Amino acid dipepetide frequency for Paraoceanicella profunda

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.052AlaAla: 21.052 ± 0.205	1.354AlaCys: 1.354 ± 0.033	6.901AlaAsp: 6.901 ± 0.076	9.168AlaGlu: 9.168 ± 0.101	4.547AlaPhe: 4.547 ± 0.062	12.945AlaGly: 12.945 ± 0.124	2.482AlaHis: 2.482 ± 0.045	5.412AlaIle: 5.412 ± 0.058	2.643AlaLys: 2.643 ± 0.045	16.511AlaLeu: 16.511 ± 0.139	3.749AlaMet: 3.749 ± 0.058	2.35AlaAsn: 2.35 ± 0.04	7.863AlaPro: 7.863 ± 0.111	4.098AlaGln: 4.098 ± 0.058	11.932AlaArg: 11.932 ± 0.122	5.938AlaSer: 5.938 ± 0.06	6.153AlaThr: 6.153 ± 0.073	9.094AlaVal: 9.094 ± 0.083	1.789AlaTrp: 1.789 ± 0.046	2.404AlaTyr: 2.404 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	1.279CysAla: 1.279 ± 0.034	0.106CysCys: 0.106 ± 0.008	0.542CysAsp: 0.542 ± 0.021	0.427CysGlu: 0.427 ± 0.018	0.333CysPhe: 0.333 ± 0.013	1.037CysGly: 1.037 ± 0.027	0.243CysHis: 0.243 ± 0.013	0.394CysIle: 0.394 ± 0.017	0.12CysLys: 0.12 ± 0.009	0.963CysLeu: 0.963 ± 0.025	0.165CysMet: 0.165 ± 0.011	0.21CysAsn: 0.21 ± 0.013	0.568CysPro: 0.568 ± 0.021	0.194CysGln: 0.194 ± 0.011	0.665CysArg: 0.665 ± 0.027	0.444CysSer: 0.444 ± 0.018	0.452CysThr: 0.452 ± 0.019	0.663CysVal: 0.663 ± 0.02	0.122CysTrp: 0.122 ± 0.01	0.181CysTyr: 0.181 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.377AspAla: 7.377 ± 0.083	0.454AspCys: 0.454 ± 0.016	2.775AspAsp: 2.775 ± 0.064	2.87AspGlu: 2.87 ± 0.051	2.056AspPhe: 2.056 ± 0.037	5.268AspGly: 5.268 ± 0.071	1.168AspHis: 1.168 ± 0.033	2.926AspIle: 2.926 ± 0.045	1.031AspLys: 1.031 ± 0.031	5.895AspLeu: 5.895 ± 0.075	1.54AspMet: 1.54 ± 0.035	0.903AspAsn: 0.903 ± 0.026	3.804AspPro: 3.804 ± 0.06	1.38AspGln: 1.38 ± 0.034	4.351AspArg: 4.351 ± 0.057	2.061AspSer: 2.061 ± 0.038	3.167AspThr: 3.167 ± 0.054	3.774AspVal: 3.774 ± 0.055	1.147AspTrp: 1.147 ± 0.028	1.368AspTyr: 1.368 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	9.158GluAla: 9.158 ± 0.118	0.357GluCys: 0.357 ± 0.017	3.096GluAsp: 3.096 ± 0.05	3.605GluGlu: 3.605 ± 0.063	1.656GluPhe: 1.656 ± 0.038	5.154GluGly: 5.154 ± 0.064	1.137GluHis: 1.137 ± 0.027	3.527GluIle: 3.527 ± 0.052	1.672GluLys: 1.672 ± 0.044	4.952GluLeu: 4.952 ± 0.063	1.689GluMet: 1.689 ± 0.039	1.382GluAsn: 1.382 ± 0.032	2.672GluPro: 2.672 ± 0.045	1.744GluGln: 1.744 ± 0.035	4.839GluArg: 4.839 ± 0.064	2.2GluSer: 2.2 ± 0.039	3.837GluThr: 3.837 ± 0.05	4.052GluVal: 4.052 ± 0.054	0.634GluTrp: 0.634 ± 0.023	0.933GluTyr: 0.933 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.607PheAla: 4.607 ± 0.056	0.391PheCys: 0.391 ± 0.017	2.498PheAsp: 2.498 ± 0.039	2.125PheGlu: 2.125 ± 0.039	1.23PhePhe: 1.23 ± 0.033	3.595PheGly: 3.595 ± 0.062	0.792PheHis: 0.792 ± 0.022	1.503PheIle: 1.503 ± 0.037	0.603PheLys: 0.603 ± 0.024	3.429PheLeu: 3.429 ± 0.054	0.734PheMet: 0.734 ± 0.021	0.845PheAsn: 0.845 ± 0.023	1.639PhePro: 1.639 ± 0.034	0.818PheGln: 0.818 ± 0.02	2.467PheArg: 2.467 ± 0.046	2.034PheSer: 2.034 ± 0.035	2.049PheThr: 2.049 ± 0.039	2.559PheVal: 2.559 ± 0.045	0.543PheTrp: 0.543 ± 0.018	0.821PheTyr: 0.821 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	12.097GlyAla: 12.097 ± 0.123	0.949GlyCys: 0.949 ± 0.026	4.416GlyAsp: 4.416 ± 0.087	4.847GlyGlu: 4.847 ± 0.062	3.694GlyPhe: 3.694 ± 0.053	8.295GlyGly: 8.295 ± 0.161	2.019GlyHis: 2.019 ± 0.038	4.3GlyIle: 4.3 ± 0.067	2.299GlyLys: 2.299 ± 0.046	10.525GlyLeu: 10.525 ± 0.105	2.717GlyMet: 2.717 ± 0.045	1.814GlyAsn: 1.814 ± 0.047	4.853GlyPro: 4.853 ± 0.07	2.771GlyGln: 2.771 ± 0.04	7.345GlyArg: 7.345 ± 0.085	4.371GlySer: 4.371 ± 0.066	4.922GlyThr: 4.922 ± 0.067	6.653GlyVal: 6.653 ± 0.083	1.584GlyTrp: 1.584 ± 0.037	2.17GlyTyr: 2.17 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.626HisAla: 2.626 ± 0.049	0.242HisCys: 0.242 ± 0.014	1.248HisAsp: 1.248 ± 0.031	1.032HisGlu: 1.032 ± 0.026	0.798HisPhe: 0.798 ± 0.027	1.992HisGly: 1.992 ± 0.04	0.54HisHis: 0.54 ± 0.022	0.82HisIle: 0.82 ± 0.025	0.328HisLys: 0.328 ± 0.015	2.021HisLeu: 2.021 ± 0.036	0.507HisMet: 0.507 ± 0.022	0.386HisAsn: 0.386 ± 0.016	1.432HisPro: 1.432 ± 0.033	0.48HisGln: 0.48 ± 0.022	1.453HisArg: 1.453 ± 0.033	0.855HisSer: 0.855 ± 0.025	0.82HisThr: 0.82 ± 0.025	1.652HisVal: 1.652 ± 0.037	0.355HisTrp: 0.355 ± 0.015	0.5HisTyr: 0.5 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.849IleAla: 6.849 ± 0.071	0.525IleCys: 0.525 ± 0.017	3.207IleAsp: 3.207 ± 0.053	2.85IleGlu: 2.85 ± 0.044	1.527IlePhe: 1.527 ± 0.034	4.58IleGly: 4.58 ± 0.06	0.823IleHis: 0.823 ± 0.025	1.845IleIle: 1.845 ± 0.043	0.734IleLys: 0.734 ± 0.026	4.302IleLeu: 4.302 ± 0.057	0.849IleMet: 0.849 ± 0.026	0.968IleAsn: 0.968 ± 0.025	2.215IlePro: 2.215 ± 0.041	0.862IleGln: 0.862 ± 0.026	3.325IleArg: 3.325 ± 0.055	2.639IleSer: 2.639 ± 0.043	2.63IleThr: 2.63 ± 0.044	3.413IleVal: 3.413 ± 0.059	0.59IleTrp: 0.59 ± 0.02	0.938IleTyr: 0.938 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	