Amino acid dipepetide frequency for Weissella cryptocerci

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.944AlaAla: 7.944 ± 0.139
0.176AlaCys: 0.176 ± 0.016
5.683AlaAsp: 5.683 ± 0.115
5.026AlaGlu: 5.026 ± 0.104
3.537AlaPhe: 3.537 ± 0.083
6.506AlaGly: 6.506 ± 0.104
1.639AlaHis: 1.639 ± 0.046
5.997AlaIle: 5.997 ± 0.111
6.432AlaLys: 6.432 ± 0.108
7.906AlaLeu: 7.906 ± 0.123
2.44AlaMet: 2.44 ± 0.06
4.722AlaAsn: 4.722 ± 0.089
2.741AlaPro: 2.741 ± 0.064
3.89AlaGln: 3.89 ± 0.087
2.907AlaArg: 2.907 ± 0.063
4.773AlaSer: 4.773 ± 0.094
6.507AlaThr: 6.507 ± 0.125
6.281AlaVal: 6.281 ± 0.092
0.845AlaTrp: 0.845 ± 0.038
2.723AlaTyr: 2.723 ± 0.063
0.0AlaXaa: 0.0 ± 0.0
Cys
0.169CysAla: 0.169 ± 0.017
0.024CysCys: 0.024 ± 0.005
0.102CysAsp: 0.102 ± 0.01
0.121CysGlu: 0.121 ± 0.012
0.078CysPhe: 0.078 ± 0.011
0.26CysGly: 0.26 ± 0.02
0.047CysHis: 0.047 ± 0.009
0.142CysIle: 0.142 ± 0.015
0.086CysLys: 0.086 ± 0.011
0.205CysLeu: 0.205 ± 0.019
0.048CysMet: 0.048 ± 0.008
0.089CysAsn: 0.089 ± 0.011
0.125CysPro: 0.125 ± 0.014
0.079CysGln: 0.079 ± 0.01
0.078CysArg: 0.078 ± 0.01
0.138CysSer: 0.138 ± 0.016
0.127CysThr: 0.127 ± 0.015
0.156CysVal: 0.156 ± 0.016
0.05CysTrp: 0.05 ± 0.007
0.084CysTyr: 0.084 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
5.119AspAla: 5.119 ± 0.104
0.147AspCys: 0.147 ± 0.015
3.75AspAsp: 3.75 ± 0.099
4.472AspGlu: 4.472 ± 0.093
2.761AspPhe: 2.761 ± 0.065
4.293AspGly: 4.293 ± 0.105
0.927AspHis: 0.927 ± 0.035
3.781AspIle: 3.781 ± 0.065
3.649AspLys: 3.649 ± 0.072
5.319AspLeu: 5.319 ± 0.088
1.551AspMet: 1.551 ± 0.04
2.95AspAsn: 2.95 ± 0.083
1.722AspPro: 1.722 ± 0.051
2.074AspGln: 2.074 ± 0.06
1.843AspArg: 1.843 ± 0.049
3.127AspSer: 3.127 ± 0.073
3.453AspThr: 3.453 ± 0.085
4.384AspVal: 4.384 ± 0.091
0.73AspTrp: 0.73 ± 0.036
2.464AspTyr: 2.464 ± 0.055
0.0AspXaa: 0.0 ± 0.0
Glu
4.615GluAla: 4.615 ± 0.095
0.093GluCys: 0.093 ± 0.011
2.77GluAsp: 2.77 ± 0.085
2.961GluGlu: 2.961 ± 0.082
2.668GluPhe: 2.668 ± 0.062
2.608GluGly: 2.608 ± 0.07
1.209GluHis: 1.209 ± 0.037
4.192GluIle: 4.192 ± 0.078
3.687GluLys: 3.687 ± 0.086
6.301GluLeu: 6.301 ± 0.122
1.726GluMet: 1.726 ± 0.053
3.093GluAsn: 3.093 ± 0.069
1.823GluPro: 1.823 ± 0.062
2.469GluGln: 2.469 ± 0.069
2.394GluArg: 2.394 ± 0.066
2.581GluSer: 2.581 ± 0.059
3.311GluThr: 3.311 ± 0.074
3.917GluVal: 3.917 ± 0.076
0.584GluTrp: 0.584 ± 0.029
