Amino acid dipepetide frequency for Caldicellulosiruptor owensensis (strain ATCC 700167 / DSM 13100 / OL)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.238AlaAla: 4.238 ± 0.102	0.741AlaCys: 0.741 ± 0.039	2.748AlaAsp: 2.748 ± 0.061	3.728AlaGlu: 3.728 ± 0.082	2.752AlaPhe: 2.752 ± 0.07	3.853AlaGly: 3.853 ± 0.087	0.908AlaHis: 0.908 ± 0.037	5.842AlaIle: 5.842 ± 0.101	5.754AlaLys: 5.754 ± 0.09	5.899AlaLeu: 5.899 ± 0.114	1.439AlaMet: 1.439 ± 0.051	2.504AlaAsn: 2.504 ± 0.069	1.354AlaPro: 1.354 ± 0.049	2.13AlaGln: 2.13 ± 0.064	2.427AlaArg: 2.427 ± 0.065	3.175AlaSer: 3.175 ± 0.072	2.846AlaThr: 2.846 ± 0.071	4.424AlaVal: 4.424 ± 0.09	0.414AlaTrp: 0.414 ± 0.023	2.226AlaTyr: 2.226 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.674CysAla: 0.674 ± 0.031	0.159CysCys: 0.159 ± 0.016	0.657CysAsp: 0.657 ± 0.032	0.866CysGlu: 0.866 ± 0.034	0.513CysPhe: 0.513 ± 0.024	1.064CysGly: 1.064 ± 0.046	0.201CysHis: 0.201 ± 0.017	0.972CysIle: 0.972 ± 0.043	0.894CysLys: 0.894 ± 0.034	0.85CysLeu: 0.85 ± 0.033	0.232CysMet: 0.232 ± 0.019	0.419CysAsn: 0.419 ± 0.028	0.524CysPro: 0.524 ± 0.031	0.277CysGln: 0.277 ± 0.022	0.435CysArg: 0.435 ± 0.027	0.726CysSer: 0.726 ± 0.033	0.419CysThr: 0.419 ± 0.027	0.761CysVal: 0.761 ± 0.035	0.118CysTrp: 0.118 ± 0.015	0.427CysTyr: 0.427 ± 0.028	0.0CysXaa: 0.0 ± 0.0
Asp	2.691AspAla: 2.691 ± 0.061	0.508AspCys: 0.508 ± 0.027	2.463AspAsp: 2.463 ± 0.069	4.57AspGlu: 4.57 ± 0.089	2.986AspPhe: 2.986 ± 0.066	3.335AspGly: 3.335 ± 0.079	0.634AspHis: 0.634 ± 0.031	5.729AspIle: 5.729 ± 0.094	4.396AspLys: 4.396 ± 0.097	4.382AspLeu: 4.382 ± 0.074	1.233AspMet: 1.233 ± 0.04	2.056AspAsn: 2.056 ± 0.054	1.655AspPro: 1.655 ± 0.047	0.964AspGln: 0.964 ± 0.035	2.196AspArg: 2.196 ± 0.053	2.818AspSer: 2.818 ± 0.059	2.323AspThr: 2.323 ± 0.063	4.17AspVal: 4.17 ± 0.087	0.491AspTrp: 0.491 ± 0.03	2.329AspTyr: 2.329 ± 0.059	0.0AspXaa: 0.0 ± 0.0
Glu	4.292GluAla: 4.292 ± 0.089	0.683GluCys: 0.683 ± 0.032	4.135GluAsp: 4.135 ± 0.095	6.665GluGlu: 6.665 ± 0.136	3.711GluPhe: 3.711 ± 0.076	4.249GluGly: 4.249 ± 0.089	0.957GluHis: 0.957 ± 0.038	7.955GluIle: 7.955 ± 0.138	8.712GluLys: 8.712 ± 0.152	6.435GluLeu: 6.435 ± 0.112	1.886GluMet: 1.886 ± 0.057	4.959GluAsn: 4.959 ± 0.084	1.517GluPro: 1.517 ± 0.051	1.87GluGln: 1.87 ± 0.061	3.474GluArg: 3.474 ± 0.083	3.139GluSer: 3.139 ± 0.07	2.57GluThr: 2.57 ± 0.064	5.626GluVal: 5.626 ± 0.092	0.565GluTrp: 0.565 ± 0.03	3.368GluTyr: 3.368 ± 0.068	0.0GluXaa: 0.0 ± 0.0
