: 1.929 ± 0.05	0.521HisHis: 0.521 ± 0.026	0.633HisIle: 0.633 ± 0.023	0.218HisLys: 0.218 ± 0.017	2.035HisLeu: 2.035 ± 0.051	0.255HisMet: 0.255 ± 0.018	0.306HisAsn: 0.306 ± 0.019	1.54HisPro: 1.54 ± 0.041	0.467HisGln: 0.467 ± 0.027	1.645HisArg: 1.645 ± 0.051	0.841HisSer: 0.841 ± 0.027	0.896HisThr: 0.896 ± 0.04	1.565HisVal: 1.565 ± 0.039	0.326HisTrp: 0.326 ± 0.019	0.448HisTyr: 0.448 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.805IleAla: 6.805 ± 0.09	0.203IleCys: 0.203 ± 0.016	3.023IleAsp: 3.023 ± 0.065	2.642IleGlu: 2.642 ± 0.056	1.088IlePhe: 1.088 ± 0.042	4.442IleGly: 4.442 ± 0.086	0.655IleHis: 0.655 ± 0.024	1.57IleIle: 1.57 ± 0.05	0.721IleLys: 0.721 ± 0.031	3.603IleLeu: 3.603 ± 0.07	0.522IleMet: 0.522 ± 0.024	0.782IleAsn: 0.782 ± 0.03	2.54IlePro: 2.54 ± 0.056	1.027IleGln: 1.027 ± 0.034	3.194IleArg: 3.194 ± 0.06	2.171IleSer: 2.171 ± 0.059	2.643IleThr: 2.643 ± 0.062	4.664IleVal: 4.664 ± 0.084	0.466IleTrp: 0.466 ± 0.024	0.702IleTyr: 0.702 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	2.213LysAla: 2.213 ± 0.064	0.048LysCys: 0.048 ± 0.007	0.896LysAsp: 0.896 ± 0.037	0.868LysGlu: 0.868 ± 0.031	0.467LysPhe: 0.467 ± 0.022	1.348LysGly: 1.348 ± 0.049	0.351LysHis: 0.351 ± 0.018	0.783LysIle: 0.783 ± 0.034	0.676LysLys: 0.676 ± 0.038	1.934LysLeu: 1.934 ± 0.045	0.307LysMet: 0.307 ± 0.018	0.441LysAsn: 0.441 ± 0.022	1.056LysPro: 1.056 ± 0.037	0.594LysGln: 0.594 ± 0.027	1.342LysArg: 1.342 ± 0.042	1.009LysSer: 1.009 ± 0.04	1.206LysThr: 1.206 ± 0.041	1.601LysVal: 1.601 ± 0.053	0.208LysTrp: 0.208 ± 0.015	0.413LysTyr: 0.413 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	16.575LeuAla: 16.575 ± 0.173	0.467LeuCys: 0.467 ± 0.023	6.914LeuAsp: 6.914 ± 0.1	5.857LeuGlu: 5.857 ± 0.09	2.899LeuPhe: 2.899 ± 0.063	10.152LeuGly: 10.152 ± 0.113	1.835LeuHis: 1.835 ± 0.045	4.026LeuIle: 4.026 ± 0.083	1.557LeuLys: 1.557 ± 0.05	10.959LeuLeu: 10.959 ± 0.16	1.382LeuMet: 1.382 ± 0.036	1.68LeuAsn: 1.68 ± 0.05	5.84LeuPro: 5.84 ± 0.102	2.415LeuGln: 2.415 ± 0.052	7.573LeuArg: 7.573 ± 0.109	5.295LeuSer: 5.295 ± 0.077	6.013LeuThr: 6.013 ± 0.104	10.682LeuVal: 10.682 ± 0.153	1.337LeuTrp: 1.337 ± 0.043	1.681LeuTyr: 1.681 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	1.858MetAla: 1.858 ± 0.051	0.1MetCys: 0.1 ± 0.012	0.67MetAsp: 0.67 ± 0.027	0.586MetGlu: 0.586 ± 0.028	0.444MetPhe: 0.444 ± 0.02	1.176MetGly: 1.176 ± 0.038	0.284MetHis: 0.284 ± 0.018	0.68MetIle: 0.68 ± 0.026	0.307MetLys: 0.307 ± 0.02	1.655MetLeu: 1.655 ± 0.042	0.232MetMet: 0.232 ± 0.019	0.428MetAsn: 0.428 ± 0.02	1.007MetPro: 1.007 ± 0.035	0.427MetGln: 0.427 ± 0.023	1.3MetArg: 1.3 ± 0.034	1.271MetSer: 1.271 ± 0.033	1.54MetThr: 1.54 ± 0.044	1.189MetVal: 1.189 ± 0.042	0.183MetTrp: 0.183 ± 0.014	0.236MetTyr: 0.236 