Amino acid dipepetide frequency for Erythrobacteraceae bacterium CFH 75059

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.95AlaAla: 22.95 ± 0.282	1.246AlaCys: 1.246 ± 0.056	7.949AlaAsp: 7.949 ± 0.123	8.298AlaGlu: 8.298 ± 0.136	4.431AlaPhe: 4.431 ± 0.096	13.105AlaGly: 13.105 ± 0.155	2.543AlaHis: 2.543 ± 0.069	5.581AlaIle: 5.581 ± 0.088	2.548AlaLys: 2.548 ± 0.081	15.607AlaLeu: 15.607 ± 0.201	3.615AlaMet: 3.615 ± 0.069	2.71AlaAsn: 2.71 ± 0.057	6.963AlaPro: 6.963 ± 0.124	5.12AlaGln: 5.12 ± 0.101	12.33AlaArg: 12.33 ± 0.148	6.536AlaSer: 6.536 ± 0.109	6.407AlaThr: 6.407 ± 0.109	10.077AlaVal: 10.077 ± 0.132	1.694AlaTrp: 1.694 ± 0.057	2.362AlaTyr: 2.362 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	1.247CysAla: 1.247 ± 0.043	0.087CysCys: 0.087 ± 0.011	0.599CysAsp: 0.599 ± 0.03	0.444CysGlu: 0.444 ± 0.026	0.283CysPhe: 0.283 ± 0.02	0.97CysGly: 0.97 ± 0.044	0.22CysHis: 0.22 ± 0.015	0.333CysIle: 0.333 ± 0.021	0.12CysLys: 0.12 ± 0.013	0.764CysLeu: 0.764 ± 0.034	0.141CysMet: 0.141 ± 0.014	0.181CysAsn: 0.181 ± 0.017	0.478CysPro: 0.478 ± 0.027	0.196CysGln: 0.196 ± 0.017	0.712CysArg: 0.712 ± 0.035	0.429CysSer: 0.429 ± 0.027	0.467CysThr: 0.467 ± 0.027	0.606CysVal: 0.606 ± 0.032	0.113CysTrp: 0.113 ± 0.014	0.174CysTyr: 0.174 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	8.472AspAla: 8.472 ± 0.147	0.471AspCys: 0.471 ± 0.028	3.125AspAsp: 3.125 ± 0.078	3.766AspGlu: 3.766 ± 0.084	1.821AspPhe: 1.821 ± 0.047	5.692AspGly: 5.692 ± 0.093	1.308AspHis: 1.308 ± 0.048	2.291AspIle: 2.291 ± 0.062	1.09AspLys: 1.09 ± 0.04	5.781AspLeu: 5.781 ± 0.09	1.182AspMet: 1.182 ± 0.037	1.137AspAsn: 1.137 ± 0.046	3.903AspPro: 3.903 ± 0.081	1.602AspGln: 1.602 ± 0.047	4.997AspArg: 4.997 ± 0.091	2.149AspSer: 2.149 ± 0.052	2.865AspThr: 2.865 ± 0.065	3.924AspVal: 3.924 ± 0.082	1.009AspTrp: 1.009 ± 0.041	1.272AspTyr: 1.272 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	8.031GluAla: 8.031 ± 0.126	0.364GluCys: 0.364 ± 0.022	2.851GluAsp: 2.851 ± 0.076	3.534GluGlu: 3.534 ± 0.082	1.485GluPhe: 1.485 ± 0.048	4.469GluGly: 4.469 ± 0.095	1.338GluHis: 1.338 ± 0.044	2.461GluIle: 2.461 ± 0.062	1.338GluLys: 1.338 ± 0.058	5.11GluLeu: 5.11 ± 0.096	1.173GluMet: 1.173 ± 0.041	1.269GluAsn: 1.269 ± 0.041	2.994GluPro: 2.994 ± 0.068	2.555GluGln: 2.555 ± 0.074	6.155GluArg: 6.155 ± 0.114	2.014GluSer: 2.014 ± 0.056	2.813GluThr: 2.813 ± 0.057	3.973GluVal: 3.973 ± 0.086	0.821GluTrp: 0.821 ± 0.038	0.932GluTyr: 0.932 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	5.14PheAla: 5.14 ± 0.097	0.336PheCys: 0.336 ± 0.02	2.494PheAsp: 2.494 ± 0.06	1.786PheGlu: 1.786 ± 0.047	1.27PhePhe: 1.27 ± 0.054	3.435PheGly: 3.435 ± 0.079	0.676PheHis: 0.676 ± 0.028	1.34PheIle: 1.34 ± 0.044	0.613PheLys: 0.613 ± 0.035	3.007PheLeu: 3.007 ± 0.077	0.671PheMet: 0.671 ± 0.03	0.911PheAsn: 0.911 ± 0.039	1.421PhePro: 1.421 ± 0.048	0.809PheGln: 0.809 ± 0.035	2.347PheArg: 2.347 ± 0.055	1.785PheSer: 1.785 ± 0.053	2.011PheThr: 2.011 ± 0.051	2.642PheVal: 2.642 ± 0.067	0.531PheTrp: 0.531 ± 0.025	0.809PheTyr: 0.809 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	11.282GlyAla: 11.282 ± 0.146	0.909GlyCys: 0.909 ± 0.039	4.852GlyAsp: 4.852 ± 0.082	5.2GlyGlu: 5.2 ± 0.086	3.471GlyPhe: 3.471 ± 0.083	8.36GlyGly: 8.36 ± 0.165	1.921GlyHis: 1.921 ± 0.054	3.854GlyIle: 3.854 ± 0.076	2.178GlyLys: 2.178 ± 0.064	8.52GlyLeu: 8.52 ± 0.116	2.175GlyMet: 2.175 ± 0.056	2.043GlyAsn: 2.043 ± 0.062	3.797GlyPro: 3.797 ± 0.069	2.991GlyGln: 2.991 ± 0.06	7.662GlyArg: 7.662 ± 0.124	4.804GlySer: 4.804 ± 0.09	5.153GlyThr: 5.153 ± 0.097	6.371GlyVal: 6.371 ± 0.101	1.636GlyTrp: 1.636 ± 0.048	1.941GlyTyr: 1.941 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	2.814HisAla: 2.814 ± 0.085	0.29HisCys: 0.29 ± 0.023	1.267HisAsp: 1.267 ± 0.045	1.045HisGlu: 1.045 ± 0.04	0.726HisPhe: 0.726 ± 0.032	2.21HisGly: 2.21 ± 0.057	0.637HisHis: 0.637 ± 0.033	0.76HisIle: 0.76 ± 0.031	0.357HisLys: 0.357 ± 0.023	2.118HisLeu: 2.118 ± 0.059	0.391HisMet: 0.391 ± 0.028	0.425HisAsn: 0.425 ± 0.027	1.477HisPro: 1.477 ± 0.053	0.581HisGln: 0.581 ± 0.03	1.91HisArg: 1.91 ± 0.055	0.876HisSer: 0.876 ± 0.035	0.844HisThr: 0.844 ± 0.038	1.506HisVal: 1.506 ± 0.052	0.409HisTrp: 0.409 ± 0.026	0.535HisTyr: 0.535 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.655IleAla: 6.655 ± 0.114	0.418IleCys: 0.418 ± 0.023	3.087IleAsp: 3.087 ± 0.071	2.708IleGlu: 2.708 ± 0.071	1.251IlePhe: 1.251 ± 0.047	4.298IleGly: 4.298 ± 0.08	0.731IleHis: 0.731 ± 0.033	1.717IleIle: 1.717 ± 0.059	0.896IleLys: 0.896 ± 0.042	3.329IleLeu: 3.329 ± 0.068	0.764IleMet: 0.764 ± 0.031	1.141IleAsn: 1.141 ± 0.048	1.881IlePro: 1.881 ± 0.05	0.877IleGln: 0.877 ± 0.039	3.006IleArg: 3.006 ± 0.071	1.947IleSer: 1.947 ± 0.058	2.35IleThr: 2.35 ± 0.058	3.6IleVal: 3.6 ± 0.076	0.455IleTrp: 0.455 ± 0.025	0.845IleTyr: 0.845 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	2.824LysAla: 2.824 ± 0.071	0.106LysCys: 0.106 ± 0.012	1.016LysAsp: 1.016 ± 0.047	0.929LysGlu: 0.929 ± 0.047	0.478LysPhe: 0.478 ± 0.029	1.772LysGly: 1.772 ± 0.055	0.422LysHis: 0.422 ± 0.029	0.88LysIle: 0.88 ± 0.034	0.629LysLys: 0.629 ± 0.041	2.139LysLeu: 2.139 ± 0.073	0.447LysMet: 0.447 ± 0.029	0.465LysAsn: 0.465 ± 0.026	1.267LysPro: 1.267 ± 0.039	0.626LysGln: 0.626 ± 0.035	1.786LysArg: 1.786 ± 0.065	0.929LysSer: 0.929 ± 0.044	1.066LysThr: 1.066 ± 0.043	1.524LysVal: 1.524 ± 0.053	0.223LysTrp: 0.223 ± 0.017	0.386LysTyr: 0.386 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	15.944LeuAla: 15.944 ± 0.19	0.854LeuCys: 0.854 ± 0.034	6.29LeuAsp: 6.29 ± 0.114	5.314LeuGlu: 5.314 ± 0.086	3.657LeuPhe: 3.657 ± 0.092	8.572LeuGly: 8.572 ± 0.122	2.098LeuHis: 2.098 ± 0.062	3.916LeuIle: 3.916 ± 0.091	2.146LeuLys: 2.146 ± 0.068	11.231LeuLeu: 11.231 ± 0.191	1.995LeuMet: 1.995 ± 0.057	2.142LeuAsn: 2.142 ± 0.065	6.119LeuPro: 6.119 ± 0.107	2.782LeuGln: 2.782 ± 0.069	8.661LeuArg: 8.661 ± 0.123	5.714LeuSer: 5.714 ± 0.087	5.334LeuThr: 5.334 ± 0.096	8.141LeuVal: 8.141 ± 0.11	1.298LeuTrp: 1.298 ± 0.042	1.81LeuTyr: 1.81 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	3.025MetAla: 3.025 ± 0.068	0.136MetCys: 0.136 ± 0.013	1.015MetAsp: 1.015 ± 0.039	0.957MetGlu: 0.957 ± 0.039	0.58MetPhe: 0.58 ± 0.029	1.592MetGly: 1.592 ± 0.04	0.449MetHis: 0.449 ± 0.028	1.077MetIle: 1.077 ± 0.041	0.645MetLys: 0.645 ± 0.032	2.455MetLeu: 2.455 ± 0.072	0.538MetMet: 0.538 ± 0.029	0.666MetAsn: 0.666 ± 0.027	1.377MetPro: 1.377 ± 0.045	0.741MetGln: 0.741 ± 0.037	1.923MetArg: 1.923 ± 0.051	1.234MetSer: 1.234 ± 0.038	1.557MetThr: 1.557 ± 0.048	1.463MetVal: 1.463 ± 0.05	0.184MetTrp: 0.184 ± 0.018	0.228MetTyr: 0.228 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.062AsnAla: 3.062 ± 0.073	0.216AsnCys: 0.216 ± 0.017	1.124AsnAsp: 1.124 ± 0.042	1.051AsnGlu: 1.051 ± 0.04	0.786AsnPhe: 0.786 ± 0.038	2.024AsnGly: 2.024 ± 0.07	0.434AsnHis: 0.434 ± 0.024	1.066AsnIle: 1.066 ± 0.042	0.432AsnLys: 0.432 ± 0.028	2.256AsnLeu: 2.256 ± 0.069	0.423AsnMet: 0.423 ± 0.024	0.487AsnAsn: 0.487 ± 0.029	1.614AsnPro: 1.614 ± 0.054	0.616AsnGln: 0.616 ± 0.034	1.907AsnArg: 1.907 ± 0.051	1.008AsnSer: 1.008 ± 0.039	1.095AsnThr: 1.095 ± 0.042	1.615AsnVal: 1.615 ± 0.053	0.315AsnTrp: 0.315 ± 0.022	0.486AsnTyr: 0.486 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	8.408ProAla: 8.408 ± 0.146	0.38ProCys: 0.38 ± 0.024	4.041ProAsp: 4.041 ± 0.08	3.609ProGlu: 3.609 ± 0.083	1.865ProPhe: 1.865 ± 0.049	5.099ProGly: 5.099 ± 0.085	1.192ProHis: 1.192 ± 0.042	1.85ProIle: 1.85 ± 0.053	0.816ProLys: 0.816 ± 0.038	5.634ProLeu: 5.634 ± 0.102	1.051ProMet: 1.051 ± 0.036	1.044ProAsn: 1.044 ± 0.039	3.635ProPro: 3.635 ± 0.099	1.947ProGln: 1.947 ± 0.06	3.986ProArg: 3.986 ± 0.087	2.623ProSer: 2.623 ± 0.069	2.211ProThr: 2.211 ± 0.05	4.866ProVal: 4.866 ± 0.077	0.755ProTrp: 0.755 ± 0.033	1.002ProTyr: 1.002 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	4.343GlnAla: 4.343 ± 0.092	0.203GlnCys: 0.203 ± 0.017	1.506GlnAsp: 1.506 ± 0.043	1.579GlnGlu: 1.579 ± 0.052	1.093GlnPhe: 1.093 ± 0.033	2.527GlnGly: 2.527 ± 0.067	0.693GlnHis: 0.693 ± 0.03	1.665GlnIle: 1.665 ± 0.059	0.629GlnLys: 0.629 ± 0.032	3.303GlnLeu: 3.303 ± 0.07	0.776GlnMet: 0.776 ± 0.036	0.725GlnAsn: 0.725 ± 0.033	2.162GlnPro: 2.162 ± 0.065	1.44GlnGln: 1.44 ± 0.059	2.943GlnArg: 2.943 ± 0.071	1.509GlnSer: 1.509 ± 0.052	1.669GlnThr: 1.669 ± 0.053	2.523GlnVal: 2.523 ± 0.059	0.458GlnTrp: 0.458 ± 0.023	0.525GlnTyr: 0.525 ± 0.025	0.001GlnXaa: 0.001 ± 0.002
Arg	10.554ArgAla: 10.554 ± 0.148	0.726ArgCys: 0.726 ± 0.034	4.95ArgAsp: 4.95 ± 0.081	4.824ArgGlu: 4.824 ± 0.081	3.39ArgPhe: 3.39 ± 0.072	6.062ArgGly: 6.062 ± 0.099	2.216ArgHis: 2.216 ± 0.062	4.199ArgIle: 4.199 ± 0.08	1.656ArgLys: 1.656 ± 0.06	10.058ArgLeu: 10.058 ± 0.157	2.213ArgMet: 2.213 ± 0.053	1.807ArgAsn: 1.807 ± 0.056	4.649ArgPro: 4.649 ± 0.082	3.132ArgGln: 3.132 ± 0.075	8.01ArgArg: 8.01 ± 0.139	4.225ArgSer: 4.225 ± 0.073	4.198ArgThr: 4.198 ± 0.075	6.027ArgVal: 6.027 ± 0.088	1.491ArgTrp: 1.491 ± 0.042	1.779ArgTyr: 1.779 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	6.535SerAla: 6.535 ± 0.094	0.383SerCys: 0.383 ± 0.023	2.723SerAsp: 2.723 ± 0.065	2.298SerGlu: 2.298 ± 0.06	1.902SerPhe: 1.902 ± 0.053	5.342SerGly: 5.342 ± 0.094	0.964SerHis: 0.964 ± 0.038	1.921SerIle: 1.921 ± 0.061	0.883SerLys: 0.883 ± 0.035	4.854SerLeu: 4.854 ± 0.092	1.041SerMet: 1.041 ± 0.042	1.041SerAsn: 1.041 ± 0.037	2.782SerPro: 2.782 ± 0.07	1.33SerGln: 1.33 ± 0.049	4.122SerArg: 4.122 ± 0.091	2.368SerSer: 2.368 ± 0.064	2.366SerThr: 2.366 ± 0.066	3.467SerVal: 3.467 ± 0.068	0.709SerTrp: 0.709 ± 0.032	1.031SerTyr: 1.031 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.703ThrAla: 6.703 ± 0.103	0.434ThrCys: 0.434 ± 0.028	2.688ThrAsp: 2.688 ± 0.063	2.216ThrGlu: 2.216 ± 0.059	1.776ThrPhe: 1.776 ± 0.054	5.524ThrGly: 5.524 ± 0.107	0.967ThrHis: 0.967 ± 0.036	2.305ThrIle: 2.305 ± 0.069	0.867ThrLys: 0.867 ± 0.04	5.865ThrLeu: 5.865 ± 0.105	1.064ThrMet: 1.064 ± 0.041	1.115ThrAsn: 1.115 ± 0.044	3.352ThrPro: 3.352 ± 0.07	1.47ThrGln: 1.47 ± 0.05	4.128ThrArg: 4.128 ± 0.086	2.336ThrSer: 2.336 ± 0.062	2.584ThrThr: 2.584 ± 0.08	4.302ThrVal: 4.302 ± 0.093	0.621ThrTrp: 0.621 ± 0.029	1.025ThrTyr: 1.025 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	10.154ValAla: 10.154 ± 0.142	0.641ValCys: 0.641 ± 0.027	4.24ValAsp: 4.24 ± 0.084	4.562ValGlu: 4.562 ± 0.09	2.542ValPhe: 2.542 ± 0.059	5.255ValGly: 5.255 ± 0.096	1.483ValHis: 1.483 ± 0.046	3.429ValIle: 3.429 ± 0.074	1.419ValLys: 1.419 ± 0.051	8.147ValLeu: 8.147 ± 0.13	1.583ValMet: 1.583 ± 0.052	1.769ValAsn: 1.769 ± 0.056	4.522ValPro: 4.522 ± 0.076	2.2ValGln: 2.2 ± 0.061	6.158ValArg: 6.158 ± 0.101	3.812ValSer: 3.812 ± 0.092	4.634ValThr: 4.634 ± 0.095	5.756ValVal: 5.756 ± 0.105	0.995ValTrp: 0.995 ± 0.042	1.246ValTyr: 1.246 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	1.39TrpAla: 1.39 ± 0.045	0.152TrpCys: 0.152 ± 0.017	0.735TrpAsp: 0.735 ± 0.037	0.592TrpGlu: 0.592 ± 0.027	0.552TrpPhe: 0.552 ± 0.031	0.896TrpGly: 0.896 ± 0.038	0.407TrpHis: 0.407 ± 0.025	0.612TrpIle: 0.612 ± 0.031	0.287TrpLys: 0.287 ± 0.02	1.933TrpLeu: 1.933 ± 0.059	0.283TrpMet: 0.283 ± 0.022	0.444TrpAsn: 0.444 ± 0.025	0.732TrpPro: 0.732 ± 0.036	0.66TrpGln: 0.66 ± 0.031	1.546TrpArg: 1.546 ± 0.049	0.874TrpSer: 0.874 ± 0.036	0.806TrpThr: 0.806 ± 0.042	0.841TrpVal: 0.841 ± 0.039	0.257TrpTrp: 0.257 ± 0.019	0.251TrpTyr: 0.251 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.536TyrAla: 2.536 ± 0.057	0.213TyrCys: 0.213 ± 0.019	1.305TyrAsp: 1.305 ± 0.05	0.967TyrGlu: 0.967 ± 0.042	0.674TyrPhe: 0.674 ± 0.031	1.915TyrGly: 1.915 ± 0.054	0.48TyrHis: 0.48 ± 0.026	0.7TyrIle: 0.7 ± 0.032	0.365TyrLys: 0.365 ± 0.023	1.905TyrLeu: 1.905 ± 0.052	0.315TyrMet: 0.315 ± 0.022	0.496TyrAsn: 0.496 ± 0.029	0.889TyrPro: 0.889 ± 0.039	0.597TyrGln: 0.597 ± 0.026	1.878TyrArg: 1.878 ± 0.051	0.89TyrSer: 0.89 ± 0.039	0.912TyrThr: 0.912 ± 0.039	1.321TyrVal: 1.321 ± 0.041	0.278TyrTrp: 0.278 ± 0.021	0.455TyrTyr: 0.455 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.002	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2149 proteins (689682 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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