Phe	3.162PheAla: 3.162 ± 0.082	0.71PheCys: 0.71 ± 0.036	3.175PheAsp: 3.175 ± 0.073	4.536PheGlu: 4.536 ± 0.091	2.355PhePhe: 2.355 ± 0.073	3.246PheGly: 3.246 ± 0.077	0.601PheHis: 0.601 ± 0.032	4.014PheIle: 4.014 ± 0.082	3.774PheLys: 3.774 ± 0.079	4.959PheLeu: 4.959 ± 0.101	1.051PheMet: 1.051 ± 0.036	2.166PheAsn: 2.166 ± 0.062	1.402PhePro: 1.402 ± 0.044	0.921PheGln: 0.921 ± 0.039	1.624PheArg: 1.624 ± 0.05	3.638PheSer: 3.638 ± 0.076	2.029PheThr: 2.029 ± 0.059	3.891PheVal: 3.891 ± 0.088	0.492PheTrp: 0.492 ± 0.025	2.275PheTyr: 2.275 ± 0.067	0.0PheXaa: 0.0 ± 0.0
Gly	3.712GlyAla: 3.712 ± 0.094	0.863GlyCys: 0.863 ± 0.041	2.677GlyAsp: 2.677 ± 0.068	3.848GlyGlu: 3.848 ± 0.077	3.471GlyPhe: 3.471 ± 0.066	3.856GlyGly: 3.856 ± 0.103	0.954GlyHis: 0.954 ± 0.046	6.563GlyIle: 6.563 ± 0.105	5.648GlyLys: 5.648 ± 0.096	5.24GlyLeu: 5.24 ± 0.105	1.465GlyMet: 1.465 ± 0.048	2.589GlyAsn: 2.589 ± 0.071	1.471GlyPro: 1.471 ± 0.047	1.63GlyGln: 1.63 ± 0.056	2.758GlyArg: 2.758 ± 0.071	3.233GlySer: 3.233 ± 0.074	2.915GlyThr: 2.915 ± 0.067	4.415GlyVal: 4.415 ± 0.085	0.53GlyTrp: 0.53 ± 0.027	3.038GlyTyr: 3.038 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	0.768HisAla: 0.768 ± 0.041	0.175HisCys: 0.175 ± 0.017	0.671HisAsp: 0.671 ± 0.032	0.809HisGlu: 0.809 ± 0.037	0.824HisPhe: 0.824 ± 0.033	0.983HisGly: 0.983 ± 0.038	0.309HisHis: 0.309 ± 0.024	1.208HisIle: 1.208 ± 0.043	0.855HisLys: 0.855 ± 0.034	1.341HisLeu: 1.341 ± 0.042	0.263HisMet: 0.263 ± 0.018	0.632HisAsn: 0.632 ± 0.032	0.816HisPro: 0.816 ± 0.035	0.44HisGln: 0.44 ± 0.026	0.616HisArg: 0.616 ± 0.028	0.731HisSer: 0.731 ± 0.033	0.666HisThr: 0.666 ± 0.032	0.813HisVal: 0.813 ± 0.031	0.131HisTrp: 0.131 ± 0.012	0.569HisTyr: 0.569 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.087IleAla: 6.087 ± 0.112	1.113IleCys: 1.113 ± 0.04	5.56IleAsp: 5.56 ± 0.102	8.244IleGlu: 8.244 ± 0.135	4.536IlePhe: 4.536 ± 0.1	5.456IleGly: 5.456 ± 0.093	1.073IleHis: 1.073 ± 0.038	7.726IleIle: 7.726 ± 0.136	8.103IleLys: 8.103 ± 0.129	9.45IleLeu: 9.45 ± 0.164	1.878IleMet: 1.878 ± 0.052	4.298IleAsn: 4.298 ± 0.088	3.38IlePro: 3.38 ± 0.079	2.223IleGln: 2.223 ± 0.054	3.355IleArg: 3.355 ± 0.065	6.149IleSer: 6.149 ± 0.093	4.197IleThr: 4.197 ± 0.075	7.024IleVal: 7.024 ± 0.104	0.605IleTrp: 0.605 ± 0.028	3.62IleTyr: 3.62 ± 0.071	0.0IleXaa: 0.0 ± 0.0