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.345AsnAla: 2.345 ± 0.055	0.11AsnCys: 0.11 ± 0.01	0.957AsnAsp: 0.957 ± 0.033	0.857AsnGlu: 0.857 ± 0.032	0.632AsnPhe: 0.632 ± 0.027	1.761AsnGly: 1.761 ± 0.049	0.329AsnHis: 0.329 ± 0.017	0.762AsnIle: 0.762 ± 0.031	0.334AsnLys: 0.334 ± 0.019	1.817AsnLeu: 1.817 ± 0.045	0.283AsnMet: 0.283 ± 0.017	0.418AsnAsn: 0.418 ± 0.023	1.476AsnPro: 1.476 ± 0.041	0.496AsnGln: 0.496 ± 0.023	1.156AsnArg: 1.156 ± 0.039	0.868AsnSer: 0.868 ± 0.035	1.051AsnThr: 1.051 ± 0.034	1.565AsnVal: 1.565 ± 0.042	0.327AsnTrp: 0.327 ± 0.02	0.452AsnTyr: 0.452 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	7.67ProAla: 7.67 ± 0.138	0.172ProCys: 0.172 ± 0.015	4.029ProAsp: 4.029 ± 0.074	4.254ProGlu: 4.254 ± 0.084	1.66ProPhe: 1.66 ± 0.045	5.246ProGly: 5.246 ± 0.086	1.097ProHis: 1.097 ± 0.045	2.058ProIle: 2.058 ± 0.048	0.941ProLys: 0.941 ± 0.039	5.101ProLeu: 5.101 ± 0.093	0.754ProMet: 0.754 ± 0.029	0.969ProAsn: 0.969 ± 0.033	2.57ProPro: 2.57 ± 0.099	1.385ProGln: 1.385 ± 0.041	3.574ProArg: 3.574 ± 0.074	2.966ProSer: 2.966 ± 0.07	3.256ProThr: 3.256 ± 0.073	5.187ProVal: 5.187 ± 0.094	0.886ProTrp: 0.886 ± 0.033	1.103ProTyr: 1.103 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.384GlnAla: 3.384 ± 0.069	0.09GlnCys: 0.09 ± 0.01	1.111GlnAsp: 1.111 ± 0.034	1.246GlnGlu: 1.246 ± 0.04	0.803GlnPhe: 0.803 ± 0.031	1.878GlnGly: 1.878 ± 0.055	0.556GlnHis: 0.556 ± 0.023	1.121GlnIle: 1.121 ± 0.039	0.592GlnLys: 0.592 ± 0.024	3.68GlnLeu: 3.68 ± 0.077	0.377GlnMet: 0.377 ± 0.021	0.61GlnAsn: 0.61 ± 0.027	1.412GlnPro: 1.412 ± 0.053	1.123GlnGln: 1.123 ± 0.039	2.197GlnArg: 2.197 ± 0.056	1.29GlnSer: 1.29 ± 0.043	1.388GlnThr: 1.388 ± 0.037	2.19GlnVal: 2.19 ± 0.048	0.367GlnTrp: 0.367 ± 0.02	0.596GlnTyr: 0.596 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	9.581ArgAla: 9.581 ± 0.13	0.272ArgCys: 0.272 ± 0.018	4.195ArgAsp: 4.195 ± 0.077	4.799ArgGlu: 4.799 ± 0.085	2.502ArgPhe: 2.502 ± 0.06	5.749ArgGly: 5.749 ± 0.084	1.639ArgHis: 1.639 ± 0.049	3.978ArgIle: 3.978 ± 0.063	1.2ArgLys: 1.2 ± 0.044	7.583ArgLeu: 7.583 ± 0.109	1.694ArgMet: 1.694 ± 0.04	1.256ArgAsn: 1.256 ± 0.035	3.716ArgPro: 3.716 ± 0.081	1.845ArgGln: 1.845 ± 0.047	6.879ArgArg: 6.879 ± 0.128	3.725ArgSer: 3.725 ± 0.075	4.234ArgThr: 4.234 ± 0.075	6.403ArgVal: 6.403 ± 0.097	1.239ArgTrp: 1.239 ± 0.046	1.653ArgTyr: 1.653 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.882SerAla: 6.882 ± 0.152	0.27SerCys: 0.27 ± 0.019	2.992SerAsp: 2.992 ± 0.064	2.658SerGlu: 2.658 ± 0.057	1.828SerPhe: 1.828 ± 0.044	5.87SerGly: 5.87 ± 0.138	0.922SerHis: 0.922 ± 0.038	2.376SerIle: 2.376 ± 0.057	0.94SerLys: 0.94 ± 0.034	4.986SerLeu: 4.986 ± 0.08	0.999SerMet: 0.999 ± 0.028	0.981SerAsn: 0.981 ± 0.034	2.933SerPro: 2.933 ± 0.065	1.208SerGln: 1.208 ± 0.041	3.618SerArg: 3.618 ± 0.066	3.224SerSer: 3.224 ± 0.096	3.478SerThr: 3.478 ± 0.092	4.456SerVal: 4.456 ± 0.097	0.94SerTrp: 0.94 ± 0.033	1.321SerTyr: 1.321 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	8.017ThrAla: 8.017 ± 0.197	0.199ThrCys: 0.199 ± 0.015	3.208ThrAsp: 3.208 ± 0.064	2.902ThrGlu: 2.902 ± 0.057	1.77ThrPhe: 1.77 ± 0.039	6.028ThrGly: 6.028 ± 0.113	1.04ThrHis: 1.04 ± 0.033	2.905ThrIle: 2.905 ± 0.074	0.981ThrLys: 0.981 ± 0.04	6.085ThrLeu: 6.085 ± 0.09	0.828ThrMet: 0.828 ± 0.027	1.06ThrAsn: 1.06 ± 0.035	4.069ThrPro: 4.069 ± 0.081	1.406ThrGln: 1.406 ± 0.041	4.007ThrArg: 4.007 ± 0.069	3.283ThrSer: 3.283 ± 0.103	3.905ThrThr: 3.905 ± 0.123	6.084ThrVal: 6.084 ± 0.132	0.825ThrTrp: 0.825 ± 0.033	0.834ThrTyr: 0.834 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	12.891ValAla: 12.891 ± 0.15	0.422ValCys: 0.422 ± 0.022	5.953ValAsp: 5.953 ± 0.091	5.267ValGlu: 5.267 ± 0.095	3.037ValPhe: 3.037 ± 0.063	7.775ValGly: 7.775 ± 0.109	1.675ValHis: 1.675 ± 0.048	4.053ValIle: 4.053 ± 0.076	1.601ValLys: 1.601 ± 0.044	10.13ValLeu: 10.13 ± 0.134	1.322ValMet: 1.322 ± 0.038	1.714ValAsn: 1.714 ± 0.043	4.887ValPro: 4.887 ± 0.089	2.187ValGln: 2.187 ± 0.048	6.075ValArg: 6.075 ± 0.092	4.909ValSer: 4.909 ± 0.094	6.053ValThr: 6.053 ± 0.126	9.731ValVal: 9.731 ± 0.118	1.119ValTrp: 1.119 ± 0.037	1.607ValTyr: 1.607 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	1.673TrpAla: 1.673 ± 0.053	0.085TrpCys: 0.085 ± 0.009	0.808TrpAsp: 0.808 ± 0.028	0.69TrpGlu: 0.69 ± 0.028	0.608TrpPhe: 0.608 ± 0.026	1.101TrpGly: 1.101 ± 0.035	0.321TrpHis: 0.321 ± 0.019	0.713TrpIle: 0.713 ± 0.027	0.287TrpLys: 0.287 ± 0.016	1.76TrpLeu: 1.76 ± 0.051	0.32TrpMet: 0.32 ± 0.02	0.456TrpAsn: 0.456 ± 0.023	0.753TrpPro: 0.753 ± 0.03	0.471TrpGln: 0.471 ± 0.024	1.202TrpArg: 1.202 ± 0.037	0.911TrpSer: 0.911 ± 0.033	0.907TrpThr: 0.907 ± 0.034	1.254TrpVal: 1.254 ± 0.039	0.378TrpTrp: 0.378 ± 0.02	0.302TrpTyr: 0.302 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.583TyrAla: 2.583 ± 0.055	0.115TyrCys: 0.115 ± 0.009	1.265TyrAsp: 1.265 ± 0.037	1.13TyrGlu: 1.13 ± 0.041	0.694TyrPhe: 0.694 ± 0.029	1.927TyrGly: 1.927 ± 0.047	0.313TyrHis: 0.313 ± 0.018	0.646TyrIle: 0.646 ± 0.027	0.326TyrLys: 0.326 ± 0.021	2.376TyrLeu: 2.376 ± 0.057	0.202TyrMet: 0.202 ± 0.015	0.41TyrAsn: 0.41 ± 0.022	1.087TyrPro: 1.087 ± 0.039	0.619TyrGln: 0.619 ± 0.031	1.7TyrArg: 1.7 ± 0.046	1.027TyrSer: 1.027 ± 0.036	1.195TyrThr: 1.195 ± 0.034	1.592TyrVal: 1.592 ± 0.038	0.325TyrTrp: 0.325 ± 0.02	0.433TyrTyr: 0.433 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2836 proteins (943967 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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