Amino acid dipepetide frequency for Clostridium sartagoforme

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.716AlaAla: 3.716 ± 0.074	0.582AlaCys: 0.582 ± 0.025	2.601AlaAsp: 2.601 ± 0.065	3.584AlaGlu: 3.584 ± 0.07	2.524AlaPhe: 2.524 ± 0.057	3.769AlaGly: 3.769 ± 0.067	0.741AlaHis: 0.741 ± 0.028	6.039AlaIle: 6.039 ± 0.091	4.709AlaLys: 4.709 ± 0.072	6.072AlaLeu: 6.072 ± 0.082	1.531AlaMet: 1.531 ± 0.043	2.844AlaAsn: 2.844 ± 0.07	1.368AlaPro: 1.368 ± 0.039	1.258AlaGln: 1.258 ± 0.033	1.834AlaArg: 1.834 ± 0.048	3.474AlaSer: 3.474 ± 0.064	2.884AlaThr: 2.884 ± 0.061	3.924AlaVal: 3.924 ± 0.069	0.374AlaTrp: 0.374 ± 0.019	2.151AlaTyr: 2.151 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.448CysAla: 0.448 ± 0.026	0.14CysCys: 0.14 ± 0.013	0.572CysAsp: 0.572 ± 0.026	0.631CysGlu: 0.631 ± 0.027	0.377CysPhe: 0.377 ± 0.019	0.887CysGly: 0.887 ± 0.034	0.174CysHis: 0.174 ± 0.014	0.954CysIle: 0.954 ± 0.032	0.776CysLys: 0.776 ± 0.031	0.72CysLeu: 0.72 ± 0.028	0.22CysMet: 0.22 ± 0.013	0.658CysAsn: 0.658 ± 0.025	0.365CysPro: 0.365 ± 0.018	0.174CysGln: 0.174 ± 0.013	0.313CysArg: 0.313 ± 0.019	0.624CysSer: 0.624 ± 0.026	0.49CysThr: 0.49 ± 0.021	0.509CysVal: 0.509 ± 0.024	0.052CysTrp: 0.052 ± 0.007	0.387CysTyr: 0.387 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	2.717AspAla: 2.717 ± 0.061	0.454AspCys: 0.454 ± 0.023	2.753AspAsp: 2.753 ± 0.061	4.816AspGlu: 4.816 ± 0.079	2.925AspPhe: 2.925 ± 0.052	3.668AspGly: 3.668 ± 0.075	0.574AspHis: 0.574 ± 0.024	6.372AspIle: 6.372 ± 0.093	5.683AspLys: 5.683 ± 0.077	5.289AspLeu: 5.289 ± 0.068	1.474AspMet: 1.474 ± 0.038	3.84AspAsn: 3.84 ± 0.073	1.305AspPro: 1.305 ± 0.036	0.72AspGln: 0.72 ± 0.026	1.771AspArg: 1.771 ± 0.044	3.367AspSer: 3.367 ± 0.069	2.535AspThr: 2.535 ± 0.044	3.594AspVal: 3.594 ± 0.066	0.35AspTrp: 0.35 ± 0.02	2.806AspTyr: 2.806 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	4.737GluAla: 4.737 ± 0.071	0.579GluCys: 0.579 ± 0.023	5.087GluAsp: 5.087 ± 0.078	8.206GluGlu: 8.206 ± 0.13	3.11GluPhe: 3.11 ± 0.06	4.602GluGly: 4.602 ± 0.068	0.741GluHis: 0.741 ± 0.025	7.763GluIle: 7.763 ± 0.109	7.323GluLys: 7.323 ± 0.097	6.765GluLeu: 6.765 ± 0.098	1.889GluMet: 1.889 ± 0.045	5.542GluAsn: 5.542 ± 0.083	1.385GluPro: 1.385 ± 0.036	1.287GluGln: 1.287 ± 0.036	2.538GluArg: 2.538 ± 0.055	3.838GluSer: 3.838 ± 0.068	2.874GluThr: 2.874 ± 0.062	5.931GluVal: 5.931 ± 0.076	0.437GluTrp: 0.437 ± 0.02	3.301GluTyr: 3.301 ± 0.062	0.0GluXaa: 0.0 ± 0.0
Phe	2.257PheAla: 2.257 ± 0.055	0.37PheCys: 0.37 ± 0.021	2.544PheAsp: 2.544 ± 0.049	2.825PheGlu: 2.825 ± 0.052	1.939PhePhe: 1.939 ± 0.049	2.86PheGly: 2.86 ± 0.063	0.482PheHis: 0.482 ± 0.023	5.046PheIle: 5.046 ± 0.092	3.888PheLys: 3.888 ± 0.07	3.914PheLeu: 3.914 ± 0.073	1.114PheMet: 1.114 ± 0.034	3.335PheAsn: 3.335 ± 0.057	1.14PhePro: 1.14 ± 0.036	0.822PheGln: 0.822 ± 0.026	1.275PheArg: 1.275 ± 0.037	3.192PheSer: 3.192 ± 0.065	2.41PheThr: 2.41 ± 0.05	2.541PheVal: 2.541 ± 0.05	0.293PheTrp: 0.293 ± 0.017	1.843PheTyr: 1.843 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	4.134GlyAla: 4.134 ± 0.074	0.792GlyCys: 0.792 ± 0.033	3.486GlyAsp: 3.486 ± 0.064	4.62GlyGlu: 4.62 ± 0.073	3.206GlyPhe: 3.206 ± 0.059	4.437GlyGly: 4.437 ± 0.077	0.901GlyHis: 0.901 ± 0.033	6.682GlyIle: 6.682 ± 0.093	5.179GlyLys: 5.179 ± 0.074	5.821GlyLeu: 5.821 ± 0.08	1.641GlyMet: 1.641 ± 0.043	3.492GlyAsn: 3.492 ± 0.081	1.218GlyPro: 1.218 ± 0.041	1.319GlyGln: 1.319 ± 0.04	2.26GlyArg: 2.26 ± 0.051	3.94GlySer: 3.94 ± 0.067	3.412GlyThr: 3.412 ± 0.065	4.885GlyVal: 4.885 ± 0.073	0.487GlyTrp: 0.487 ± 0.022	3.083GlyTyr: 3.083 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	0.584HisAla: 0.584 ± 0.026	0.179HisCys: 0.179 ± 0.014	0.583HisAsp: 0.583 ± 0.027	0.723HisGlu: 0.723 ± 0.023	0.571HisPhe: 0.571 ± 0.026	0.913HisGly: 0.913 ± 0.028	0.281HisHis: 0.281 ± 0.017	1.2HisIle: 1.2 ± 0.031	0.925HisLys: 0.925 ± 0.029	1.085HisLeu: 1.085 ± 0.029	0.313HisMet: 0.313 ± 0.016	0.83HisAsn: 0.83 ± 0.028	0.564HisPro: 0.564 ± 0.026	0.271HisGln: 0.271 ± 0.015	0.472HisArg: 0.472 ± 0.021	0.779HisSer: 0.779 ± 0.026	0.558HisThr: 0.558 ± 0.023	0.61HisVal: 0.61 ± 0.026	0.098HisTrp: 0.098 ± 0.012	0.52HisTyr: 0.52 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.935IleAla: 5.935 ± 0.084	1.08IleCys: 1.08 ± 0.032	6.239IleAsp: 6.239 ± 0.078	7.61IleGlu: 7.61 ± 0.104	4.369IlePhe: 4.369 ± 0.087	6.218IleGly: 6.218 ± 0.08	1.145IleHis: 1.145 ± 0.035	9.814IleIle: 9.814 ± 0.15	8.732IleLys: 8.732 ± 0.108	9.424IleLeu: 9.424 ± 0.109	2.326IleMet: 2.326 ± 0.053	7.065IleAsn: 7.065 ± 0.086	3.181IlePro: 3.181 ± 0.06	1.925IleGln: 1.925 ± 0.042	3.201IleArg: 3.201 ± 0.055	7.306IleSer: 7.306 ± 0.1	5.049IleThr: 5.049 ± 0.08	6.366IleVal: 6.366 ± 0.079	0.529IleTrp: 0.529 ± 0.021	3.831IleTyr: 3.831 ± 0.074	0.0IleXaa: 0.0 ± 0.0
Lys	4.922LysAla: 4.922 ± 0.078	0.684LysCys: 0.684 ± 0.028	6.223LysAsp: 6.223 ± 0.087	9.592LysGlu: 9.592 ± 0.114	3.181LysPhe: 3.181 ± 0.059	5.193LysGly: 5.193 ± 0.071	0.929LysHis: 0.929 ± 0.031	7.778LysIle: 7.778 ± 0.098	7.503LysLys: 7.503 ± 0.093	7.469LysLeu: 7.469 ± 0.091	2.112LysMet: 2.112 ± 0.049	5.94LysAsn: 5.94 ± 0.087	1.885LysPro: 1.885 ± 0.043	1.576LysGln: 1.576 ± 0.042	2.889LysArg: 2.889 ± 0.055	5.188LysSer: 5.188 ± 0.067	3.723LysThr: 3.723 ± 0.062	6.465LysVal: 6.465 ± 0.083	0.559LysTrp: 0.559 ± 0.027	4.066LysTyr: 4.066 ± 0.067	0.0LysXaa: 0.0 ± 0.0
Leu	5.267LeuAla: 5.267 ± 0.081	0.898LeuCys: 0.898 ± 0.029	5.354LeuAsp: 5.354 ± 0.072	6.805LeuGlu: 6.805 ± 0.094	3.9LeuPhe: 3.9 ± 0.072	6.215LeuGly: 6.215 ± 0.094	1.039LeuHis: 1.039 ± 0.031	8.818LeuIle: 8.818 ± 0.124	8.283LeuLys: 8.283 ± 0.1	8.109LeuLeu: 8.109 ± 0.123	2.237LeuMet: 2.237 ± 0.053	6.194LeuAsn: 6.194 ± 0.085	2.759LeuPro: 2.759 ± 0.054	1.891LeuGln: 1.891 ± 0.039	3.116LeuArg: 3.116 ± 0.062	6.995LeuSer: 6.995 ± 0.098	4.561LeuThr: 4.561 ± 0.066	5.755LeuVal: 5.755 ± 0.077	0.589LeuTrp: 0.589 ± 0.027	3.31LeuTyr: 3.31 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	1.67MetAla: 1.67 ± 0.044	0.173MetCys: 0.173 ± 0.013	1.427MetAsp: 1.427 ± 0.033	1.759MetGlu: 1.759 ± 0.041	0.941MetPhe: 0.941 ± 0.033	1.7MetGly: 1.7 ± 0.046	0.326MetHis: 0.326 ± 0.016	2.21MetIle: 2.21 ± 0.048	2.418MetLys: 2.418 ± 0.05	2.126MetLeu: 2.126 ± 0.045	0.674MetMet: 0.674 ± 0.026	1.498MetAsn: 1.498 ± 0.045	0.912MetPro: 0.912 ± 0.03	0.631MetGln: 0.631 ± 0.021	0.812MetArg: 0.812 ± 0.03	1.595MetSer: 1.595 ± 0.041	1.148MetThr: 1.148 ± 0.035	1.568MetVal: 1.568 ± 0.043	0.133MetTrp: 0.133 ± 0.011	0.809MetTyr: 0.809 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	2.826AsnAla: 2.826 ± 0.062	0.579AsnCys: 0.579 ± 0.024	3.349AsnAsp: 3.349 ± 0.063	4.916AsnGlu: 4.916 ± 0.071	2.691AsnPhe: 2.691 ± 0.054	4.089AsnGly: 4.089 ± 0.088	0.754AsnHis: 0.754 ± 0.026	7.529AsnIle: 7.529 ± 0.086	6.583AsnLys: 6.583 ± 0.096	5.967AsnLeu: 5.967 ± 0.085	1.656AsnMet: 1.656 ± 0.05	5.323AsnAsn: 5.323 ± 0.092	2.14AsnPro: 2.14 ± 0.043	1.191AsnGln: 1.191 ± 0.037	1.919AsnArg: 1.919 ± 0.041	4.478AsnSer: 4.478 ± 0.078	3.08AsnThr: 3.08 ± 0.06	3.512AsnVal: 3.512 ± 0.055	0.437AsnTrp: 0.437 ± 0.025	3.017AsnTyr: 3.017 ± 0.055	0.0AsnXaa: 0.0 ± 0.0
Pro	1.392ProAla: 1.392 ± 0.042	0.236ProCys: 0.236 ± 0.016	1.326ProAsp: 1.326 ± 0.036	2.115ProGlu: 2.115 ± 0.049	1.341ProPhe: 1.341 ± 0.041	1.622ProGly: 1.622 ± 0.047	0.398ProHis: 0.398 ± 0.017	2.714ProIle: 2.714 ± 0.051	2.1ProLys: 2.1 ± 0.044	2.493ProLeu: 2.493 ± 0.05	0.702ProMet: 0.702 ± 0.027	1.594ProAsn: 1.594 ± 0.042	0.522ProPro: 0.522 ± 0.026	0.62ProGln: 0.62 ± 0.024	0.796ProArg: 0.796 ± 0.029	1.796ProSer: 1.796 ± 0.038	1.441ProThr: 1.441 ± 0.034	1.93ProVal: 1.93 ± 0.047	0.269ProTrp: 0.269 ± 0.017	1.243ProTyr: 1.243 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	1.181GlnAla: 1.181 ± 0.034	0.195GlnCys: 0.195 ± 0.013	1.031GlnAsp: 1.031 ± 0.033	1.528GlnGlu: 1.528 ± 0.045	0.788GlnPhe: 0.788 ± 0.028	1.516GlnGly: 1.516 ± 0.044	0.243GlnHis: 0.243 ± 0.014	1.799GlnIle: 1.799 ± 0.043	1.572GlnLys: 1.572 ± 0.039	1.742GlnLeu: 1.742 ± 0.043	0.481GlnMet: 0.481 ± 0.024	1.192GlnAsn: 1.192 ± 0.031	0.474GlnPro: 0.474 ± 0.023	0.448GlnGln: 0.448 ± 0.022	0.789GlnArg: 0.789 ± 0.028	1.165GlnSer: 1.165 ± 0.036	0.813GlnThr: 0.813 ± 0.026	1.289GlnVal: 1.289 ± 0.034	0.191GlnTrp: 0.191 ± 0.013	0.893GlnTyr: 0.893 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	1.805ArgAla: 1.805 ± 0.041	0.316ArgCys: 0.316 ± 0.016	1.897ArgAsp: 1.897 ± 0.037	2.972ArgGlu: 2.972 ± 0.056	1.439ArgPhe: 1.439 ± 0.036	2.027ArgGly: 2.027 ± 0.045	0.419ArgHis: 0.419 ± 0.02	3.093ArgIle: 3.093 ± 0.059	2.841ArgLys: 2.841 ± 0.057	2.944ArgLeu: 2.944 ± 0.055	0.922ArgMet: 0.922 ± 0.033	1.964ArgAsn: 1.964 ± 0.048	0.791ArgPro: 0.791 ± 0.029	0.71ArgGln: 0.71 ± 0.029	1.417ArgArg: 1.417 ± 0.041	1.683ArgSer: 1.683 ± 0.037	1.483ArgThr: 1.483 ± 0.033	2.259ArgVal: 2.259 ± 0.048	0.238ArgTrp: 0.238 ± 0.015	1.445ArgTyr: 1.445 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	3.192SerAla: 3.192 ± 0.057	0.569SerCys: 0.569 ± 0.026	3.318SerAsp: 3.318 ± 0.056	4.236SerGlu: 4.236 ± 0.069	3.297SerPhe: 3.297 ± 0.054	4.351SerGly: 4.351 ± 0.07	0.824SerHis: 0.824 ± 0.031	7.24SerIle: 7.24 ± 0.096	5.882SerLys: 5.882 ± 0.084	6.595SerLeu: 6.595 ± 0.095	1.527SerMet: 1.527 ± 0.04	4.42SerAsn: 4.42 ± 0.08	1.598SerPro: 1.598 ± 0.04	1.365SerGln: 1.365 ± 0.039	2.119SerArg: 2.119 ± 0.051	4.483SerSer: 4.483 ± 0.071	3.326SerThr: 3.326 ± 0.062	3.685SerVal: 3.685 ± 0.064	0.41SerTrp: 0.41 ± 0.022	2.891SerTyr: 2.891 ± 0.059	0.0SerXaa: 0.0 ± 0.0
Thr	2.916ThrAla: 2.916 ± 0.059	0.44ThrCys: 0.44 ± 0.02	2.298ThrAsp: 2.298 ± 0.058	3.043ThrGlu: 3.043 ± 0.052	2.326ThrPhe: 2.326 ± 0.054	3.488ThrGly: 3.488 ± 0.069	0.664ThrHis: 0.664 ± 0.024	4.987ThrIle: 4.987 ± 0.076	3.597ThrLys: 3.597 ± 0.065	4.925ThrLeu: 4.925 ± 0.076	1.051ThrMet: 1.051 ± 0.035	2.802ThrAsn: 2.802 ± 0.058	1.762ThrPro: 1.762 ± 0.041	0.938ThrGln: 0.938 ± 0.028	1.466ThrArg: 1.466 ± 0.041	3.356ThrSer: 3.356 ± 0.056	2.706ThrThr: 2.706 ± 0.057	3.384ThrVal: 3.384 ± 0.073	0.372ThrTrp: 0.372 ± 0.022	1.859ThrTyr: 1.859 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	3.969ValAla: 3.969 ± 0.077	0.68ValCys: 0.68 ± 0.03	4.071ValAsp: 4.071 ± 0.076	4.611ValGlu: 4.611 ± 0.077	2.887ValPhe: 2.887 ± 0.061	4.325ValGly: 4.325 ± 0.07	0.787ValHis: 0.787 ± 0.028	6.449ValIle: 6.449 ± 0.086	5.464ValLys: 5.464 ± 0.07	6.107ValLeu: 6.107 ± 0.081	1.512ValMet: 1.512 ± 0.039	4.057ValAsn: 4.057 ± 0.071	1.903ValPro: 1.903 ± 0.047	1.246ValGln: 1.246 ± 0.037	2.022ValArg: 2.022 ± 0.047	4.599ValSer: 4.599 ± 0.071	3.503ValThr: 3.503 ± 0.057	4.739ValVal: 4.739 ± 0.075	0.348ValTrp: 0.348 ± 0.02	2.349ValTyr: 2.349 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.389TrpAla: 0.389 ± 0.021	0.065TrpCys: 0.065 ± 0.008	0.383TrpAsp: 0.383 ± 0.019	0.413TrpGlu: 0.413 ± 0.022	0.297TrpPhe: 0.297 ± 0.02	0.503TrpGly: 0.503 ± 0.023	0.112TrpHis: 0.112 ± 0.012	0.652TrpIle: 0.652 ± 0.025	0.458TrpLys: 0.458 ± 0.019	0.567TrpLeu: 0.567 ± 0.028	0.191TrpMet: 0.191 ± 0.014	0.42TrpAsn: 0.42 ± 0.022	0.151TrpPro: 0.151 ± 0.012	0.18TrpGln: 0.18 ± 0.013	0.227TrpArg: 0.227 ± 0.017	0.464TrpSer: 0.464 ± 0.023	0.356TrpThr: 0.356 ± 0.021	0.379TrpVal: 0.379 ± 0.02	0.069TrpTrp: 0.069 ± 0.009	0.277TrpTyr: 0.277 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.921TyrAla: 1.921 ± 0.042	0.46TyrCys: 0.46 ± 0.022	2.47TyrAsp: 2.47 ± 0.058	2.93TyrGlu: 2.93 ± 0.059	1.979TyrPhe: 1.979 ± 0.047	2.615TyrGly: 2.615 ± 0.048	0.529TyrHis: 0.529 ± 0.024	4.206TyrIle: 4.206 ± 0.077	3.964TyrLys: 3.964 ± 0.067	3.96TyrLeu: 3.96 ± 0.073	0.956TyrMet: 0.956 ± 0.031	3.025TyrAsn: 3.025 ± 0.051	1.227TyrPro: 1.227 ± 0.035	0.759TyrGln: 0.759 ± 0.029	1.429TyrArg: 1.429 ± 0.04	3.006TyrSer: 3.006 ± 0.056	2.028TyrThr: 2.028 ± 0.051	2.3TyrVal: 2.3 ± 0.043	0.318TyrTrp: 0.318 ± 0.017	1.949TyrTyr: 1.949 ± 0.055	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3231 proteins (1046381 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---