Lys	4.915LysAla: 4.915 ± 0.096	0.709LysCys: 0.709 ± 0.038	5.177LysAsp: 5.177 ± 0.091	8.606LysGlu: 8.606 ± 0.152	3.406LysPhe: 3.406 ± 0.078	4.996LysGly: 4.996 ± 0.077	1.006LysHis: 1.006 ± 0.034	8.738LysIle: 8.738 ± 0.118	8.562LysLys: 8.562 ± 0.142	7.837LysLeu: 7.837 ± 0.098	2.283LysMet: 2.283 ± 0.058	5.551LysAsn: 5.551 ± 0.095	2.547LysPro: 2.547 ± 0.066	2.408LysGln: 2.408 ± 0.06	4.048LysArg: 4.048 ± 0.09	4.564LysSer: 4.564 ± 0.099	3.965LysThr: 3.965 ± 0.08	6.696LysVal: 6.696 ± 0.111	0.716LysTrp: 0.716 ± 0.032	3.565LysTyr: 3.565 ± 0.087	0.0LysXaa: 0.0 ± 0.0
Leu	5.59LeuAla: 5.59 ± 0.093	1.128LeuCys: 1.128 ± 0.039	4.623LeuAsp: 4.623 ± 0.083	6.894LeuGlu: 6.894 ± 0.127	4.477LeuPhe: 4.477 ± 0.102	5.284LeuGly: 5.284 ± 0.109	1.204LeuHis: 1.204 ± 0.046	8.168LeuIle: 8.168 ± 0.146	9.692LeuLys: 9.692 ± 0.127	8.406LeuLeu: 8.406 ± 0.146	1.965LeuMet: 1.965 ± 0.052	4.682LeuAsn: 4.682 ± 0.084	3.402LeuPro: 3.402 ± 0.08	2.905LeuGln: 2.905 ± 0.071	3.631LeuArg: 3.631 ± 0.073	6.94LeuSer: 6.94 ± 0.111	4.123LeuThr: 4.123 ± 0.077	5.687LeuVal: 5.687 ± 0.1	0.7LeuTrp: 0.7 ± 0.035	3.435LeuTyr: 3.435 ± 0.08	0.0LeuXaa: 0.0 ± 0.0
Met	1.504MetAla: 1.504 ± 0.054	0.257MetCys: 0.257 ± 0.02	1.029MetAsp: 1.029 ± 0.035	1.286MetGlu: 1.286 ± 0.042	1.027MetPhe: 1.027 ± 0.042	1.477MetGly: 1.477 ± 0.051	0.289MetHis: 0.289 ± 0.022	2.053MetIle: 2.053 ± 0.049	2.117MetLys: 2.117 ± 0.051	2.235MetLeu: 2.235 ± 0.059	0.52MetMet: 0.52 ± 0.03	1.06MetAsn: 1.06 ± 0.037	1.008MetPro: 1.008 ± 0.037	0.751MetGln: 0.751 ± 0.037	0.988MetArg: 0.988 ± 0.038	1.243MetSer: 1.243 ± 0.04	1.019MetThr: 1.019 ± 0.036	1.616MetVal: 1.616 ± 0.047	0.178MetTrp: 0.178 ± 0.017	0.796MetTyr: 0.796 ± 0.036	0.0MetXaa: 0.0 ± 0.0
Asn	2.636AsnAla: 2.636 ± 0.071	0.537AsnCys: 0.537 ± 0.026	2.094AsnAsp: 2.094 ± 0.06	3.032AsnGlu: 3.032 ± 0.069	2.649AsnPhe: 2.649 ± 0.067	3.078AsnGly: 3.078 ± 0.08	0.596AsnHis: 0.596 ± 0.027	5.257AsnIle: 5.257 ± 0.107	3.679AsnLys: 3.679 ± 0.073	5.329AsnLeu: 5.329 ± 0.09	1.229AsnMet: 1.229 ± 0.044	2.31AsnAsn: 2.31 ± 0.065	2.258AsnPro: 2.258 ± 0.056	1.603AsnGln: 1.603 ± 0.053	1.789AsnArg: 1.789 ± 0.06	2.986AsnSer: 2.986 ± 0.07	2.21AsnThr: 2.21 ± 0.055	3.676AsnVal: 3.676 ± 0.077	0.478AsnTrp: 0.478 ± 0.026	1.932AsnTyr: 1.932 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	1.818ProAla: 1.818 ± 0.062	0.309ProCys: 0.309 ± 0.02	1.979ProAsp: 1.979 ± 0.06	2.68ProGlu: 2.68 ± 0.072	1.646ProPhe: 1.646 ± 0.046	1.874ProGly: 1.874 ± 0.051	0.614ProHis: 0.614 ± 0.03	2.512ProIle: 2.512 ± 0.058	2.353ProLys: 2.353 ± 0.062	2.636ProLeu: 2.636 ± 0.062	0.644ProMet: 0.644 ± 0.031	1.541ProAsn: 1.541 ± 0.046	1.092ProPro: 1.092 ± 0.041	1.396ProGln: 1.396 ± 0.047	1.18ProArg: 1.18 ± 0.044	1.852ProSer: 1.852 ± 0.052	1.665ProThr: 1.665 ± 0.05	2.694ProVal: 2.694 ± 0.06	0.322ProTrp: 0.322 ± 0.022	1.512ProTyr: 1.512 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	1.623GlnAla: 1.623 ± 0.052	0.188GlnCys: 0.188 ± 0.017	1.45GlnAsp: 1.45 ± 0.046	2.219GlnGlu: 2.219 ± 0.063	1.094GlnPhe: 1.094 ± 0.04	1.439GlnGly: 1.439 ± 0.042	0.403GlnHis: 0.403 ± 0.028	2.698GlnIle: 2.698 ± 0.068	3.64GlnLys: 3.64 ± 0.076	2.469GlnLeu: 2.469 ± 0.057	0.768GlnMet: 0.768 ± 0.032	1.949GlnAsn: 1.949 ± 0.059	0.869GlnPro: 0.869 ± 0.039	1.255GlnGln: 1.255 ± 0.053	1.399GlnArg: 1.399 ± 0.049	1.357GlnSer: 1.357 ± 0.051	1.457GlnThr: 1.457 ± 0.053	1.644GlnVal: 1.644 ± 0.049	0.193GlnTrp: 0.193 ± 0.018	0.959GlnTyr: 0.959 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	2.281ArgAla: 2.281 ± 0.058	0.423ArgCys: 0.423 ± 0.028	1.773ArgAsp: 1.773 ± 0.052	3.237ArgGlu: 3.237 ± 0.082	2.319ArgPhe: 2.319 ± 0.064	2.366ArgGly: 2.366 ± 0.057	0.599ArgHis: 0.599 ± 0.029	3.985ArgIle: 3.985 ± 0.072	3.53ArgLys: 3.53 ± 0.085	3.937ArgLeu: 3.937 ± 0.088	1.021ArgMet: 1.021 ± 0.038	1.873ArgAsn: 1.873 ± 0.055	1.269ArgPro: 1.269 ± 0.048	1.21ArgGln: 1.21 ± 0.046	1.922ArgArg: 1.922 ± 0.065	1.637ArgSer: 1.637 ± 0.047	1.698ArgThr: 1.698 ± 0.057	2.814ArgVal: 2.814 ± 0.07	0.397ArgTrp: 0.397 ± 0.025	1.831ArgTyr: 1.831 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	3.194SerAla: 3.194 ± 0.081	0.661SerCys: 0.661 ± 0.036	2.804SerAsp: 2.804 ± 0.069	3.82SerGlu: 3.82 ± 0.076	3.27SerPhe: 3.27 ± 0.071	3.822SerGly: 3.822 ± 0.091	0.879SerHis: 0.879 ± 0.038	5.447SerIle: 5.447 ± 0.102	5.137SerLys: 5.137 ± 0.086	5.421SerLeu: 5.421 ± 0.096	1.182SerMet: 1.182 ± 0.049	2.788SerAsn: 2.788 ± 0.073	1.901SerPro: 1.901 ± 0.047	2.209SerGln: 2.209 ± 0.064	2.13SerArg: 2.13 ± 0.063	4.392SerSer: 4.392 ± 0.091	2.937SerThr: 2.937 ± 0.069	3.695SerVal: 3.695 ± 0.082	0.498SerTrp: 0.498 ± 0.033	2.444SerTyr: 2.444 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	2.81ThrAla: 2.81 ± 0.072	0.465ThrCys: 0.465 ± 0.029	2.14ThrAsp: 2.14 ± 0.058	2.596ThrGlu: 2.596 ± 0.062	2.303ThrPhe: 2.303 ± 0.057	3.275ThrGly: 3.275 ± 0.078	0.705ThrHis: 0.705 ± 0.034	4.193ThrIle: 4.193 ± 0.084	3.583ThrLys: 3.583 ± 0.074	4.175ThrLeu: 4.175 ± 0.074	0.856ThrMet: 0.856 ± 0.038	2.141ThrAsn: 2.141 ± 0.058	1.77ThrPro: 1.77 ± 0.054	1.468ThrGln: 1.468 ± 0.048	1.734ThrArg: 1.734 ± 0.043	2.755ThrSer: 2.755 ± 0.072	2.521ThrThr: 2.521 ± 0.07	3.36ThrVal: 3.36 ± 0.081	0.345ThrTrp: 0.345 ± 0.024	1.862ThrTyr: 1.862 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	4.727ValAla: 4.727 ± 0.083	0.959ValCys: 0.959 ± 0.04	4.155ValAsp: 4.155 ± 0.089	5.57ValGlu: 5.57 ± 0.095	3.713ValPhe: 3.713 ± 0.077	4.3ValGly: 4.3 ± 0.083	0.858ValHis: 0.858 ± 0.038	6.413ValIle: 6.413 ± 0.093	5.973ValLys: 5.973 ± 0.102	7.151ValLeu: 7.151 ± 0.106	1.542ValMet: 1.542 ± 0.051	3.143ValAsn: 3.143 ± 0.066	2.398ValPro: 2.398 ± 0.06	1.76ValGln: 1.76 ± 0.047	2.534ValArg: 2.534 ± 0.06	4.226ValSer: 4.226 ± 0.075	3.153ValThr: 3.153 ± 0.086	5.836ValVal: 5.836 ± 0.112	0.585ValTrp: 0.585 ± 0.032	3.111ValTyr: 3.111 ± 0.072	0.0ValXaa: 0.0 ± 0.0
Trp	0.64TrpAla: 0.64 ± 0.034	0.117TrpCys: 0.117 ± 0.013	0.459TrpAsp: 0.459 ± 0.026	0.585TrpGlu: 0.585 ± 0.032	0.481TrpPhe: 0.481 ± 0.028	0.554TrpGly: 0.554 ± 0.033	0.185TrpHis: 0.185 ± 0.017	0.608TrpIle: 0.608 ± 0.029	0.544TrpLys: 0.544 ± 0.03	0.824TrpLeu: 0.824 ± 0.03	0.165TrpMet: 0.165 ± 0.016	0.442TrpAsn: 0.442 ± 0.027	0.208TrpPro: 0.208 ± 0.02	0.361TrpGln: 0.361 ± 0.022	0.302TrpArg: 0.302 ± 0.023	0.416TrpSer: 0.416 ± 0.025	0.396TrpThr: 0.396 ± 0.025	0.491TrpVal: 0.491 ± 0.028	0.146TrpTrp: 0.146 ± 0.014	0.312TrpTyr: 0.312 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.039TyrAla: 2.039 ± 0.048	0.484TyrCys: 0.484 ± 0.026	2.16TyrAsp: 2.16 ± 0.064	2.977TyrGlu: 2.977 ± 0.066	2.489TyrPhe: 2.489 ± 0.066	2.368TyrGly: 2.368 ± 0.064	0.647TyrHis: 0.647 ± 0.032	3.996TyrIle: 3.996 ± 0.086	3.35TyrLys: 3.35 ± 0.072	3.959TyrLeu: 3.959 ± 0.088	0.827TyrMet: 0.827 ± 0.035	2.255TyrAsn: 2.255 ± 0.06	1.477TyrPro: 1.477 ± 0.047	1.292TyrGln: 1.292 ± 0.043	1.581TyrArg: 1.581 ± 0.045	2.655TyrSer: 2.655 ± 0.058	1.949TyrThr: 1.949 ± 0.06	2.776TyrVal: 2.776 ± 0.065	0.329TyrTrp: 0.329 ± 0.024	1.925TyrTyr: 1.925 ± 0.068	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2133 proteins (692621 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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