2.857LysAla: 2.857 ± 0.053	0.128LysCys: 0.128 ± 0.009	1.102LysAsp: 1.102 ± 0.03	1.056LysGlu: 1.056 ± 0.034	0.632LysPhe: 0.632 ± 0.024	2.0LysGly: 2.0 ± 0.039	0.414LysHis: 0.414 ± 0.016	1.114LysIle: 1.114 ± 0.029	0.692LysLys: 0.692 ± 0.028	2.256LysLeu: 2.256 ± 0.044	0.585LysMet: 0.585 ± 0.022	0.45LysAsn: 0.45 ± 0.02	1.395LysPro: 1.395 ± 0.038	0.581LysGln: 0.581 ± 0.019	1.612LysArg: 1.612 ± 0.037	1.214LysSer: 1.214 ± 0.032	1.324LysThr: 1.324 ± 0.03	1.746LysVal: 1.746 ± 0.039	0.286LysTrp: 0.286 ± 0.014	0.46LysTyr: 0.46 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	15.452LeuAla: 15.452 ± 0.142	1.089LeuCys: 1.089 ± 0.029	6.043LeuAsp: 6.043 ± 0.067	5.696LeuGlu: 5.696 ± 0.07	3.468LeuPhe: 3.468 ± 0.053	9.314LeuGly: 9.314 ± 0.094	1.981LeuHis: 1.981 ± 0.034	4.49LeuIle: 4.49 ± 0.062	2.358LeuLys: 2.358 ± 0.051	9.92LeuLeu: 9.92 ± 0.104	2.562LeuMet: 2.562 ± 0.046	2.166LeuAsn: 2.166 ± 0.038	6.227LeuPro: 6.227 ± 0.081	2.434LeuGln: 2.434 ± 0.043	8.359LeuArg: 8.359 ± 0.09	6.792LeuSer: 6.792 ± 0.069	5.967LeuThr: 5.967 ± 0.064	7.496LeuVal: 7.496 ± 0.087	1.283LeuTrp: 1.283 ± 0.034	1.906LeuTyr: 1.906 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.342MetAla: 3.342 ± 0.048	0.173MetCys: 0.173 ± 0.01	1.218MetAsp: 1.218 ± 0.03	1.332MetGlu: 1.332 ± 0.028	0.713MetPhe: 0.713 ± 0.023	1.991MetGly: 1.991 ± 0.038	0.455MetHis: 0.455 ± 0.017	1.33MetIle: 1.33 ± 0.034	0.839MetLys: 0.839 ± 0.025	2.69MetLeu: 2.69 ± 0.046	0.704MetMet: 0.704 ± 0.024	0.704MetAsn: 0.704 ± 0.025	1.568MetPro: 1.568 ± 0.032	0.833MetGln: 0.833 ± 0.025	1.995MetArg: 1.995 ± 0.038	1.709MetSer: 1.709 ± 0.034	1.988MetThr: 1.988 ± 0.033	1.769MetVal: 1.769 ± 0.039	0.224MetTrp: 0.224 ± 0.011	0.303MetTyr: 0.303 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.705AsnAla: 2.705 ± 0.043	0.206AsnCys: 0.206 ± 0.012	1.064AsnAsp: 1.064 ± 0.036	0.888AsnGlu: 0.888 ± 0.022	0.77AsnPhe: 0.77 ± 0.023	1.901AsnGly: 1.901 ± 0.041	0.416AsnHis: 0.416 ± 0.017	1.08AsnIle: 1.08 ± 0.029	0.403AsnLys: 0.403 ± 0.016	2.133AsnLeu: 2.133 ± 0.038	0.553AsnMet: 0.553 ± 0.018	0.477AsnAsn: 0.477 ± 0.021	1.603AsnPro: 1.603 ± 0.033	0.513AsnGln: 0.513 ± 0.02	1.564AsnArg: 1.564 ± 0.036	0.923AsnSer: 0.923 ± 0.029	1.134AsnThr: 1.134 ± 0.031	1.515AsnVal: 1.515 ± 0.028	0.346AsnTrp: 0.346 ± 0.014	0.488AsnTyr: 0.488 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	7.865ProAla: 7.865 ± 0.098	0.431ProCys: 0.431 ± 0.019	4.009ProAsp: 4.009 ± 0.055	4.894ProGlu: 4.894 ± 0.072	1.947ProPhe: 1.947 ± 0.036	6.429ProGly: 6.429 ± 0.087	1.121ProHis: 1.121 ± 0.029	1.846ProIle: 1.846 ± 0.039	1.191ProLys: 1.191 ± 0.029	5.279ProLeu: 5.279 ± 0.064	1.295ProMet: 1.295 ± 0.028	1.044ProAsn: 1.044 ± 0.026	3.055ProPro: 3.055 ± 0.066	1.63ProGln: 1.63 ± 0.04	3.749ProArg: 3.749 ± 0.055	2.576ProSer: 2.576 ± 0.05	2.229ProThr: 2.229 ± 0.043	4.733ProVal: 4.733 ± 0.067	0.79ProTrp: 0.79 ± 0.025	1.055ProTyr: 1.055 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.79GlnAla: 3.79 ± 0.055	0.187GlnCys: 0.187 ± 0.013	1.487GlnAsp: 1.487 ± 0.03	1.383GlnGlu: 1.383 ± 0.033	0.887GlnPhe: 0.887 ± 0.027	2.44GlnGly: 2.44 ± 0.041	0.475GlnHis: 0.475 ± 0.017	1.52GlnIle: 1.52 ± 0.039	0.747GlnLys: 0.747 ± 0.024	2.28GlnLeu: 2.28 ± 0.042	0.863GlnMet: 0.863 ± 0.028	0.667GlnAsn: 0.667 ± 0.024	1.545GlnPro: 1.545 ± 0.039	0.843GlnGln: 0.843 ± 0.029	2.072GlnArg: 2.072 ± 0.038	1.404GlnSer: 1.404 ± 0.036	1.376GlnThr: 1.376 ± 0.031	2.168GlnVal: 2.168 ± 0.038	0.318GlnTrp: 0.318 ± 0.015	0.493GlnTyr: 0.493 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	10.788ArgAla: 10.788 ± 0.109	0.594ArgCys: 0.594 ± 0.024	4.361ArgAsp: 4.361 ± 0.052	4.382ArgGlu: 4.382 ± 0.063	2.942ArgPhe: 2.942 ± 0.043	5.833ArgGly: 5.833 ± 0.066	1.887ArgHis: 1.887 ± 0.042	4.027ArgIle: 4.027 ± 0.051	1.738ArgLys: 1.738 ± 0.036	8.93ArgLeu: 8.93 ± 0.103	2.205ArgMet: 2.205 ± 0.037	1.617ArgAsn: 1.617 ± 0.033	4.414ArgPro: 4.414 ± 0.058	2.226ArgGln: 2.226 ± 0.045	6.776ArgArg: 6.776 ± 0.101	3.788ArgSer: 3.788 ± 0.05	3.407ArgThr: 3.407 ± 0.05	5.383ArgVal: 5.383 ± 0.063	1.003ArgTrp: 1.003 ± 0.028	1.531ArgTyr: 1.531 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	6.489SerAla: 6.489 ± 0.065	0.431SerCys: 0.431 ± 0.017	2.751SerAsp: 2.751 ± 0.048	2.606SerGlu: 2.606 ± 0.045	2.125SerPhe: 2.125 ± 0.04	5.809SerGly: 5.809 ± 0.07	0.981SerHis: 0.981 ± 0.026	2.158SerIle: 2.158 ± 0.044	1.031SerLys: 1.031 ± 0.027	5.093SerLeu: 5.093 ± 0.066	1.237SerMet: 1.237 ± 0.027	1.015SerAsn: 1.015 ± 0.027	2.966SerPro: 2.966 ± 0.056	1.31SerGln: 1.31 ± 0.025	3.705SerArg: 3.705 ± 0.054	2.476SerSer: 2.476 ± 0.052	2.399SerThr: 2.399 ± 0.047	3.794SerVal: 3.794 ± 0.057	0.718SerTrp: 0.718 ± 0.025	1.201SerTyr: 1.201 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.694ThrAla: 6.694 ± 0.076	0.468ThrCys: 0.468 ± 0.015	2.84ThrAsp: 2.84 ± 0.047	2.787ThrGlu: 2.787 ± 0.049	1.814ThrPhe: 1.814 ± 0.034	5.873ThrGly: 5.873 ± 0.065	1.005ThrHis: 1.005 ± 0.025	2.259ThrIle: 2.259 ± 0.042	0.928ThrLys: 0.928 ± 0.03	6.274ThrLeu: 6.274 ± 0.059	1.091ThrMet: 1.091 ± 0.03	0.992ThrAsn: 0.992 ± 0.027	3.741ThrPro: 3.741 ± 0.055	1.219ThrGln: 1.219 ± 0.03	3.937ThrArg: 3.937 ± 0.056	2.444ThrSer: 2.444 ± 0.04	2.579ThrThr: 2.579 ± 0.049	4.228ThrVal: 4.228 ± 0.061	0.72ThrTrp: 0.72 ± 0.022	1.093ThrTyr: 1.093 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	9.36ValAla: 9.36 ± 0.092	0.678ValCys: 0.678 ± 0.02	3.735ValAsp: 3.735 ± 0.055	4.455ValGlu: 4.455 ± 0.054	2.841ValPhe: 2.841 ± 0.048	5.162ValGly: 5.162 ± 0.065	1.363ValHis: 1.363 ± 0.032	3.745ValIle: 3.745 ± 0.061	1.778ValLys: 1.778 ± 0.04	7.808ValLeu: 7.808 ± 0.084	2.039ValMet: 2.039 ± 0.038	1.829ValAsn: 1.829 ± 0.038	3.859ValPro: 3.859 ± 0.052	1.876ValGln: 1.876 ± 0.039	4.894ValArg: 4.894 ± 0.061	4.562ValSer: 4.562 ± 0.061	4.724ValThr: 4.724 ± 0.055	5.577ValVal: 5.577 ± 0.074	0.916ValTrp: 0.916 ± 0.026	1.399ValTyr: 1.399 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.478TrpAla: 1.478 ± 0.035	0.137TrpCys: 0.137 ± 0.009	0.667TrpAsp: 0.667 ± 0.022	0.715TrpGlu: 0.715 ± 0.022	0.539TrpPhe: 0.539 ± 0.02	1.033TrpGly: 1.033 ± 0.026	0.336TrpHis: 0.336 ± 0.016	0.583TrpIle: 0.583 ± 0.021	0.368TrpLys: 0.368 ± 0.015	1.704TrpLeu: 1.704 ± 0.034	0.368TrpMet: 0.368 ± 0.015	0.384TrpAsn: 0.384 ± 0.016	0.742TrpPro: 0.742 ± 0.022	0.555TrpGln: 0.555 ± 0.019	1.243TrpArg: 1.243 ± 0.029	0.863TrpSer: 0.863 ± 0.029	0.779TrpThr: 0.779 ± 0.022	0.91TrpVal: 0.91 ± 0.025	0.235TrpTrp: 0.235 ± 0.013	0.261TrpTyr: 0.261 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.522TyrAla: 2.522 ± 0.044	0.207TyrCys: 0.207 ± 0.013	1.349TyrAsp: 1.349 ± 0.031	1.178TyrGlu: 1.178 ± 0.028	0.764TyrPhe: 0.764 ± 0.024	1.992TyrGly: 1.992 ± 0.047	0.45TyrHis: 0.45 ± 0.014	0.794TyrIle: 0.794 ± 0.026	0.402TyrLys: 0.402 ± 0.016	2.037TyrLeu: 2.037 ± 0.039	0.429TyrMet: 0.429 ± 0.017	0.478TyrAsn: 0.478 ± 0.018	1.007TyrPro: 1.007 ± 0.027	0.576TyrGln: 0.576 ± 0.022	1.549TyrArg: 1.549 ± 0.033	1.0TyrSer: 1.0 ± 0.032	1.052TyrThr: 1.052 ± 0.028	1.418TyrVal: 1.418 ± 0.034	0.3TyrTrp: 0.3 ± 0.014	0.51TyrTyr: 0.51 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4636 proteins (1511717 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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