2.196GluTyr: 2.196 ± 0.058
0.0GluXaa: 0.0 ± 0.0
Phe
3.637PheAla: 3.637 ± 0.072
0.112PheCys: 0.112 ± 0.014
3.018PheAsp: 3.018 ± 0.069
2.4PheGlu: 2.4 ± 0.07
1.881PhePhe: 1.881 ± 0.056
3.608PheGly: 3.608 ± 0.066
0.743PheHis: 0.743 ± 0.032
2.957PheIle: 2.957 ± 0.077
2.6PheLys: 2.6 ± 0.059
3.324PheLeu: 3.324 ± 0.074
1.115PheMet: 1.115 ± 0.038
2.342PheAsn: 2.342 ± 0.056
1.276PhePro: 1.276 ± 0.039
1.313PheGln: 1.313 ± 0.043
1.325PheArg: 1.325 ± 0.043
2.845PheSer: 2.845 ± 0.066
2.833PheThr: 2.833 ± 0.059
3.264PheVal: 3.264 ± 0.066
0.501PheTrp: 0.501 ± 0.025
1.437PheTyr: 1.437 ± 0.045
0.0PheXaa: 0.0 ± 0.0
Gly
5.531GlyAla: 5.531 ± 0.108
0.171GlyCys: 0.171 ± 0.016
3.719GlyAsp: 3.719 ± 0.081
3.492GlyGlu: 3.492 ± 0.072
3.073GlyPhe: 3.073 ± 0.069
4.427GlyGly: 4.427 ± 0.109
1.472GlyHis: 1.472 ± 0.046
5.175GlyIle: 5.175 ± 0.103
4.613GlyLys: 4.613 ± 0.076
6.531GlyLeu: 6.531 ± 0.104
2.191GlyMet: 2.191 ± 0.065
3.273GlyAsn: 3.273 ± 0.088
1.336GlyPro: 1.336 ± 0.04
2.829GlyGln: 2.829 ± 0.064
2.497GlyArg: 2.497 ± 0.057
4.135GlySer: 4.135 ± 0.075
4.925GlyThr: 4.925 ± 0.111
5.241GlyVal: 5.241 ± 0.085
0.798GlyTrp: 0.798 ± 0.031
2.884GlyTyr: 2.884 ± 0.063
0.0GlyXaa: 0.0 ± 0.0
His
1.561HisAla: 1.561 ± 0.045
0.04HisCys: 0.04 ± 0.007
1.259HisAsp: 1.259 ± 0.039
1.218HisGlu: 1.218 ± 0.037
0.93HisPhe: 0.93 ± 0.033
1.501HisGly: 1.501 ± 0.043
0.459HisHis: 0.459 ± 0.025
1.225HisIle: 1.225 ± 0.043
0.985HisLys: 0.985 ± 0.036
1.721HisLeu: 1.721 ± 0.048
0.501HisMet: 0.501 ± 0.027
0.886HisAsn: 0.886 ± 0.034
0.809HisPro: 0.809 ± 0.034
0.809HisGln: 0.809 ± 0.037
0.765HisArg: 0.765 ± 0.031
0.987HisSer: 0.987 ± 0.036
1.072HisThr: 1.072 ± 0.04
1.476HisVal: 1.476 ± 0.048
0.255HisTrp: 0.255 ± 0.018
0.775HisTyr: 0.775 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.543IleAla: 6.543 ± 0.087
0.166IleCys: 0.166 ± 0.016
4.256IleAsp: 4.256 ± 0.081
3.965IleGlu: 3.965 ± 0.078
2.856IlePhe: 2.856 ± 0.073
5.231IleGly: 5.231 ± 0.104
1.106IleHis: 1.106 ± 0.04
4.826IleIle: 4.826 ± 0.1
4.259IleLys: 4.259 ± 0.076
5.978IleLeu: 5.978 ± 0.121
1.744IleMet: 1.744 ± 0.062
3.627IleAsn: 3.627 ± 0.074
2.682IlePro: 2.682 ± 0.067
2.425IleGln: 2.425 ± 0.058
2.277IleArg: 2.277 ± 0.058
4.21IleSer: 4.21 ± 0.078
4.775IleThr: 4.775 ± 0.081
5.192IleVal: 5.192 ± 0.093
0.647IleTrp: 0.647 ± 0.029
2.091IleTyr: 2.091 ± 0.056
0.0IleXaa: 0.0 ± 0.0
Lys
5.351LysAla: 5.351 ± 0.114
0.091LysCys: 0.091 ± 0.011
3.101LysAsp: 3.101 ± 0.082
3.083LysGlu: 3.083 ± 0.084
2.371LysPhe: 2.371 ± 0.057
3.373LysGly: 3.373 ± 0.07
1.382LysHis: 1.382 ± 0.042
4.29LysIle: 4.29 ± 0.07
4.966LysLys: 4.966 ± 0.123
6.066LysLeu: 6.066 ± 0.089
2.155LysMet: 2.155 ± 0.054
3.661LysAsn: 3.661 ± 0.088
2.409LysPro: 2.409 ± 0.063
3.394LysGln: 3.394 ± 0.078
2.823LysArg: 2.823 ± 0.061
3.513LysSer: 3.513 ± 0.084
4.345LysThr: 4.345 ± 0.071
4.558LysVal: 4.558 ± 0.08
0.626LysTrp: 0.626 ± 0.028
2.658LysTyr: 2.658 ± 0.06
0.0LysXaa: 0.0 ± 0.0
Leu
9.402LeuAla: 9.402 ± 0.156
0.201LeuCys: 0.201 ± 0.016
5.085LeuAsp: 5.085 ± 0.089
4.56LeuGlu: 4.56 ± 0.103
3.668LeuPhe: 3.668 ± 0.078
6.379LeuGly: 6.379 ± 0.105
1.73LeuHis: 1.73 ± 0.046
6.365LeuIle: 6.365 ± 0.118
5.467LeuLys: 5.467 ± 0.092
8.393LeuLeu: 8.393 ± 0.154
2.425LeuMet: 2.425 ± 0.06
4.681LeuAsn: 4.681 ± 0.081
3.961LeuPro: 3.961 ± 0.082
3.8LeuGln: 3.8 ± 0.086
3.53LeuArg: 3.53 ± 0.076
5.637LeuSer: 5.637 ± 0.089
6.735LeuThr: 6.735 ± 0.11
7.129LeuVal: 7.129 ± 0.116
0.844LeuTrp: 0.844 ± 0.035
2.554LeuTyr: 2.554 ± 0.06
0.0LeuXaa: 0.0 ± 0.0
Met
2.51MetAla: 2.51 ± 0.054
0.053MetCys: 0.053 ± 0.009
1.466MetAsp: 1.466 ± 0.043
1.141MetGlu: 1.141 ± 0.043
1.053MetPhe: 1.053 ± 0.043
1.702MetGly: 1.702 ± 0.047
0.528MetHis: 0.528 ± 0.026
1.926MetIle: 1.926 ± 0.058
1.9MetLys: 1.9 ± 0.049
2.523MetLeu: 2.523 ± 0.072
0.897MetMet: 0.897 ± 0.036
1.477MetAsn: 1.477 ± 0.039
1.184MetPro: 1.184 ± 0.045
1.271MetGln: 1.271 ± 0.041
1.122MetArg: 1.122 ± 0.04
1.601MetSer: 1.601 ± 0.049
1.999MetThr: 1.999 ± 0.043
1.816MetVal: 1.816 ± 0.055
0.205MetTrp: 0.205 ± 0.016
0.791MetTyr: 0.791 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
4.194AsnAla: 4.194 ± 0.097
0.156AsnCys: 0.156 ± 0.017
3.024AsnAsp: 3.024 ± 0.067
3.092AsnGlu: 3.092 ± 0.067
2.149AsnPhe: 2.149 ± 0.052
4.153AsnGly: 4.153 ± 0.089
1.02AsnHis: 1.02 ± 0.036
3.258AsnIle: 3.258 ± 0.068
3.225AsnLys: 3.225 ± 0.079
4.495AsnLeu: 4.495 ± 0.096
1.322AsnMet: 1.322 ± 0.042
2.77AsnAsn: 2.77 ± 0.092
2.24AsnPro: 2.24 ± 0.056
2.287AsnGln: 2.287 ± 0.07
2.0AsnArg: 2.0 ± 0.051
2.876AsnSer: 2.876 ± 0.072
2.957AsnThr: 2.957 ± 0.085
3.797AsnVal: 3.797 ± 0.082
0.625AsnTrp: 0.625 ± 0.026
2.01AsnTyr: 2.01 ± 0.065
0.0AsnXaa: 0.0 ± 0.0
Pro
3.354ProAla: 3.354 ± 0.086
0.054ProCys: 0.054 ± 0.008
2.289ProAsp: 2.289 ± 0.057
2.467ProGlu: 2.467 ± 0.069
1.511ProPhe: 1.511 ± 0.045
2.123ProGly: 2.123 ± 0.069
0.581ProHis: 0.581 ± 0.028
2.444ProIle: 2.444 ± 0.059
2.286ProLys: 2.286 ± 0.06
2.936ProLeu: 2.936 ± 0.064
0.874ProMet: 0.874 ± 0.035
1.872ProAsn: 1.872 ± 0.061
0.454ProPro: 0.454 ± 0.025
1.283ProGln: 1.283 ± 0.043
1.063ProArg: 1.063 ± 0.039
2.061ProSer: 2.061 ± 0.06
2.726ProThr: 2.726 ± 0.077
3.013ProVal: 3.013 ± 0.066
0.302ProTrp: 0.302 ± 0.019
1.196ProTyr: 1.196 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
4.275GlnAla: 4.275 ± 0.094
0.073GlnCys: 0.073 ± 0.012
1.784GlnAsp: 1.784 ± 0.049
1.891GlnGlu: 1.891 ± 0.057
1.759GlnPhe: 1.759 ± 0.049
2.23GlnGly: 2.23 ± 0.056
0.869GlnHis: 0.869 ± 0.037
2.835GlnIle: 2.835 ± 0.064
2.424GlnLys: 2.424 ± 0.06
4.492GlnLeu: 4.492 ± 0.093
1.145GlnMet: 1.145 ± 0.036
2.161GlnAsn: 2.161 ± 0.06
1.639GlnPro: 1.639 ± 0.046
2.301GlnGln: 2.301 ± 0.077
1.828GlnArg: 1.828 ± 0.054
2.141GlnSer: 2.141 ± 0.051
2.82GlnThr: 2.82 ± 0.056
3.335GlnVal: 3.335 ± 0.072
0.409GlnTrp: 0.409 ± 0.021
1.526GlnTyr: 1.526 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
2.786ArgAla: 2.786 ± 0.061
0.084ArgCys: 0.084 ± 0.012
2.131ArgAsp: 2.131 ± 0.058
2.427ArgGlu: 2.427 ± 0.066
1.684ArgPhe: 1.684 ± 0.05
2.295ArgGly: 2.295 ± 0.057
0.8ArgHis: 0.8 ± 0.034
2.536ArgIle: 2.536 ± 0.066
2.54ArgLys: 2.54 ± 0.057
3.571ArgLeu: 3.571 ± 0.08
1.055ArgMet: 1.055 ± 0.031
1.896ArgAsn: 1.896 ± 0.046
1.177ArgPro: 1.177 ± 0.041
1.767ArgGln: 1.767 ± 0.046
1.676ArgArg: 1.676 ± 0.056
1.746ArgSer: 1.746 ± 0.054
2.224ArgThr: 2.224 ± 0.048
2.774ArgVal: 2.774 ± 0.063
0.392ArgTrp: 0.392 ± 0.022
1.477ArgTyr: 1.477 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
4.846SerAla: 4.846 ± 0.085
0.114SerCys: 0.114 ± 0.011
3.399SerAsp: 3.399 ± 0.09
3.066SerGlu: 3.066 ± 0.069
2.698SerPhe: 2.698 ± 0.064
4.427SerGly: 4.427 ± 0.087
1.069SerHis: 1.069 ± 0.038
3.881SerIle: 3.881 ± 0.074
3.516SerLys: 3.516 ± 0.069
5.316SerLeu: 5.316 ± 0.081
1.473SerMet: 1.473 ± 0.042
2.828SerAsn: 2.828 ± 0.069
1.722SerPro: 1.722 ± 0.053
2.223SerGln: 2.223 ± 0.058
2.058SerArg: 2.058 ± 0.052
3.659SerSer: 3.659 ± 0.104
3.795SerThr: 3.795 ± 0.087
4.296SerVal: 4.296 ± 0.081
0.663SerTrp: 0.663 ± 0.032
2.088SerTyr: 2.088 ± 0.059
0.0SerXaa: 0.0 ± 0.0
Thr
6.071ThrAla: 6.071 ± 0.104
0.136ThrCys: 0.136 ± 0.013
4.324ThrAsp: 4.324 ± 0.101
3.486ThrGlu: 3.486 ± 0.075
2.784ThrPhe: 2.784 ± 0.054
4.946ThrGly: 4.946 ± 0.096
1.25ThrHis: 1.25 ± 0.041
4.904ThrIle: 4.904 ± 0.084
4.503ThrLys: 4.503 ± 0.115
5.954ThrLeu: 5.954 ± 0.101
1.518ThrMet: 1.518 ± 0.044
3.466ThrAsn: 3.466 ± 0.082
3.164ThrPro: 3.164 ± 0.107
2.495ThrGln: 2.495 ± 0.058
2.116ThrArg: 2.116 ± 0.046
3.881ThrSer: 3.881 ± 0.077
5.234ThrThr: 5.234 ± 0.164
5.209ThrVal: 5.209 ± 0.088
0.8ThrTrp: 0.8 ± 0.037
2.31ThrTyr: 2.31 ± 0.069
0.0ThrXaa: 0.0 ± 0.0
Val
7.151ValAla: 7.151 ± 0.101
0.177ValCys: 0.177 ± 0.017
4.529ValAsp: 4.529 ± 0.086
3.945ValGlu: 3.945 ± 0.081
2.848ValPhe: 2.848 ± 0.071
5.164ValGly: 5.164 ± 0.082
1.288ValHis: 1.288 ± 0.042
5.497ValIle: 5.497 ± 0.099
4.638ValLys: 4.638 ± 0.086
6.745ValLeu: 6.745 ± 0.111
1.907ValMet: 1.907 ± 0.053
3.654ValAsn: 3.654 ± 0.071
2.912ValPro: 2.912 ± 0.075
2.72ValGln: 2.72 ± 0.065
2.591ValArg: 2.591 ± 0.057
4.515ValSer: 4.515 ± 0.087
5.746ValThr: 5.746 ± 0.091
6.155ValVal: 6.155 ± 0.11
0.698ValTrp: 0.698 ± 0.027
2.318ValTyr: 2.318 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
0.747TrpAla: 0.747 ± 0.034
0.034TrpCys: 0.034 ± 0.007
0.585TrpAsp: 0.585 ± 0.031
0.487TrpGlu: 0.487 ± 0.028
0.518TrpPhe: 0.518 ± 0.027
0.658TrpGly: 0.658 ± 0.034
0.272TrpHis: 0.272 ± 0.018
0.677TrpIle: 0.677 ± 0.031
0.491TrpLys: 0.491 ± 0.024
1.298TrpLeu: 1.298 ± 0.046
0.262TrpMet: 0.262 ± 0.019
0.542TrpAsn: 0.542 ± 0.032
0.289TrpPro: 0.289 ± 0.021
0.633TrpGln: 0.633 ± 0.032
0.528TrpArg: 0.528 ± 0.026
0.657TrpSer: 0.657 ± 0.033
0.67TrpThr: 0.67 ± 0.031
0.647TrpVal: 0.647 ± 0.033
0.16TrpTrp: 0.16 ± 0.015
0.433TrpTyr: 0.433 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.873TyrAla: 2.873 ± 0.059
0.104TyrCys: 0.104 ± 0.011
2.245TyrAsp: 2.245 ± 0.059
1.901TyrGlu: 1.901 ± 0.048
1.703TyrPhe: 1.703 ± 0.058
2.43TyrGly: 2.43 ± 0.049
0.84TyrHis: 0.84 ± 0.035
1.945TyrIle: 1.945 ± 0.052
1.949TyrLys: 1.949 ± 0.053
3.472TyrLeu: 3.472 ± 0.073
0.814TyrMet: 0.814 ± 0.032
1.661TyrAsn: 1.661 ± 0.052
1.224TyrPro: 1.224 ± 0.041
1.874TyrGln: 1.874 ± 0.057
1.619TyrArg: 1.619 ± 0.044
2.053TyrSer: 2.053 ± 0.057
2.293TyrThr: 2.293 ± 0.073
2.562TyrVal: 2.562 ± 0.058
0.453TyrTrp: 0.453 ± 0.021
1.535TyrTyr: 1.535 ± 0.053
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2588 proteins (794941 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski