Amino acid dipepetide frequency for Apis mellifera associated microvirus 31

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.491AlaAla: 12.491 ± 2.338
0.0AlaCys: 0.0 ± 0.0
7.348AlaAsp: 7.348 ± 2.177
5.143AlaGlu: 5.143 ± 2.197
3.674AlaPhe: 3.674 ± 1.325
8.817AlaGly: 8.817 ± 1.799
2.204AlaHis: 2.204 ± 1.433
5.878AlaIle: 5.878 ± 2.916
5.143AlaLys: 5.143 ± 1.665
5.878AlaLeu: 5.878 ± 2.336
1.47AlaMet: 1.47 ± 0.768
2.939AlaAsn: 2.939 ± 1.411
5.878AlaPro: 5.878 ± 2.576
4.409AlaGln: 4.409 ± 2.433
4.409AlaArg: 4.409 ± 1.134
10.287AlaSer: 10.287 ± 2.87
7.348AlaThr: 7.348 ± 1.224
6.613AlaVal: 6.613 ± 1.952
0.735AlaTrp: 0.735 ± 0.989
4.409AlaTyr: 4.409 ± 0.679
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
1.47CysGly: 1.47 ± 1.458
0.0CysHis: 0.0 ± 0.0
0.735CysIle: 0.735 ± 0.729
0.0CysLys: 0.0 ± 0.0
2.204CysLeu: 2.204 ± 0.821
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
1.47CysArg: 1.47 ± 1.135
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.735CysTyr: 0.735 ± 0.729
0.0CysXaa: 0.0 ± 0.0
Asp
6.613AspAla: 6.613 ± 2.036
0.0AspCys: 0.0 ± 0.0
2.939AspAsp: 2.939 ± 0.855
2.939AspGlu: 2.939 ± 0.692
4.409AspPhe: 4.409 ± 2.255
1.47AspGly: 1.47 ± 0.561
0.735AspHis: 0.735 ± 0.989
2.204AspIle: 2.204 ± 1.09
2.939AspLys: 2.939 ± 1.688
2.939AspLeu: 2.939 ± 0.958
2.204AspMet: 2.204 ± 1.672
2.204AspAsn: 2.204 ± 1.09
5.143AspPro: 5.143 ± 2.653
0.735AspGln: 0.735 ± 0.807
3.674AspArg: 3.674 ± 1.674
2.939AspSer: 2.939 ± 1.886
4.409AspThr: 4.409 ± 1.576
1.47AspVal: 1.47 ± 0.706
0.735AspTrp: 0.735 ± 0.537
2.939AspTyr: 2.939 ± 2.15
0.0AspXaa: 0.0 ± 0.0
Glu
4.409GluAla: 4.409 ± 2.397
0.0GluCys: 0.0 ± 0.0
3.674GluAsp: 3.674 ± 1.122
2.204GluGlu: 2.204 ± 1.09
1.47GluPhe: 1.47 ± 1.063
0.735GluGly: 0.735 ± 0.537
2.204GluHis: 2.204 ± 1.09
5.878GluIle: 5.878 ± 3.777
2.204GluLys: 2.204 ± 1.865
3.674GluLeu: 3.674 ± 1.134
0.735GluMet: 0.735 ± 1.112
1.47GluAsn: 1.47 ± 0.561
5.143GluPro: 5.143 ± 2.768
2.204GluGln: 2.204 ± 1.09
5.143GluArg: 5.143 ± 2.264
2.204GluSer: 2.204 ± 0.609
4.409GluThr: 4.409 ± 1.236
3.674GluVal: 3.674 ± 1.122
0.735GluTrp: 0.735 ± 0.622
4.409GluTyr: 4.409 ± 1.113
0.0GluXaa: 0.0 ± 0.0
Phe
3.674PheAla: 3.674 ± 1.191
0.735PheCys: 0.735 ± 0.807
3.674PheAsp: 3.674 ± 0.624
3.674PheGlu: 3.674 ± 1.966
2.204PhePhe: 2.204 ± 0.609
4.409PheGly: 4.409 ± 0.679
0.735PheHis: 0.735 ± 0.729
1.47PheIle: 1.47 ± 1.075
0.735PheLys: 0.735 ± 0.989
2.939PheLeu: 2.939 ± 2.059
0.0PheMet: 0.0 ± 0.0
0.735PheAsn: 0.735 ± 0.537
3.674PhePro: 3.674 ± 1.931
2.204PheGln: 2.204 ± 0.81
5.143PheArg: 5.143 ± 2.137
2.204PheSer: 2.204 ± 1.052
2.939PheThr: 2.939 ± 1.461
2.204PheVal: 2.204 ± 0.821
0.735PheTrp: 0.735 ± 0.537
0.735PheTyr: 0.735 ± 0.729
0.0PheXaa: 0.0 ± 0.0
Gly
4.409GlyAla: 4.409 ± 1.629
0.735GlyCys: 0.735 ± 0.729
2.204GlyAsp: 2.204 ± 0.873
4.409GlyGlu: 4.409 ± 2.578
3.674GlyPhe: 3.674 ± 1.148
3.674GlyGly: 3.674 ± 1.755
0.735GlyHis: 0.735 ± 0.807
5.143GlyIle: 5.143 ± 0.848
2.939GlyLys: 2.939 ± 1.143
6.613GlyLeu: 6.613 ± 1.023
1.47GlyMet: 1.47 ± 0.706
2.939GlyAsn: 2.939 ± 1.411
2.204GlyPro: 2.204 ± 1.185
4.409GlyGln: 4.409 ± 0.776
2.939GlyArg: 2.939 ± 1.121
5.143GlySer: 5.143 ± 1.665
2.939GlyThr: 2.939 ± 0.744
3.674GlyVal: 3.674 ± 1.226
0.735GlyTrp: 0.735 ± 0.622
2.204GlyTyr: 2.204 ± 0.821
0.0GlyXaa: 0.0 ± 0.0
His
1.47HisAla: 1.47 ± 0.887
0.0HisCys: 0.0 ± 0.0
2.204HisAsp: 2.204 ± 1.672
0.0HisGlu: 0.0 ± 0.0
2.204HisPhe: 2.204 ± 1.052
1.47HisGly: 1.47 ± 0.561
1.47HisHis: 1.47 ± 1.458
0.0HisIle: 0.0 ± 0.0
1.47HisLys: 1.47 ± 0.706
2.204HisLeu: 2.204 ± 1.185
1.47HisMet: 1.47 ± 0.875
0.0HisAsn: 0.0 ± 0.0
0.0HisPro: 0.0 ± 0.0
0.735HisGln: 0.735 ± 0.622
0.0HisArg: 0.0 ± 0.0
0.735HisSer: 0.735 ± 0.537
1.47HisThr: 1.47 ± 0.875
1.47HisVal: 1.47 ± 0.887
1.47HisTrp: 1.47 ± 1.075
1.47HisTyr: 1.47 ± 0.561
0.0HisXaa: 0.0 ± 0.0
Ile
8.817IleAla: 8.817 ± 2.192
0.0IleCys: 0.0 ± 0.0
3.674IleAsp: 3.674 ± 0.425
1.47IleGlu: 1.47 ± 0.706
2.204IlePhe: 2.204 ± 1.052
1.47IleGly: 1.47 ± 0.875
0.735IleHis: 0.735 ± 0.537
0.0IleIle: 0.0 ± 0.0
2.204IleLys: 2.204 ± 1.185
4.409IleLeu: 4.409 ± 1.113
2.204IleMet: 2.204 ± 1.126
5.878IleAsn: 5.878 ± 1.97
2.939IlePro: 2.939 ± 0.692
0.735IleGln: 0.735 ± 0.729
5.143IleArg: 5.143 ± 2.204
3.674IleSer: 3.674 ± 1.118
0.735IleThr: 0.735 ± 0.537
2.204IleVal: 2.204 ± 1.083
0.735IleTrp: 0.735 ± 0.537
1.47IleTyr: 1.47 ± 1.075
0.0IleXaa: 0.0 ± 0.0
Lys
5.143LysAla: 5.143 ± 1.665
0.0LysCys: 0.0 ± 0.0
3.674LysAsp: 3.674 ± 1.122
3.674LysGlu: 3.674 ± 1.122
2.204LysPhe: 2.204 ± 1.801
2.939LysGly: 2.939 ± 1.799
1.47LysHis: 1.47 ± 1.458
1.47LysIle: 1.47 ± 0.561
5.878LysLys: 5.878 ± 4.352
3.674LysLeu: 3.674 ± 3.095
1.47LysMet: 1.47 ± 0.706
2.204LysAsn: 2.204 ± 1.486
2.204LysPro: 2.204 ± 1.642
4.409LysGln: 4.409 ± 2.307
2.939LysArg: 2.939 ± 1.143
2.204LysSer: 2.204 ± 1.465
4.409LysThr: 4.409 ± 1.562
0.735LysVal: 0.735 ± 0.729
0.0LysTrp: 0.0 ± 0.0
0.0LysTyr: 0.0 ± 0.0
0.0LysXaa: 0.0 ± 0.0
Leu
8.082LeuAla: 8.082 ± 2.786
0.735LeuCys: 0.735 ± 0.537
3.674LeuAsp: 3.674 ± 1.968
2.939LeuGlu: 2.939 ± 1.261
4.409LeuPhe: 4.409 ± 2.737
5.143LeuGly: 5.143 ± 1.403
0.735LeuHis: 0.735 ± 0.729
0.735LeuIle: 0.735 ± 0.537
7.348LeuLys: 7.348 ± 2.775
5.878LeuLeu: 5.878 ± 1.386
3.674LeuMet: 3.674 ± 0.662
1.47LeuAsn: 1.47 ± 0.706
8.082LeuPro: 8.082 ± 1.774
3.674LeuGln: 3.674 ± 1.226
4.409LeuArg: 4.409 ± 2.737
7.348LeuSer: 7.348 ± 1.152
3.674LeuThr: 3.674 ± 1.704
1.47LeuVal: 1.47 ± 1.458
1.47LeuTrp: 1.47 ± 0.561
1.47LeuTyr: 1.47 ± 0.887
0.0LeuXaa: 0.0 ± 0.0
Met
0.735MetAla: 0.735 ± 0.622
0.0MetCys: 0.0 ± 0.0
0.735MetAsp: 0.735 ± 0.537
2.204MetGlu: 2.204 ± 1.465
0.0MetPhe: 0.0 ± 0.0
1.47MetGly: 1.47 ± 0.706
0.0MetHis: 0.0 ± 0.0
1.47MetIle: 1.47 ± 0.561
2.204MetLys: 2.204 ± 1.141
1.47MetLeu: 1.47 ± 0.768
0.0MetMet: 0.0 ± 0.0
0.735MetAsn: 0.735 ± 0.989
3.674MetPro: 3.674 ± 0.997
1.47MetGln: 1.47 ± 1.243
1.47MetArg: 1.47 ± 1.063
2.204MetSer: 2.204 ± 0.609
2.204MetThr: 2.204 ± 0.81
0.735MetVal: 0.735 ± 0.622
0.0MetTrp: 0.0 ± 0.0
2.204MetTyr: 2.204 ± 1.486
0.0MetXaa: 0.0 ± 0.0
Asn
2.939AsnAla: 2.939 ± 1.411
0.735AsnCys: 0.735 ± 0.729
2.204AsnAsp: 2.204 ± 0.761
4.409AsnGlu: 4.409 ± 2.728
0.735AsnPhe: 0.735 ± 0.622
0.0AsnGly: 0.0 ± 0.0
0.735AsnHis: 0.735 ± 0.537
3.674AsnIle: 3.674 ± 1.036
2.204AsnLys: 2.204 ± 0.873
2.939AsnLeu: 2.939 ± 1.27
0.0AsnMet: 0.0 ± 0.0
0.735AsnAsn: 0.735 ± 0.622
2.939AsnPro: 2.939 ± 0.744
0.735AsnGln: 0.735 ± 0.537
2.939AsnArg: 2.939 ± 0.744
1.47AsnSer: 1.47 ± 0.561
2.204AsnThr: 2.204 ± 1.09
5.143AsnVal: 5.143 ± 3.118
0.0AsnTrp: 0.0 ± 0.0
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
5.878ProAla: 5.878 ± 3.883
1.47ProCys: 1.47 ± 1.458
2.204ProAsp: 2.204 ± 1.052
4.409ProGlu: 4.409 ± 1.134
1.47ProPhe: 1.47 ± 0.768
8.082ProGly: 8.082 ± 3.624
2.204ProHis: 2.204 ± 1.185
6.613ProIle: 6.613 ± 3.183
2.939ProLys: 2.939 ± 2.328
7.348ProLeu: 7.348 ± 1.103
0.0ProMet: 0.0 ± 0.0
2.204ProAsn: 2.204 ± 1.185
5.143ProPro: 5.143 ± 2.5
3.674ProGln: 3.674 ± 1.148
2.939ProArg: 2.939 ± 1.72
3.674ProSer: 3.674 ± 1.646
3.674ProThr: 3.674 ± 1.595
3.674ProVal: 3.674 ± 2.676
0.735ProTrp: 0.735 ± 0.537
2.204ProTyr: 2.204 ± 1.052
0.0ProXaa: 0.0 ± 0.0
Gln
8.082GlnAla: 8.082 ± 3.963
1.47GlnCys: 1.47 ± 1.458
2.939GlnAsp: 2.939 ± 1.536
3.674GlnGlu: 3.674 ± 2.058
0.735GlnPhe: 0.735 ± 0.537
2.204GlnGly: 2.204 ± 1.612
0.735GlnHis: 0.735 ± 0.537
1.47GlnIle: 1.47 ± 0.904
0.735GlnLys: 0.735 ± 0.537
0.735GlnLeu: 0.735 ± 0.537
2.939GlnMet: 2.939 ± 1.199
1.47GlnAsn: 1.47 ± 1.243
1.47GlnPro: 1.47 ± 1.135
2.939GlnGln: 2.939 ± 1.567
2.204GlnArg: 2.204 ± 1.217
0.735GlnSer: 0.735 ± 0.537
2.939GlnThr: 2.939 ± 1.411
0.0GlnVal: 0.0 ± 0.0
0.735GlnTrp: 0.735 ± 0.729
1.47GlnTyr: 1.47 ± 0.875
0.0GlnXaa: 0.0 ± 0.0
Arg
5.143ArgAla: 5.143 ± 1.373
0.0ArgCys: 0.0 ± 0.0
0.735ArgAsp: 0.735 ± 0.729
5.143ArgGlu: 5.143 ± 1.337
3.674ArgPhe: 3.674 ± 2.042
3.674ArgGly: 3.674 ± 1.134
1.47ArgHis: 1.47 ± 1.075
2.204ArgIle: 2.204 ± 0.81
3.674ArgLys: 3.674 ± 1.098
8.082ArgLeu: 8.082 ± 2.528
2.204ArgMet: 2.204 ± 1.415
2.204ArgAsn: 2.204 ± 0.821
3.674ArgPro: 3.674 ± 2.602
0.735ArgGln: 0.735 ± 0.729
2.939ArgArg: 2.939 ± 1.727
3.674ArgSer: 3.674 ± 1.098
6.613ArgThr: 6.613 ± 1.522
3.674ArgVal: 3.674 ± 1.768
0.735ArgTrp: 0.735 ± 0.537
6.613ArgTyr: 6.613 ± 0.7
0.0ArgXaa: 0.0 ± 0.0
Ser
8.817SerAla: 8.817 ± 1.881
0.735SerCys: 0.735 ± 0.537
1.47SerAsp: 1.47 ± 0.561
2.204SerGlu: 2.204 ± 0.609
4.409SerPhe: 4.409 ± 0.956
4.409SerGly: 4.409 ± 1.466
1.47SerHis: 1.47 ± 0.706
2.939SerIle: 2.939 ± 1.483
2.939SerLys: 2.939 ± 2.979
5.143SerLeu: 5.143 ± 1.657
1.47SerMet: 1.47 ± 1.075
2.204SerAsn: 2.204 ± 0.873
4.409SerPro: 4.409 ± 3.062
0.735SerGln: 0.735 ± 0.622
6.613SerArg: 6.613 ± 2.767
3.674SerSer: 3.674 ± 1.122
7.348SerThr: 7.348 ± 1.61
3.674SerVal: 3.674 ± 1.768
0.735SerTrp: 0.735 ± 0.537
1.47SerTyr: 1.47 ± 1.075
0.0SerXaa: 0.0 ± 0.0
Thr
8.817ThrAla: 8.817 ± 3.591
0.0ThrCys: 0.0 ± 0.0
3.674ThrAsp: 3.674 ± 1.122
2.939ThrGlu: 2.939 ± 1.228
2.204ThrPhe: 2.204 ± 0.609
7.348ThrGly: 7.348 ± 1.338
1.47ThrHis: 1.47 ± 0.561
5.878ThrIle: 5.878 ± 1.831
2.204ThrLys: 2.204 ± 0.873
4.409ThrLeu: 4.409 ± 2.737
1.47ThrMet: 1.47 ± 0.875
1.47ThrAsn: 1.47 ± 1.075
4.409ThrPro: 4.409 ± 1.901
1.47ThrGln: 1.47 ± 1.075
5.143ThrArg: 5.143 ± 1.201
5.878ThrSer: 5.878 ± 1.549
3.674ThrThr: 3.674 ± 2.687
1.47ThrVal: 1.47 ± 1.135
0.735ThrTrp: 0.735 ± 0.622
2.204ThrTyr: 2.204 ± 0.609
0.0ThrXaa: 0.0 ± 0.0
Val
4.409ValAla: 4.409 ± 0.679
0.0ValCys: 0.0 ± 0.0
2.204ValAsp: 2.204 ± 0.81
1.47ValGlu: 1.47 ± 1.075
0.0ValPhe: 0.0 ± 0.0
1.47ValGly: 1.47 ± 0.561
0.735ValHis: 0.735 ± 0.989
2.204ValIle: 2.204 ± 1.486
1.47ValLys: 1.47 ± 1.458
3.674ValLeu: 3.674 ± 1.148
0.0ValMet: 0.0 ± 0.0
4.409ValAsn: 4.409 ± 1.875
5.878ValPro: 5.878 ± 1.029
2.204ValGln: 2.204 ± 1.597
2.939ValArg: 2.939 ± 1.567
5.143ValSer: 5.143 ± 1.148
4.409ValThr: 4.409 ± 2.285
2.939ValVal: 2.939 ± 1.143
0.0ValTrp: 0.0 ± 0.0
2.204ValTyr: 2.204 ± 1.09
0.0ValXaa: 0.0 ± 0.0
Trp
1.47TrpAla: 1.47 ± 0.561
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
2.204TrpGlu: 2.204 ± 1.612
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
1.47TrpHis: 1.47 ± 0.561
0.735TrpIle: 0.735 ± 0.622
0.0TrpLys: 0.0 ± 0.0
0.0TrpLeu: 0.0 ± 0.0
0.735TrpMet: 0.735 ± 0.989
0.735TrpAsn: 0.735 ± 0.537
0.735TrpPro: 0.735 ± 0.537
0.735TrpGln: 0.735 ± 0.622
0.735TrpArg: 0.735 ± 0.622
0.735TrpSer: 0.735 ± 0.537
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.735TrpTyr: 0.735 ± 0.537
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.674TyrAla: 3.674 ± 1.134
0.0TyrCys: 0.0 ± 0.0
4.409TyrAsp: 4.409 ± 1.218
2.204TyrGlu: 2.204 ± 1.09
5.143TyrPhe: 5.143 ± 2.07
2.939TyrGly: 2.939 ± 1.261
0.0TyrHis: 0.0 ± 0.0
0.0TyrIle: 0.0 ± 0.0
1.47TyrLys: 1.47 ± 0.561
2.204TyrLeu: 2.204 ± 1.09
0.735TyrMet: 0.735 ± 0.537
0.735TyrAsn: 0.735 ± 0.622
2.939TyrPro: 2.939 ± 0.744
1.47TyrGln: 1.47 ± 1.075
3.674TyrArg: 3.674 ± 2.073
2.939TyrSer: 2.939 ± 1.121
1.47TyrThr: 1.47 ± 1.164
2.939TyrVal: 2.939 ± 1.121
0.0TyrTrp: 0.0 ± 0.0
0.735TyrTyr: 0.735 ± 0.537
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1362 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski